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Cyclin-dependent kinase 9 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
DinaciclibIC504.0 [1], 178.0 [2]
Sns-032IC504.0 [1], 458.0 [2], 550.0 [3]
Sns-032Ki4.0 [1]
AlvocidibIC5020.0 [1]
AlvocidibKi3.0 [1]
PalbociclibIC50794.33 [1], 892.0 [2]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC5034.0 [1]
4-N-[5-[(5-Tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]cyclohexane-1,4-diamineIC50355.0 [1], 10000.0 [2]
2-[4-[4-(4,5-Difluoro-8-methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2,4,6,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexyl]acetic acidIC5058.0 [1], 82.0 [2]
4-[4-(8-Methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2,4,6,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexane-1-carboxylic acidIC50120.0 [1], 150.0 [2]
3-[4-(4-Fluoro-8-methyl-8,13,15-triazatetracyclo[9.6.1.02,7.014,18]octadeca-1(18),2(7),3,5,11,14,16-heptaen-12-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclobutane-1-carboxylic acidIC50150.0 [1], 160.0 [2]
4-[4-(16-Fluoro-8-methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2,4,6,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexane-1-carboxylic acidIC5063.0 [1], 80.0 [2]
2-[4-[4-(8-Methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2,4,6,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexyl]acetic acidIC5090.0 [1], 110.0 [2]
2-[4-[4-(4-Fluoro-8-methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2(7),3,5,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexyl]acetic acidIC5048.0 [1], 64.0 [2]
3-[4-[(9S)-9-Ethyl-4-fluoro-8-methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2(7),3,5,10,13,15-heptaen-11-yl]-3,6-dihydro-2H-pyridin-1-yl]cyclobutane-1-carboxylic acidIC50110.0 [1]
2-[4-[4-(16-Fluoro-8-methyl-8,12,14-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(17),2,4,6,10,13,15-heptaen-11-yl)-3,6-dihydro-2H-pyridin-1-yl]cyclohexyl]acetic acidIC5071.0 [1], 73.0 [2]
[[2,3-Difluoro-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamideIC502.0 [1], 3.0 [2]
Ethyl N-[[3-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamateIC508.0 [1], 38.0 [2]
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amineIC507.0 [1], 106.0 [2]
Ethyl N-[[3-[[5-fluoro-4-(4-fluoro-2-phenylmethoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamateIC509.0 [1], 12.0 [2]
5-Fluoro-4-(4-fluoro-2-phenylmethoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amineIC505.0 [1], 8.0 [2]
[[3-[[5-Fluoro-4-(4-fluoro-2-phenylmethoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamideIC5025.0 [1], 35.0 [2]
1-[[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]-3-methylureaIC507.0 [1], 23.0 [2]
Ethyl N-[[3-fluoro-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamateIC508.0 [1], 12.0 [2]
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[3-fluoro-5-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amineIC509.0 [1], 37.0 [2]
[[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamideIC507.0 [1], 11.0 [2]
[Ethyl-[[3-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl]-oxo-lambda6-sulfanylidene]cyanamideIC502.0 [1], 9.0 [2]
N-[3-[(Ethylsulfonimidoyl)methyl]phenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amineIC507.0 [1], 125.0 [2]
N-[3,4-Difluoro-5-[(methylsulfonimidoyl)methyl]phenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amineIC504.0 [1], 57.0 [2]
[[3-Bromo-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamideIC502.0 [1], 4.0 [2]
N-[3-Bromo-5-[(methylsulfonimidoyl)methyl]phenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amineIC503.0 [1], 4.0 [2]
[[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]-5-methoxyphenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamideIC501.0 [1], 4.0 [2]
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[3-methoxy-5-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amineIC504.0 [1], 6.0 [2]
[[3-[[4-(2-Ethoxy-4-fluorophenyl)-5-fluoropyrimidin-2-yl]amino]-5-fluorophenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamideIC505.0 [1], 8.0 [2]
4-(2-Ethoxy-4-fluorophenyl)-5-fluoro-N-[3-fluoro-5-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amineIC505.0 [1], 73.0 [2]
[[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]-5-(trifluoromethyl)phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamideIC504.0 [1]
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]-5-(trifluoromethyl)phenyl]pyrimidin-2-amineIC502.0 [1], 3.0 [2]
N-[3-[(Ethylsulfonimidoyl)methyl]-5-fluorophenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amineIC505.0 [1], 45.0 [2]
[[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]-5-(1,1,2,2,2-pentafluoroethyl)phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamideIC508.0 [1], 25.0 [2]
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]-5-(1,1,2,2,2-pentafluoroethyl)phenyl]pyrimidin-2-amineIC505.0 [1], 6.0 [2]
[Cyclopropyl-[[3-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl]-oxo-lambda6-sulfanylidene]cyanamideIC502.0 [1], 5.0 [2]
N-[3-[(Cyclopropylsulfonimidoyl)methyl]phenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amineIC5014.0 [1], 279.0 [2]
[Cyclopropyl-[[3-fluoro-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl]-oxo-lambda6-sulfanylidene]cyanamideIC504.0 [1], 6.0 [2]
