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Coagulation factor VII Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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RazaxabanKi2300.0 [1], 15000.0 [2]
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(3S,6R,9S,14S,17R,20S,23R,26S,29R,32S,35R)-9-[[(2S)-2-[[(2S)-2-Acetamidopropanoyl]amino]-4-methylpentanoyl]amino]-3-(2-amino-2-oxoethyl)-29-[(2S)-butan-2-yl]-6,26-bis(carboxymethyl)-23,32-bis[3-(diaminomethylideneamino)propyl]-17-[(4-hydroxyphenyl)methyl]-20-(1H-indol-3-ylmethyl)-2,5,8,16,19,22,25,28,31,34-decaoxo-11,12-dithia-1,4,7,15,18,21,24,27,30,33-decazabicyclo[33.3.0]octatriacontane-14-carbonyl]amino]-5-amino-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-5-[(2-amino-2-oxoethyl)amino]-5-oxopentanoic acidIC501.1 [1], 9.2 [2], 9.7 [3], 11.0 [4]
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(3S,6R,9S,14S,17R,20S,23R,26S,29R,32S,35R)-3-(2-amino-2-oxoethyl)-29-[(2S)-butan-2-yl]-6,26-bis(carboxymethyl)-23,32-bis[3-(diaminomethylideneamino)propyl]-17-[(4-hydroxyphenyl)methyl]-20-(1H-indol-3-ylmethyl)-9-[[(2S)-4-methyl-2-[[(2S)-2-[[4-(naphthalen-2-ylsulfonylamino)-4-oxobutanoyl]amino]propanoyl]amino]pentanoyl]amino]-2,5,8,16,19,22,25,28,31,34-decaoxo-11,12-dithia-1,4,7,15,18,21,24,27,30,33-decazabicyclo[33.3.0]octatriacontane-14-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-5-[(2-amino-2-oxoethyl)amino]-5-oxopentanoic acidIC501.0 [1], 2.5 [2], 3.6 [3], 24.0 [4]
CID 9845742IC50340.0 [1]
(2S)-2-[[(2R)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-phenylpropanamideIC5042.0 [1]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-1-oxo-3-pyridin-3-ylpropan-2-yl]-3-phenylpropanamideIC50200.0 [1]
(2S)-2-[[(2R)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]butanediamideIC501000.0 [1], 1030.0 [2]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-3-(2-fluorophenyl)-1-oxopropan-2-yl]-3-phenylpropanamideIC5090.0 [1]
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(3S,6S,9R,14R,17S,20S,23S,26S,29S,32S,35S)-3-(2-amino-2-oxoethyl)-29-[(2S)-butan-2-yl]-6,26-bis(carboxymethyl)-23,32-bis[3-(diaminomethylideneamino)propyl]-9-[[(2S)-2-[[(2S)-2-[6-[hydroxy(naphthalen-2-yloxy)phosphoryl]oxyhexanoylamino]propanoyl]amino]-4-methylpentanoyl]amino]-17-[(4-hydroxyphenyl)methyl]-20-(1H-indol-3-ylmethyl)-2,5,8,16,19,22,25,28,31,34-decaoxo-11,12-dithia-1,4,7,15,18,21,24,27,30,33-decazabicyclo[33.3.0]octatriacontane-14-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-5-[(2-amino-2-oxoethyl)amino]-5-oxopentanoic acidIC501.9 [1], 2.0 [2], 9.2 [3]
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(3S,6S,9R,14R,17S,20S,23S,26S,29S,32S,35S)-3-(2-amino-2-oxoethyl)-29-[(2S)-butan-2-yl]-6,26-bis(carboxymethyl)-23,32-bis[3-(diaminomethylideneamino)propyl]-9-[[(2S)-2-[[(2S)-2-[6-[(4,4-diphenylcyclohexyl)oxy-hydroxyphosphoryl]oxyhexanoylamino]propanoyl]amino]-4-methylpentanoyl]amino]-17-[(4-hydroxyphenyl)methyl]-20-(1H-indol-3-ylmethyl)-2,5,8,16,19,22,25,28,31,34-decaoxo-11,12-dithia-1,4,7,15,18,21,24,27,30,33-decazabicyclo[33.3.0]octatriacontane-14-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-5-[(2-amino-2-oxoethyl)amino]-5-oxopentanoic acidIC503.4 [1], 4.0 [2], 90.0 [3]
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(3S,6S,9R,14R,17S,20S,23S,26S,29S,32S,35S)-3-(2-amino-2-oxoethyl)-29-[(2S)-butan-2-yl]-6,26-bis(carboxymethyl)-23,32-bis[3-(diaminomethylideneamino)propyl]-17-[(4-hydroxyphenyl)methyl]-9-[[(2S)-2-[[(2S)-2-[6-[hydroxy(5-phenylpentoxy)phosphoryl]oxyhexanoylamino]propanoyl]amino]-4-methylpentanoyl]amino]-20-(1H-indol-3-ylmethyl)-2,5,8,16,19,22,25,28,31,34-decaoxo-11,12-dithia-1,4,7,15,18,21,24,27,30,33-decazabicyclo[33.3.0]octatriacontane-14-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-5-[(2-amino-2-oxoethyl)amino]-5-oxopentanoic acidIC502.0 [1], 2.4 [2], 22.0 [3]
2-[3-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide;hydrochlorideKi15000.0 [1]
Hemi-babimKi74.0 [1], 26000.0 [2]
