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Coagulation factor VII/tissue factor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
BenzamideKi49000000.0 [1]
3-Amino-5-[1-[2-[(4-carbamimidoylphenyl)methylamino]-2-oxoethyl]-3-chloro-6-oxo-5-(propan-2-ylamino)pyrazin-2-yl]benzoic acidIC5016.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[6-(3,5-diaminophenyl)-2-oxo-3-(propan-2-ylamino)pyridin-1-yl]acetamideIC5052.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-2-oxo-6-phenyl-3-(2-phenylethylamino)pyrazin-1-yl]acetamideIC50630.0 [1]
7-Chloro-3,4-dihydroisoquinolin-1(2H)-oneKi8900000.0 [1]
2-[3-(5-Carbamimidoyl-1H-indol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic AcidKi3.0 [1]
2-[3-(Benzylamino)-5-chloro-2-oxo-6-phenylpyrazin-1-yl]-N-[(4-carbamimidoylphenyl)methyl]acetamideIC50770.0 [1]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.16 [1]
(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6(21),7,9,16(20),17-hexaene-3,12-dioneKi400.0 [1]
(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-ethylsulfonyl-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-3,12-dioneKi8.0 [1]
(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-ethylsulfonyl-17-methyl-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi1.6 [1]
(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamideKi9.7 [1], 11.0 [2]
(11R)-11-[(1-Aminoisoquinolin-6-yl)amino]-16-cyclopropylsulfonyl-13-methyl-2,13-diazatricyclo[13.3.1.16,10]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dioneKi5.0 [1], 58.0 [2]
(5R)-5-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-19-cyclopropylsulfonyl-3,13-dimethyl-3,13,15-triazatricyclo[14.3.1.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-4,14-dioneKi14.0 [1], 200.0 [2]
(5R,11R)-5-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-19-cyclopropylsulfonyl-9-methoxy-3,11,13-trimethyl-3,13,15-triazatricyclo[14.3.1.16,10]henicosa-1(19),6(21),7,9,16(20),17-hexaene-4,14-dioneKi3.8 [1], 5.0 [2]
Arachidonic acidIC50105000.0 [1]
NicotinamideKi8000000.0 [1]
Oleic acidIC5080000.0 [1]
Linoleic acidIC5041000.0 [1]
Eicosapentaenoic acidIC5078000.0 [1]
Linolenic acidIC5030000.0 [1]
Dihomo-gamma-linolenic acidIC5075000.0 [1]
BenzamidineKi240000.0 [1]
gamma-Linolenic acidIC5030000.0 [1]
Palmitoleic acidIC50120000.0 [1]
Ginkgolic acidIC5032000.0 [1]
1-HydroxyisoquinolineKi19000000.0 [1]
Myristoleic acidIC5066000.0 [1]
1-AminoisoquinolineKi4000000.0 [1]
2,4-Dichlorobenzyl alcoholKi13000000.0 [1]
Eicosadienoic acidIC5052000.0 [1]
11,14,17-Eicosatrienoic acidIC50100000.0 [1]
1-(1-Naphthyl)ethanolKi16000000.0 [1]
5-Chloroindole-2-carboxylic acidKi3500000.0 [1]
5-ChloroindoleKi4300000.0 [1]
4-Chloro-2-methoxyphenolKi16000000.0 [1]
5-ChlorobenzotriazoleKi8700000.0 [1]
(Z)-2-(Heptadec-10-en-1-yl)-6-hydroxybenzoic acidIC5068000.0 [1]
CID 9845742IC50340.0 [1]
2-[2-(3-Aminophenyl)-3-chloro-5-(cyclobutylamino)-6-oxopyrazin-1-yl]-N-[(4-carbamimidoylphenyl)methyl]acetamideIC5020.0 [1]
CID 10181104IC502800.0 [1]
2-[3-(6-Carbamimidoyl-1H-benzimidazol-2-yl)-5-(5-fluoro-2-hydroxyphenyl)-4-hydroxyphenyl]butanedioic acidKi4.0 [1]
4-Bromo-2-methoxyphenolKi13000000.0 [1]
2-[3-(5-Carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic acidKi15.0 [1]
2-[3-(5-Carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]butanedioic acidKi22.0 [1]
2-[2-[(4-Carbamimidoylphenyl)carbamoyl]phenyl]-5-(2-methylpropylcarbamoyl)benzoic acidIC500.12 [1]
