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Complement factor D Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1-[2-[(1R,3S,5R)-3-[[(1S)-1-(3-Chloro-2-fluorophenyl)ethyl]carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl]pyrazolo[3,4-c]pyridine-3-carboxamideIC5029.0 [1], 30.0 [2], 70.0 [3], 144.0 [4]
Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carbamoyl)pyrrolidine-1-carboxamido)-methyl)benzoateIC5014000.0 [1]
DanicopanIC504.0 [1], 15.0 [2]
(1R,3S,5R)-3-N-(6-Bromopyridin-2-yl)-2-N-(1-carbamoylindol-3-yl)-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamideIC505.0 [1], 6.0 [2], 9.0 [3]
(2S)-N-(6-Bromopyridin-2-yl)-3-[2-(3-carbamoylpyrazolo[3,4-b]pyridin-1-yl)acetyl]-1,3-thiazolidine-2-carboxamideIC5019.0 [1], 27.31 [2], 205.0 [3]
(2S)-1-N-(1-Carbamoylindol-3-yl)-2-N-[3-(trifluoromethoxy)phenyl]pyrrolidine-1,2-dicarboxamideIC50500.0 [1], 800.0 [2]
1-[2-[(1R,3S,5R)-3-[(3-Bromo-2-fluorophenyl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl]indazole-3-carboxamideIC5010.0 [1], 150.0 [2]
(1R,3S,5R)-2-N-(1-Carbamoylindol-3-yl)-3-N-[3-(trifluoromethoxy)phenyl]-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamideIC5050.0 [1], 210.0 [2], 1250.0 [3]
1-[2-[(1R,3S,5R)-3-[(6-Bromopyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl]indazole-3-carboxamideIC505.0 [1], 9.0 [2], 11.0 [3]
1-[2-[(1R,3S,5R)-3-[(6-Bromopyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl]indole-3-carboxamideIC5066.0 [1], 1860.0 [2]
(2-Carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylateIC5096.0 [1], 98.0 [2]
Example 373 [WO2012093101]IC501.0 [1]
(1R,3S,5R)-2-N-(1-Carbamoylindol-3-yl)-3-N-[6-(trifluoromethyl)pyridin-2-yl]-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamideIC5014.0 [1], 22.0 [2]
(2s)-N-(6-Bromopyridin-2-Yl)-3-[(1h-Indazol-1-Yl)acetyl]-1,3-Thiazolidine-2-CarboxamideIC5077.0 [1], 2180.0 [2]
(1R,3S,5R)-2-N-(1-Carbamoylindol-3-yl)-3-N-[2-fluoro-3-(trifluoromethyl)phenyl]-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamideIC5023.0 [1], 587.0 [2]
1-[2-[(1R,3S,5R)-3-[(6-Bromopyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl]pyrazolo[3,4-b]pyridine-3-carboxamideIC5031.95 [1], 47.0 [2]
(1R,3S,5R)-N-(6-Bromopyridin-2-yl)-2-(2-indazol-1-ylacetyl)-2-azabicyclo[3.1.0]hexane-3-carboxamideIC5019.0 [1], 6600.0 [2]
(1R,3S,5R)-2-[2-(3-Acetylindazol-1-yl)acetyl]-N-(6-bromopyridin-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamideIC5015.0 [1], 35.0 [2]
3-[3-(Aminomethyl)phenyl]-5-(3-methylbutanoylamino)-N-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamideIC503400.0 [1], 11000.0 [2]
Tert-butyl 2-[1-carbamoyl-3-[[(1R,3S,5R)-3-[(3-chloro-2-fluorophenyl)methylcarbamoyl]-2-azabicyclo[3.1.0]hexane-2-carbonyl]amino]indol-6-yl]acetateIC503.0 [1]
(2R)-1-N-(1-Carbamoylindol-3-yl)-2-N-[3-(trifluoromethoxy)phenyl]pyrrolidine-1,2-dicarboxamideIC5018300.0 [1], 30000.0 [2]
2-[1-Carbamoyl-3-[[(2S,4R)-2-[(3-chloro-2-fluorophenyl)methylcarbamoyl]-4-fluoro-4-methylpyrrolidine-1-carbonyl]amino]indol-5-yl]oxyacetic acidIC502.0 [1]
(2S,4S)-1-N-(1-Carbamoylindol-3-yl)-4-fluoro-2-N-[3-(trifluoromethoxy)phenyl]pyrrolidine-1,2-dicarboxamideIC50700.0 [1]