CID 10181104IC502800.0 [1]
4-[3-[2-Oxo-2-[[(S)-alpha-methyl-3-bromobenzyl]amino]ethyl]ureido]benzamidineKi27.0 [1]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]-3-phenylpropanamideIC50110.0 [1]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-3-(3-chlorophenyl)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-1-oxopropan-2-yl]-3-phenylpropanamideIC50230.0 [1]
(2S)-2-[[(2R)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-3-cyano-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]propanamideIC501450.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[2-hydroxy-6-phenyl-3-(propan-2-ylamino)phenyl]acetamideIC502500.0 [1]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-3-(3-methylphenyl)-1-oxopropan-2-yl]-3-phenylpropanamideIC50170.0 [1]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-1-oxo-3-[3-(trifluoromethyl)phenyl]propan-2-yl]-3-phenylpropanamideIC50800.0 [1]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-3-(3,4-difluorophenyl)-1-oxopropan-2-yl]-3-phenylpropanamideIC50160.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[2-methoxy-6-phenyl-3-(propan-2-ylamino)phenyl]acetamideIC5014700.0 [1]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-3-(3-fluorophenyl)-1-oxopropan-2-yl]-3-phenylpropanamideIC50200.0 [1]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-3-(4-cyanophenyl)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-1-oxopropan-2-yl]-3-phenylpropanamideIC50340.0 [1]
(2R)-2-(Benzylsulfonylamino)-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-3-(2-methylphenyl)-1-oxopropan-2-yl]-3-phenylpropanamideIC50240.0 [1]
4-[3-[2-Oxo-2-[[(S)-alpha-methyl-3-methoxybenzyl]amino]ethyl]ureido]benzamidineKi35.0 [1]
2-[3-(4-Carbamimidoyl-phenyl)-ureido]-N-((S)-1-phenyl-ethyl)-acetamideKi430.0 [1]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.17 [1], 270.0 [2]
2-[3-(4-Carbamimidoyl-phenyl)-ureido]-N-(3,4-dichloro-benzyl)-acetamideKi970.0 [1]
N-Benzyl-2-(4-carbamimidoylanilino)-2-(3,4-diethoxyphenyl)acetamideKi40.0 [1]
(2S,3R)-2-[[(2R)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-methylpentanamideIC50300.0 [1]
2-[3-[(2S,4R)-6-Carbamimidoyl-4-methyl-4-phenyl-2,3-dihydro-1H-quinolin-2-yl]-5-(3-methylbutanoylamino)phenyl]-5-carbamoylbenzoic acidKi630.0 [1], 1010.0 [2]
N-[(1S)-1-[4-(3-Amino-1H-indazol-6-yl)pyridin-2-yl]-2-phenylethyl]-4-(aminomethyl)cyclohexane-1-carboxamideKi10890.0 [1]
2-[[(1R)-2-[[2-[(4-Carbamimidoylphenyl)methylcarbamoyl]-1,3-dihydroinden-2-yl]amino]-1-cyclohexyl-2-oxoethyl]amino]acetic acidIC508900.0 [1]
2-[[(1R)-2-[[2-[(4-Carbamimidoylphenyl)methylcarbamoyl]-1,3-dihydroinden-2-yl]amino]-1-cyclohexyl-2-oxoethyl]amino]acetic acidKi7000.0 [1]
(2R,15R)-2-[(1-Amino-7-fluoroisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.23 [1], 790.0 [2]
2-(1H-Imidazol-4-yl)-1H-benzoimidazole-5-carboxamidineKi900.0 [1], 370000.0 [2]
2-(1H-Benzo[d]imidazol-2-yl)-1H-benzo[d]imidazole-5-carboxamidineKi460.0 [1], 440000.0 [2]
(2S)-2-[[(2S)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-N-[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]-3-phenylpropanamideIC5026000.0 [1]
(2S)-2-[[(2S)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-N-[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]-3-phenylpropanamideKi43000.0 [1]
Benzyl N-[(2R)-1-[[(2S)-1-[[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC5016000.0 [1]
Benzyl N-[(2R)-1-[[(2S)-1-[[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateKi8000.0 [1]
Benzyl N-[(2S)-1-[[(2S)-1-[[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateIC50109000.0 [1]
Benzyl N-[(2S)-1-[[(2S)-1-[[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamateKi89000.0 [1]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-N,N,4,15,17-pentamethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-7-carboxamideKi2.5 [1], 650.0 [2]
