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Cyclin-dependent kinase 8/19 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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8-(3-Chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-oneIC505.0 [1]
8-[2-Azanyl-3-Chloranyl-5-(1-Methylindazol-5-Yl)pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-OneIC5011.8 [1]
8-[3-(3-Azanyl-2~{h}-Indazol-6-Yl)-5-Chloranyl-Pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-OneIC5013.6 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC501.4 [1]
5-[5-Chloro-4-[1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxideIC5073.5 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-methyl-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC500.7 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-(trifluoromethyl)-2,3,8-triazaspiro[4.5]dec-1-en-4-oneIC503.7 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-methyl-2,3,8-triazaspiro[4.5]dec-1-en-4-oneIC500.08 [1]
9-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,4,9-triazaspiro[5.5]undecane-2,5-dioneIC5034.3 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-oneIC508.7 [1]
8-[3-Chloro-5-[4-[1-(2-hydroxyethyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC504.6 [1]
8-[3-[4-(1-Methylpyrazol-4-yl)phenyl]-5-(trifluoromethyl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC5023.8 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5023.0 [1]
8-[3-Chloro-5-[4-(1,2-dimethylimidazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5019.5 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2-methyl-1,3,8-triazaspiro[4.5]dec-1-en-4-oneIC5033.5 [1]
8-[3-[4-(1-Methylpyrazol-4-yl)phenyl]-5-(trifluoromethyl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC503.5 [1]
8-[3-Chloro-5-[4-[1-(2-hydroxy-2-methylpropyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5013.1 [1]
8-[3-Fluoro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC5055.4 [1]
8-[3-Fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC5013.6 [1]
8-[3-(3-Amino-1-methylindazol-6-yl)-5-chloropyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC501.8 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5035.5 [1]
8-[3-Fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5014.5 [1]
8-[3-Chloro-5-[3-(methylamino)-1H-indazol-6-yl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC502.9 [1]
1-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-4-[2-(dimethylamino)ethyl]piperidine-4-carbonitrileIC507.4 [1]
8-[3-(1-Methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)-5-(trifluoromethyl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC500.6 [1]
5-[5-Chloro-4-(1-methyl-1,8-diazaspiro[4.5]decan-8-yl)pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxideIC50342.0 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decaneIC50621.0 [1]
5-[5-Chloro-4-[1-(3-methoxypropyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxideIC5086.3 [1]
5-[5-Chloro-4-[1-(3-methylsulfonylpropyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxideIC5075.4 [1]
8-[3-Chloro-5-(2,2-dioxo-1,3-dihydro-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC50115.3 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC501.0 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-6-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5015.0 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-3-oxa-1,8-diazaspiro[4.5]decan-2-oneIC503433.0 [1]
8-[3-Chloro-5-[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5023.9 [1]
8-[3-Chloro-5-[4-[1-(2-pyrrolidin-1-ylethyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5022.3 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC5014.6 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-4,4-dimethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC50109.0 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-methyl-1,3,8-triazaspiro[4.5]decan-4-oneIC502.4 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-(2,2,2-trifluoroethyl)-1,3,8-triazaspiro[4.5]decan-4-oneIC504.0 [1]
8-[2-Amino-3-chloro-5-(1-propan-2-ylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5058.3 [1]
8-[3-Fluoro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC50186.0 [1]
8-[3-Chloro-5-[3-(dimethylamino)-1-methylindazol-6-yl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC50110.0 [1]
8-[2-Amino-5-(3-amino-1H-indazol-6-yl)-3-chloropyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5042.5 [1]
8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC505.3 [1]
8-[2-Amino-3-chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC505.2 [1]
8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC5012.8 [1]
8-[2-Amino-3-chloro-5-(1-methylindazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC5036.0 [1]
8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC508.7 [1]
8-[2-Amino-3-chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC501.1 [1]
8-[2-Amino-5-[4-(1-methylpyrazol-4-yl)phenyl]-3-(trifluoromethyl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC5012.7 [1]
8-[2-Amino-5-[4-(1-methylpyrazol-4-yl)phenyl]-3-(trifluoromethyl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC502.1 [1]
8-[2-Amino-3-fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC50101.0 [1]
8-[2-Amino-3-fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5018.4 [1]
8-[2-Amino-3-chloro-5-[4-[1-(2-hydroxy-2-methylpropyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC508.6 [1]
8-[2-Amino-3-chloro-5-[4-(1-propan-2-ylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5022.5 [1]
Items per page: 1 - 10 of 55
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cyclin-dependent kinase 8/19 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-8-19-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Cyclin-dependent kinase 8/19 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-8-19-inhibitors-ic50-ki.
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