(2S)-1-N-(1-Carbamoylindol-3-yl)-4,4-difluoro-2-N-[3-(trifluoromethoxy)phenyl]pyrrolidine-1,2-dicarboxamideIC50450.0 [1]
(2S)-1-N-(1-Carbamoylindol-3-yl)-2-N-[3-(trifluoromethoxy)phenyl]piperidine-1,2-dicarboxamideIC5022000.0 [1], 22200.0 [2]
(2S,4R)-1-N-(1-Carbamoylindol-3-yl)-4-fluoro-2-N-[3-(trifluoromethoxy)phenyl]pyrrolidine-1,2-dicarboxamideIC5048.0 [1], 50.0 [2]
(2S,4S)-1-N-(1-Carbamoylindol-3-yl)-4-hydroxy-2-N-[3-(trifluoromethoxy)phenyl]pyrrolidine-1,2-dicarboxamideIC501400.0 [1], 1425.0 [2]
(2S,4S)-4-Amino-1-N-(1-carbamoylindol-3-yl)-2-N-[3-(trifluoromethoxy)phenyl]pyrrolidine-1,2-dicarboxamideIC50500.0 [1], 667.0 [2]
(2S,4R)-1-N-(1-Carbamoylindol-3-yl)-4-methyl-2-N-[3-(trifluoromethoxy)phenyl]pyrrolidine-1,2-dicarboxamideIC50850.0 [1]
(2S,4S)-4-Amino-1-N-(1-carbamoylindol-3-yl)-2-N-(2-hydroxy-2-phenylethyl)pyrrolidine-1,2-dicarboxamideIC5024750.0 [1]
(1R,3S,5R)-2-N-(1-Carbamoylindol-3-yl)-3-N-[2-fluoro-3-(trifluoromethoxy)phenyl]-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamideIC5012.0 [1], 250.0 [2]
(2S,4S)-1-N-(1-Carbamoylindol-3-yl)-4-methyl-2-N-[3-(trifluoromethoxy)phenyl]pyrrolidine-1,2-dicarboxamideIC50300.0 [1]
Isatoic anhydrideIC502900.0 [1]
5-Methylsulfanyl-4-[4-(5-propyl-1-pyridin-2-ylpyrazol-4-yl)-1,3-thiazol-2-yl]thiophene-2-carboximidamideIC503700.0 [1]
2-[2-[[3-[3-[(1S)-1-Amino-2-hydroxyethyl]phenyl]-5-(hydroxymethyl)phenyl]methoxy]phenyl]acetic acidIC504.0 [1]
4-[(1R)-3-[4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-1-(ethylamino)-3-oxopropyl]benzonitrileIC501.0 [1]
2-Acetyloxy-5-(4-acetyloxy-3-carboxyphenyl)benzoic acidIC50100.0 [1]
2-[2-[[3-[3-(2-Amino-2-oxoethyl)-2-fluorophenyl]-5-(1-methylpyrazol-4-yl)phenyl]methoxy]phenyl]acetic acidIC5023.0 [1]
(S)-N2-Benzhydryl-N1-(1-methyl-1H-indol-3-yl)pyrrolidine-1,2-dicarboxamideIC505800.0 [1]
(1R,3S,5R)-2-N-(1-Carbamoylindol-3-yl)-3-N-(3-chlorophenyl)-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamideIC50150.0 [1]
(2S)-1-N-(1-Methylindol-3-yl)-2-N-[3-(trifluoromethoxy)phenyl]pyrrolidine-1,2-dicarboxamideIC5020000.0 [1]
3-[[3-[3-(Aminomethyl)anilino]-2H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]phenolIC5020000.0 [1]
(2S)-2-[[4-[3-(Aminomethyl)anilino]quinazolin-2-yl]amino]-3-methylbutanoic acidIC5075000.0 [1]
(1R,2S)-2-[[4-[3-(Aminomethyl)anilino]quinazolin-2-yl]amino]cyclohexane-1-carboxylic acidIC5084000.0 [1]
N-[3-[3-(Aminomethyl)phenyl]phenyl]-3-methylbutanamideIC50120000.0 [1]
3-[3-(Aminomethyl)phenyl]-N-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamideIC5054000.0 [1]
Methyl 3-[[(2S)-2-[[3-(trifluoromethoxy)phenyl]carbamoyl]pyrrolidine-1-carbonyl]amino]benzoateIC5030000.0 [1]
3-[2-[(1R,3S,5R)-3-[[2-Fluoro-3-(trifluoromethoxy)phenyl]carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl]indole-1-carboxamideIC50370.0 [1]
Methyl 4-methyl-3-[[(2S)-2-[[3-(trifluoromethoxy)phenyl]carbamoyl]pyrrolidine-1-carbonyl]amino]benzoateIC5017000.0 [1]
(2S)-2-[[4-[3-(Aminomethyl)anilino]pyrimidin-2-yl]amino]-3-methylbutanoic acidIC5044000.0 [1]
N-[3-[3-(Aminomethyl)phenyl]phenyl]-2-phenylacetamideIC5043000.0 [1]
3-[3-(Aminomethyl)phenyl]-N-benzylbenzamideIC50310000.0 [1]
N-[3-[3-(Aminomethyl)phenyl]phenyl]benzamideIC50257000.0 [1]
