![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_7bfac7be1a991d1d508432f91e80551f.svg) | 8-(3-Chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one | IC50 | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_212383dfe7364b45c2a341c88a68fd1f.svg) | 8-[2-Azanyl-3-Chloranyl-5-(1-Methylindazol-5-Yl)pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-One | IC50 | 11.8 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_5cca12c4fa2755887a8f7def95dfdcd2.svg) | 8-[3-(3-Azanyl-2~{h}-Indazol-6-Yl)-5-Chloranyl-Pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-One | IC50 | 13.6 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_a93c5e7f5bf57468319a4308a110b4ea.svg) | 8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | IC50 | 1.4 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_fe975879ca22e4d3b80dc80ed83e5e8e.svg) | 5-[5-Chloro-4-[1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxide | IC50 | 73.5 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_5ffdbaeb6425c524abced98b7e15961f.svg) | 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-methyl-1,3,8-triazaspiro[4.5]decane-2,4-dione | IC50 | 0.7 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_a17aebbdfc89178c7f467a4807719a15.svg) | 8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-(trifluoromethyl)-2,3,8-triazaspiro[4.5]dec-1-en-4-one | IC50 | 3.7 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_8f56bc10b95c328370ff42fc9c31886f.svg) | 8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-methyl-2,3,8-triazaspiro[4.5]dec-1-en-4-one | IC50 | 0.08 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_78c683d5085dbb40ef6c5988b58a9462.svg) | 9-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,4,9-triazaspiro[5.5]undecane-2,5-dione | IC50 | 34.3 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_ccf91b7c1e7dd6a9ad2aa42ce36ddf81.svg) | 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 8.7 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_9c79ceb4d89c18c308f1591b0976ae74.svg) | 8-[3-Chloro-5-[4-[1-(2-hydroxyethyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 4.6 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_ec76c833b8d02c9f6342a3094b519269.svg) | 8-[3-[4-(1-Methylpyrazol-4-yl)phenyl]-5-(trifluoromethyl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | IC50 | 23.8 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_a182a4e83ab79d3817ad69679cc7bdda.svg) | 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dione | IC50 | 23.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_f68b3479bd0e29a0325f40e35ec8d21a.svg) | 8-[3-Chloro-5-[4-(1,2-dimethylimidazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 19.5 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_7b272950a9a21472755ef06d1ad18b4a.svg) | 8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2-methyl-1,3,8-triazaspiro[4.5]dec-1-en-4-one | IC50 | 33.5 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_eb6be8d25d16b3080c9b78e0c5a1b650.svg) | 8-[3-[4-(1-Methylpyrazol-4-yl)phenyl]-5-(trifluoromethyl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 3.5 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_4e1c830b27d3ae17a2c340377f73c21a.svg) | 8-[3-Chloro-5-[4-[1-(2-hydroxy-2-methylpropyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 13.1 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_27f33cc45c110acd52d9fe148339d9a3.svg) | 8-[3-Fluoro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | IC50 | 55.4 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_9a63c23cd2eca681029c7fa62f78d542.svg) | 8-[3-Fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | IC50 | 13.6 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_b0a71b75269641fdd0bd7b46e3a5d14c.svg) | 8-[3-(3-Amino-1-methylindazol-6-yl)-5-chloropyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 1.8 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_47202047941c8db63a85f5a880e9a5c6.svg) | 8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dione | IC50 | 35.5 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_734594d389ae4a54e14ff222d9646e14.svg) | 8-[3-Fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 14.5 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_7ee3dd259f46e12c7d71f69edf45a3d4.svg) | 8-[3-Chloro-5-[3-(methylamino)-1H-indazol-6-yl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 2.9 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_d5b20d7087a8762e43c1b4cc8e6e3587.svg) | 1-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-4-[2-(dimethylamino)ethyl]piperidine-4-carbonitrile | IC50 | 7.4 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_8b7173720500c473e778d1040f892eb8.svg) | 8-[3-(1-Methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)-5-(trifluoromethyl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 0.6 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_de49d520e09ef5f7f53818d8c03c2804.svg) | 5-[5-Chloro-4-(1-methyl-1,8-diazaspiro[4.5]decan-8-yl)pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxide | IC50 | 342.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_ddd943ea5ac22d94cbed5e56e659dc1f.svg) | 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decane | IC50 | 621.