Cyclin-dependent kinase 5/CDK5 activator 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Seliciclib	IC50	270.0 [1]
	Staurosporine	IC50	1.2 [1], 3.8 [2], 4.0 [3], 10.0 [4], 100.0 [5]
	Harmine	IC50	8000.0 [1], 10000.0 [2], 21000.0 [3]
	Kenpaullone	IC50	849.18 [1], 850.0 [2], 1000.0 [3]
	Indirubin	IC50	5000.0 [1], 5500.0 [2], 10000.0 [3]
	4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol	IC50	160.0 [1], 200.0 [2]
	Alvocidib	IC50	60.0 [1], 170.0 [2]
	6-Bromoindirubin-3'-oxime	IC50	83.0 [1]
	Indirubin-3'-monoxime	IC50	100.0 [1]
	Alsterpaullone	IC50	39.99 [1], 40.0 [2], 330.0 [3]
	4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide	IC50	13.0 [1], 10000.0 [2]
	4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide	Ki	18.0 [1]
	Leucettine L41	IC50	410.0 [1], 10000.0 [2], 30000.0 [3]
	Leucettamine B	IC50	10000.0 [1], 100000.0 [2]
	1-(6-Oxo-2,3,4,10b-tetrahydro-1H-pyrido[2,1-a]isoindol-10-yl)-3-pyridin-2-ylurea	IC50	70.0 [1], 80.0 [2]
	Doramapimod	IC50	30000.0 [1]
	Dinaciclib	IC50	1.0 [1], 45.0 [2]
	Purvalanol A	IC50	75.0 [1]
	1-Azakenpaullone	IC50	4200.0 [1]
	Paullone	IC50	4200.0 [1], 10092.53 [2]
	4-(1H-Indol-3-yl)pyrimidin-2-amine	IC50	5000.0 [1], 140000.0 [2]
	Aureusidin	IC50	3500.0 [1], 4810.0 [2]
	4-(5-Bromo-1H-indol-3-yl)pyrimidin-2-amine	IC50	1200.0 [1], 6000.0 [2]
	1-[2-(2,6-Dichlorobenzyl)-4-thiazolyl]-3-morpholinourea	IC50	1000.0 [1]
	1-[2-(2,6-Dichlorobenzyl)-4-thiazolyl]-3-morpholinourea	Ki	500.0 [1]
	4-(4-Methoxy-1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-2-Amine	IC50	170.0 [1]
	4-(1H-Pyrrolo[2,3-B]pyridin-3-YL)pyrimidin-2-amine	IC50	510.0 [1]
	(2R)-2-{[4-(Benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol	IC50	43.0 [1], 70.0 [2]
	Meridianin D	IC50	1200.0 [1], 5500.0 [2]
	Thieno analogue of kenpaullone	IC50	3999.45 [1], 4000.0 [2]
	Hovetrichoside C	IC50	44440.0 [1], 50000.0 [2]
	6-Phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 37	IC50	13000.0 [1]
	3-[4-(Pyridin-4-yl)-1,3-thiazol-2-yl]-1,2,3,4-tetrahydroquinazolin-2-one	IC50	77.0 [1]
	3-[2-(Pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetrahydroquinazolin-2-one	IC50	79.0 [1]
	3-(3-(Hydroxyimino)indolin-2-ylidene)-1-methylindolin-2-one	IC50	100000.0 [1]
	8-Methoxy-1-methyl-3,5-dihydropyridazino[4,5-b]indol-4-one	IC50	10000.0 [1]
	{4-Amino-2-[(4-Chlorophenyl)amino]-1,3-Thiazol-5-Yl}(3-Nitrophenyl)methanone	IC50	750.0 [1], 2000.0 [2]
	N-(2-(Dimethylamino)ethyl)-8-isopropyl-9-oxo-8,9-dihydrothiazolo[5,4-f]quinazoline-2-carboxamidine	IC50	4000.0 [1]
	4-(4-Propoxy-1h-Pyrrolo[2,3-B]pyridin-3-Yl)pyrimidin-2-Amine	IC50	3.0 [1]
	Meriolin 9	IC50	10000.0 [1], 73000.0 [2]
	Meriolin 2	IC50	50.0 [1]
	2-(1-Methyl-2-oxoindolin-3-ylidene)indolin-3-one	IC50	100000.0 [1]
	6-Hydroxy-3-methoxy-4-phenylbenzo[4,3-b]pyridine	IC50	6300.0 [1]
	6-Hydroxy-3-methoxy-4-phenylbenzo[4,3-b]pyridine	Ki	217000.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	1-(6-Oxo-2,3,4,10b-tetrahydro-1H-pyrido[2,1-a]isoindol-10-yl)-3-pyrazin-2-ylurea	IC50	70.0 [1], 80.0 [2]
	6-Methyl-N-[3-[4-[(2-naphthalen-1-ylacetyl)amino]imidazol-1-yl]cyclobutyl]pyridine-2-carboxamide	IC50	6.0 [1], 230.0 [2]
	6-Chloro-N-[3-[4-[(2-naphthalen-1-ylacetyl)amino]imidazol-1-yl]cyclobutyl]pyridine-2-carboxamide	IC50	6.0 [1], 673.0 [2]
	N-[3-[4-[(2-Naphthalen-1-ylacetyl)amino]imidazol-1-yl]cyclobutyl]pyridine-2-carboxamide	IC50	14.0 [1], 1300.0 [2]
	7-(Morpholin-4-ylmethyl)-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetrahydroquinazolin-2-one	IC50	62.0 [1]
