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CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CID 76072859IC5020.0 [1]
Ethyl 4-hydroxy-2-(4-pyridyl)-1,3-thiazole-5-carboxylateIC50405.0 [1]
CDC7 Inhibitor C10CIC500.7 [1], 1.7 [2], 190.0 [3]
2-(Cyclopentylmethyl)-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-oneIC501.5 [1], 5.6 [2], 70.0 [3]
6-Pyridin-4-yl-2-(pyrrolidin-1-ylmethyl)-3H-thieno[3,2-d]pyrimidin-4-oneIC5012.0 [1], 150.0 [2], 350.0 [3]
6-(1H-Pyrazol-4-yl)-2-(pyrrolidin-1-ylmethyl)-3H-thieno[3,2-d]pyrimidin-4-oneIC504.5 [1], 77.0 [2], 190.0 [3]
2-[(Dimethylamino)methyl]-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-oneIC501.5 [1], 2.2 [2], 140.0 [3]
Methyl 2-(2-chloroanilino)-4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]furan-3-carboxylateIC500.6 [1], 191.0 [2]
1'-(4-Fluorophenyl)-1'-hydroxy-6-(5-methyl-1H-pyrazol-4-yl)spiro[1,3-dihydrothieno[3,2-d]pyrimidine-2,4'-cyclohexane]-4-oneIC501.2 [1], 170.0 [2]
1'-Cyclohexyl-1'-hydroxy-6-(5-methyl-1H-pyrazol-4-yl)spiro[1,3-dihydrothieno[3,2-d]pyrimidine-2,4'-cyclohexane]-4-oneIC502.0 [1], 380.0 [2]
5-Thiazolecarboxamide, 4-hydroxy-2-(4-pyridinyl)-IC50115.0 [1], 50000.0 [2]
4-Phenyl-2-pyridin-4-yl-1,3-thiazole-5-carboxamideIC50101.0 [1], 23600.0 [2]
4-Methoxy-2-pyridin-4-yl-1,3-thiazole-5-carboxamideIC5095.5 [1], 9930.0 [2]
4-(2,4-Dichlorophenyl)-2-pyridin-4-yl-1,3-thiazole-5-carboxamideIC5014.3 [1], 11500.0 [2]
2-(2-Aminopyrimidin-4-yl)-4-(2-fluorophenyl)-1,3-thiazole-5-carboxamideIC5017.8 [1], 1070.0 [2]
2-(2-Aminopyrimidin-4-yl)-4-[2-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamideIC5018.4 [1], 2040.0 [2]
2-(2-Aminopyrimidin-4-yl)-4-(2,5-difluorophenyl)-1,3-thiazole-5-carboxamideIC5032.8 [1], 3620.0 [2]
2-(2-Aminopyrimidin-4-yl)-4-(3,5-dichlorophenyl)-1,3-thiazole-5-carboxamideIC5062.3 [1], 8500.0 [2]
2-(2-Aminopyrimidin-4-yl)-4-(2-chloro-4-methylphenyl)-1,3-thiazole-5-carboxamideIC506.04 [1], 1400.0 [2]
2-(2-Aminopyrimidin-4-yl)-4-(dimethylamino)-1,3-thiazole-5-carboxamideIC5020.5 [1], 1870.0 [2]
DanusertibIC5010000.0 [1]
EntrectinibIC5010000.0 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamideIC5010000.0 [1]
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamideIC5010000.0 [1]
Pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amineKi1200.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
11,13-Dimethyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(13),2(7),3,5,9,11-hexaen-6-amineKi40.0 [1]
2-(Cyclohexylamino)-6-phenyl-4(3H)-pyrimidinoneKi230.0 [1]
2-(Cyclohexylamino)-4-pyridin-4-yl-1H-pyrimidin-6-oneKi2.0 [1]
12-Phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-6-amineKi900.0 [1]
Ethyl 4-hydroxy-2-phenyl-1,3-thiazole-5-carboxylateIC5046700.0 [1]
Ethyl 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxylateIC5020500.0 [1]
6-(Cyclohexylamino)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyridin-2-oneKi0.5 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
CID 90643548IC506.81 [1]
11,13-Dimethyl-12-prop-2-enyl-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-6-amineKi2.0 [1]
3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-olIC5010000.0 [1]
8-Methyl-11-thia-9,14,16-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1,7,9,12,14,16-hexaen-13-amineKi0.5 [1]
Ethyl 4-hydroxy-2-(4-methoxyphenyl)-1,3-thiazole-5-carboxylateIC50125000.0 [1]
N-[(3-Fluorophenyl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC5010.0 [1]
N-(Pyridin-3-ylmethyl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC50190.0 [1]
2-(Cyclohexylamino)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi0.07 [1]
2-(Benzylamino)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi0.07 [1]
2-Anilino-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi0.12 [1]
2-(4-Hydroxypiperidin-1-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi0.2 [1]
2-(Oxan-4-ylamino)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi0.14 [1]
2-[Cyclohexyl(methyl)amino]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi0.09 [1]
2-[Bis(2-methoxyethyl)amino]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi0.18 [1]
2-Morpholin-4-yl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi0.18 [1]
2-(4-Methoxypiperidin-1-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi0.2 [1]
2-[(1-Methylpiperidin-4-yl)amino]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi0.11 [1]
2-Phenyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi0.25 [1]
N-Hydroxy-4-phenyl-2-pyridin-4-yl-1,3-thiazole-5-carboxamideIC501690.0 [1]