(2R,15R)-2-[(1-Amino-8-fluoroisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi1.0 [1], 100.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-diethoxyphosphoryl-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.62 [1], 390.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-N,N-diethyl-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-7-carboxamideKi0.57 [1], 600.0 [2]
1-[(2R,15R)-2-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaen-7-yl]cyclopropane-1-carboxylic acidKi0.55 [1], 1100.0 [2]
(2R,15R)-2-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.43 [1], 650.0 [2]
2-[[(2R)-1-[[1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-4-piperidin-4-ylbutan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidIC50133000.0 [1]
2-[[(2R)-1-[[1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-4-piperidin-4-ylbutan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acidKi100000.0 [1]
[(2R)-3-[[(2R)-1-[(2S,3Ar,5S,6S,7aS)-2-[2-[1-(diaminomethylidene)-2,5-dihydropyrrol-1-ium-3-yl]ethylcarbamoyl]-5,6-dihydroxy-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-2-methoxy-3-oxopropyl] hydrogen sulfateKi108.0 [1], 110.0 [2]
(2R)-2-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-14-hydroxy-4,17,20-trimethyl-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-3,12-dioneKi2.3 [1], 1620.0 [2]
(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-N-ethyl-15,15-difluoro-4,17,20-trimethyl-3,12-dioxo-N-(1,3-thiazol-2-ylmethyl)-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-7-carboxamideKi2.2 [1], 300.0 [2]
(2R,15R)-2-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-7-[(2S)-1-methoxypropan-2-yl]sulfonyl-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi1.8 [1], 550.0 [2]
(2R)-2-[(2R,15R)-2-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaen-7-yl]-4,4-difluorobutanoic acidKi0.9 [1], 320.0 [2]
(2R,15R)-2-[(1-Amino-8-fluoroisoquinolin-6-yl)amino]-8-fluoro-4,15,17-trimethyl-7-propan-2-ylsulfonyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.36 [1], 120.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-[(2R)-2-cyclopropyl-2-hydroxyethoxy]-8-fluoro-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.34 [1], 550.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-tert-butylsulfonyl-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.31 [1], 780.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-N-ethyl-4,15,17-trimethyl-3,12-dioxo-N-(1,3-thiazol-2-ylmethyl)-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-7-carboxamideKi0.3 [1], 330.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-8-fluoro-7-(3-methoxypropoxy)-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.2 [1], 290.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-15-(fluoromethyl)-4,17-dimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.28 [1], 200.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-8-fluoro-7-[(2R)-1-hydroxypropan-2-yl]oxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.17 [1], 70.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-8-fluoro-7-[(3R,4S)-4-hydroxyoxolan-3-yl]oxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.23 [1], 320.0 [2]
(2R,15R)-2-[(1-Amino-7-fluoroisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-8-fluoro-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.17 [1], 750.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-(1,3-difluoropropan-2-yloxy)-8-fluoro-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.15 [1], 41.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-8-fluoro-4,15,17-trimethyl-7-[2-(2-oxopyrrolidin-1-yl)ethoxy]-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.14 [1], 210.0 [2]
(2R,15R)-2-[(1-Amino-7-fluoroisoquinolin-6-yl)amino]-8-fluoro-4,15,17-trimethyl-7-propan-2-ylsulfonyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.14 [1], 2100.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-8-fluoro-7-[(2S)-1-methoxypropan-2-yl]oxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.14 [1], 190.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-8-fluoro-4,15,17-trimethyl-7-[(3R)-oxolan-3-yl]oxy-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.05 [1], 290.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-4,15,17-trimethyl-7-[1-(2H-tetrazol-5-yl)cyclopropyl]-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.12 [1], 230.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-8-fluoro-7-[(2S)-2-hydroxypropoxy]-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.46 [1], 400.0 [2]
