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Cyclin-dependent kinase 7/ cyclin H Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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▼
Standard Values (in nM)
▲
▼
SeliciclibIC50500.0 [1]
Sns-032IC5062.0 [1]
4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenolIC5026000.0 [1]
(2R)-2-{[4-(Benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-olIC5043.0 [1], 500.0 [2]
[4-(2-Amino-4-methyl-thiazol-5-YL)-pyrimidin-2-YL]-(3-nitro-phenyl)-amineKi70.0 [1]
StaurosporineIC50910.0 [1]
AlvocidibIC50400.0 [1]
HarmineIC5010000.0 [1]
PalbociclibKi5000.0 [1]
MilciclibIC50150.0 [1]
O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purineIC504400.0 [1]
4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amineKi10000.0 [1]
Pha-793887IC5010.0 [1]
BS-181IC5021.0 [1]
Leucettine L41IC5010000.0 [1]
RGB-286638 free baseIC502.0 [1]
Cdk/Crk InhibitorIC5071.0 [1]
(2S,3S)-3-((7-(Benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)butane-1,2,4-triolIC50250.0 [1]
Leucettamine BIC5010000.0 [1]
CID 71561915Ki91.0 [1]
3,5-Diamino-4-phenylazopyrazoleIC50100000.0 [1]
Cyc065IC50193.0 [1]
3-[[5-Cyano-4-[4-Methyl-2-(Methylamino)-1,3-Thiazol-5-Yl]pyrimidin-2-Yl]amino]benzenesulfonamideKi114.0 [1]
(2R)-2-[[9-Propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]butan-1-olIC50180.0 [1]
Cyclapolin 9IC50100000.0 [1]
(2R)-2-[[9-Propan-2-yl-6-(pyridin-2-ylmethylamino)purin-2-yl]amino]butan-1-olIC5040.0 [1]
(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-(3-nitro-phenyl)-amineKi790.0 [1]
(2R)-2-[[9-Propan-2-yl-6-(pyridin-4-ylmethylamino)purin-2-yl]amino]butan-1-olIC50740.0 [1]
4-[4-Methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-[3-(morpholine-4-carbonyl)anilino]pyrimidine-5-carbonitrileKi1870.0 [1]
4-(4-Methyl-2-(methylamino)thiazol-5-yl)-2-(3-nitrophenylamino)pyrimidine-5-carbonitrileKi260.0 [1]
2-Bromo-N-(2,5-dichlorothiophen-3-yl)sulfonyl-N-phenylacetamideIC5033400.0 [1]
(2r)-2-{[7-(Benzylamino)-3-(Propan-2-Yl)-1h-Pyrazolo[4,3-D]pyrimidin-5-Yl]amino}butan-1-OlIC50160.0 [1]
2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 30Ki417.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-[3-(4-Acetyl-1,4-diazepan-1-yl)anilino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrileKi210.0 [1]
2-[3-(1,4-Diazepan-1-yl)anilino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrileKi46.0 [1]
N-Methyl-5-[2-(3-nitroanilino)pyrimidin-4-yl]-4-phenyl-1,3-thiazol-2-amineKi5000.0 [1]
4-Methyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamideIC50400.0 [1]
2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-, 3-oxideIC50100000.0 [1]
3-[[4-[4-[(3-Chlorophenyl)amino]-1,3,5-triazin-2-yl]-2-pyridinyl]amino]-1-PropanolIC50126.0 [1]
(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-olIC503900.0 [1]
(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-olIC505800.0 [1]
(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-olIC502400.0 [1]
(3RS,4R)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2,2-dimethyl-hexan-3-olIC503700.0 [1]
(3S)-3-[[6-(Benzylamino)-9-propan-2-ylpurin-2-yl]amino]pentan-2-olIC50690.0 [1]
(3S)-3-[[6-(Benzylamino)-9-propan-2-ylpurin-2-yl]amino]-2-methylpentan-2-olIC502000.0 [1]
(3RS,4R)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-hexan-3-olIC501200.0 [1]
(3RS,4S)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2-methyl-hexan-3-olIC503000.0 [1]
(R)-3-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2-methyl-pentan-2-olIC503700.0 [1]
(4R)-4-[[6-(Benzylamino)-9-propan-2-ylpurin-2-yl]amino]-2-methylhexan-3-olIC504400.0 [1]
(3RS,4S)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-2,2-dimethyl-hexan-3-olIC504300.0 [1]
(3RS,4S)-4-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-hexan-3-olIC501100.0 [1]
(3S)-3-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-olIC504300.0 [1]
(3R)-3-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-olIC504200.0 [1]
(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-olIC501200.0 [1]
(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-olIC502600.0 [1]
(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-2-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-olIC503300.0 [1]
(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-phenyl-amineKi2200.0 [1]
4-N,4-N-Dimethyl-1-N-(2-methyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-8-yl)benzene-1,4-diamineKi60.0 [1]
(6-Chloro-pyridin-3-yl)-(2-methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-amineKi1400.0 [1]