2-(Cyclohexylamino)-4-pyridin-3-yl-1H-pyrimidin-6-oneKi1200.0 [1]
4-(2-Aminopyrimidin-4-yl)-2-(cyclohexylamino)-1H-pyrimidin-6-oneKi5.0 [1]
2-(Cyclohexylamino)-4-(1H-pyrazol-4-yl)-1H-pyrimidin-6-oneKi15.0 [1]
2-(Cyclohexylamino)-4-(1H-indazol-5-yl)-1H-pyrimidin-6-oneKi0.5 [1]
4-(Cyclohexylamino)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-1,3,5-triazin-2-oneKi0.3 [1]
4-(Cyclohexylamino)-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-2-oneKi1.4 [1]
2-(Benzhydrylamino)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrimidin-6-oneKi328.0 [1]
Ethyl 2-anilino-4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]furan-3-carboxylateIC503.3 [1]
Ethyl 2-anilino-5-[(Z)-(5-chloropyrrolo[2,3-b]pyridin-3-ylidene)methyl]-4-hydroxyfuran-3-carboxylateIC5044.0 [1]
N-[(R)-Cyclopropyl-(2-fluorophenyl)methyl]-5-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1,3,4-oxadiazol-2-amineIC501.5 [1]
N-(Pyridin-2-ylmethyl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC50170.0 [1]
N-[(1R)-2-Methyl-1-phenylpropyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC502.0 [1]
N-[(R)-Cyclopropyl-(2-fluoropyridin-3-yl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC500.69 [1]
N-[(R)-Cyclopropyl-(2-fluoropyridin-3-yl)methyl]-5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC501.1 [1]
N-(2-Phenylpropan-2-yl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC50120.0 [1]
N-[(1R)-1-Phenylpropyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC504.0 [1]
N-[(R)-Cyclopropyl-(2-fluoropyridin-3-yl)methyl]-5-(6-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC503.9 [1]
N-[(4-Fluorophenyl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC5025.0 [1]
N-[(1S)-1-Phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC5035.0 [1]
N-[(R)-Cyclopropyl-(2-fluorophenyl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC500.85 [1]
N-(Pyridin-4-ylmethyl)-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC50110.0 [1]
N-[(1R)-1-Phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC5032.0 [1]
N-[(R)-Cyclopropyl(phenyl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC501.0 [1]
N-[(R)-Cyclopropyl-(3-fluoropyridin-4-yl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC501.8 [1]
N-Benzyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC5024.0 [1]
N-[(2-Fluorophenyl)methyl]-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-oxadiazol-2-amineIC5035.0 [1]
2-Cyclohexyl-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-oneIC502.7 [1]
2-Methyl-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-oneIC5075.0 [1]
4-Hydroxy-2-pyridin-4-yl-1,3-thiazole-5-carboxylic acid;hydrochlorideIC506130.0 [1]
4-Hydroxy-N-methyl-2-pyridin-4-yl-1,3-thiazole-5-carboxamideIC508980.0 [1]
N-Benzyl-4-hydroxy-2-pyridin-4-yl-1,3-thiazole-5-carboxamideIC5011600.0 [1]
4-Hydroxy-N,N-dimethyl-2-pyridin-4-yl-1,3-thiazole-5-carboxamideIC5024400.0 [1]
Ethyl 4-hydroxy-2-pyridin-3-yl-1,3-thiazole-5-carboxylate;2,2,2-trifluoroacetic acidIC5032000.0 [1]
Ethyl 4-hydroxy-2-pyridin-2-yl-1,3-thiazole-5-carboxylateIC50125000.0 [1]
Ethyl 2-(2-ethylpyridin-4-yl)-4-hydroxy-1,3-thiazole-5-carboxylateIC507500.0 [1]
Ethyl 2-(2-aminopyrimidin-4-yl)-4-hydroxy-1,3-thiazole-5-carboxylateIC5041.5 [1]
Ethyl 4-hydroxy-2-pyrazin-2-yl-1,3-thiazole-5-carboxylateIC5026500.0 [1]
Ethyl 4-hydroxy-2-thiophen-3-yl-1,3-thiazole-5-carboxylateIC5029600.0 [1]
Ethyl 2-tert-butyl-4-hydroxy-1,3-thiazole-5-carboxylateIC50125000.0 [1]
6-(5-Methyl-1H-pyrazol-4-yl)-2-phenyl-3H-thieno[3,2-d]pyrimidin-4-oneIC5015.0 [1]
2-(Methylaminomethyl)-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-one;dihydrochlorideIC501.4 [1]
6-(5-Methyl-1H-pyrazol-4-yl)-2-[[(3R)-3-methylpyrrolidin-1-yl]methyl]-3H-thieno[3,2-d]pyrimidin-4-oneIC502.7 [1]
6-(5-Methyl-1H-pyrazol-4-yl)-2-[(3-phenylpyrrolidin-1-yl)methyl]-3H-thieno[3,2-d]pyrimidin-4-oneIC507.0 [1]
6-(5-Ethyl-1H-pyrazol-4-yl)-2-(pyrrolidin-1-ylmethyl)-3H-thieno[3,2-d]pyrimidin-4-one;dihydrochlorideIC502.5 [1]
2-[[(3S)-3-Fluoropyrrolidin-1-yl]methyl]-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-oneIC501.1 [1]
6-(5-Methyl-1H-pyrazol-4-yl)-2-(2-pyrrolidin-1-ylethyl)-3H-thieno[3,2-d]pyrimidin-4-oneIC50140.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/cdc7-dbf4-cell-division-cycle-7-related-protein-kinase-activator-of-s-phase-kinase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cdc7-dbf4-cell-division-cycle-7-related-protein-kinase-activator-of-s-phase-kinase-inhibitors-ic50-ki.
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