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Cell division protein kinase 8 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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[(2s)-2-(4-Chlorophenyl)pyrrolidin-1-Yl](3-Methyl-1h-Pyrazolo[3,4-B]pyridin-5-Yl)methanoneIC506.5 [1], 8.0 [2], 9.0 [3], 32.0 [4], 52.0 [5]
N-Methyl-3-[(1-methylindazol-5-yl)methyl]-2H-indazole-5-carboxamideIC5049.0 [1], 65.0 [2], 340.0 [3], 710.0 [4]
SorafenibIC50199.0 [1], 1620.0 [2], 4520.0 [3]
LinifanibIC5014.0 [1], 1290.0 [2], 5170.0 [3]
Cortistatin AIC5012.0 [1]
8-(3-Chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-oneIC507.2 [1]
2-Amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrileIC50500.0 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3-methoxyazetidin-1-yl)methanoneIC507.2 [1]
2-[(3R)-12-(4-Morpholin-4-ylcyclohexyl)oxy-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-3-yl]acetamideIC5022.0 [1]
8-[2-Azanyl-3-Chloranyl-5-(1-Methylindazol-5-Yl)pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-OneIC502.3 [1]
(2R)-1-[4-[4-[(5-Chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-3,5-dimethylpyrazol-1-yl]piperidin-1-yl]-2-hydroxypropan-1-oneIC50810.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC5010000.0 [1]
8-[3-(3-Azanyl-2~{h}-Indazol-6-Yl)-5-Chloranyl-Pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-OneIC501.7 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC502.3 [1]
5-[5-Chloro-4-[1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3H-2,1-benzothiazole 2,2-dioxideIC5049.2 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-methyl-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5017.5 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-(trifluoromethyl)-2,3,8-triazaspiro[4.5]dec-1-en-4-oneIC5012.0 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-methyl-2,3,8-triazaspiro[4.5]dec-1-en-4-oneIC502.7 [1]
9-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,4,9-triazaspiro[5.5]undecane-2,5-dioneIC504.2 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-oneIC503.9 [1]
8-[3-Chloro-5-[4-[1-(2-hydroxyethyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC505.5 [1]
8-[3-[4-(1-Methylpyrazol-4-yl)phenyl]-5-(trifluoromethyl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC5032.8 [1]
8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC507.0 [1]
8-[3-Chloro-5-[4-(1,2-dimethylimidazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5020.5 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2-methyl-1,3,8-triazaspiro[4.5]dec-1-en-4-oneIC504.5 [1]
8-[3-[4-(1-Methylpyrazol-4-yl)phenyl]-5-(trifluoromethyl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC5014.7 [1]
8-[3-Chloro-5-[4-[1-(2-hydroxy-2-methylpropyl)pyrazol-4-yl]phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC501.6 [1]
8-[3-Fluoro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC5020.6 [1]
8-[3-Fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneIC504.3 [1]
8-[3-(3-Amino-1-methylindazol-6-yl)-5-chloropyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC503.2 [1]
8-[3-Chloro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC502.4 [1]
8-[3-Fluoro-5-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC503.8 [1]
8-[3-Chloro-5-[3-(methylamino)-1H-indazol-6-yl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneIC502.8 [1]
1-[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]pyrrolidin-2-oneIC5030.0 [1]
[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(3-methoxy-3-methylazetidin-1-yl)methanoneIC5023.1 [1]
3-[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-1,3-oxazolidin-2-oneIC5024.0 [1]
[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(3-methoxyazetidin-1-yl)methanoneIC5021.0 [1]
2-(1-Methylimidazol-2-yl)-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridineIC504.7 [1]
[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(3,3-difluoroazetidin-1-yl)methanoneIC5017.9 [1]
N-Cyclopropyl-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinoline-6-carboxamideIC501.1 [1]
2-(2-Methylpyrazol-3-yl)-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridineIC501946.0 [1]
2-[4-[4-(1-Methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-1,2-thiazolidine 1,1-dioxideIC5087.0 [1]
[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(azetidin-1-yl)methanoneIC5070.0 [1]
N-Methyl-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridine-2-carboxamideIC500.2 [1]
1-Amino-N-cyclopropyl-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinoline-6-carboxamideIC509.0 [1]
2-[4-[4-(1-Methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-1,3-oxazoleIC5016.0 [1]
N-Methyl-8-(1-methylindazol-6-yl)-1,6-naphthyridine-2-carboxamideIC504.6 [1]
4-[4-(1-Methylpyrazol-4-yl)phenyl]isoquinoline-6-sulfonamideIC5043.0 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3,3-difluoroazetidin-1-yl)methanoneIC505.8 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(azetidin-1-yl)methanoneIC5010.7 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-piperazin-1-ylmethanoneIC50559.0 [1]
