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Cyclin-dependent kinase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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SeliciclibIC50450.0 [1]
(5Z)-5-(Quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-oneIC5019.0 [1]
(5Z)-5-(Quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-oneKi35.0 [1]
(Z)-2-((1R,2S)-2-Phenylcyclopropylamino)-5-(quinolin-6-ylmethylene)thiazol-4(5H)-oneIC502340.0 [1], 2410.0 [2], 2490.0 [3], 3340.0 [4], 6580.0 [5]
(Z)-2-((1R,2S)-2-Phenylcyclopropylamino)-5-(quinolin-6-ylmethylene)thiazol-4(5H)-oneKi20.0 [1]
(5Z)-2-Imino-5-(quinolin-6-ylmethylidene)-1,3-thiazolidin-4-oneIC501280.0 [1], 1820.0 [2], 1860.0 [3], 2530.0 [4], 3100.0 [5]
(5Z)-2-Imino-5-(quinolin-6-ylmethylidene)-1,3-thiazolidin-4-oneKi150.0 [1]
AlvocidibIC5030.0 [1]
AlvocidibKi70.0 [1]
StaurosporineIC500.4 [1], 4.9 [2], 8.0 [3], 18.0 [4]
OlomoucineIC504600.0 [1], 6000.0 [2], 7000.0 [3]
DinaciclibIC503.0 [1], 72.0 [2]
(R,Z)-2-(1-Hydroxy-3-phenylpropan-2-ylamino)-5-(quinolin-6-ylmethylene)thiazol-4(5H)-oneIC501390.0 [1], 1580.0 [2], 2030.0 [3], 3070.0 [4]
2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanolIC50650.0 [1]
VatalanibIC5010000.0 [1]
NintedanibIC5010000.0 [1]
6-Bromoindirubin-3'-oximeIC50320.0 [1]
AlsterpaulloneIC5035.0 [1]
Purvalanol AIC5050.0 [1], 35000.0 [2]
4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acidIC50100000.0 [1]
(3Z)-3-(1H-Imidazol-5-ylmethylene)-5-methoxy-1H-indol-2(3H)-oneIC5040.0 [1], 55.0 [2]
6-Cyclohexylmethyloxy-5-nitroso-pyrimidine-2,4-diamineIC502900.0 [1]
6-Cyclohexylmethyloxy-5-nitroso-pyrimidine-2,4-diamineKi2500.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC50170.0 [1], 250.0 [2]
6-O-Cyclohexylmethyl guanineIC507000.0 [1]
6-O-Cyclohexylmethyl guanineKi5000.0 [1]
3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanolIC505.2 [1], 17.0 [2]
PDGF Receptor Tyrosine Kinase Inhibitor IVIC5010000.0 [1], 100000.0 [2]
Cdk2 Inhibitor IIIC50780.0 [1]
N9-Isopropyl-olomoucineIC502000.0 [1], 9400.0 [2]
Aristolactam AIIIaIC50200.0 [1], 214.0 [2]
Oxindole-Based Inhibitor 29IC5015.0 [1]
Oxindole-Based Inhibitor 22IC5010.0 [1]
Oxindole-Based Inhibitor 20IC50300.0 [1]
4-[1-(2-Hydroxy-1H-indol-3-yl)ethylideneamino]benzenesulfonamideIC502300.0 [1]
4-[[5-(Dimethylamino)-2-hydroxy-1H-indol-3-yl]methylideneamino]benzenesulfonamideIC502800.0 [1]
4-[(7-Hydroxy-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-yl)methylideneamino]benzenesulfonamideIC5029.0 [1]
Oxindole-Based Inhibitor 60IC5074.0 [1]
Oxindole-Based Inhibitor 66IC50790.0 [1]
Oxindole-Based Inhibitor 81IC5012.0 [1]
Oxindole-Based Inhibitor 43IC50330.0 [1]
(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amineIC50100.0 [1]
4-[[5-(Isobutoxycarbonyl)-2-oxoindoline-3-ylidenemethyl]amino]benzenesulfonamideIC5019.0 [1]
Oxindole-Based Inhibitor 58IC5060.0 [1], 69.0 [2]
Oxindole-Based Inhibitor 59IC50230.0 [1]
Oxindole-Based Inhibitor 62IC5060.0 [1]
TrkA InhibitorIC503000.0 [1]
N'-(Pyrrolidino[2,1-B]isoindolin-4-ON-8-YL)-N-(pyridin-2-YL)ureaIC50122.0 [1], 1800.0 [2]
Oxindole-Based Inhibitor 27IC5037.0 [1]
Oxindole-Based Inhibitor 31IC5041.0 [1]
Oxindole-Based Inhibitor 49IC50350.0 [1]
Oxindole-Based Inhibitor 50IC50170.0 [1]
Oxindole-Based Inhibitor 56IC502.8 [1]