	(5Z)-2-(2-Aminoethylimino)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methylimidazolidin-4-one	IC50	910.0 [1], 100000.0 [2]
	2-[(E)-2-(2,6-Dichlorophenyl)ethenyl]-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one	IC50	15.5 [1], 15.7 [2]
	N-[3-[6-[(4-Acetamidocyclohexyl)amino]purin-9-yl]cyclobutyl]-6-methylpyridine-2-carboxamide	IC50	27.0 [1], 30.0 [2]
	N-[1-(cis-3-Hydroxycyclobutyl)-1H-imidazol-4-yl]-2-(4-methoxyphenyl)acetamide	IC50	95.0 [1], 1090.0 [2]
	3-(6-Chloro-5-fluoro-1-methylindol-3-yl)-4-[6-(hydroxymethyl)-1-benzofuran-3-yl]pyrrole-2,5-dione	IC50	16100.0 [1], 18900.0 [2]
	3-(6-Chloro-5-fluoro-1-methylindol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)pyrrole-2,5-dione	IC50	61600.0 [1], 108000.0 [2]
	3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(6-hydroxymethylbenzofuran-3-yl)pyrrole-2,5-dione	IC50	1130.0 [1], 1160.0 [2]
	3-Benzofuran-3-yl-4-(7-methoxymethyl-1-methyl-1H-indol-3-yl)pyrrole-2,5-dione	IC50	12700.0 [1], 12900.0 [2]
	Methyl 3-[4-[[2-(4-methoxyphenyl)acetyl]amino]imidazol-1-yl]cyclobutane-1-carboxylate	IC50	145.0 [1], 4380.0 [2]
	N-[1-(3-Acetamidocyclobutyl)imidazol-4-yl]-2-naphthalen-1-ylacetamide	IC50	8.0 [1], 30000.0 [2]
	N-[3-[4-[(2-Naphthalen-1-ylacetyl)amino]imidazol-1-yl]cyclobutyl]pyridine-3-carboxamide	IC50	46.0 [1], 30000.0 [2]
	Aureusidin 6-O-beta-glucoside	IC50	22320.0 [1], 24330.0 [2]
	6-Methoxy-4-phenyl-3-phenylmethoxy-[1]benzofuro[2,3-b]pyridine	Ki	25100.0 [1], 26100.0 [2]
	7-Methyl-4-phenyl-3-phenylmethoxy-[1]benzofuro[2,3-b]pyridin-6-ol	Ki	25300.0 [1]
	12-Phenyl-13-phenylmethoxy-17-oxa-15-azatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,8,11,13,15-octaen-8-ol	Ki	2100.0 [1]
	7-Fluoro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetrahydroquinazolin-2-one	IC50	16.0 [1]
	Quercetin	IC50	23000.0 [1]
	Apigenin	IC50	1600.0 [1]
	Kaempferol	IC50	51000.0 [1]
	Luteolin	IC50	3800.0 [1]
	Chrysin	IC50	3100.0 [1]
	Indigo	IC50	100000.0 [1]
	Fisetin	IC50	570.0 [1]
	Palbociclib	IC50	10000.0 [1]
	Olomoucine	IC50	7000.0 [1]
	Hyperoside	IC50	10280.0 [1]
	Abemaciclib	IC50	405.0 [1]
	N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-YL)urea	IC50	100000000.0 [1]
	Purvalanol B	IC50	6.0 [1]
	Fascaplysin	IC50	20000.0 [1]
	Sns-032	IC50	340.0 [1]
	Manzamine A	IC50	1500.0 [1]
	Sulfuretin	IC50	37030.0 [1]
	Hymenialdisine	IC50	28.0 [1]
	Milciclib	IC50	265.0 [1]
	Cercosporamide	IC50	5600.0 [1]
	Amg-458	IC50	100000.0 [1]
	Olomoucine II	IC50	270.0 [1]
	Pha-793887	IC50	5.0 [1]
	Cupressuflavone	IC50	9290.0 [1]
	BS-181	IC50	3700.0 [1]
	7-Bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one	IC50	33000.0 [1]
	3-(2-Aminopyrimidin-4-yl)-1H-indol-4-ol	IC50	3000.0 [1]
	RGB-286638 free base	IC50	2.0 [1]
	1,3,5,8-Tetrahydroxyxanthone	IC50	200.0 [1]
	N-(3-Chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine	IC50	10000.0 [1]
	(3-((6-(2-Methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methanesulfonamide	IC50	4960.0 [1]
	Nms-P937 (nms1286937)	IC50	10000.0 [1]
	Indirubin deriv. 8a	IC50	2400.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Cyclin-dependent kinase 5/CDK5 activator 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-5-cdk5-activator-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Cyclin-dependent kinase 5/CDK5 activator 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-5-cdk5-activator-1-inhibitors-ic50-ki.
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