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Corticotropin releasing factor receptor 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amineIC504.0 [1], 50.0 [2]
3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amineKi3.5 [1], 7.8 [2], 8.3 [3], 12.0 [4]
Butyl-(2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo(2,3-d)pyrimidin-4-yl)ethylamineIC5011.0 [1], 15.85 [2]
CID 9909468IC5039.81 [1], 82.0 [2]
CID 9909468Ki1.7 [1], 1.8 [2], 2.0 [3]
AntalarminIC5018.62 [1]
AntalarminKi0.84 [1], 2.51 [2], 3.1 [3], 32.0 [4]
Nbi 27914Ki1.7 [1], 2.0 [2]
3-(4-Methoxy-2-methylphenyl)-2,5-dimethyl-N-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-amineIC5010.0 [1]
3-(4-Methoxy-2-methylphenyl)-2,5-dimethyl-N-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-amineKi1.0 [1], 1.5 [2]
Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-propyl-amineIC505.0 [1], 16.0 [2]
Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-propyl-amineKi1.58 [1], 1.7 [2]
PexacerfontIC504.5 [1], 6.1 [2], 340.0 [3], 10000.0 [4]
Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-propyl-amineIC5029.0 [1]
Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-propyl-amineKi1.3 [1], 1.6 [2], 3.2 [3]
8-(2,4-Dichlorophenyl)-2-methyl-N,N-dipropylquinolin-4-amineIC5017.0 [1]
8-(2,4-Dichlorophenyl)-2-methyl-N,N-dipropylquinolin-4-amineKi0.9 [1]
3-[5-(Dimethylamino)-3-methylpyridin-2-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amineIC50150.0 [1], 160.0 [2]
3-[5-(Dimethylamino)-3-methylpyridin-2-yl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amineKi10.0 [1]
2,5-Dimethyl-3-(3-methyl-5-nitropyridin-2-yl)-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amineIC50180.0 [1]
2,5-Dimethyl-3-(3-methyl-5-nitropyridin-2-yl)-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amineKi9.1 [1]
N-Butyl-N-ethyl-1,5-dimethyl-3-(2,4-dichlorophenyl)-1H-pyrazolo[4,3-b]pyridine-7-amineIC5016.0 [1]
N-Butyl-N-ethyl-1,5-dimethyl-3-(2,4-dichlorophenyl)-1H-pyrazolo[4,3-b]pyridine-7-amineKi2.0 [1]
1-(2-Methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipropylisoquinolin-4-amineIC5012.0 [1]
1-(2-Methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipropylisoquinolin-4-amineKi6.0 [1], 12.0 [2]
2-[2,6-Dimethoxy-4-(methoxymethyl)phenyl]-3,8-dimethyl-N,N-dipropylquinolin-5-amineIC5070.0 [1], 88.0 [2]
2-[2,6-Dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methylquinolin-5-amineIC50184.0 [1], 381.0 [2]
3-Chloro-2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methylquinolin-5-amineIC5045.0 [1], 81.0 [2]
2-[2,6-Dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-3-fluoro-8-methylquinolin-5-amineIC50131.0 [1], 144.0 [2]
2-[2,6-Dimethoxy-4-(methoxymethyl)phenyl]-N-ethyl-N-(2-methoxyethyl)-3,8-dimethylquinolin-5-amineIC5023.0 [1], 109.0 [2]
2-[2,6-Dimethoxy-4-(methoxymethyl)phenoxy]-3-methyl-N,N-dipropylquinolin-5-amineIC50138.0 [1], 163.0 [2]
Dibutyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amineIC505.0 [1], 15.8 [2]
Dibutyl-[3-(2,4-dichloro-phenyl)-1,5-dimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amineKi0.62 [1]
4-Chloro-2-(2,4-dichloro-6-methylphenoxy)-7-(1-ethylpropyl)-1-methyl-1H-benzimidazoleIC504.1 [1], 22.0 [2], 32.0 [3], 44.0 [4]
4-(1-Ethyl-propoxy)-3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridineIC506.8 [1], 92.0 [2]
4-(1-Ethyl-propoxy)-3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridineKi8.5 [1]
