Corticotropin releasing factor receptor 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	9-Chloro-6-[(1R)-1-(difluoromethoxy)-2,2,2-trifluoroethyl]-1-(2-methoxy-4,6-dimethylpyrimidin-5-yl)-3,4-dihydro-2H-pyrimido[1,2-a]benzimidazole	IC50	10000.0 [1]
	Cipargamin	IC50	30000.0 [1]
	3,6-Dimethyl-N-(Pentan-3-Yl)-2-(2,4,6-Trimethylphenoxy)pyridin-4-Amine	Ki	10000.0 [1]
	Pexacerfont	IC50	1000.0 [1]
	Corticorelin ovine triflutate	Ki	86.4 [1]
	CID 44362115	IC50	6.2 [1]
	CID 44388660	IC50	1.6 [1]
	Unii-7FC996zzl5	IC50	1000.0 [1]
	N-(Cyclopropylmethyl)-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethyl-N-(oxan-4-ylmethyl)pyrazolo[1,5-a]pyridin-3-amine;4-methylbenzenesulfonic acid	Ki	10000.0 [1]
	N-Butyl-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-(oxan-4-yl)pyrazolo[5,1-b][1,3]thiazol-7-amine	IC50	10000.0 [1]
	[5-(2,4-Dichloro-phenyl)-1-methyl-1H-[1,2,4]triazol-3-yl]-dicyclopropylmethyl-propyl-amine	Ki	10000.0 [1]
	[3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine	Ki	10000.0 [1]
	CID 44321641	Ki	3.6 [1]
	5-[[Cyclopropylmethyl(propyl)amino]methyl]-N-(2,4,6-trichlorophenyl)-4-(trifluoromethyl)-1,3-thiazol-2-amine	IC50	10000.0 [1]
	3-(2,4-Dichlorophenyl)-7-(dicyclopropylmethyl)-8-ethyl-1-methyl-2H-purin-6-one	IC50	10000.0 [1]
	3-(2,4-Dichlorophenyl)-8-ethyl-7-heptan-4-yl-1-methyl-2H-purin-6-one	IC50	10000.0 [1]
	8-(4-Methoxy-2,5-dimethylphenyl)-N,N-bis(2-methoxyethyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine	IC50	1000.0 [1]
	8-(2-Chloro-5-fluoro-4-methoxyphenyl)-2,7-dimethyl-N-pentan-3-ylpyrazolo[1,5-a][1,3,5]triazin-4-amine	IC50	1000.0 [1]
	CID 44290454	Ki	2.73 [1]
	CID 56661338	IC50	0.62 [1]
	CID 56668206	IC50	46.0 [1]
	CID 56668215	IC50	10.0 [1]
	CID 56675099	IC50	69.0 [1]
	CID 73345508	IC50	1.9 [1]
	CID 73345509	IC50	1.1 [1]
	CID 73346924	IC50	4.9 [1]
	CID 73348542	IC50	5.5 [1]
	CID 73348776	Ki	1.26 [1]
	CID 73349901	IC50	0.42 [1]
	CID 73350007	IC50	500.0 [1]
	CID 73350131	IC50	1.3 [1]
	CID 73350133	IC50	100.0 [1]
	CID 73351508	IC50	60.0 [1]
	CID 73351515	IC50	5.0 [1]
	CID 73351613	IC50	17.8 [1]
	CID 73351614	IC50	0.92 [1]
	CID 73351615	IC50	0.51 [1]
	CID 73351616	IC50	0.61 [1]
	CID 73353094	IC50	0.57 [1]
	CID 73353095	IC50	81.0 [1]
	CID 73353096	IC50	6.2 [1]
	CID 73353098	IC50	0.72 [1]
	CID 73354615	IC50	1.3 [1]
	CID 73354788	Ki	12.2 [1]
	CID 73356172	IC50	0.6 [1]
	CID 73356174	IC50	1.2 [1]
	CID 73356175	IC50	100.0 [1]
	N-[(2R)-Butan-2-yl]-8-(2,4-dimethoxy-6-methylphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine	IC50	1000.0 [1]
	5-Chloro-N-[4-[(5'-fluoro-2'-oxospiro[cyclopropane-1,3'-indole]-1'-yl)methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	811.0 [1]
	5-Chloro-N-[4-[(6-chloro-3-fluoro-3-methyl-2-oxoindol-1-yl)methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	876.0 [1]
	5-Chloro-N-[4-[(3-ethyl-2-oxobenzimidazol-1-yl)methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	256.0 [1]
	5-Chloro-2-methyl-N-[4-[[3-(2-methylpropyl)-2-oxobenzimidazol-1-yl]methyl]cyclohexyl]pyridine-3-carboxamide	IC50	296.0 [1]
