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CREB-binding protein/Histone acetyltransferase p300 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CurcuminIC5025000.0 [1]
N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[(3S)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]acetamideIC50121.0 [1], 760.0 [2]
N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[(3S)-6-(methylcarbamoylamino)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamideIC50170.0 [1], 470.0 [2]
N-Benzyl-N-[(1R)-1-cyclopropyl-2,2,2-trifluoroethyl]-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]acetamideIC5032.0 [1], 45.0 [2]
N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]acetamideIC5025.0 [1], 47.0 [2]
1-[3-[4-(1-Methylpyrazol-4-yl)anilino]-1-[(3R)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5020.0 [1], 730.0 [2]
3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N-propan-2-ylbenzamideIC5030.0 [1], 960.0 [2]
1-[1-(Cyclopropylmethyl)-3-[3-(1-methylpyrazol-4-yl)anilino]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5020.0 [1], 340.0 [2]
1-[1-(Cyclopropylmethyl)-3-(3-pyridin-3-ylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5030.0 [1], 500.0 [2]
1-[1-(Cyclopropylmethyl)-3-(3-pyridin-4-ylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5020.0 [1], 280.0 [2]
CID 121373027IC5020.0 [1], 430.0 [2]
1-[1-Methyl-3-[4-(1-methylpyrazol-4-yl)anilino]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5040.0 [1], 980.0 [2]
3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N-methylbenzamideIC5070.0 [1], 2000.0 [2]
1-[1-(Cyclopropylmethyl)-3-(3-pyridin-2-ylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5030.0 [1], 560.0 [2]
1-[1-(Cyclopropylmethyl)-3-[3-(1H-pyrazol-4-yl)anilino]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5030.0 [1], 330.0 [2]
1-[1-(Cyclopropylmethyl)-3-[3-(1,2-oxazol-4-yl)anilino]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5030.0 [1], 540.0 [2]
1-[1-(Cyclopropylmethyl)-3-[3-(2-methylpyrazol-3-yl)anilino]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5030.0 [1], 980.0 [2]
CID 121373164IC5030.0 [1], 980.0 [2]
1-[3-[4-(1-Methylpyrazol-4-yl)anilino]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5030.0 [1], 760.0 [2]
3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N-ethylbenzamideIC5040.0 [1], 1500.0 [2]
1-[1-(Cyclopropylmethyl)-3-(3-phenylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5010.0 [1], 2500.0 [2]
3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N-propylbenzamideIC5030.0 [1], 1300.0 [2]
1-[3-[4-(1-Methylpyrazol-4-yl)anilino]-1-(oxetan-3-yl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5040.0 [1], 1200.0 [2]
N-Benzyl-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamideIC5060.0 [1], 101.0 [2]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-oneIC5025000.0 [1]
[[(3R)-4-[[3-[2-[2-[[(5S)-5-Acetamido-6-amino-6-oxohexyl]amino]-2-oxoethyl]sulfanylethylamino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methyl hydrogen phosphateKi19.0 [1]
(4r)-6-(1-Tert-Butyl-1h-Pyrazol-4-Yl)-4-Methyl-1,3,4,5-Tetrahydro-2h-1,5-Benzodiazepin-2-OneIC50470.0 [1]
(4r)-4-Methyl-1,3,4,5-tetrahydro-2h-1,5-benzodiazepin-2-oneIC5014000.0 [1]
1-(3-Phenylazanyl-1,4,6,7-Tetrahydropyrazolo[4,3-C]pyridin-5-Yl)ethanoneIC50620.0 [1]
2-(6-Acetamido-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl)-N-benzyl-N-(1-cyclopropylethyl)acetamideIC50780.0 [1]
N-Benzyl-2-(7-cyano-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl)-N-(1-cyclopropylethyl)acetamideIC5027800.0 [1]
1'-[2-[Benzyl(1-cyclopropylethyl)amino]-2-oxoethyl]-2',5'-dioxospiro[2,3-dihydroindene-1,4'-imidazolidine]-5-carboxamideIC504860.0 [1]
N-Benzyl-2-(6-cyclopropyl-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl)-N-(1-cyclopropylethyl)acetamideIC501710.0 [1]
N-Benzyl-2-(6-cyano-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl)-N-(1-cyclopropylethyl)acetamideIC502500.0 [1]
N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[6-(methylcarbamoylamino)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamideIC50240.0 [1]
Methyl N-[1'-[2-[benzyl-[(1S)-1-cyclopropylethyl]amino]-2-oxoethyl]-2',5'-dioxospiro[2,3-dihydroindene-1,4'-imidazolidine]-5-yl]carbamateIC501000.0 [1]
N-Benzyl-N-(1-cyclopropylethyl)-2-(6-methoxy-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl)acetamideIC501600.0 [1]
N-Benzyl-N-(1-cyclopropylethyl)-2-[6-(hydroxymethyl)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamideIC5014000.0 [1]
N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[6-(methanesulfonamido)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamideIC5016000.0 [1]