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_7279c26ad22f6082f09fd09910167f55.svg) | 5-[5-Chloro-4-[1-(3-methoxypropyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxide | IC50 | 86.3 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_dda54eaa3ad88065d37267c13926b534.svg) | 5-[5-Chloro-4-[1-(3-methylsulfonylpropyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxide | IC50 | 75.4 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_2314fa94c6f3727735894a67139fee8b.svg) | 8-[3-Chloro-5-(2,2-dioxo-1,3-dihydro-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 115.3 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_e5690ff115ed9f2fa9067e02683ca808.svg) | 8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_1852a4dc0bc7416d33ee46c4f3110f58.svg) | 8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-6-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_49f6d56f91da53f806ff5d49345a0386.svg) | 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-3-oxa-1,8-diazaspiro[4.5]decan-2-one | IC50 | 3433.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_d3928a9e868e9d0791bcbdc4a7bced39.svg) | 8-[3-Chloro-5-[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 23.9 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_2e2c5a6ad3c976aa125d9085a768dc5b.svg) | 8-[3-Chloro-5-[4-[1-(2-pyrrolidin-1-ylethyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 22.3 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_7cc8f9cbe12e8605e989aca42053c5cc.svg) | 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | IC50 | 14.6 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_760e773b8bf5080b19666253203eb627.svg) | 8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-4,4-dimethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one | IC50 | 109.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_411c01bf12ab164405f056ec4875e192.svg) | 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-methyl-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 2.4 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_08a9bad09244ec72b53e29f5e3b85068.svg) | 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-(2,2,2-trifluoroethyl)-1,3,8-triazaspiro[4.5]decan-4-one | IC50 | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_aaafe43bc131dc91bdfb0012c5df532c.svg) | 8-[2-Amino-3-chloro-5-(1-propan-2-ylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 58.3 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_b9c586c265fb3f9bbc852335aa5d216e.svg) | 8-[3-Fluoro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 186.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_12ea5c85150b7795e1ed4687e5c1cb91.svg) | 8-[3-Chloro-5-[3-(dimethylamino)-1-methylindazol-6-yl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 110.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_a66d3899f108a7467e5dba9f350201c9.svg) | 8-[2-Amino-5-(3-amino-1H-indazol-6-yl)-3-chloropyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 42.5 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_f965ccdd168f871dab3a74c14cd77084.svg) | 8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dione | IC50 | 5.3 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_412da7e61f6a999d11d2a4ef3bbb2ac5.svg) | 8-[2-Amino-3-chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | IC50 | 5.2 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_270cd14b0571cee7ff415ede91c4f8ef.svg) | 8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | IC50 | 12.8 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_ade1eed20303600591718baf4d3c3ba2.svg) | 8-[2-Amino-3-chloro-5-(1-methylindazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | IC50 | 36.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_4c3ccf8db4b3a78e1aa93bd50b1e3ed9.svg) | 8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 8.7 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_7e1c481f16161f81701af337b5507abd.svg) | 8-[2-Amino-3-chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 1.1 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_42158bb3993b05356dae279519fb4e2c.svg) | 8-[2-Amino-5-[4-(1-methylpyrazol-4-yl)phenyl]-3-(trifluoromethyl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | IC50 | 12.7 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_531bac82236792d8e341f7b701064184.svg) | 8-[2-Amino-5-[4-(1-methylpyrazol-4-yl)phenyl]-3-(trifluoromethyl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 2.1 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_126399142c936f62a5a4137fbfacd997.svg) | 8-[2-Amino-3-fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | IC50 | 101.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_e4a0175c0feb5094ec64bce3f5339613.svg) | 8-[2-Amino-3-fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 18.4 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_f8597741a8a15c840e5c63b742f5b08b.svg) | 8-[2-Amino-3-chloro-5-[4-[1-(2-hydroxy-2-methylpropyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 8.6 [1] |
![](https://images.aatbio.com/dataset/ic50/cyclin-dependent-kinase-8-19_1f91e7a3859018886cfa45251f67fb9e.svg) | 8-[2-Amino-3-chloro-5-[4-(1-propan-2-ylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | IC50 | 22.5 [1] |