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Cyclin-dependent kinase 7 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
PDGF Receptor Tyrosine Kinase Inhibitor IVIC5010000.0 [1], 56700.0 [2]
(2~{R},3~{S})-3-[[9-Propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-olIC501300.0 [1]
3-[5-(Morpholin-4-ylmethyl)-1h-indol-2-yl]-1h-indazole-6-carbonitrileIC5011.0 [1]
CrizotinibIC5010000.0 [1]
AlvocidibIC50875.0 [1]
PalbociclibIC5010000.0 [1]
CID 11612883IC50197.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC5010000.0 [1]
4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amineKi10000.0 [1]
BS-181IC50134.0 [1]
CID 73602827IC503.2 [1]
8-[2-Methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5010000.0 [1]
[4-(2-Amino-4-methyl-thiazol-5-YL)-pyrimidin-2-YL]-(3-nitro-phenyl)-amineKi70.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi1525.0 [1]
1-(4-(4-(4-(4-Methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanoneKi1080.0 [1]
2(3H)-Thiazolone, 3,4-diMethyl-5-[2-[[4-(1-piperazinyl)phenyl]aMino]-4-pyriMidinyl]-Ki2.3 [1]
(2R)-1-[4-[4-[(5-Chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-3,5-dimethylpyrazol-1-yl]piperidin-1-yl]-2-hydroxypropan-1-oneIC50300.0 [1]
N-(4-Morpholin-4-ylpyridin-2-yl)-5-(5-pyrimidin-5-ylpyridin-3-yl)-1,3-thiazol-2-amineIC5010000.0 [1]
N-(4-Piperazin-1-ylpyridin-2-yl)-5-[5-(1H-pyrazol-4-yl)pyridin-3-yl]-1,3-thiazol-2-amineIC50260.0 [1]
5-[2-[[4-(4-Acetylpiperazin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]-N-(2-aminoethyl)pyridine-3-carboxamideIC50210.0 [1]
N-(2-Aminoethyl)-5-[2-[[4-(4-methylsulfonylpiperazin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]pyridine-3-carboxamideIC50170.0 [1]
N-(2-Aminoethyl)-5-[2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl]pyridine-3-carboxamideIC50340.0 [1]
5-(6-Methylpyridin-3-yl)-N-(4-piperazin-1-ylpyridin-2-yl)-1,3-thiazol-2-amineIC5020000.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC502730.0 [1]
N-(5-(2-(Cyclohexyloxy)pyrimidin-4-yl)thiazol-2-yl)pyridin-2-amineIC5020.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
N-[4-(2,4-Dimethyl-thiazol-5-YL)-pyrimidin-2-YL]-N',N'-dimethyl-benzene-1,4-diamineKi4012.0 [1]
2-Bromo-N-(2,5-dichlorothiophen-3-yl)sulfonyl-N-phenylacetamideIC5020000.0 [1]
1-Morpholin-4-yl-2-[4-[2-[(5-pyridin-3-yl-1,3-thiazol-2-yl)amino]pyridin-4-yl]piperazin-1-yl]ethanoneIC501760.0 [1]
N-(4-Morpholin-4-ylpyridin-2-yl)-5-(5-pyridin-3-ylpyridin-3-yl)-1,3-thiazol-2-amineIC5010000.0 [1]
1-(4-(4-(4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanoneKi2804.0 [1]
4-(2,4-Dimethylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amineKi10000.0 [1]
N-Ethyl-4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amineKi10000.0 [1]
N,4-Dimethyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amineKi10000.0 [1]
(3R)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-olIC503100.0 [1]
(3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-olIC502500.0 [1]
4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyphenyl)pyrimidin-2-amineKi243.0 [1]
N-(4-(4-(2-(Ethylamino)-4-methylthiazol-5-yl)pyrimidin-2-ylamino)benzyl)acetamideKi171.0 [1]
N-Ethyl-4-methyl-5-(2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)thiazol-2-amineKi1395.0 [1]
N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)thiazol-2-amineKi370.0 [1]
4-(2,4-Dimethylthiazol-5-yl)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrimidin-2-amineKi10000.0 [1]
3-[2-(4-Amino-1-ethylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamideIC5010000.0 [1]
(2S,3R)-3-[[9-Propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-olIC50500.0 [1]
(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-olIC501100.0 [1]
(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-olIC501500.0 [1]
(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-olIC502200.0 [1]
(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-olIC503500.0 [1]
(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-olIC501600.0 [1]
(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-olIC503500.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamideIC50841.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-N-methylbenzenesulfonamideIC5010000.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-N,2-dimethylbenzenesulfonamideIC5010000.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-N-methyl-3-nitrobenzenesulfonamideIC509244.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-N,3-dimethylbenzenesulfonamideIC5010000.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-3-methoxy-N-methylbenzenesulfonamideIC5010000.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-N-methyl-3-(trifluoromethoxy)benzenesulfonamideIC5010000.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-3-cyano-N-methylbenzenesulfonamideIC5010000.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-N-methyl-4-nitrobenzenesulfonamideIC5010000.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-4-fluoro-N-methylbenzenesulfonamideIC5010000.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-N-methylpyridine-3-sulfonamideIC5010000.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-N-methyl-1-oxidopyridin-1-ium-3-sulfonamideIC5010000.0 [1]
