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Coagulation factor XII Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1-(4-Chlorobenzoyl)-3-pyridin-3-yl-1H-1,2,4-triazol-5-amineIC50490.0 [1], 4970.0 [2], 5270.0 [3], 5830.0 [4]
[5-Amino-3-(furan-2-yl)-1,2,4-triazol-1-yl]-(3,4-dimethoxyphenyl)methanoneIC50320.0 [1], 430.0 [2], 830.0 [3], 860.0 [4]
(5-Amino-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(2-methoxyphenyl)methanoneIC50680.0 [1], 1850.0 [2], 2430.0 [3], 2630.0 [4]
1-(4-Methoxybenzoyl)-3-pyridin-3-yl-1H-1,2,4-triazol-5-amineIC5050.0 [1], 400.0 [2], 1190.0 [3], 1230.0 [4]
[5-Amino-3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl](phenyl)methanoneIC50210.0 [1], 600.0 [2], 750.0 [3], 810.0 [4]
1H-1,2,4-Triazol-5-amine, 1-(3,4-dimethoxybenzoyl)-3-(3-pyridinyl)-IC50160.0 [1], 190.0 [2], 970.0 [3], 1080.0 [4]
8-Bromo-6-chloro-2-oxo-N-phenylchromene-3-carboxamideIC504400.0 [1], 16000.0 [2]
Unii-vwj4vvz3OUKi3000.0 [1]
Phenyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylateIC5050000.0 [1]
Benzotriazol-1-yl-(3,4-dimethoxyphenyl)methanoneIC5026700.0 [1]
Methyl N-[4-[5-chloro-2-[(1S)-1-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-2-phenylethyl]-1H-imidazol-4-yl]phenyl]carbamateKi3050.0 [1]
6-(Chloromethyl)-2-oxo-N-phenylchromene-3-carboxamideIC5017000.0 [1]
(E)-2-(1H-Benzimidazol-2-yl)-3-(3,4-dimethoxyphenyl)prop-2-enenitrileIC5050000.0 [1]
(2E)-2-(1H-Benzimidazol-2-yl)-3-(4-methylphenyl)prop-2-enenitrileIC5050000.0 [1]
1H-Benzotriazol-1-yl(4-methoxyphenyl)methanoneIC509390.0 [1]
6-Methyl-2-oxo-N-phenylchromene-3-carboxamideIC5023000.0 [1]
4-[(2R)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N,N-dimethylpiperazine-1-carboxamideKi61000.0 [1]
N-(3-Chlorophenyl)-6-methyl-2-oxochromene-3-carboxamideIC5031000.0 [1]
N-(4-Chlorophenyl)-6-methyl-2-oxochromene-3-carboxamideIC5034000.0 [1]
6-Methyl-N-(3-methylphenyl)-2-oxo-2H-chromene-3-carboxamideIC5010000.0 [1]
6-Methyl-N-(4-methylphenyl)-2-oxochromene-3-carboxamideIC5020000.0 [1]
2-Oxo-N-phenyl-2H-chromene-3-carboxamideIC5042000.0 [1]
3-(4-Methoxyphenyl)-2-(5-methyl-1H-benzimidazol-2-yl)acrylonitrileIC5050000.0 [1]
Methyl N-[(14S)-14-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-9-oxo-8,16,18-triazatricyclo[13.2.1.02,7]octadeca-1(17),2(7),3,5,15-pentaen-5-yl]carbamateKi3050.0 [1]
alpha-(Phenylmethylene)-1H-benzimidazole-2-acetonitrileIC5050000.0 [1]
Methyl N-[(12E,15S)-15-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-9-oxo-8,17,19-triazatricyclo[14.2.1.02,7]nonadeca-1(18),2(7),3,5,12,16-hexaen-5-yl]carbamateKi3050.0 [1]
(1H-Benzo[d][1,2,3]triazol-1-yl)(3-nitrophenyl)methanoneIC5050000.0 [1]
1H-Benzotriazol-1-yl(3,5-dimethoxyphenyl)methanoneIC5025400.0 [1]
1-(4-Chlorobenzoyl)-1H-benzotriazoleIC5031700.0 [1]
(3,5-Dimethyl-1H-pyrazol-1-yl)(furan-2-yl)methanoneIC5043590.0 [1]
1-(2-Furoyl)-1H-benzotriazoleIC5034100.0 [1]
1-(2-Methoxybenzoyl)-1H-1,2,3-benzotriazoleIC507210.0 [1]
(2R)-2-(Benzylsulfonylamino)-5-(diaminomethylideneamino)-N-[2-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-2-oxoethyl]pentanamideIC5050.0 [1]
H-D-Pro-Phe-Arg-chloromethylketoneIC50180.0 [1]
3-[(2R)-3-(4-Formylpiperazin-1-yl)-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamideKi53000.0 [1]
3-[(2R)-3-(4-Methylpiperazin-1-yl)-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamideKi280000.0 [1]
3-[(2R)-3-(4-Acetylpiperazin-1-yl)-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamideKi200000.0 [1]
3-[(2R)-3-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamideKi400000.0 [1]
3-[(2R)-3-(4-Methylsulfonylpiperazin-1-yl)-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamideKi52000.0 [1]
N-[(1S)-1-[4-(3-Amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl]-4-(aminomethyl)cyclohexane-1-carboxamide;2,2,2-trifluoroacetic acidKi9218.0 [1]
4-[[(2S)-2-[[(E)-3-[5-Chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-3-[4-[(4-methylpiperazine-1-carbonyl)amino]phenyl]propanoyl]amino]benzoic acidKi3700.0 [1]
8-Bromo-6-chloro-N-(3-hydroxyphenyl)-2-oxochromene-3-carboxamideIC5034000.0 [1]
8-Bromo-6-chloro-N-(5-chloro-2-hydroxyphenyl)-2-oxochromene-3-carboxamideIC505000.0 [1]
8-Bromo-6-chloro-N-(4-hydroxyphenyl)-2-oxochromene-3-carboxamideIC5041000.0 [1]
8-Bromo-6-chloro-N-(2-hydroxyphenyl)-2-oxochromene-3-carboxamideIC507000.0 [1]
8-Bromo-6-chloro-N-(4-chloro-2-hydroxyphenyl)-2-oxochromene-3-carboxamideIC508000.0 [1]
N-[(6-Amino-2-methylpyridin-3-yl)methyl]-1-[[4-(pyrazol-1-ylmethyl)phenyl]methyl]pyrazole-4-carboxamideIC501000000.0 [1]
(12E)-20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,12,18,20,22,27(30),28-nonaen-26-oneIC50200000.0 [1]
(13Z)-20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,13,18,20,22,27(30),28-nonaen-26-oneIC50200000.0 [1]
20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,13,18,20,22,27(30),28-nonaen-26-oneIC50200000.0 [1]
(13E)-20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,13,18,20,22,27(30),28-nonaen-26-oneIC50200000.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-18-(2,2-dimethylpropyl)-36-(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi3000.0 [1]