3-(2,4-Dichlorophenyl)-9-heptan-4-yl-6-methyl-1,2,5,9-tetrazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraeneKi4.0 [1], 4.5 [2], 5.01 [3]
CID 44388660IC500.9 [1]
CID 44388660Ki0.8 [1]
7-Chloro-2-N-(4-chloro-2-methoxy-6-methylphenyl)-4-N,4-N-diethyl-3-methylbenzimidazole-2,4-diamineIC509.5 [1], 24.0 [2]
2-N-(Cyclopropylmethyl)-6-methyl-2-N-propyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamineKi57.0 [1]
3-(2-Bromo-4-propan-2-ylphenyl)-N,N-bis(2-methoxyethyl)-5-methyltriazolo[4,5-d]pyrimidin-7-amineKi3.7 [1]
2-(4-Chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methyl-5-pentan-3-yloxypyrimidineIC507.0 [1]
2-(4-Chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methyl-5-pentan-3-yloxypyrimidineKi9.0 [1]
N-Butyl-N-ethyl-2,3,6-trimethyl-1-(2,4,6-trimethylphenyl)pyrrolo[2,3-b]pyridin-4-amineIC5016.0 [1]
N-Butyl-N-ethyl-2,3,6-trimethyl-1-(2,4,6-trimethylphenyl)pyrrolo[2,3-b]pyridin-4-amineKi2.6 [1]
7-Chloro-2-N-(4-chloro-2-methoxy-6-methylphenyl)-3-methyl-4-N,4-N-dipropylbenzimidazole-2,4-diamineIC509.5 [1], 88.0 [2]
Pyrazolo(1,5-a)pyrimidin-7-amine, 3-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)-2,5-dimethyl-N-propyl-IC5076.0 [1]
Pyrazolo(1,5-a)pyrimidin-7-amine, 3-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)-2,5-dimethyl-N-propyl-Ki3.4 [1]
N-(2-Chloro-4,6-dimethylphenyl)-1-(1,3-dimethoxypropan-2-yl)-6-methyltriazolo[4,5-c]pyridin-4-amine;methanesulfonic acidIC5075.0 [1], 79.0 [2]
N-(2-Chloro-4,6-dimethylphenyl)-1-(1,3-dimethoxypropan-2-yl)-6-methyltriazolo[4,5-c]pyridin-4-amine;methanesulfonic acidKi3.3 [1]
CP-154526 hydrochlorideKi1.6 [1], 2.7 [2]
(10S)-9-(Cyclopropylmethyl)-3-(2,4-dichlorophenyl)-10-ethyl-6-methyl-1,2,5,9-tetrazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraeneIC5079.43 [1]
(10S)-9-(Cyclopropylmethyl)-3-(2,4-dichlorophenyl)-10-ethyl-6-methyl-1,2,5,9-tetrazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraeneKi3.16 [1]
7,9,11,20,22,24-Hexahydroxy-13,16-dimethyloctacyclo[13.11.1.12,10.03,8.04,25.019,27.021,26.014,28]octacosa-1(27),2(28),3,6,8,10,12,14,16,19,21,23,25-tridecaene-5,18-dioneIC50300.0 [1]
4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine;hydrochlorideKi2.0 [1]
3-(4-Chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl-8-(pentan-3-yl)imidazo[1,2-b]pyridazineKi0.2 [1]
E-2508 Free baseIC5023.0 [1], 50.0 [2]
3-Methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-N-pentan-3-ylpyrazin-2-amineIC5093.0 [1]
3-Methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-N-pentan-3-ylpyrazin-2-amineKi1.0 [1]
2-[Ethyl(2-bromo-4-isopropylphenyl)amino]-4-morpholino-6-methylpyrimidineKi22.0 [1], 63.0 [2]
N,N-Bis(2-methoxyethyl)-2,7-dimethyl-8-(4-(76Br)bromanyl-2-chlorophenyl)pyrazolo[1,5-a][1,3,5]triazin-4-amineKi2.0 [1]
[3-(2,4-Dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-d]pyrimidin-7-yl]-dipropyl-amineKi2.0 [1]
N-Butyl-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-(oxan-4-yl)pyrazolo[5,1-b][1,3]thiazol-7-amineIC507.1 [1], 70.0 [2]
4-N-(Cyclopropylmethyl)-2,5-dimethyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamineKi2.3 [1]
[5-(2,4-Dichloro-phenyl)-1-methyl-1H-[1,2,4]triazol-3-yl]-dicyclopropylmethyl-propyl-amineKi9.0 [1], 9.2 [2]
(2-Bromo-4,6-dimethoxy-phenyl)-(4,6-dimethyl-pyrimidin-2-yl)-ethyl-amineKi12.0 [1]
5-Bromo-4-N-(cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamineKi2.0 [1]
[5-(2,4-Dichloro-phenyl)-1H-[1,2,4]triazol-3-yl]-dicyclopropylmethyl-propyl-amineKi2400.0 [1], 4500.0 [2]
9-(2-Bromo-4-propan-2-ylphenyl)-6-[butyl(ethyl)amino]-2,7-dimethylpurin-8-oneKi5.0 [1]