3-[3-(Aminomethyl)phenyl]-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]benzamideIC5098000.0 [1]
N-[3-[3-(Aminomethyl)phenyl]phenyl]acetamideIC50690000.0 [1]
N-[3-[3-(Aminomethyl)phenyl]phenyl]-3-phenylpropanamideIC50140000.0 [1]
(1R,3S,5R)-3-N-(3-Bromophenyl)-2-N-(1-carbamoylindol-3-yl)-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamideIC5045.0 [1]
(1S,2S,5R)-3-N-(1-Carbamoylindol-3-yl)-2-N-[3-(trifluoromethoxy)phenyl]-3-azabicyclo[3.1.0]hexane-2,3-dicarboxamideIC50650.0 [1]
(1R,3S,5R)-2-N-(1-Carbamoylindol-3-yl)-3-N-[3-(difluoromethoxy)phenyl]-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamideIC50150.0 [1]
(1R,3S,5R)-2-N-(1-Carbamoylindol-3-yl)-3-N-(3-methoxyphenyl)-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamideIC50320.0 [1]
1-[2-[(1R,3S,5R)-3-[(6-Bromopyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl]-5-(fluoromethyl)pyrazolo[3,4-c]pyridine-3-carboxamideIC502.0 [1]
1-[2-[(1R,3S,5R)-3-[(6-Iodopyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl]indazole-3-carboxamideIC503.0 [1]
5,7-Dimethyl-1-[2-oxo-2-[(1R,3S,5R)-3-[[6-(trifluoromethyl)pyridin-2-yl]carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]ethyl]pyrazolo[3,4-c]pyridine-3-carboxamideIC506.0 [1]
2-Acetyloxy-5-[(4-acetyloxy-3-carboxyphenyl)methyl]benzoic acidIC50100.0 [1]
[(3S)-4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-ethylpiperazin-1-yl]-[(1R,2R)-1-amino-1,2,3,4-tetrahydronaphthalen-2-yl]methanoneIC502660.0 [1]
(3R)-3-Amino-1-[(3S)-4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-methylpiperazin-1-yl]-3-[4-(trifluoromethyl)phenyl]propan-1-oneIC5040.0 [1]
2-[(3S)-4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-methylpiperazine-1-carbonyl]-1H-indole-5-carbonitrileIC5015.0 [1]
(3R)-3-Amino-1-[4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-(4-methylphenyl)propan-1-oneIC5070.0 [1]
2-[(3S)-4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-propylpiperazine-1-carbonyl]-1H-indole-5-carbonitrileIC5011.0 [1]
(3R)-1-[4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-cyclohexyl-3-(methylamino)propan-1-oneIC5080.0 [1]
4-[(1R)-1-Amino-3-[(3S)-4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-propylpiperazin-1-yl]-3-oxopropyl]benzonitrileIC5010.0 [1]
(3R)-3-Amino-1-[(3S)-4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-phenylpiperazin-1-yl]-3-(4-fluorophenyl)propan-1-oneIC507.0 [1]
4-[(1R)-3-[(3R,5S)-4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3,5-dimethylpiperazin-1-yl]-3-oxo-1-(propan-2-ylamino)propyl]benzonitrileIC5011.0 [1]
4-[(1R)-1-Amino-3-[(3S)-4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-ethylpiperazin-1-yl]-3-oxopropyl]benzonitrileIC507.0 [1]
4-[(1R)-3-[4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-oxo-1-(propan-2-ylamino)propyl]benzonitrileIC503.0 [1]
(3R)-3-Amino-1-[(3S)-4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-ethylpiperazin-1-yl]-3-[4-(trifluoromethyl)phenyl]propan-1-oneIC5090.0 [1]
(3R)-3-Amino-1-[4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-cyclopentylpropan-1-oneIC50100.0 [1]
4-[(1R)-1-Amino-3-[(3S)-4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-methylpiperazin-1-yl]-3-oxopropyl]benzonitrileIC509.0 [1]
