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Complement C1r Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
NafamostatIC5012000.0 [1]
2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-oneIC5016700.0 [1]
2-(2-Iodo-phenylamino)-7-trifluoromethyl-benzo[d][1,3]oxazin-4-oneIC50400.0 [1], 4000.0 [2]
2-(2-Nitrophenyl)-3,1-benzoxazin-4-oneIC5015000.0 [1], 36300.0 [2], 62500.0 [3]
2-(2-Bromophenyl)-4H-3,1-benzoxazin-4-oneIC509500.0 [1], 32000.0 [2], 46000.0 [3]
2-(2-Fluorophenyl)-4H-3,1-benzoxazin-4-oneIC5012100.0 [1], 62500.0 [2]
5-Chloro-2-(2-iodo-phenyl)-benzo[d][1,3]oxazin-4-oneIC503000.0 [1], 13500.0 [2], 57000.0 [3]
2-(2-Trifluoromethyl-phenyl)-benzo[d][1,3]oxazin-4-oneIC504200.0 [1], 35400.0 [2], 62500.0 [3]
2-(2-Iodo-benzyl)-benzo[d][1,3]oxazin-4-oneIC506000.0 [1], 26000.0 [2], 40000.0 [3]
2-(2-Iodo-phenyl)-6-methoxy-benzo[d][1,3]oxazin-4-oneIC505000.0 [1], 62500.0 [2]
2-(2-Iodo-phenyl)-6-methyl-benzo[d][1,3]oxazin-4-oneIC5010000.0 [1], 51000.0 [2], 62500.0 [3]
2-(2-Iodo-phenyl)-naphtho[2,3-d][1,3]oxazin-4-oneIC50700.0 [1], 62500.0 [2]
6,7-Dichloro-2-(2-iodo-phenyl)-benzo[d][1,3]oxazin-4-oneIC501700.0 [1], 62500.0 [2]
2-(2-Iodo-phenyl)-5-methyl-benzo[d][1,3]oxazin-4-oneIC507500.0 [1], 62500.0 [2]
6-Chloro-2-(2-iodo-phenyl)-benzo[d][1,3]oxazin-4-oneIC503000.0 [1], 7800.0 [2], 27300.0 [3]
2-(2-Chlorophenyl)-4H-3,1-benzoxazin-4-oneIC5017300.0 [1], 45000.0 [2], 62500.0 [3]
2-(2-Methoxyphenyl)-4H-3,1-benzoxazin-4-oneIC5017700.0 [1], 62500.0 [2]
2-(2-Fluoroanilino)-4H-3,1-benzoxazin-4-oneIC5050000.0 [1], 62500.0 [2]
2-(2-Chloroanilino)-4H-3,1-benzoxazin-4-oneIC506500.0 [1], 8000.0 [2]
4-Methoxy-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC50700.0 [1], 6000.0 [2]
2-(2-Iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC503500.0 [1], 14700.0 [2]
7-Chloro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC50700.0 [1], 900.0 [2]
5-Chloro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC5014500.0 [1], 62500.0 [2]
2-(2-Iodo-phenylamino)-naphtho[2,3-d][1,3]oxazin-4-oneIC50200.0 [1], 16600.0 [2]
2-(2-Chloro-phenylamino)-7-nitro-benzo[d][1,3]oxazin-4-oneIC501400.0 [1], 62500.0 [2]
7-Fluoro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC501700.0 [1], 2800.0 [2]
2-(2,6-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4-oneIC50900.0 [1]
2-(2,6-Dichloro-phenylamino)-7-trifluoromethyl-benzo[d][1,3]oxazin-4-oneIC501500.0 [1], 4200.0 [2]
6-Chloro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC504000.0 [1], 62500.0 [2]
2-(2-Iodo-phenylamino)-6,7-dimethoxy-benzo[d][1,3]oxazin-4-oneIC5047000.0 [1]
2-(2-Trifluoromethoxy-phenylamino)-benzo[d][1,3]oxazin-4-oneIC504000.0 [1], 62500.0 [2]
2-[Methyl(2-iodophenyl)amino]-4H-3,1-benzoxazin-4-oneIC501400.0 [1], 16600.0 [2]
2-(2-Iodo-phenylamino)-6-methoxy-benzo[d][1,3]oxazin-4-oneIC5055000.0 [1], 62500.0 [2]
7-Chloro-2-(2-chloro-phenylamino)-benzo[d][1,3]oxazin-4-oneIC50800.0 [1]
2-(2-Chloro-phenylamino)-7-methyl-benzo[d][1,3]oxazin-4-oneIC50900.0 [1], 1400.0 [2]
2-[(2-Chlorophenyl)amino]-6,7-dichloro-4H-3,1-benzoxazin-4-oneIC502000.0 [1], 62500.0 [2]
2-(2-Iodo-phenylamino)-7-methyl-benzo[d][1,3]oxazin-4-oneIC50800.0 [1], 1500.0 [2]
2-(2-Bromo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC505100.0 [1], 15200.0 [2]
6,7-Dichloro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC50500.0 [1], 62500.0 [2]
6,7-Difluoro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC507000.0 [1], 62500.0 [2]
2-(2-Iodo-phenylamino)-7-nitro-benzo[d][1,3]oxazin-4-oneIC50800.0 [1], 7800.0 [2]
2-(2,5-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4-oneIC502000.0 [1]
N-Methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC504000.0 [1], 6000.0 [2]
4-Tert-Butyl-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC5060000.0 [1]
N-Ethyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC503200.0 [1], 8300.0 [2]
4-Chloro-N-ethyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC5030000.0 [1], 62000.0 [2]
2-Bromo-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC502800.0 [1], 25000.0 [2]
2,6-Dichloro-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC507500.0 [1], 62000.0 [2]
3-Chloro-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC5024000.0 [1], 58000.0 [2]
4-Amino-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC507000.0 [1], 62000.0 [2]
2-(o-Tolylamino)-[3,1]benzoxazin-4-oneIC5031000.0 [1], 38000.0 [2]
