CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	CID 76072859	IC50	20.0 [1]
	Ethyl 4-hydroxy-2-(4-pyridyl)-1,3-thiazole-5-carboxylate	IC50	405.0 [1]
	CDC7 Inhibitor C10C	IC50	0.7 [1], 1.7 [2], 190.0 [3]
	2-(Cyclopentylmethyl)-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-one	IC50	1.5 [1], 5.6 [2], 70.0 [3]
	6-Pyridin-4-yl-2-(pyrrolidin-1-ylmethyl)-3H-thieno[3,2-d]pyrimidin-4-one	IC50	12.0 [1], 150.0 [2], 350.0 [3]
	6-(1H-Pyrazol-4-yl)-2-(pyrrolidin-1-ylmethyl)-3H-thieno[3,2-d]pyrimidin-4-one	IC50	4.5 [1], 77.0 [2], 190.0 [3]
	2-[(Dimethylamino)methyl]-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-one	IC50	1.5 [1], 2.2 [2], 140.0 [3]
	Methyl 2-(2-chloroanilino)-4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]furan-3-carboxylate	IC50	0.6 [1], 191.0 [2]
	1'-(4-Fluorophenyl)-1'-hydroxy-6-(5-methyl-1H-pyrazol-4-yl)spiro[1,3-dihydrothieno[3,2-d]pyrimidine-2,4'-cyclohexane]-4-one	IC50	1.2 [1], 170.0 [2]
	1'-Cyclohexyl-1'-hydroxy-6-(5-methyl-1H-pyrazol-4-yl)spiro[1,3-dihydrothieno[3,2-d]pyrimidine-2,4'-cyclohexane]-4-one	IC50	2.0 [1], 380.0 [2]
	5-Thiazolecarboxamide, 4-hydroxy-2-(4-pyridinyl)-	IC50	115.0 [1], 50000.0 [2]
	4-Phenyl-2-pyridin-4-yl-1,3-thiazole-5-carboxamide	IC50	101.0 [1], 23600.0 [2]
	4-Methoxy-2-pyridin-4-yl-1,3-thiazole-5-carboxamide	IC50	95.5 [1], 9930.0 [2]
	4-(2,4-Dichlorophenyl)-2-pyridin-4-yl-1,3-thiazole-5-carboxamide	IC50	14.3 [1], 11500.0 [2]
	2-(2-Aminopyrimidin-4-yl)-4-(2-fluorophenyl)-1,3-thiazole-5-carboxamide	IC50	17.8 [1], 1070.0 [2]
	2-(2-Aminopyrimidin-4-yl)-4-[2-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide	IC50	18.4 [1], 2040.0 [2]
	2-(2-Aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)-1,3-thiazole-5-carboxamide	IC50	32.8 [1], 3620.0 [2]
	2-(2-Aminopyrimidin-4-yl)-4-(3,5-dichlorophenyl)-1,3-thiazole-5-carboxamide	IC50	62.3 [1], 8500.0 [2]
	2-(2-Aminopyrimidin-4-yl)-4-(2-chloro-4-methylphenyl)-1,3-thiazole-5-carboxamide	IC50	6.04 [1], 1400.0 [2]
	2-(2-Aminopyrimidin-4-yl)-4-(dimethylamino)-1,3-thiazole-5-carboxamide	IC50	20.5 [1], 1870.0 [2]
	Danusertib	IC50	10000.0 [1]
	Entrectinib	IC50	10000.0 [1]
	Nms-P937 (nms1286937)	IC50	10000.0 [1]
	N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamide	IC50	10000.0 [1]
	2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide	IC50	10000.0 [1]
	Pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amine	Ki	1200.0 [1]
	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	IC50	10000.0 [1]
	11,13-Dimethyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(13),2(7),3,5,9,11-hexaen-6-amine	Ki	40.0 [1]
	2-(Cyclohexylamino)-6-phenyl-4(3H)-pyrimidinone	Ki	230.0 [1]
	2-(Cyclohexylamino)-4-pyridin-4-yl-1H-pyrimidin-6-one	Ki	2.0 [1]
	12-Phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-6-amine	Ki	900.0 [1]
	Ethyl 4-hydroxy-2-phenyl-1,3-thiazole-5-carboxylate	IC50	46700.0 [1]
	Ethyl 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxylate	IC50	20500.0 [1]
	6-(Cyclohexylamino)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyridin-2-one	Ki	0.5 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	CID 90643548	IC50	6.81 [1]