(3R)-3-Amino-1-[(2R,5S)-4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-2,5-dimethylpiperazin-1-yl]-3-(4-fluorophenyl)propan-1-oneIC5050.0 [1]
3-[(1R)-1-Amino-3-[4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-oxopropyl]benzonitrileIC5040.0 [1]
4-[(1R)-1-Amino-3-[4-[4-amino-8-fluoro-6-methoxy-7-(2-methoxyethoxy)quinazolin-2-yl]piperazin-1-yl]-3-oxopropyl]benzonitrileIC50110.0 [1]
1-[4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-2-[(2S)-1-(2-methylpropyl)pyrrolidin-2-yl]ethanoneIC50170.0 [1]
4-[(E)-3-[(3S)-4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-methylpiperazin-1-yl]-3-oxoprop-1-enyl]benzonitrileIC5020.0 [1]
(3S)-3-Amino-1-[(3S)-4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-methylpiperazin-1-yl]-4-phenylbutan-1-oneIC502250.0 [1]
4-[(1R)-1-Amino-3-[4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-oxopropyl]benzonitrileIC5010.0 [1]
4-[(1R)-3-[4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-1-(methylamino)-3-oxopropyl]benzonitrileIC504.0 [1]
(3R)-3-Amino-1-[4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-(2,4-difluorophenyl)propan-1-oneIC50450.0 [1]
(3R)-3-Amino-1-[4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-(4-chlorophenyl)propan-1-oneIC5090.0 [1]
(E)-1-[4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-cyclopropylprop-2-en-1-oneIC50500.0 [1]
(3S)-3-Amino-1-[(3S)-4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-methylpiperazin-1-yl]-5-methylhexan-1-oneIC50240.0 [1]
1-[(3S)-4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-phenylpiperazin-1-yl]-2-[(2S)-piperidin-2-yl]ethanoneIC5020.0 [1]
1-[(3S)-4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-phenylpiperazin-1-yl]-2-[(2S)-azetidin-2-yl]ethanoneIC50610.0 [1]
(3R)-3-Amino-1-[4-(4-amino-5-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-(4-fluorophenyl)propan-1-oneIC5030.0 [1]
(3R)-3-Amino-1-[4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-(furan-2-yl)propan-1-oneIC5090.0 [1]
(3R)-1-[4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-3-(methylamino)-3-phenylpropan-1-oneIC5050.0 [1]
(3R)-3-Amino-1-[(3S)-4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-propylpiperazin-1-yl]-3-[4-(trifluoromethyl)phenyl]propan-1-oneIC5060.0 [1]
1-[4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-2-[(3S)-piperidin-3-yl]ethanoneIC503870.0 [1]
[(3S)-4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-methylpiperazin-1-yl]-[(1R,2R)-1-amino-1,2,3,4-tetrahydronaphthalen-2-yl]methanoneIC501070.0 [1]
[(3S)-4-(4-Amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-methylpiperazin-1-yl]-(5-fluoro-1H-indol-2-yl)methanoneIC5090.0 [1]
(3R)-3-Amino-1-[(3S)-4-(4-amino-8-fluoro-6,7-dimethoxyquinazolin-2-yl)-3-ethylpiperazin-1-yl]-3-(4-fluorophenyl)propan-1-oneIC5030.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Complement factor D Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/complement-factor-d-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Complement factor D Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/complement-factor-d-inhibitors-ic50-ki.
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