5-Bromo-N-[(E)-(5-chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-N,2-dimethylbenzenesulfonamideIC5010000.0 [1]
3-[[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-methylsulfamoyl]-4-methylbenzoic acidIC5010000.0 [1]
N-[(E)-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-5-cyano-N,2-dimethylbenzenesulfonamideIC503590.0 [1]
N,2-Dimethyl-N-[(E)-(5-methylpyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-5-nitrobenzenesulfonamideIC508750.0 [1]
N-[(E)-[5-(3,4-Dimethoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamideIC5010000.0 [1]
N,2-Dimethyl-5-nitro-N-[(E)-(5-pyridin-3-ylpyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]benzenesulfonamideIC5010000.0 [1]
N-[(E)-[5-(6-Methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl]methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamideIC5010000.0 [1]
N-[(E)-(5-Cyanopyrazolo[1,5-a]pyrimidin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamideIC501811.0 [1]
N-[2-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)ethyl]-5-cyano-N,2-dimethylbenzenesulfonamideIC5010000.0 [1]
5-Chloro-3-[1-(2-methyl-5-nitrophenyl)sulfonylpyrazol-4-yl]pyrazolo[1,5-a]pyrimidineIC501680.0 [1]
6-[4-[(5-Tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-N-[3-(dimethylamino)propyl]imidazo[2,1-b][1,3]thiazole-3-carboxamideIC5010000.0 [1]
1-[[3-Propan-2-yl-7-[(4-pyridin-2-ylphenyl)methylamino]-2H-pyrazolo[4,3-d]pyrimidin-5-yl]amino]propan-2-olIC502780.0 [1]
1-[4-[4-[(5-Chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]pyrazol-1-yl]piperidin-1-yl]ethanoneIC5021.0 [1]
Methyl 3-[5-(morpholin-4-ylmethyl)-1h-indol-2-yl]-1h-indazole-6-carboxylateIC506500.0 [1]
(5-{3-[5-(Piperidin-1-Ylmethyl)-1h-Indol-2-Yl]-1h-Indazol-6-Yl}-2h-1,2,3-Triazol-4-Yl)methanolIC5056.0 [1]
[5-[3-[5-[(4-Fluoropiperidin-1-yl)methyl]-1H-indol-2-yl]-1H-indazol-6-yl]-2H-triazol-4-yl]methanamineIC50300.0 [1]
3-{5-[(4-Acetylpiperazin-1-yl)methyl]-1H-indol-2-yl}-1H-indazole-6-carbonitrileIC5039.0 [1]
2-Methoxy-4-{3-[5-(piperidin-1-ylmethyl)-1h-indol-2-yl]-1h-indazol-6-yl}phenolIC50310.0 [1]
[5-[3-[5-[(4-Fluoropiperidin-1-yl)methyl]-1H-indol-2-yl]-1H-indazol-6-yl]-2H-triazol-4-yl]methanolIC50180.0 [1]
3-[5-(Morpholin-4-ylmethyl)-1h-indol-2-yl]-1h-indazole-6-carboxamideIC501300.0 [1]
N-Methyl-3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-1H-indazole-6-carboxamideIC504900.0 [1]
CID 135559058IC50100000.0 [1]
4-({2-[6-(1H-Pyrazol-4-yl)-1H-indazol-3-yl]-1H-indol-5-yl}methyl)morpholineIC5025.0 [1]
4-({2-[6-(1H-Pyrazol-5-yl)-1H-indazol-3-yl]-1H-indol-5-yl}methyl)morpholineIC5034.0 [1]
4-{3-[5-(Piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazol-6-yl}-1,2-thiazoleIC5018.0 [1]
2-{3-[5-(Piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazol-6-yl}-1,3-thiazoleIC504000.0 [1]
3-[5-(Piperidin-1-ylmethyl)-1h-indol-2-yl]-6-(1h-1,2,3-triazol-1-yl)-1h-indazoleIC5057.0 [1]
6-(5-Methyl-1H-1,2,3-triazol-1-yl)-3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazoleIC50420.0 [1]
3-[5-(Piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(1H-pyrazol-1-yl)-1H-indazoleIC502300.0 [1]
3-[5-(Piperidin-1-ylmethyl)-1h-indol-2-yl]-6-(2h-1,2,3-triazol-2-yl)-1h-indazoleIC50480.0 [1]
6-Phenyl-3-[5-(piperidin-1-ylmethyl)-1h-indol-2-yl]-1h-indazoleIC507000.0 [1]
5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-oneIC5010000.0 [1]
N-[2-(Dimethylamino)ethyl]-N-methyl-4-[(8-methylsulfanyl-5,6-dihydropyrimido[4,5-f]quinazolin-2-yl)amino]benzamideIC503600.0 [1]
N-(4-Piperazin-1-ylpyridin-2-yl)-5-pyrimidin-5-yl-1,3-thiazol-2-amineIC5011000.0 [1]
5-(6-Methylpyridin-3-yl)-N-(6-piperazin-1-ylpyridin-2-yl)-1,3-thiazol-2-amineIC501000.0 [1]
N-(6-Piperazin-1-ylpyridin-2-yl)-5-pyrimidin-5-yl-1,3-thiazol-2-amineIC50410.0 [1]
5-(5-Bromopyridin-3-yl)-N-(4-piperazin-1-ylpyridin-2-yl)-1,3-thiazol-2-amineIC50480.0 [1]
5-[5-(1-Methylpyrazol-4-yl)pyridin-3-yl]-N-(4-piperazin-1-ylpyridin-2-yl)-1,3-thiazol-2-amineIC502000.0 [1]
5-{2-[(4-Morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl}nicotinamideIC503700.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cyclin-dependent kinase 7 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-7-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Cyclin-dependent kinase 7 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-7-inhibitors-ic50-ki.
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