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CDK8/Cyclin C Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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Standard Values (in nM)
▲
▼
StaurosporineIC506.0 [1], 15.0 [2]
Senexin BIC5024.0 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3-methoxyazetidin-1-yl)methanoneIC501.1 [1], 5.1 [2]
3-Chloranyl-4-Pyridin-4-Yl-1h-Pyrrole-2-CarboxamideIC505.0 [1], 7.0 [2]
[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(3-methoxyazetidin-1-yl)methanoneIC5012.0 [1], 32.7 [2]
[(3R)-3-Hydroxypyrrolidin-1-yl]-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanoneIC502.0 [1], 6.0 [2]
N-Methyl-3-[(1-methylindazol-5-yl)methyl]-2H-indazole-5-carboxamideIC5010.0 [1], 53.0 [2]
Cortistatin AIC505.0 [1]
CID 78357764IC5016.0 [1]
8-[2-Azanyl-3-Chloranyl-5-(1-Methylindazol-5-Yl)pyridin-4-Yl]-2,8-Diazaspiro[4.5]decan-1-OneIC504.9 [1]
[(2s)-2-(4-Chlorophenyl)pyrrolidin-1-Yl](3-Methyl-1h-Pyrazolo[3,4-B]pyridin-5-Yl)methanoneIC502.6 [1]
4-(Phenethylamino)quinazoline-6-carbonitrileIC50280.0 [1]
4-(4-Cyano-phenoxy)-thieno[2,3-c]pyridine-2-carboxylic acid amideIC505.1 [1]
4-(4-Acetylamino-phenoxy)-thieno[2,3-c]pyridine-2-carboxylic acid amideIC5029.0 [1]
CDK12 inhibitor 2IC5010000.0 [1]
4-[[[4-[5-Chloro-2-[[4-(2-methoxyethylamino)cyclohexyl]amino]pyridin-4-yl]-1,3-thiazol-2-yl]amino]methyl]oxane-4-carbonitrileIC5010000.0 [1]
4-(4-Chlorophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridineIC501.1 [1]
4-[4-[2-(2H-Tetrazol-5-yl)thieno[2,3-c]pyridin-4-yl]oxyphenyl]benzamideIC503.0 [1]
4-(4-Iodophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridineIC500.7 [1]
4-Phenoxy-2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridineIC508.3 [1]
2-(2H-Tetrazol-5-yl)-4-(p-tolyloxy)thieno[2,3-c]pyridineIC501.6 [1]
4-(4-Methylphenoxy)thieno[2,3-c]pyridine-2-carboxamideIC506.0 [1]
4-(4-Chlorophenoxy)thieno[2,3-c]pyridine-2-carboxamideIC506.2 [1]
4-(4-Chlorophenoxy)-N,N-dimethylthieno[2,3-c]pyridine-2-carboxamideIC5075.0 [1]
N-Ethyl-4-(4-chlorophenoxy)thieno[2,3-c]pyridine-2-carboxamideIC5016.0 [1]
N-Methyl-4-(4-chlorophenoxy)thieno[2,3-c]pyridine-2-carboxamideIC508.2 [1]
4-(4-Methoxy-phenoxy)-thieno[2,3-c]pyridine-2-carboxylic acid amideIC5025.0 [1]
4-(4-Chlorophenoxy)-N-cyclopropylthieno[2,3-c]pyridine-2-carboxamideIC5024.0 [1]
CID 10892544IC5062.0 [1]
4-(4-Chlorophenoxy)thieno[2,3-c]pyridine-2-carboxylic acidIC502.8 [1]
3-Ethyl-4-pyridin-4-yl-1H-pyrrole-2-carboxamideIC5013.0 [1]
3-Methyl-4-pyridin-4-yl-1H-pyrrole-2-carboxamideIC508.0 [1]
4-(4-Iodophenoxy)-N-Methylthieno[2,3-C]pyridine-2-CarboxamideIC505.3 [1]
1-[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]pyrrolidin-2-oneIC502.4 [1]
[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(3-methoxy-3-methylazetidin-1-yl)methanoneIC5044.0 [1]
3-[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-1,3-oxazolidin-2-oneIC5020.0 [1]
2-(1-Methylimidazol-2-yl)-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridineIC500.71 [1]
[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(3,3-difluoroazetidin-1-yl)methanoneIC5012.0 [1]
N-Cyclopropyl-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinoline-6-carboxamideIC502.1 [1]
2-(2-Methylpyrazol-3-yl)-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridineIC50470.0 [1]
2-[4-[4-(1-Methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-1,2-thiazolidine 1,1-dioxideIC506.7 [1]
[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(azetidin-1-yl)methanoneIC5036.0 [1]
N-Methyl-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridine-2-carboxamideIC503.6 [1]
1-Amino-N-cyclopropyl-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinoline-6-carboxamideIC509.1 [1]
2-[4-[4-(1-Methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-1,3-oxazoleIC5034.0 [1]
N-Methyl-8-(1-methylindazol-6-yl)-1,6-naphthyridine-2-carboxamideIC506.9 [1]
4-[4-(1-Methylpyrazol-4-yl)phenyl]isoquinoline-6-sulfonamideIC505.6 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3,3-difluoroazetidin-1-yl)methanoneIC5017.0 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(azetidin-1-yl)methanoneIC5021.0 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-piperazin-1-ylmethanoneIC50100.0 [1]
(3,3-Difluoroazetidin-1-yl)-[8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]methanoneIC5026.0 [1]
N-[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]acetamideIC5029.0 [1]
(3,3-Difluoroazetidin-1-yl)-[4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]methanoneIC506.2 [1]
8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridine-2-carboxylic acidIC504.7 [1]