2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-chromen-4-oneIC50100.0 [1], 300.0 [2]
(3R)-9-Methoxy-3-methyl-1,2,3,4-tetrahydrobenzothiopheno[3,2-e][1,4]diazepin-5-oneIC5012.0 [1]
N-[1-[(3-Fluorophenyl)methyl]indazol-5-yl]-5-[[(2S)-morpholin-2-yl]methoxymethyl]pyrrolo[2,1-f][1,2,4]triazin-4-amineIC5050000.0 [1]
Oxindole-Based Inhibitor 57IC50130.0 [1]
4-[(2-Hydroxy-7-methyl-1H-indol-3-yl)methylideneamino]benzenesulfonamideIC501000.0 [1], 10000.0 [2]
Oxindole-Based Inhibitor 44IC5077.0 [1]
Oxindole-Based Inhibitor 61IC5051.0 [1]
4-[[2-Hydroxy-4-(hydroxymethyl)-1H-indol-3-yl]methylideneamino]benzenesulfonamideIC501700.0 [1]
4-[1-(5-Chloro-2-hydroxy-1H-indol-3-yl)ethylideneamino]benzenesulfonamideIC50220.0 [1]
4-[[5-(Methoxycarbonyl)-2-oxoindoline-3-ylidenemethyl]amino]benzenesulfonamideIC5012.0 [1]
4-[[2-Hydroxy-6-(hydroxymethyl)-1H-indol-3-yl]methylideneamino]benzenesulfonamideIC50740.0 [1]
Oxindole-Based Inhibitor 40IC501000.0 [1]
Oxindole-Based Inhibitor 17IC501300.0 [1]
Oxindole-Based Inhibitor 25IC50110.0 [1]
Oxindole-Based Inhibitor 26IC5046.0 [1]
Oxindole-Based Inhibitor 28IC5019.0 [1]
Oxindole-Based Inhibitor 30IC50550.0 [1]
Oxindole-Based Inhibitor 32IC50290.0 [1]
Oxindole-Based Inhibitor 35IC50150.0 [1]
Oxindole-Based Inhibitor 36IC50250.0 [1]
Oxindole-Based Inhibitor 39IC501000.0 [1]
Oxindole-Based Inhibitor 41IC50290.0 [1]
Oxindole-Based Inhibitor 42IC5095.0 [1]
Oxindole-Based Inhibitor 45IC50210.0 [1]
Oxindole-Based Inhibitor 46IC50710.0 [1]
4-[(5-Amino-2-hydroxy-1H-indol-3-yl)diazenyl]benzenesulfonamideIC501400.0 [1]
Oxindole-Based Inhibitor 64IC50520.0 [1]
Oxindole-Based Inhibitor 65IC50660.0 [1]
Oxindole-Based Inhibitor 69IC501000.0 [1], 10000.0 [2]
Oxindole-Based Inhibitor 73IC50250.0 [1]
Oxindole-Based Inhibitor 74IC501700.0 [1]
Oxindole-Based Inhibitor 75IC5087.0 [1]
Oxindole-Based Inhibitor 79IC5043.0 [1]
4-[(5-Chloro-2-hydroxy-7-methyl-1H-indol-3-yl)methylideneamino]benzenesulfonamideIC501000.0 [1], 10000.0 [2]
4-(2-Chlorophenyl)-9-hydroxy-6-(3-hydroxypropyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dioneIC50250.0 [1]
Pyrazole-3-yl urea deriv. 15bIC50120.0 [1], 1800.0 [2]
[(2R)-1-[6-(3-Chloroanilino)-9-propan-2-ylpurin-2-yl]pyrrolidin-2-yl]methanolIC50430.0 [1], 620000.0 [2]
2-Hydroxy-3-[(4-sulfamoylphenyl)iminomethyl]-1H-indole-5-carboxylic acidIC50150.0 [1]
4-[[5-(5-Oxazolyl)-2-oxoindoline-3-ylidenemethyl]amino]benzenesulfonamideIC5017.0 [1]
4-[[1-[5-(5-Oxazolyl)-2-oxoindoline-3-ylidene]ethyl]amino]benzenesulfonamideIC507.1 [1]
4-[[4-(Ethoxycarbonyl)-2-oxoindoline-3-ylidenemethyl]amino]benzenesulfonamideIC50130.0 [1]
4-[[5-(3-Methylbutyryl)-2-oxoindoline-3-ylidenemethyl]amino]benzenesulfonamideIC5016.0 [1]
Oxindole-Based Inhibitor 82IC5015.0 [1]
Oxindole-Based Inhibitor 51IC50130.0 [1]
Oxindole-Based Inhibitor 63IC509.3 [1]
Oxindole-Based Inhibitor 67IC501000.0 [1], 10000.0 [2]
Oxindole-Based Inhibitor 76IC50120.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cyclin-dependent kinase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/cyclin-dependent-kinase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Cyclin-dependent kinase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-dependent-kinase-1-inhibitors-ic50-ki.
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