	11,13-Dimethyl-12-prop-2-enyl-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-6-amine	Ki	2.0 [1]
	3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-ol	IC50	10000.0 [1]
	8-Methyl-11-thia-9,14,16-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1,7,9,12,14,16-hexaen-13-amine	Ki	0.5 [1]
	Ethyl 4-hydroxy-2-(4-methoxyphenyl)-1,3-thiazole-5-carboxylate	IC50	125000.0 [1]
	N-[(3-Fluorophenyl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	10.0 [1]
	N-(Pyridin-3-ylmethyl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	190.0 [1]
	2-(Cyclohexylamino)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	0.07 [1]
	2-(Benzylamino)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	0.07 [1]
	2-Anilino-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	0.12 [1]
	2-(4-Hydroxypiperidin-1-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	0.2 [1]
	2-(Oxan-4-ylamino)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	0.14 [1]
	2-[Cyclohexyl(methyl)amino]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	0.09 [1]
	2-[Bis(2-methoxyethyl)amino]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	0.18 [1]
	2-Morpholin-4-yl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	0.18 [1]
	2-(4-Methoxypiperidin-1-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	0.2 [1]
	2-[(1-Methylpiperidin-4-yl)amino]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	0.11 [1]
	2-Phenyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	0.25 [1]
	N-Hydroxy-4-phenyl-2-pyridin-4-yl-1,3-thiazole-5-carboxamide	IC50	1690.0 [1]
	2-(Cyclohexylamino)-4-pyridin-3-yl-1H-pyrimidin-6-one	Ki	1200.0 [1]
	4-(2-Aminopyrimidin-4-yl)-2-(cyclohexylamino)-1H-pyrimidin-6-one	Ki	5.0 [1]
	2-(Cyclohexylamino)-4-(1H-pyrazol-4-yl)-1H-pyrimidin-6-one	Ki	15.0 [1]
	2-(Cyclohexylamino)-4-(1H-indazol-5-yl)-1H-pyrimidin-6-one	Ki	0.5 [1]
	4-(Cyclohexylamino)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-1,3,5-triazin-2-one	Ki	0.3 [1]
	4-(Cyclohexylamino)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-2-one	Ki	1.4 [1]
	2-(Benzhydrylamino)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-one	Ki	328.0 [1]
	Ethyl 2-anilino-4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]furan-3-carboxylate	IC50	3.3 [1]
	Ethyl 2-anilino-5-[(Z)-(5-chloropyrrolo[2,3-b]pyridin-3-ylidene)methyl]-4-hydroxyfuran-3-carboxylate	IC50	44.0 [1]
	N-[(R)-Cyclopropyl-(2-fluorophenyl)methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazol-2-amine	IC50	1.5 [1]
	N-(Pyridin-2-ylmethyl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	170.0 [1]
	N-[(1R)-2-Methyl-1-phenylpropyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	2.0 [1]
	N-[(R)-Cyclopropyl-(2-fluoropyridin-3-yl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	0.69 [1]
	N-[(R)-Cyclopropyl-(2-fluoropyridin-3-yl)methyl]-5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	1.1 [1]
	N-(2-Phenylpropan-2-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	120.0 [1]
	N-[(1R)-1-Phenylpropyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	4.0 [1]