(2R,15R)-2-[(1-Amino-7-fluoroisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-19-fluoro-17-methoxy-4,15-dimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.25 [1], 270.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-8-fluoro-7-[(2S)-1-hydroxypropan-2-yl]oxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.14 [1], 50.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-8-fluoro-7-[(1-isocyanocyclopropyl)methoxy]-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.44 [1], 490.0 [2]
(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-ethylsulfonyl-17,20-dimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-3,12-dioneKi1.1 [1], 70.0 [2]
(2R)-2-[(1-Amino-8-fluoroisoquinolin-6-yl)amino]-4-methyl-7-propan-2-ylsulfonyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-3,12-dioneKi38.0 [1], 3330.0 [2]
(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-ethylsulfonyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-3,12-dioneKi11.0 [1], 110.0 [2]
(15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-8-fluoro-4,15,17-trimethyl-7-[(3S)-oxolan-3-yl]oxy-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.02 [1], 100.0 [2]
(2R,15R)-2-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-7-ethylsulfonyl-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi2.3 [1], 270.0 [2]
(2R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-15,15-difluoro-4,17,20-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(19),6,8,10(21),16(20),17-hexaene-3,12-dioneKi2.0 [1], 290.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-(azetidine-1-carbonyl)-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi1.2 [1], 630.0 [2]
(2R,15R)-2-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-7-propan-2-ylsulfonyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi1.2 [1], 700.0 [2]
(2R,15R)-2-[(1-Amino-8-fluoroisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-8-fluoro-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.66 [1], 96.0 [2]
(2R)-2-[(2R,15R)-2-[(1-Amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaen-7-yl]butanoic acidKi0.61 [1], 380.0 [2]
(2R,15R)-2-[(1-Aminoisoquinolin-6-yl)amino]-7-cyclopropylsulfonyl-15-(difluoromethyl)-4,17-dimethyl-13-oxa-4,11-diazatricyclo[14.2.2.16,10]henicosa-1(18),6,8,10(21),16,19-hexaene-3,12-dioneKi0.5 [1], 180.0 [2]
MelagatranIC503300.0 [1]
2-[3-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamideKi15000.0 [1]
Anabaenopeptin FIC5035000.0 [1]
Anabaenopeptin BIC50100000.0 [1]
Bms-740808Ki2800.0 [1]
6-Chloro-2-(2-Hydroxybiphenyl-3-yl)-1H-Indole-5-CarboxamidineKi1700.0 [1]
3-{5-[Amino(iminio)methyl]-1H-indol-2-YL}-1,1'-biphenyl-2-olateKi160.0 [1]
Unii-vwj4vvz3OUKi13000.0 [1]
N-[(1R,2S,5S)-2-[(5-Chloro-1H-indole-2-carbonyl)amino]-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamideKi100000.0 [1]
N-[(4-Carbamimidoylphenyl)methyl]-2-[6-(3,5-diaminophenyl)-2-oxo-3-(propan-2-ylamino)pyridin-1-yl]acetamideIC5052.0 [1]
Methyl N-[4-[5-chloro-2-[(1S)-1-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-2-phenylethyl]-1H-imidazol-4-yl]phenyl]carbamateKi13400.0 [1]
2-[2-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-sulfamoylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamideKi15000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Coagulation factor VII Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/coagulation-factor-vii-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Coagulation factor VII Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/coagulation-factor-vii-inhibitors-ic50-ki.
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