4-Guanidino-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC501500.0 [1], 3000.0 [2]
N-Methyl-N-(4-oxo-3,1-benzoxazin-2-yl)naphthalene-1-sulfonamideIC506000.0 [1], 10000.0 [2]
2-[(2,6-Dichlorophenyl)amino]-7-chloro-4H-3,1-benzoxazin-4-oneIC50400.0 [1], 900.0 [2]
2-(4-Oxo-4H-3,1-benzooxazine-2-yl)benzoic acidIC5062500.0 [1]
7-Chloro-2-(2-iodophenyl)-4H-3,1-benzoxazin-4-oneIC5062500.0 [1]
2-(3-Iodo-phenyl)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(2-Hydroxyphenyl)-4H-3,1-benzoxazin-4-oneIC5062500.0 [1]
2-(2-Iodo-phenyl)-7-nitro-benzo[d][1,3]oxazin-4-oneIC5022000.0 [1], 62500.0 [2]
2-(2-Iodo-phenyl)-7-methyl-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(2-Iodo-phenyl)-7-methoxy-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(2-Iodo-phenyl)-6,7-dimethoxy-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(4-Iodo-phenyl)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
SepimostatKi6400.0 [1]
4H-3,1-Benzoxazin-4-one, 2-(methylamino)-IC5062500.0 [1]
2-Anilino-4H-3,1-benzoxazin-4-oneIC5062500.0 [1]
2-Isopropylamino-5-methyl-4H-3,1-benzoxazin-4-oneIC5062500.0 [1]
2-Amino-4H-3,1-benzoxazin-4-oneIC5062500.0 [1]
2-(2,2,2-Trifluoro-ethylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(2-Methylsulfanyl-phenylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(2-Iodo-phenylamino)-5-methyl-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(4-Iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
5,7-Dichloro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(Tetrahydro-thiophen-3-ylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(Thiazol-2-ylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-([1,3,4]Thiadiazol-2-ylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(2,6-Dimethyl-phenylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-[2-(2-Iodo-phenyl)-ethylamino]-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(2-Iodo-phenylamino)-7-isopropyl-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(2-Iodo-phenylamino)-6-methyl-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-[Ethyl-(2-iodo-phenyl)-amino]-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(2-Iodo-benzylamino)-benzo[d][1,3]oxazin-4-oneIC5062600.0 [1]
2-(1H-1,2,4-Triazol-5-ylamino)-3,1-benzoxazin-4-oneIC5062500.0 [1]
2-(2-Iodo-phenylamino)-7-methoxy-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(3-Iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
7-Cyclohexyl-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-[(Thiophen-3-ylmethyl)-amino]-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
2-(Thiazolidin-2-ylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
7-Dimethylamino-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazin-4-oneIC5062500.0 [1]
N-[(5-Carbamimidoylthiophen-2-yl)methyl]-1-[(2R)-2-[[2-(2,6-dichlorophenyl)acetyl]amino]-3-methylbutanoyl]-2,5-dihydropyrrole-2-carboxamideIC50600.0 [1]
4-Chloro-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC5062000.0 [1]
4,N-Dimethyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC507800.0 [1]
3,4-Dichloro-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC5062500.0 [1]
N-Methyl-4-nitro-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC5031000.0 [1]
4-Cyano-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamideIC5020000.0 [1]
4-Methoxy-N-methyl-N-(4-oxo-4H-benzo[d][1,3]thiazin-2-yl)-benzenesulfonamideIC5062500.0 [1]
N-Methyl-N-(4-oxo-4H-benzo[d][1,3]thiazin-2-yl)-benzenesulfonamideIC5062500.0 [1]
(19S,22R)-22-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,12,21-trioxo-2,6,9,13,20-pentazatetracyclo[22.2.2.26,9.214,17]dotriaconta-1(27),14(30),15,17(29),24(28),25-hexaene-19-carboxamide;2,2,2-trifluoroacetic acidKi35000.0 [1]
(17S,20R)-20-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,10,19-trioxo-2,5,8,11,18-pentazatetracyclo[20.2.2.25,8.212,15]triaconta-1(25),12,14,22(26),23,27-hexaene-17-carboxamide;2,2,2-trifluoroacetic acidKi50000.0 [1]
Items per page: 1 - 10 of 99
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References

This online tool may be cited as follows

MLA

"Quest Database™ Complement C1r Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/complement-c1r-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Complement C1r Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/complement-c1r-inhibitors-ic50-ki.
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