N-(Benzenesulfonyl)-2-(4-carbamimidoylanilino)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamideKi1.3 [1]
2-[(4-Carbamimidoylphenyl)amino]-2-(3,5-diethoxyphenyl)acetic acidKi190.0 [1]
6-Methyl-N-(4-methylphenyl)-2-oxochromene-3-carboxamideIC5050000.0 [1]
Methyl 1H-indole-4-carboxylateKi13000000.0 [1]
(2S)-N-[(4-Carbamimidoylphenyl)methyl]-2-[[(2R)-2-(ethylsulfonylamino)-3-(4-phenylphenyl)propanoyl]amino]pentanediamideIC5093.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-4-oxo-8,8-dipropyl-3-(propylamino)-6,7-dihydropyrrolo[1,2-a]pyrimidine-6-carboxamideKi620.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-(3,3-dimethylbutan-2-ylamino)-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamideKi84.0 [1]
2-[(2-Amino-3H-benzimidazol-5-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamideKi670.0 [1]
2-[(1-Aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)-N-(3-hydroxyphenyl)sulfonylacetamideKi26.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-(ethylamino)-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamideKi19.0 [1]
(6S)-3-(Tert-butylamino)-N-[(4-carbamimidoylphenyl)methyl]-1-chloro-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamideKi68.0 [1]
N-(Benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)-2-(isoquinolin-6-ylamino)acetamideKi70.0 [1]
2-[(1-Aminoisoquinolin-6-yl)amino]-N-(3-aminophenyl)sulfonyl-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamideKi48.0 [1]
3-[[2-[(1-Aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetyl]sulfamoyl]benzamideKi18.0 [1]
2-(2-Fluorophenyl)pyrido[2,3-d][1,3]oxazin-4-oneIC502800.0 [1]
2-(2-Fluorophenyl)pyrazino[2,3-d][1,3]oxazin-4-oneIC50200000.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-8,8-dimethyl-3-[(5-methylfuran-2-yl)methylamino]-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamideKi190.0 [1]
2-[(4-Aminoquinazolin-7-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamideKi390.0 [1]
2-[5-(5-Carbamimidoyl-1H-indol-2-yl)-6-hydroxy-3'-nitro-biphenyl-3-yl]-succinic acidKi1.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-(cyclopropylamino)-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamideKi37.0 [1]
2-[(3-Amino-1H-indazol-6-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamideKi2900.0 [1]
2-[(1-Aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)-N-(4-hydroxyphenyl)sulfonylacetamideKi7.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-4-oxo-3-(propylamino)-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carboxamideKi186.0 [1]
2-Hydroxy-3-(5-amidino-1H-indole-2-yl)-3'-aminobiphenyl-5-acetic acidKi12.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-8,8-diethyl-4-oxo-3-(propylamino)-6,7-dihydropyrrolo[1,2-a]pyrimidine-6-carboxamideKi75.0 [1]
2-[(1-Aminoisoquinolin-6-yl)amino]-N-benzyl-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamideKi930.0 [1]
2-[(1-Aminoisoquinolin-6-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamideKi16.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-8,8-dimethyl-4-oxo-3-(propan-2-ylamino)-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamideKi17.0 [1]
2-[(1-Aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)-N-(4-methylphenyl)sulfonylacetamideKi197.0 [1]
2-Hydroxy-3-(5-amidino-1H-indole-2-yl)biphenyl-5-acetic acidKi41.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-[[1-(hydroxymethyl)cyclopentyl]amino]-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamideKi70.0 [1]