(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2R)-2-Amino-3-(4-carbamimidamidophenyl)propanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoic acidKi15.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi10.2 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-12-[(3-methylphenyl)methyl]-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi3.7 [1]
(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-Amino-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris[3-(diaminomethylideneamino)propyl]-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidKi330.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-36-(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-18-propan-2-yl-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi570.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-36-[(2S)-butan-2-yl]-15,30,39-tris(3-carbamimidamidopropyl)-18-(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi78.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,21S,24R,27S,30S,33S,36S,39R)-39-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-18-(3-amino-3-oxopropyl)-36-benzyl-12,21,33-tris(3-carbamimidamidopropyl)-27-(hydroxymethyl)-15,30-bis(2-methylpropyl)-4,11,14,17,20,23,26,29,32,35,38,44,47-tridecaoxo-7,41,50-trithia-1,3,10,13,16,19,22,25,28,31,34,37,45-tridecazatricyclo[22.22.5.13,45]dopentacontane-9-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi29.4 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-18-(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-36-propyl-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi72.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-33-(2-carboxyethyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi3000.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-18-(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-36-pentan-3-yl-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi38.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-[(4-tert-butylphenyl)methyl]-15,30,39-tris(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi1000.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-12-[(4-nitrophenyl)methyl]-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi1.64 [1]
(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(1R,7S,10S,13S,16S,22S,25S,28S,40R,43S,46S,49S,52S,58S,61S)-40-Acetamido-43,52-bis(2-amino-2-oxoethyl)-13-(carboxymethyl)-46-[(1R)-1-hydroxyethyl]-10,49,61-tris(1H-indol-3-ylmethyl)-16-methyl-25-(2-methylpropyl)-2,8,11,14,17,23,26,41,44,47,50,53,59,62-tetradecaoxo-30,38,65-trithia-3,9,12,15,18,24,27,42,45,48,51,54,60,63-tetradecazahexacyclo[32.29.3.132,36.03,7.018,22.054,58]heptahexaconta-32,34,36(67)-triene-28-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acidKi50000.0 [1]
(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-33-(3-Amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-9-[[(2S)-2,6-diaminohexanoyl]amino]-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoic acidKi9.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-36-(2-methylpropyl)-18-(2-methylsulfanylethyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi3000.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15-(5-aminopentyl)-12-benzyl-30,39-bis(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi51.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-12-(naphthalen-2-ylmethyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi6.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-18-methyl-36-(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi3000.0 [1]
(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(7R,10S,13S,16S,22S,25S,28S,31R,34S,37S,45S,48S,51R)-51-Acetamido-45-benzyl-10-[(2S)-butan-2-yl]-34-(4-carbamimidamidobutyl)-13-(carboxymethyl)-48-(hydroxymethyl)-22,25,37-tris[(4-hydroxyphenyl)methyl]-9,12,15,21,24,27,30,33,36,39,44,47,50-tridecaoxo-28-propan-2-yl-5,53,58-trithia-8,11,14,20,23,26,29,32,35,38,43,46,49-tridecazapentacyclo[29.25.3.13,55.016,20.040,43]hexaconta-1(56),2,55(60)-triene-7-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acidKi50000.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15-(2-carbamimidamidoethyl)-30,39-bis(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi156.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,21S,24R,27S,30S,33S,36S,39R)-39-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-18-(3-amino-3-oxopropyl)-36-benzyl-12,21,33-tris(3-carbamimidamidopropyl)-27-(carboxymethyl)-15,30-bis(2-methylpropyl)-4,11,14,17,20,23,26,29,32,35,38,44,47-tridecaoxo-7,41,50-trithia-1,3,10,13,16,19,22,25,28,31,34,37,45-tridecazatricyclo[22.22.5.13,45]dopentacontane-9-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi120.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-12-[(3-fluorophenyl)methyl]-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi4.5 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-12-(1H-indol-3-ylmethyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi12.0 [1]