	5-Chloro-2-methyl-N-[4-[(3-methyl-2-oxobenzimidazol-1-yl)methyl]cyclohexyl]pyridine-3-carboxamide	IC50	3560.0 [1]
	5-Chloro-N-[4-[(3-fluoro-3,5,6-trimethyl-2-oxoindol-1-yl)methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	4760.0 [1]
	2-Chloro-N-[4-[(6-fluoro-2-oxo-3H-indol-1-yl)methyl]cyclohexyl]-5-(trifluoromethyl)benzamide	IC50	3874.0 [1]
	5-Chloro-N-[4-[(3,3-dimethyl-2-oxoindol-1-yl)methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	3795.0 [1]
	5-Chloro-N-[4-[(6-chloro-3,3-dimethyl-2-oxoindol-1-yl)methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	4620.0 [1]
	5-Chloro-N-[4-[(6-chloro-3,3-difluoro-2-oxoindol-1-yl)methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	3124.0 [1]
	2-Chloro-N-[4-[(7-methoxy-3,3-dimethyl-2-oxoindol-1-yl)methyl]cyclohexyl]-5-(trifluoromethyl)benzamide	IC50	1685.0 [1]
	5-Chloro-N-[4-[[(3S)-3-fluoro-3-methyl-2-oxoindol-1-yl]methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	4587.0 [1]
	5-Chloro-N-[4-[(6-methoxy-3,3-dimethyl-2-oxoindol-1-yl)methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	3045.0 [1]
	2-Chloro-5-(trifluoromethyl)-N-[4-[(3,3,7-trimethyl-2-oxoindol-1-yl)methyl]cyclohexyl]benzamide	IC50	2137.0 [1]
	5-Chloro-2-methyl-N-[4-[(3,3,4-trimethyl-2-oxoindol-1-yl)methyl]cyclohexyl]pyridine-3-carboxamide	IC50	4810.0 [1]
	2-Chloro-N-[4-[[[4-(2-chloro-4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]amino]methyl]cyclohexyl]-5-(trifluoromethyl)benzamide	IC50	727.0 [1]
	5-Chloro-N-[4-[[3-(4-fluorophenyl)-5-methylpyrazol-1-yl]methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	4630.0 [1]
	5-Chloro-2-methyl-N-[4-[(5-methyl-3-pyridin-3-ylpyrazol-1-yl)methyl]cyclohexyl]pyridine-3-carboxamide	IC50	3737.0 [1]
	2-Chloro-N-[4-[[4-chloro-3-(hydroxymethyl)pyrazol-1-yl]methyl]cyclohexyl]-5-(trifluoromethyl)benzamide	IC50	4847.0 [1]
	2-Chloro-N-[4-[(3-ethyl-5-methylpyrazol-1-yl)methyl]cyclohexyl]-5-(trifluoromethyl)benzamide	IC50	2026.0 [1]
	5-Chloro-2-methyl-N-[4-[(5-methyl-3-phenylpyrazol-1-yl)methyl]cyclohexyl]pyridine-3-carboxamide	IC50	4943.0 [1]
	5-Chloro-N-[4-[[(5-ethyl-4-methyl-1H-pyrazol-3-yl)amino]methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	4878.0 [1]
	2-Chloro-N-[4-[(3-ethyl-2-oxobenzimidazol-1-yl)methyl]cyclohexyl]-5-(trifluoromethyl)benzamide	IC50	1948.0 [1]
	5-Chloro-N-[4-[(7-chloro-3,3-dimethyl-2-oxoindol-1-yl)methyl]cyclohexyl]-2-methylpyridine-3-carboxamide	IC50	936.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 72 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Corticotropin releasing factor receptor 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/corticotropin-releasing-factor-receptor-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Corticotropin releasing factor receptor 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/corticotropin-releasing-factor-receptor-2-inhibitors-ic50-ki.
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