2-(2,6-Difluoro-phenyl)-7-nitro-benzo[d][1,3]oxazin-4-oneIC50820.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-8,8-dimethyl-3-(methylamino)-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamideKi24.0 [1]
H-D-Pro-Phe-Arg-chloromethylketoneIC501500.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-(cyclobutylamino)-4-oxo-8,8-dipropyl-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamideKi28.0 [1]
2-[(3-Amino-1,2-benzoxazol-6-yl)amino]-N-(benzenesulfonyl)-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamideKi1940.0 [1]
2-[(1-Aminoisoquinolin-6-yl)amino]-N-(4-aminophenyl)sulfonyl-2-(3-ethoxy-4-propan-2-yloxyphenyl)acetamideKi9.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-8,8-dimethyl-3-(2-methylpropylamino)-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamideKi43.0 [1]
(6S)-N-[(4-Carbamimidoylphenyl)methyl]-1-chloro-3-(cyclobutylamino)-8,8-dimethyl-4-oxo-6,7-dihydropyrrolo[1,2-a]pyrazine-6-carboxamideKi23.0 [1]
2-[(8Z,11Z)-Heptadeca-8,11-dienyl]-6-hydroxybenzoic acidIC5033000.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-3-(2-methoxyethylamino)-2-oxo-6-phenylpyrazin-1-yl]acetamideIC50880.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[3-chloro-2-[3-(methylamino)phenyl]-6-oxo-5-(2-phenylethylamino)pyrazin-1-yl]acetamideIC50600.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-2-oxo-6-phenyl-3-[2-[3-(trifluoromethyl)phenyl]ethylamino]pyrazin-1-yl]acetamideIC5030000.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-3-[2-(dimethylamino)ethylamino]-2-oxo-6-phenylpyrazin-1-yl]acetamideIC5020900.0 [1]
2-[5-Chloro-2-oxo-6-phenyl-3-(2-phenylethylamino)pyrazin-1-yl]-N-(2-pyridin-4-ylethyl)acetamideIC50100000.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-3-(2-hydroxyethylamino)-2-oxo-6-phenylpyrazin-1-yl]acetamideIC50500.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-3-(cyclohexylamino)-2-oxo-6-phenylpyrazin-1-yl]acetamideIC501400.0 [1]
N-(1H-Benzimidazol-2-ylmethyl)-2-[5-chloro-2-oxo-6-phenyl-3-(2-phenylethylamino)pyrazin-1-yl]acetamideIC50100000.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[3-chloro-2-[3-(methanesulfonamido)phenyl]-6-oxo-5-(2-phenylethylamino)pyrazin-1-yl]acetamideIC50600.0 [1]
3-[1-[2-[(4-Carbamimidoylphenyl)methylamino]-2-oxoethyl]-3-chloro-6-oxo-5-(propan-2-ylamino)pyrazin-2-yl]benzoic acidIC50360.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[3-chloro-2-methyl-6-oxo-5-(2-phenylethylamino)pyrazin-1-yl]acetamideIC504280.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[5-chloro-2-oxo-3-(2-phenylethylamino)-6-[2-(trifluoromethyl)phenyl]pyrazin-1-yl]acetamideIC502700.0 [1]
N-[(3-Carbamimidoylphenyl)methyl]-2-[2-oxo-6-phenyl-3-(2-phenylethylamino)pyrazin-1-yl]acetamideIC5030000.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[3-chloro-5-(cyclobutylamino)-2-(3-hydroxyphenyl)-6-oxopyrazin-1-yl]acetamideIC50200.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Coagulation factor VII/tissue factor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/coagulation-factor-vii-tissue-factor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Coagulation factor VII/tissue factor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/coagulation-factor-vii-tissue-factor-inhibitors-ic50-ki.
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