(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2R)-2-Amino-6-carbamimidamidohexanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoic acidKi8.8 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-36-methyl-18-(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi1040.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-12-[(2-methylphenyl)methyl]-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi40.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-18-butyl-15,30,39-tris(3-carbamimidamidopropyl)-36-(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi3000.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-12-[(2-fluorophenyl)methyl]-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi26.8 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-15-(4-Aminobutyl)-9-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-30,39-bis(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi111.0 [1]
(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-12-[(4-fluorophenyl)methyl]-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoic acidKi0.84 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,21S,24R,27S,30S,33S,36S,39R)-39-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-18-(3-amino-3-oxopropyl)-36-benzyl-12,21,33-tris(3-carbamimidamidopropyl)-15,30-bis(2-methylpropyl)-4,11,14,17,20,23,26,29,32,35,38,44,47-tridecaoxo-27-propan-2-yl-7,41,50-trithia-1,3,10,13,16,19,22,25,28,31,34,37,45-tridecazatricyclo[22.22.5.13,45]dopentacontane-9-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi47.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15-[(4-carbamimidamidophenyl)methyl]-30,39-bis(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi380.0 [1]
(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-4-carbamimidamidobutanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-12-[(4-fluorophenyl)methyl]-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoic acidKi1.63 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,21S,24R,27S,30S,33S,36S,39R)-39-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-27-(2-amino-2-oxoethyl)-18-(3-amino-3-oxopropyl)-36-benzyl-12,21,33-tris(3-carbamimidamidopropyl)-15,30-bis(2-methylpropyl)-4,11,14,17,20,23,26,29,32,35,38,44,47-tridecaoxo-7,41,50-trithia-1,3,10,13,16,19,22,25,28,31,34,37,45-tridecazatricyclo[22.22.5.13,45]dopentacontane-9-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi104.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-12-(2-phenylethyl)-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi366.0 [1]
(2S)-2-[[(2S)-2-[[(9R,15S,18S,21S,27S,30R,33S,36S,39S,42S,45R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-36-(3-amino-3-oxopropyl)-18,33,42-tris(3-carbamimidamidopropyl)-21,39-bis(2-methylpropyl)-4,10,16,19,22,28,31,34,37,40,43,50,53-tridecaoxo-7,47,56-trithia-1,3,11,17,20,23,29,32,35,38,41,44,51-tridecazapentacyclo[28.22.5.13,51.011,15.023,27]octapentacontane-45-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi36.9 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15-(4-carbamimidamidobutyl)-30,39-bis(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi71.0 [1]
(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2R)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoic acidKi34.4 [1]
Octasodium;[2-(3,4-disulfonatooxyphenyl)-5-[[4-[[2-(3,4-disulfonatooxyphenyl)-4-oxo-3,7-disulfonatooxychromen-5-yl]oxymethyl]phenyl]methoxy]-4-oxo-3-sulfonatooxychromen-7-yl] sulfateIC501000000.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-18-[(2S)-butan-2-yl]-15,30,39-tris(3-carbamimidamidopropyl)-36-(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi890.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-33-(carboxymethyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi550.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-12-(pyridin-4-ylmethyl)-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi57.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-12-(naphthalen-1-ylmethyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi10.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-12-[(4-iodophenyl)methyl]-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi92.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-36-(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-18-propyl-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi220.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-15,30,39-tris(3-carbamimidamidopropyl)-12-[(4-methylphenyl)methyl]-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi39.0 [1]
(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-3-methylbutanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-18,36-bis(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoic acidKi99.0 [1]
(2S)-2-[[(2S)-2-[[(9R,12S,15S,18S,24S,27R,30S,33S,36S,39S,42R)-9-[[(2S)-2-Amino-5-carbamimidamidopentanoyl]amino]-33-(3-amino-3-oxopropyl)-12-benzyl-15,30,39-tris(3-carbamimidamidopropyl)-36-(2,2-dimethylpropyl)-18-(2-methylpropyl)-4,10,13,16,19,25,28,31,34,37,40,47,50-tridecaoxo-7,44,53-trithia-1,3,11,14,17,20,26,29,32,35,38,41,48-tridecazatetracyclo[25.22.5.13,48.020,24]pentapentacontane-42-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoic acidKi17.7 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Coagulation factor XII Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/coagulation-factor-xii-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Coagulation factor XII Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/coagulation-factor-xii-inhibitors-ic50-ki.
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