1'-[2-[Benzyl(1-cyclopropylethyl)amino]-2-oxoethyl]-2',5'-dioxospiro[2,3-dihydroindene-1,4'-imidazolidine]-4-carboxamideIC5017900.0 [1]
N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-(2,5-dioxo-4-phenylimidazolidin-1-yl)acetamideIC507600.0 [1]
N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[4-(2-methylphenyl)-2,5-dioxoimidazolidin-1-yl]acetamideIC502700.0 [1]
1-[3-(3-Methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50340.0 [1]
Methyl 3-[(5-acetyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-yl)amino]benzoateIC50110.0 [1]
1-[3-(3-Methylanilino)-1-(pyridin-2-ylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5090.0 [1]
1-[3-(3-Methylanilino)-1-(pyridin-3-ylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50140.0 [1]
1-[1-(Cyclopropylmethyl)-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5060.0 [1]
1-[1-(2-Hydroxyethyl)-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50310.0 [1]
1-[3-(3-Methylanilino)-1-(pyridin-4-ylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50200.0 [1]
1-[1-Methyl-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50200.0 [1]
1-[1-Benzyl-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50140.0 [1]
3-[5-Acetyl-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propanenitrileIC50220.0 [1]
3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N-(2-methoxyethyl)benzamideIC504400.0 [1]
1-[1-Cyclopropyl-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50150.0 [1]
3-[[5-Acetyl-1-(cyclopropylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]amino]-N,N-dimethylbenzamideIC50360.0 [1]
1-[1-Ethyl-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5090.0 [1]
1-[1-(2-Methoxyethyl)-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50230.0 [1]
1-[3-[2-Fluoro-4-(1-methylpyrazol-4-yl)anilino]-1-[(3R)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50400.0 [1]
1-[3-(3-Methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]propan-1-oneIC501400.0 [1]
1-[1-(2-Cyclopropylethyl)-3-(3-methylanilino)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50180.0 [1]
1-[3-(3-Fluoroanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50430.0 [1]
1-[3-(4-Methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50300.0 [1]
1-[3-[3-(Trifluoromethyl)anilino]-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50100.0 [1]
N-(3-Methylphenyl)-5-methylsulfonyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-amineIC505000.0 [1]
1-[3-[3-(Difluoromethoxy)anilino]-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50160.0 [1]
Methyl 4-[(5-acetyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-yl)amino]benzoateIC50140.0 [1]
1-[3-(3-Methoxyanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50340.0 [1]
2,2,2-Trifluoro-1-[3-(3-methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC504300.0 [1]
1-[3-(4-Fluoroanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50910.0 [1]
1-[3-(4-Ethylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50250.0 [1]
1-[3-(2-Methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC501200.0 [1]
1-[3-(3-Ethylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC50190.0 [1]
1-[3-(3-Methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]butan-1-oneIC505000.0 [1]
1-[3-(2-Fluoroanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]ethanoneIC501400.0 [1]
Cyclopropyl-[3-(3-methylanilino)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl]methanoneIC504100.0 [1]
1-[3-(3-Methylanilino)-1-propyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanoneIC5070.0 [1]
Chembl4167931IC501600.0 [1]
N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[(3R)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamideIC505060.0 [1]
N-Benzyl-N-[(1R)-1-cyclopropylethyl]-2-[(3R)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamideIC5013000.0 [1]
N-Benzyl-N-[(1S)-1-cyclopropylethyl]-2-[(3S)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamideIC50510.0 [1]
N-Benzyl-N-[(1R)-1-cyclopropylethyl]-2-[(3S)-2',5'-dioxospiro[1,2-dihydroindene-3,4'-imidazolidine]-1'-yl]acetamideIC50990.0 [1]
Chembl4159813IC505100.0 [1]
Items per page: 1 - 10 of 82
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References

This online tool may be cited as follows

MLA

"Quest Database™ CREB-binding protein/Histone acetyltransferase p300 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/creb-binding-protein-histone-acetyltransferase-p300-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ CREB-binding protein/Histone acetyltransferase p300 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/creb-binding-protein-histone-acetyltransferase-p300-inhibitors-ic50-ki.
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