	N-[(R)-Cyclopropyl-(2-fluoropyridin-3-yl)methyl]-5-(6-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	3.9 [1]
	N-[(4-Fluorophenyl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	25.0 [1]
	N-[(1S)-1-Phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	35.0 [1]
	N-[(R)-Cyclopropyl-(2-fluorophenyl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	0.85 [1]
	N-(Pyridin-4-ylmethyl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	110.0 [1]
	N-[(1R)-1-Phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	32.0 [1]
	N-[(R)-Cyclopropyl(phenyl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	1.0 [1]
	N-[(R)-Cyclopropyl-(3-fluoropyridin-4-yl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	1.8 [1]
	N-Benzyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	24.0 [1]
	N-[(2-Fluorophenyl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amine	IC50	35.0 [1]
	2-Cyclohexyl-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-one	IC50	2.7 [1]
	2-Methyl-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-one	IC50	75.0 [1]
	4-Hydroxy-2-pyridin-4-yl-1,3-thiazole-5-carboxylic acid;hydrochloride	IC50	6130.0 [1]
	4-Hydroxy-N-methyl-2-pyridin-4-yl-1,3-thiazole-5-carboxamide	IC50	8980.0 [1]
	N-Benzyl-4-hydroxy-2-pyridin-4-yl-1,3-thiazole-5-carboxamide	IC50	11600.0 [1]
	4-Hydroxy-N,N-dimethyl-2-pyridin-4-yl-1,3-thiazole-5-carboxamide	IC50	24400.0 [1]
	Ethyl 4-hydroxy-2-pyridin-3-yl-1,3-thiazole-5-carboxylate;2,2,2-trifluoroacetic acid	IC50	32000.0 [1]
	Ethyl 4-hydroxy-2-pyridin-2-yl-1,3-thiazole-5-carboxylate	IC50	125000.0 [1]
	Ethyl 2-(2-ethylpyridin-4-yl)-4-hydroxy-1,3-thiazole-5-carboxylate	IC50	7500.0 [1]
	Ethyl 2-(2-aminopyrimidin-4-yl)-4-hydroxy-1,3-thiazole-5-carboxylate	IC50	41.5 [1]
	Ethyl 4-hydroxy-2-pyrazin-2-yl-1,3-thiazole-5-carboxylate	IC50	26500.0 [1]
	Ethyl 4-hydroxy-2-thiophen-3-yl-1,3-thiazole-5-carboxylate	IC50	29600.0 [1]
	Ethyl 2-tert-butyl-4-hydroxy-1,3-thiazole-5-carboxylate	IC50	125000.0 [1]
	6-(5-Methyl-1H-pyrazol-4-yl)-2-phenyl-3H-thieno[3,2-d]pyrimidin-4-one	IC50	15.0 [1]
	2-(Methylaminomethyl)-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-one;dihydrochloride	IC50	1.4 [1]
	6-(5-Methyl-1H-pyrazol-4-yl)-2-[[(3R)-3-methylpyrrolidin-1-yl]methyl]-3H-thieno[3,2-d]pyrimidin-4-one	IC50	2.7 [1]
	6-(5-Methyl-1H-pyrazol-4-yl)-2-[(3-phenylpyrrolidin-1-yl)methyl]-3H-thieno[3,2-d]pyrimidin-4-one	IC50	7.0 [1]
	6-(5-Ethyl-1H-pyrazol-4-yl)-2-(pyrrolidin-1-ylmethyl)-3H-thieno[3,2-d]pyrimidin-4-one;dihydrochloride	IC50	2.5 [1]
	2-[[(3S)-3-Fluoropyrrolidin-1-yl]methyl]-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-one	IC50	1.1 [1]
	6-(5-Methyl-1H-pyrazol-4-yl)-2-(2-pyrrolidin-1-ylethyl)-3H-thieno[3,2-d]pyrimidin-4-one	IC50	140.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/cdc7-dbf4-cell-division-cycle-7-related-protein-kinase-activator-of-s-phase-kinase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cdc7-dbf4-cell-division-cycle-7-related-protein-kinase-activator-of-s-phase-kinase-inhibitors-ic50-ki.
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