 | Palbociclib | IC50 | 11.0 [1] |
 | Alvocidib | IC50 | 100.0 [1] |
 | Ribociclib | IC50 | 2.0 [1], 10.0 [2] |
 | Abemaciclib | IC50 | 1.7 [1], 1.9 [2], 2.0 [3] |
 | Seliciclib | IC50 | 100.0 [1], 100000.0 [2] |
 | Nintedanib | IC50 | 10000.0 [1] |
 | Olomoucine | IC50 | 200.0 [1], 100000.0 [2] |
 | Fascaplysin | IC50 | 350.0 [1] |
 | (3Z)-3-(1H-Imidazol-5-ylmethylene)-5-methoxy-1H-indol-2(3H)-one | IC50 | 200.0 [1], 300.0 [2] |
 | PDGF Receptor Tyrosine Kinase Inhibitor IV | IC50 | 100000.0 [1] |
 | Amg-925 | IC50 | 2.4 [1], 23.0 [2] |
 | Aristolactam AIIIa | IC50 | 1420.0 [1], 2000.0 [2] |
 | N'-(Pyrrolidino[2,1-B]isoindolin-4-ON-8-YL)-N-(pyridin-2-YL)urea | IC50 | 2.0 [1], 42.0 [2] |
 | Pyrazolo[1,5-b]pyridazine deriv. 16 | IC50 | 12.0 [1] |
| Pyrazolo[1,5-b]pyridazine deriv. 16 | Ki | 150.0 [1] |
 | Pyrazolo[1,5-b]pyridazine deriv. 22 | IC50 | 2000.0 [1] |
| Pyrazolo[1,5-b]pyridazine deriv. 22 | Ki | 1990.0 [1] |
 | [4-(2-Amino-4-methyl-thiazol-5-YL)-pyrimidin-2-YL]-(3-nitro-phenyl)-amine | Ki | 53.0 [1] |
 | Pyrazole-3-yl urea deriv. 15b | IC50 | 2.3 [1], 42.0 [2] |
 | 4,6-Bis anilino pyrimidine deriv. 6 | IC50 | 8000.0 [1] |
 | (13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dione | IC50 | 6.4 [1] |
 | 2-N-(3H-Benzimidazol-5-yl)-4-N-(2-chlorophenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine | IC50 | 29.0 [1], 1000.0 [2] |
 | 1-(Dimethylamino)-3-[4-[[6-[2-fluoro-5-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenoxy]propan-2-ol | IC50 | 6000.0 [1] |
 | N-[4-(2,4-Dimethyl-thiazol-5-YL)-pyrimidin-2-YL]-N',N'-dimethyl-benzene-1,4-diamine | Ki | 960.0 [1], 1503.0 [2] |
 | 4,6-Bis anilino pyrimidine deriv. 2 | IC50 | 33000.0 [1] |
 | 4,6-Bis anilino pyrimidine deriv. 5 | IC50 | 27000.0 [1] |
 | 4,6-Bis anilino pyrimidine deriv. 7 | IC50 | 4000.0 [1] |
 | 4,6-Bis anilino pyrimidine deriv. 8 | IC50 | 23000.0 [1] |
 | 4,6-Bis anilino pyrimidine deriv. 10 | IC50 | 1000.0 [1] |
 | 2-[4-[2-Hydroxy-3-(dimethylamino)propoxy]phenylamino]-4-(phenylamino)pyrimidine | IC50 | 2000.0 [1] |
 | Pyrazolo[1,5-b]pyridazine deriv. 20 | IC50 | 25.0 [1] |
| Pyrazolo[1,5-b]pyridazine deriv. 20 | Ki | 60.0 [1] |
 | Pyrazolo[1,5-b]pyridazine deriv. 21 | IC50 | 8.0 [1] |
| Pyrazolo[1,5-b]pyridazine deriv. 21 | Ki | 20.0 [1] |
 | 7-Cyclohexyl-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-d]pyrimidin-2-amine | IC50 | 31.0 [1] |
 | Cdk4-IN-1 | IC50 | 324.0 [1], 365.0 [2] |
 | 4-[5-Chloro-3-(1-Methylethyl)-1h-Pyrazol-4-Yl]-N-(5-Piperazin-1-Ylpyridin-2-Yl)pyrimidin-2-Amine | IC50 | 223.0 [1], 467.0 [2] |
 | N-(5-Piperazin-1-ylpyridin-2-yl)-4-(5-propan-2-yl-1H-pyrazol-4-yl)pyrimidin-2-amine | IC50 | 451.0 [1], 591.0 [2] |
 | 4-(3-Chloro-5-propan-2-yl-1H-pyrazol-4-yl)-N-(5-piperidin-4-ylpyridin-2-yl)pyrimidin-2-amine | IC50 | 134.0 [1], 383.0 [2] |
 | N-[5-[4-(Dimethylamino)piperidin-1-yl]pyridin-2-yl]-4-[5-propan-2-yl-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyrimidin-2-amine | IC50 | 468.0 [1], 557.0 [2] |
 | 7-Cyclopentyl-2-[[5-[(1S,5R)-7-hydroxy-9-azatricyclo[3.3.1.03,9]nonane-3-carbonyl]pyridin-2-yl]amino]-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamide | IC50 | 187.0 [1], 264.0 [2] |
 | Sorafenib | IC50 | 3000.0 [1] |
 | Ceritinib | IC50 | 4720.0 [1] |
 | Alsterpaullone | IC50 | 10000.0 [1] |
 | Dinaciclib | IC50 | 127.0 [1] |
 | Sns-032 | Ki | 925.0 [1] |
 | Sulfuretin | IC50 | 2820.0 [1] |
 | Cfms Receptor Tyrosine Kinase Inhibitor | IC50 | 19000.0 [1] |
 | (5Z)-5-(Quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one | Ki | 2000.0 [1] |
 | 4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine | IC50 | 450.0 [1] |
 | O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine | IC50 | 1600.0 [1] |
 | Unii-NA856793UT | IC50 | 40000.0 [1] |
 | LY-2090314 | IC50 | 1800.0 [1] |
 | 4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine | Ki | 1090.0 [1] |
 | BS-181 | IC50 | 44700.0 [1] |
 | 1-Tert-butyl-3-[6-(2,6-dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimidin-7-yl]urea | IC50 | 40000.0 [1] |