(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-(4-morpholin-4-yl-phenyl)-amineKi1000.0 [1]
8-N-(3-Nitrophenyl)-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazoline-2,8-diamineKi140.0 [1]
8-N-Phenyl-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazoline-2,8-diamineKi1200.0 [1]
4-(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-ylamino)-phenolKi300.0 [1]
Methyl-(2-methyl-thiazolo[4,5-h]quinazolin-8-yl)-(3-nitro-phenyl)-amineKi10000.0 [1]
2-Methyl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amineKi10000.0 [1]
3-(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-ylamino)-phenolKi53.0 [1]
(2-Methyl-thiazolo[4,5-h]quinazolin-8-yl)-phenyl-amineKi10000.0 [1]
(6-Methoxy-pyridin-3-yl)-(2-methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-amineKi1100.0 [1]
(2-Methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-(4-trifluoromethyl-phenyl)-amineKi10000.0 [1]
Methyl-(2-methyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-8-yl)-(3-nitro-phenyl)-amineKi1800.0 [1]
N,4-Dimethyl-5-[2-(4-methyl-3-morpholin-4-ylsulfonylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amineKi150.0 [1]
(3R)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-olIC503100.0 [1]
(3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-olIC502500.0 [1]
3-[[4-[4-Methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamideKi1960.0 [1]
(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-olIC501100.0 [1]
(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-olIC501500.0 [1]
(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-olIC502200.0 [1]
(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-olIC503500.0 [1]
(3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-olIC501600.0 [1]
(3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-olIC503500.0 [1]
4-Methyl-5-[2-[(5-morpholin-4-ylpyridin-2-yl)amino]pyrimidin-4-yl]-N-propan-2-yl-1,3-thiazol-2-amineKi5000.0 [1]
N-Cyclopentyl-4-methyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-1,3-thiazol-2-amineKi1108.0 [1]
N-Cyclopentyl-5-[5-fluoro-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amineKi790.0 [1]
N-Cyclopentyl-5-[2-[[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]amino]-5-fluoropyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amineKi630.0 [1]
N-Cyclopentyl-N,4-dimethyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-1,3-thiazol-2-amineKi3200.0 [1]
N-Cyclopentyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-amineKi194.0 [1]
N-Cyclopentyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-4-(trifluoromethyl)-1,3-thiazol-2-amineKi189.0 [1]
4-Methyl-N-phenyl-5-[2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrimidin-4-yl]-1,3-thiazol-2-amineKi1660.0 [1]
4-[6-[[4-[2-(Cyclopentylamino)-4-(trifluoromethyl)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]pyridin-3-yl]piperazine-1-carbaldehydeKi1900.0 [1]
4-Methyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-N-propan-2-yl-1,3-thiazol-2-amineKi760.0 [1]
1-[4-[6-[[4-[4-Methyl-2-(propan-2-ylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]pyridin-3-yl]piperazin-1-yl]ethanoneKi4385.0 [1]
N-Cyclopentyl-4-methyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-1,3-thiazol-2-amineKi865.0 [1]
N-Cyclopentyl-5-[2-[[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino]-5-fluoropyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amineKi685.0 [1]
5-[2-[[5-(4-Aminopiperidin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-N-cyclopentyl-4-methyl-1,3-thiazol-2-amineKi1187.0 [1]
1-[4-[6-[[4-[2-(Cyclopentylamino)-4-methyl-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]pyridin-3-yl]piperazin-1-yl]ethanoneKi3453.0 [1]
N-Cyclopentyl-5-[2-[[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amineKi780.0 [1]
N-Cyclopentyl-5-[2-[[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]amino]pyrimidin-4-yl]-4-methyl-1,3-thiazol-2-amineKi211.0 [1]
N,4-Dimethyl-5-[2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-N-phenyl-1,3-thiazol-2-amineKi5000.0 [1]
5-[2-[[5-(1,4-Diazepan-1-yl)pyridin-2-yl]amino]pyrimidin-4-yl]-4-methyl-N-propan-2-yl-1,3-thiazol-2-amineKi1160.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cyclin-dependent kinase 7/ cyclin H Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-7-cyclin-h-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Cyclin-dependent kinase 7/ cyclin H Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-7-cyclin-h-inhibitors-ic50-ki.
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