8-(2,2-Dioxo-1,3-dihydro-2,1-benzothiazol-5-yl)-N-methyl-1,6-naphthyridine-2-carboxamideIC505.3 [1]
2-(1-Methylimidazol-2-yl)-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-5-amineIC50160.0 [1]
2-[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-1,3-oxazoleIC5016.0 [1]
2-(3-Methoxyazetidin-1-yl)-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridineIC50816.0 [1]
N-[4-[4-(1-Methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]acetamideIC504.9 [1]
(3-Methoxyazetidin-1-yl)-[4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]methanoneIC5011.0 [1]
6-(1-Methylimidazol-2-yl)-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolineIC505.6 [1]
Azetidin-1-yl-[8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]methanoneIC503.6 [1]
N-Methyl-8-(1-methyl-2,2-dioxo-3H-2,1-benzothiazol-5-yl)-1,6-naphthyridine-2-carboxamideIC500.9 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-morpholin-4-ylmethanoneIC5052.0 [1]
1-[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]imidazolidin-2-oneIC501.0 [1]
N-Methyl-8-(1-methylindazol-5-yl)-1,6-naphthyridine-2-carboxamideIC505.4 [1]
N-[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]acetamideIC501.8 [1]
8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridine-2-carbonitrileIC50390.0 [1]
[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-pyrrolidin-1-ylmethanoneIC503.5 [1]
(3-Methoxyazetidin-1-yl)-[8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]methanoneIC505.2 [1]
[1-Amino-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-(3-fluoro-3-methylazetidin-1-yl)methanoneIC5033.0 [1]
8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridine-2-carboxamideIC501.5 [1]
[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-morpholin-4-ylmethanoneIC5013.0 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3-methoxy-3-methylazetidin-1-yl)methanoneIC5012.0 [1]
[8-[4-(1-Methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-piperazin-1-ylmethanoneIC5025.0 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-(3-fluoro-3-methylazetidin-1-yl)methanoneIC5037.0 [1]
3-[4-[4-(1-Methylpyrazol-4-yl)phenyl]isoquinolin-6-yl]-1,3-oxazolidin-2-oneIC504.6 [1]
N-Methyl-4-[4-(1-methylpyrazol-4-yl)phenyl]isoquinoline-6-carboxamideIC504.5 [1]
[5-Amino-8-[4-(1-methylpyrazol-4-yl)phenyl]-1,6-naphthyridin-2-yl]-pyrrolidin-1-ylmethanoneIC5028.0 [1]
[2-(4-Chlorophenyl)-4-methylpiperazin-1-yl]-(3-methyl-2H-indazol-5-yl)methanoneIC5015.0 [1]
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)methanoneIC5011.0 [1]
(3-Amino-1H-indazol-5-yl)-[(2S)-2-(4-fluorophenyl)pyrrolidin-1-yl]methanoneIC5032.0 [1]
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-[3-(methylamino)-1H-indazol-5-yl]methanoneIC505.4 [1]
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[4,3-b]pyridin-5-yl)methanoneIC501.3 [1]
[3-(4-Chlorophenyl)morpholin-4-yl]-(3-methyl-2H-indazol-5-yl)methanoneIC508.5 [1]
(3-Amino-1H-indazol-5-yl)-[(2S)-2-(4-bromophenyl)pyrrolidin-1-yl]methanoneIC503.1 [1]
(3-Amino-1H-indazol-5-yl)-[(2S)-2-(4-fluorophenyl)azetidin-1-yl]methanoneIC5049.0 [1]
(3-Amino-1h-Indazol-5-Yl)[(2s)-2-(4-Fluorophenyl)piperidin-1-Yl]methanoneIC5045.0 [1]
(3-Amino-1H-indazol-5-yl)-[(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl]methanoneIC504.9 [1]
(3,3-Difluoroazetidin-1-yl)-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanoneIC507.0 [1]
3-[[4-[1-(2-Hydroxy-2-methylpropyl)pyrazol-4-yl]phenyl]methyl]-N-methyl-2H-indazole-5-carboxamideIC5016.0 [1]
3-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-2H-indazole-5-carboxamideIC50110.0 [1]
N-[2-[[3-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]amino]ethyl]acetamideIC50680.0 [1]
1-[3-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]pyrrolidin-2-oneIC5036.0 [1]
3-[(3,4-Dimethoxyphenyl)methyl]-N-methyl-2H-indazole-5-carboxamideIC502500.0 [1]
N-Methyl-3-[(3-methylphenyl)methyl]-2H-indazole-5-carboxamideIC50170.0 [1]
2-[3-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]pyridin-4-amineIC50270.0 [1]
N-[3-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanesulfonamideIC5073.0 [1]
[(3S)-3-Hydroxypyrrolidin-1-yl]-[3-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]methanoneIC503.0 [1]
[3-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-2H-indazol-5-yl]-piperazin-1-ylmethanoneIC507.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ CDK8/Cyclin C Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/cdk8-cyclin-c-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ CDK8/Cyclin C Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cdk8-cyclin-c-inhibitors-ic50-ki.
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