 | 9-Hydroxy-4-phenyl-6H-pyrrolo[3,4-C]carbazole-1,3-dione | IC50 | 3750.0 [1] |
 | 5-(2-Chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methylpyrazolo(3,4-b)(1,4)benzodiazepine | IC50 | 10000.0 [1] |
 | ZM 39923 hydrochloride | IC50 | 10000.0 [1] |
 | Ryuvidine | IC50 | 6.0 [1] |
 | 3-Imidazo[1,2-a]pyridin-3-yl-4-[10-(morpholine-4-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]pyrrole-2,5-dione | IC50 | 1700.0 [1] |
 | Indirubin-5-sulphonate | IC50 | 200.0 [1] |
 | 4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-5-indolyl]amino]-4-pyrimidinyl]amino]-1-cyclohexanol | IC50 | 1500.0 [1] |
 | Butyrolactonei | IC50 | 1000000.0 [1] |
 | N-[4-(4-Methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine | IC50 | 6.0 [1] |
 | 1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea | IC50 | 50000.0 [1] |
 | N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide | IC50 | 25000.0 [1] |
 | 1-(2-Naphthalenyl)-2-propen-1-one | IC50 | 10000.0 [1] |
 | N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamide | IC50 | 10000.0 [1] |
 | Pyrazolopyridazine 1 | Ki | 60.0 [1] |
 | N-[5-(1,1-Dioxo-1,2-thiazolidin-2-yl)-1H-indazol-3-yl]-2-(4-phenylphenyl)acetamide | IC50 | 2200.0 [1] |
 | N-(4-Chlorobenzyl)-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine | IC50 | 1000.0 [1] |
 | N-Cyclopropyl-4-(2-ethylpyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine | IC50 | 2000.0 [1] |
 | N-Cyclopropyl-4-(6-morpholinopyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine | IC50 | 400.0 [1] |
 | N-(3-Morpholinopropyl)-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine | IC50 | 3200.0 [1] |
 | 4-(Pyrazolo[1,5-b]pyridazin-3-yl)-N-(2,2,2-trifluoroethyl)pyrimidin-2-amine | IC50 | 1000.0 [1] |
 | 3-(4-(Pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-ylamino)benzonitrile | IC50 | 4.0 [1] |
 | N-(3,5-Dimethoxyphenyl)-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine | Ki | 10.0 [1] |
 | 2,4-Diamino-6-hydroxy-5-nitrosopyrimidine | IC50 | 230.0 [1] |
 | 2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-chromen-4-one | IC50 | 400.0 [1] |
 | 10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine | IC50 | 10000.0 [1] |
 | B-Raf IN 1 | IC50 | 2000.0 [1] |
 | 4-(2,4-Dimethyl-1,3-thiazol-5-YL)pyrimidin-2-amine | Ki | 16000.0 [1] |
 | 4-[4-(4-Methyl-2-methylamino-thiazol-5-YL)-pyrimidin-2-ylamino]-phenol | Ki | 320.0 [1] |
 | 8-(2-Bicyclo[2.2.1]heptanyl)-2-[4-[4-(3-hydroxypropyl)piperidin-1-yl]anilino]pyrido[2,3-d]pyrimidin-7-one | IC50 | 20.0 [1] |
 | 1-(Dimethylamino)-3-[4-[[4-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino]phenoxy]propan-2-ol | IC50 | 150.0 [1] |
 | 4-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]phenol | Ki | 320.0 [1] |
 | Pyrazolo[1,5-b]pyridazine deriv. 27 | Ki | 10.0 [1] |
 | Pyrazolo[1,5-b]pyridazine deriv. 43 | Ki | 19950.0 [1] |
 | 3-(4-Imidazo[1,2-a]pyridin-3-yl-2,5-dioxopyrrol-3-yl)-N,N-dimethyl-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-10-carboxamide | IC50 | 1500.0 [1] |
 | 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[4-(4-methylpiperazin-1-yl)but-1-ynyl]quinoline-3-carbonitrile | IC50 | 5000.0 [1] |
 | (7S)-2-(2-Aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one | IC50 | 4000.0 [1] |
 | 5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)nicotinonitrile | IC50 | 10000.0 [1] |
 | Pyrazolo[1,5-a]pyrimidine-3-carboxylate | IC50 | 10000.0 [1] |
 | 1-[4-[[4-(2,5-Dichloroanilino)pyrimidin-2-yl]amino]phenoxy]-3-(dimethylamino)propan-2-ol | IC50 | 800.0 [1] |
 | 2-Methyl-5-(phenylamino)benzothiazole-4,7-dione | IC50 | 6.0 [1] |
 | 5-[(4-Fluorophenyl)amino]-2-methylbenzothiazole-4,7-dione | IC50 | 6.3 [1] |
 | 5-[(4-Chlorophenyl)amino]-2-methylbenzothiazole-4,7-dione | IC50 | 7.0 [1] |
 | 5-[(4-Ethoxyphenyl)amino]-2-methylbenzothiazole-4,7-dione | IC50 | 20.0 [1] |
 | 8-Ethyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | IC50 | 620.0 [1] |
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