4-(3,6-Dihydro-2H-pyridin-1-yl)-6-methyl-N-(2,4,6-trimethylphenyl)-1,3,5-triazin-2-amineKi1050.0 [1]
2-N-Benzyl-6-methyl-2-N-propyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamineKi490.0 [1]
2-N-Benzyl-2-N-butyl-6-methyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamineKi1050.0 [1]
N-(Cyclopropylmethyl)-5-ethyl-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamineKi3.8 [1]
6-Methyl-2-N,2-N-bis(prop-2-enyl)-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamineKi115.0 [1]
4-N-(Cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamineKi30.0 [1]
2-N-Benzyl-2-N-ethyl-6-methyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamineKi1470.0 [1]
6-Methyl-N,N-dipropyl-N'-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamineKi130.0 [1]
2-[Ethyl(2-bromo-4-isopropylphenyl)amino]-4-(dipropylamino)-6-methylpyrimidineKi9.0 [1]
6-Methyl-4-N-[[4-(trifluoromethyl)phenyl]methyl]-2-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamineKi1690.0 [1]
2,5-Dimethyl-4-N,4-N-dipropyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamineKi2.5 [1]
2-N-(Cyclopropylmethyl)-6-ethyl-2-N-propyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamineKi10000.0 [1]
2-N,2-N-Dibutyl-6-methyl-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamineKi490.0 [1]
N-(Cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trimethylphenyl)pyrimidine-4,6-diamineKi1390.0 [1]
3-(5-Amino-3-methylpyridin-2-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amineKi85.0 [1]
[5-(2,4-Dichloro-phenyl)-2-methyl-2H-[1,2,4]triazol-3-yl]-dicyclopropylmethyl-propyl-amineKi10000.0 [1]
[5-(2,4-Dichloro-phenyl)-1-ethyl-1H-[1,2,4]triazol-3-yl]-dicyclopropylmethyl-propyl-amineKi80.0 [1]
[5-(4-Chloro-2-methoxy-phenyl)-1-methyl-1H-[1,2,4]triazol-3-yl]-dicyclopropylmethyl-propyl-amineKi26.0 [1], 28.0 [2]
[3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amineKi1.1 [1], 2.8 [2]
N-Ethyl-N-propyl-2,5-dimethyl-3-(2,4-dichlorophenyl)-2H-pyrazolo[4,3-d]pyrimidine-7-amineKi3.0 [1]
3-(2,4-Dichlorophenyl)-N,N-bis(2-methoxyethyl)-2,5-dimethylpyrazolo[4,3-d]pyrimidin-7-amineKi3.0 [1]
Butyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-2H-pyrazolo[4,3-d]pyrimidin-7-yl]-ethyl-amineKi2.0 [1]
2-N,6-Dimethyl-2-N-(2-phenylethyl)-4-N-(2,4,6-trimethylphenyl)-1,3,5-triazine-2,4-diamineKi2100.0 [1]
[5-(2,4-Dichloro-phenyl)-1-methyl-1H-[1,2,4]triazol-3-yl]-dipropyl-amineKi2600.0 [1], 3400.0 [2]
2-[Ethyl(2-bromo-4-isopropylphenyl)amino]-4-(butylethylamino)-6-methylpyrimidineKi18.0 [1], 19.0 [2]
CID 44593730IC502.0 [1]
N-(2-Methoxyethyl)-1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-N-propylpyrazolo[3,4-d]pyrimidin-4-amineKi13.0 [1]
2-[2,6-Dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-3,8-dimethylquinolin-5-amineIC5024.0 [1], 79.0 [2]
Pyrazolo(1,5-a)pyrimidin-7-amine, N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethyl-Ki5.0 [1]
Items per page: 1 - 10 of 99
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References

This online tool may be cited as follows

MLA

"Quest Database™ Corticotropin releasing factor receptor 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/corticotropin-releasing-factor-receptor-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Corticotropin releasing factor receptor 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/corticotropin-releasing-factor-receptor-1-inhibitors-ic50-ki.
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