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Cyclin-C/Cyclin-dependent kinase 19 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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8-(3-Chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-oneIC506.0 [1]
Senexin BIC504.2 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3-methoxyazetidin-1-yl)methanoneIC505.6 [1]
8-[2-Azanyl-3-Chloranyl-5-(1-Methylindazol-5-Yl)pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-OneIC502.6 [1]
8-[3-(3-Azanyl-2~{h}-Indazol-6-Yl)-5-Chloranyl-Pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-OneIC503.3 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC501.8 [1]
5-[5-Chloro-4-[1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxideIC5018.4 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-methyl-2,3,8-triazaspiro[4.5]dec-1-en-4-oneIC501.0 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-oneIC508.4 [1]
8-[3-Chloro-5-[4-[1-(2-hydroxyethyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC502.5 [1]
8-[3-[4-(1-Methylpyrazol-4-yl)phenyl]-5-(trifluoromethyl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC507.8 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC505.6 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2-methyl-1,3,8-triazaspiro[4.5]dec-1-en-4-oneIC504.8 [1]
8-[3-Chloro-5-[4-[1-(2-hydroxy-2-methylpropyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC501.4 [1]
8-[3-Fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC503.0 [1]
8-[3-Chloro-5-[3-(methylamino)-1H-indazol-6-yl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC503.2 [1]
[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(3-methoxyazetidin-1-yl)methanoneIC5018.8 [1]
[(3R)-3-Hydroxypyrrolidin-1-yl]-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanoneIC504.0 [1]
N-Methyl-3-[(1-methylindazol-5-yl)methyl]-2H-indazole-5-carboxamideIC5026.0 [1]
8-Methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxylic acidIC5012.0 [1]
8-Methoxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC502.8 [1]
8-Pyridin-3-yloxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC502.7 [1]
8-Methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC501.3 [1]
8-Methylsulfonyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC50110.0 [1]
8-Methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carbonitrileIC5046.0 [1]
8-Pyridin-2-yloxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC5025.0 [1]
8-Methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2,3]benzothiadiazole-6-carboxamideIC50130.0 [1]
8-Phenoxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC500.55 [1]
8-(6-Aminopyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC501.1 [1]
Cdk8/19-IN-1IC500.99 [1]
8-Methylsulfinyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC50150.0 [1]
8-[6-[(2-Hydroxy-2-methylpropyl)carbamoyl]pyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC502.4 [1]
8-(2-Methylpyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC500.77 [1]
8-[6-(Methylcarbamoyl)pyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC501.0 [1]
8-(2-Methyl-1-oxidopyridin-1-ium-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC509.3 [1]
8-[6-(2-Methoxyethylcarbamoyl)-2-methylpyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC501.3 [1]
8-(4-Methylpyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC506.6 [1]
8-Methylsulfanyl-N-(1,2-oxazol-3-yl)-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC5015.0 [1]
8-(6-Methylpyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC501.3 [1]
N-Methyl-8-methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC5022.0 [1]
8-[6-(Methylamino)pyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC500.36 [1]
8-[6-(2-Ethoxyethylcarbamoyl)pyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC501.9 [1]
8-Methylsulfanyl-N-(1,2-thiazol-3-yl)-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC5093.0 [1]
8-(6-Acetamidopyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC500.57 [1]
N,N-Dimethyl-8-methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC50120.0 [1]
8-(5-Methylpyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC509.2 [1]
8-Methylsulfanyl-N-phenyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC50700.0 [1]
8-(6-Carbamoylpyridin-3-yl)oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC500.97 [1]
8-Methylsulfanyl-N-pyridin-2-yl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC50400.0 [1]
N-(1-Methylpyrazol-3-yl)-8-methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC5065.0 [1]
8-[6-(Dimethylcarbamoyl)pyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamideIC5021.0 [1]
(E)-3-[4-(1-Cyclopropylpyrazol-4-yl)pyridin-3-yl]-N-[4-(morpholin-4-ylmethyl)phenyl]prop-2-enamideIC507.6 [1]
(E)-N-[4-(Morpholin-4-ylmethyl)phenyl]-3-[4-(1H-pyrazol-4-yl)pyridin-3-yl]prop-2-enamideIC50100.0 [1]
3-[4-(1-Methylpyrazol-4-yl)pyridin-3-yl]-N-[4-(morpholin-4-ylmethyl)phenyl]propanamideIC5050.0 [1]
(E)-3-[4-(1-Methylpyrazol-4-yl)pyridin-3-yl]-N-[4-(morpholin-4-ylmethyl)phenyl]prop-2-enamideIC5015.0 [1]
3-[4-(1-Cyclopropylpyrazol-4-yl)pyridin-3-yl]-N-[4-(morpholin-4-ylmethyl)phenyl]propanamideIC5041.0 [1]
8-[3-(1-Methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)-5-(trifluoromethyl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC501.9 [1]
5-[5-Chloro-4-(1-methyl-1,8-diazaspiro[4.5]decan-8-yl)pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxideIC5022.7 [1]
5-[5-Chloro-4-[1-(3-methoxypropyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxideIC5090.7 [1]
8-[3-Chloro-5-(2,2-dioxo-1,3-dihydro-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC502.5 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC501.8 [1]
8-[3-Chloro-5-[4-[1-(2-pyrrolidin-1-ylethyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5020.6 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC507.5 [1]
8-Methylsulfanyl-4,5-dihydrothieno[3,4-g][1,2]benzoxazole-6-carboxamideIC5071.0 [1]
1-Methyl-8-methylsulfanyl-4,5-dihydrothieno[3,4-g]indazole-6-carboxamideIC5019.0 [1]
8-Methylsulfanyl-4,5-dihydro-1H-thieno[3,4-g]indazole-6-carboxamideIC503100.0 [1]
Unii-6lgr0ryy5QIC5010.0 [1]
8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC503.3 [1]
8-[2-Amino-3-chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC502.1 [1]
8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC505.7 [1]
8-[2-Amino-3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC503.5 [1]
8-[2-Amino-3-chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC503.1 [1]
8-[2-Amino-5-[4-(1-methylpyrazol-4-yl)phenyl]-3-(trifluoromethyl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC509.5 [1]
8-[2-Amino-3-fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC502.7 [1]
Items per page: 1 - 10 of 74
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cyclin-C/Cyclin-dependent kinase 19 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/cyclin-c-cyclin-dependent-kinase-19-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Cyclin-C/Cyclin-dependent kinase 19 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-c-cyclin-dependent-kinase-19-inhibitors-ic50-ki.
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