(3,3-Difluoroazetidin-1-yl)-[8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]methanoneIC5012.6 [1]
N-[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]acetamideIC5076.0 [1]
(3,3-Difluoroazetidin-1-yl)-[4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]methanoneIC5019.4 [1]
8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridine-2-carboxylic acidIC50590.0 [1]
8-(2,2-Dioxo-1,3-dihydro-2,1-benzothiazol-5-yl)-N-methyl-1,6-naphthyridine-2-carboxamideIC5011.2 [1]
2-(1-Methylimidazol-2-yl)-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-5-amineIC5087.0 [1]
2-[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-1,3-oxazoleIC5045.0 [1]
2-(3-Methoxyazetidin-1-yl)-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridineIC501418.0 [1]
N-[4-[4-(1-Methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]acetamideIC5034.0 [1]
(3-Methoxyazetidin-1-yl)-[4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]methanoneIC5016.0 [1]
6-(1-Methylimidazol-2-yl)-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolineIC507.3 [1]
Azetidin-1-yl-[8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]methanoneIC502.0 [1]
N-Methyl-8-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)-1,6-naphthyridine-2-carboxamideIC501.7 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-morpholin-4-ylmethanoneIC5073.0 [1]
1-[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]imidazolidin-2-oneIC504.2 [1]
N-Methyl-8-(1-methylindazol-5-yl)-1,6-naphthyridine-2-carboxamideIC503.4 [1]
N-[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]acetamideIC5017.5 [1]
8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridine-2-carbonitrileIC50396.0 [1]
[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-pyrrolidin-1-ylmethanoneIC509.9 [1]
(3-Methoxyazetidin-1-yl)-[8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]methanoneIC502.5 [1]
[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(3-fluoro-3-methylazetidin-1-yl)methanoneIC5020.2 [1]
8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridine-2-carboxamideIC500.5 [1]
[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-morpholin-4-ylmethanoneIC5027.8 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3-methoxy-3-methylazetidin-1-yl)methanoneIC508.2 [1]
[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-piperazin-1-ylmethanoneIC5065.0 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3-fluoro-3-methylazetidin-1-yl)methanoneIC509.8 [1]
3-[4-[4-(1-Methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-1,3-oxazolidin-2-oneIC504.7 [1]
N-Methyl-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinoline-6-carboxamideIC500.6 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-pyrrolidin-1-ylmethanoneIC5035.5 [1]
[2-(4-Chlorophenyl)-4-methylpiperazin-1-yl]-(3-methyl-2H-indazol-5-yl)methanoneIC50230.0 [1]
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)methanoneIC50125.0 [1]
(3-Amino-1H-indazol-5-yl)-[(2S)-2-(4-fluorophenyl)pyrrolidin-1-yl]methanoneIC50120.0 [1]
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-[3-(methylamino)-1H-indazol-5-yl]methanoneIC5012.0 [1]
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[4,3-b]pyridin-5-yl)methanoneIC502.8 [1]
[3-(4-Chlorophenyl)morpholin-4-yl]-(3-methyl-2H-indazol-5-yl)methanoneIC50115.0 [1]
(3-Amino-1H-indazol-5-yl)-[(2S)-2-(4-bromophenyl)pyrrolidin-1-yl]methanoneIC5019.0 [1]
(3-Amino-1H-indazol-5-yl)-[(2S)-2-(4-fluorophenyl)azetidin-1-yl]methanoneIC50435.0 [1]
(3-Amino-1h-Indazol-5-Yl)[(2s)-2-(4-Fluorophenyl)piperidin-1-Yl]methanoneIC50800.0 [1]
(3-Amino-1H-indazol-5-yl)-[(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl]methanoneIC5028.0 [1]
(3,3-Difluoroazetidin-1-yl)-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanoneIC5025.0 [1]
3-[[4-[1-(2-Hydroxy-2-methylpropyl)pyrazol-4-yl]phenyl]methyl]-N-methyl-2H-indazole-5-carboxamideIC5076.0 [1]
3-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-2H-indazole-5-carboxamideIC50270.0 [1]
N-[2-[[3-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]amino]ethyl]acetamideIC5010000.0 [1]
1-[3-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]pyrrolidin-2-oneIC5082.0 [1]
3-[(3,4-Dimethoxyphenyl)methyl]-N-methyl-2H-indazole-5-carboxamideIC5010000.0 [1]
N-Methyl-3-[(3-methylphenyl)methyl]-2H-indazole-5-carboxamideIC501900.0 [1]
2-[3-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]pyridin-4-amineIC501500.0 [1]
N-[3-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanesulfonamideIC50710.0 [1]
[(3R)-3-Hydroxypyrrolidin-1-yl]-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanoneIC5042.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cell division protein kinase 8 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/cell-division-protein-kinase-8-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Cell division protein kinase 8 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cell-division-protein-kinase-8-inhibitors-ic50-ki.
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