N-[3-[(Cyclopropylsulfonimidoyl)methyl]-5-fluorophenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amineIC507.0 [1], 51.0 [2]
5-Fluoro-4-[4-fluoro-2-[(4-fluorophenyl)methoxy]phenyl]-N-[3-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amineIC504.0 [1], 5.0 [2]
[[3-Chloro-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamideIC502.0 [1], 4.0 [2]
N-[3-Chloro-5-[(methylsulfonimidoyl)methyl]phenyl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amineIC505.0 [1], 7.0 [2]
[[3-[[5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]-5-methylphenyl]methyl-methyl-oxo-lambda6-sulfanylidene]cyanamideIC502.0 [1], 3.0 [2]
2-Methoxyethyl N-[[3-fluoro-5-[[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamateIC503.0 [1]
4-(3,4-Dihydro-2H-chromen-8-yl)-5-fluoro-N-[3-[(methylsulfonimidoyl)methyl]phenyl]pyrimidin-2-amineIC508.0 [1], 67.0 [2]
Ethyl N-[[3-[[4-(3,4-dihydro-2H-chromen-8-yl)-5-fluoropyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamateIC5014.0 [1]
Ethyl N-[[3-[[4-(2,3-dihydro-1-benzofuran-7-yl)-5-fluoropyrimidin-2-yl]amino]phenyl]methyl-methyl-oxo-lambda6-sulfanylidene]carbamateIC509.0 [1], 10.0 [2]
2-[4-[4-[4-(5-Fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydro-2H-pyridin-1-yl]cyclohexyl]acetic acidIC5057.0 [1], 71.0 [2]
SulfuretinIC502160.0 [1]
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamideIC5010.0 [1]
Pik-75IC501.4 [1]
(16E)-14-Methyl-20-oxa-5,7,14,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),16,21,23-decaeneIC503.0 [1]
4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amineKi480.0 [1]
BS-181IC502180.0 [1]
4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenolIC50350.0 [1]
Cdk/Crk InhibitorIC509.0 [1]
IlorasertibIC5010000.0 [1]
Atuveciclib RacemateIC50385.0 [1]
2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl)amino]pyridin-4-Yl}benzamideKi111.0 [1]
2-(2-Amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-oneIC5029.0 [1]
Cyc065IC50100.0 [1]
[4-(2-Amino-4-methyl-thiazol-5-YL)-pyrimidin-2-YL]-(3-nitro-phenyl)-amineKi4.0 [1]
(7S)-2-(2-Aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneIC5028.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi1644.0 [1]
(2~{R},3~{S})-3-[[9-Propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-olIC50107.0 [1]
1-(4-(4-(4-(4-Methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanoneKi448.0 [1]
(2R)-1-[4-[4-[(5-Chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-3,5-dimethylpyrazol-1-yl]piperidin-1-yl]-2-hydroxypropan-1-oneIC50450.0 [1]
N-{4-[(7-Hydroxy-6-Methoxyquinazolin-4-Yl)amino]phenyl}benzamideIC5030000.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC505330.0 [1]
5-(2-Aminopyrimidin-4-yl)-2-(2,4-dichlorophenyl)-1H-pyrrole-3-carboxamideIC5010.0 [1]
N-(5-(2-(Cyclohexyloxy)pyrimidin-4-yl)thiazol-2-yl)pyridin-2-amineIC502.5 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
N-[4-(2,4-Dimethyl-thiazol-5-YL)-pyrimidin-2-YL]-N',N'-dimethyl-benzene-1,4-diamineKi575.0 [1]
3-Methyl-5-pyridin-3-yl-2H-indazoleIC50630.96 [1]
BMS-387032 analog 19IC50550.0 [1]
1-(4-(4-(4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanoneKi1153.0 [1]
4-(2,4-Dimethylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amineKi10000.0 [1]
N-Ethyl-4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amineKi559.0 [1]
N,4-Dimethyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amineKi2605.0 [1]
5-(((5-(Tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-amineIC5010000.0 [1]
2-(2-Aminopyrimidin-4-yl)-7-(propan-2-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-oneIC5031.0 [1]
4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyphenyl)pyrimidin-2-amineKi11.0 [1]
N-(4-(4-(2-(Ethylamino)-4-methylthiazol-5-yl)pyrimidin-2-ylamino)benzyl)acetamideKi9.0 [1]
N-Ethyl-4-methyl-5-(2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)thiazol-2-amineKi564.0 [1]
N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)thiazol-2-amineKi6.0 [1]
4-(2,4-Dimethylthiazol-5-yl)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrimidin-2-amineKi1472.0 [1]
N-[4-[[7-(2-Amino-2-oxoethoxy)-6-methoxyquinazolin-4-yl]amino]phenyl]benzamideIC5030000.0 [1]
N-[4-[(4-Hydroxy-3-methoxybenzoyl)amino]phenyl]pyridine-2-carboxamideIC5030000.0 [1]
N-(4-Benzamidophenyl)-4-hydroxy-3-methoxybenzamideIC5030000.0 [1]
2-Amino-N-(4-benzamidophenyl)-4-hydroxy-5-methoxybenzamideIC5030000.0 [1]
2-[4-[(4-Benzamidophenyl)carbamoyl]-2-methoxyphenoxy]acetic acidIC5030000.0 [1]
N-[4-[[3-(2,4-Dioxo-1H-pyrimidin-5-yl)benzoyl]amino]phenyl]pyridine-2-carboxamideIC5030000.0 [1]
N-[4-[[3-(2,4-Dioxo-1H-pyrimidin-5-yl)-4-methoxybenzoyl]amino]phenyl]pyridine-2-carboxamideIC5030000.0 [1]
N-[4-[[3-(2,4-Dioxo-1,3-diazinan-1-yl)-5-methoxybenzoyl]amino]phenyl]pyridine-2-carboxamideIC5030000.0 [1]
N-[4-[[3-(2,4-Dioxo-1H-pyrimidin-5-yl)-5-methoxybenzoyl]amino]phenyl]piperidine-2-carboxamideIC5030000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cyclin-dependent kinase 9 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-9-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Cyclin-dependent kinase 9 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-9-inhibitors-ic50-ki.
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