![](https://images.aatbio.com/dataset/ic50/cathepsin-s_6ace68f1f9ffeb30b3f60199676d80f4.svg) | Balicatib | IC50 | 2900.0 [1], 65000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_6ace68f1f9ffeb30b3f60199676d80f4.svg) | Balicatib | Ki | 28000.0 [1], 30100.0 [2], 65000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_d59228230ff3d3f6d8053610694e3a38.svg) | (2R)-N-(Cyanomethyl)-4-methyl-2-[3-(4-piperazin-1-ylphenyl)phenyl]pentanamide | IC50 | 1340.0 [1], 2010.0 [2], 20000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_d59228230ff3d3f6d8053610694e3a38.svg) | (2R)-N-(Cyanomethyl)-4-methyl-2-[3-(4-piperazin-1-ylphenyl)phenyl]pentanamide | Ki | 1695.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_58a13d447b2aa652406967c385c766ed.svg) | L-873724 | IC50 | 95.0 [1], 178.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_6d51fc49241900e0897c14c48a0cb82c.svg) | 1-Methyl-6-[4-(2-piperidin-4-ylethoxy)-3-(trifluoromethyl)phenyl]imidazo[4,5-c]pyridine-4-carbonitrile | IC50 | 8.0 [1], 8.3 [2], 9.0 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_3b28a7a77d653e53f34a79c77e254810.svg) | 6-[4-[3-(Dimethylamino)propoxy]-3-(trifluoromethyl)phenyl]-1-methylimidazo[4,5-c]pyridine-4-carbonitrile | IC50 | 32.0 [1], 41.0 [2], 84.0 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_e001630f5f26ea9f6c6749e7a0031dfe.svg) | N-(1-((Cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamide | IC50 | 790.0 [1], 10000.0 [2], 47000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_e001630f5f26ea9f6c6749e7a0031dfe.svg) | N-(1-((Cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamide | Ki | 47000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_a4e3b472643e0b4d81a9fc64505e7574.svg) | 4-Propyl-6-(3-(trifluoromethyl)phenyl)pyrimidine-2-carbonitrile | IC50 | 41.0 [1], 60.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_7b8d9d41a92c7bceaf75336e63f47a76.svg) | N-[(2S)-1-[2-(4-Methoxyanilino)ethylamino]-4-methyl-1-oxopentan-2-yl]-3-methylbenzamide | IC50 | 70.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_7b8d9d41a92c7bceaf75336e63f47a76.svg) | N-[(2S)-1-[2-(4-Methoxyanilino)ethylamino]-4-methyl-1-oxopentan-2-yl]-3-methylbenzamide | Ki | 62.0 [1], 68.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_84be55801240cba8f6441b4e2e524999.svg) | N-[(2S)-4-Methyl-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamide | IC50 | 80.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_84be55801240cba8f6441b4e2e524999.svg) | N-[(2S)-4-Methyl-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamide | Ki | 4.0 [1], 4.3 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_1ca0312e58231928578cf86a1f59e60c.svg) | [1-[5-Carbamoyl-3-(4-iodophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(2-cyanophenyl)piperazin-1-yl]propan-2-yl] carbamate | IC50 | 10.0 [1], 20.0 [2], 800.0 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_0c4958df7945e49ea8579d51209c701f.svg) | 1-[4-[2-[2-Chloro-5-[5-methylsulfonyl-1-(3-morpholin-4-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]phenyl]ethynyl]phenyl]-N-[(4-chlorophenyl)methyl]methanamine | IC50 | 140.0 [1], 1500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_fbc3a14ddef7c4012ec5bb7a78931e3b.svg) | 5-Methylsulfonyl-3-[3-(2-piperidin-1-ylethylsulfanyl)-4-(trifluoromethyl)phenyl]-1-(3-piperidin-1-ylpropyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine | IC50 | 380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_844c0d5c843469b3e0c9d511ae5115f9.svg) | 1-[1-[3-[5-Methylsulfonyl-3-[3-(2-piperidin-1-ylethylsulfanyl)-4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]pyrrolidin-2-one | IC50 | 40.0 [1], 170.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_6ce71f9ed90c4c6e9533c870dc5a7042.svg) | 6-[4-[3-(4-Ethylpiperazin-1-yl)propoxy]-3-(trifluoromethyl)phenyl]-1-methylimidazo[4,5-c]pyridine-4-carbonitrile | IC50 | 7.2 [1], 63.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_10dc71397a31afdca91b0bae47a61ee9.svg) | 2-[3-[3-[2-(4-Fluoropiperidin-1-yl)ethylsulfanyl]-4-(trifluoromethyl)phenyl]-1-[(2S)-2-hydroxy-3-piperidin-1-ylpropyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoacetamide | IC50 | 70.0 [1], 190.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_6d1af22bb3c4f7dc9c7419b79f082b70.svg) | 1-Methyl-6-[4-[2-(2-oxopyrrolidin-1-yl)ethoxy]-3-(trifluoromethyl)phenyl]imidazo[4,5-c]pyridine-4-carbonitrile | IC50 | 7.8 [1], 1420.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_5350189dac26406f68cde10a157774d5.svg) | N-[(2S)-4-Methyl-1-oxo-1-[[(4S)-3-oxo-1-[2-(3-pyridin-2-ylphenyl)acetyl]azepan-4-yl]amino]pentan-2-yl]-5-(2-morpholin-4-ylethoxy)-1-benzofuran-2-carboxamide | IC50 | 8.3 [1], 940.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_5350189dac26406f68cde10a157774d5.svg) | N-[(2S)-4-Methyl-1-oxo-1-[[(4S)-3-oxo-1-[2-(3-pyridin-2-ylphenyl)acetyl]azepan-4-yl]amino]pentan-2-yl]-5-(2-morpholin-4-ylethoxy)-1-benzofuran-2-carboxamide | Ki | 8.3 [1], 14.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_f26c60ae3ead18822b99a23fc3cb3999.svg) | Odanacatib | IC50 | 45.0 [1], 60.0 [2], 183.0 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_66d860806664d9ba5e34e91f610e2d15.svg) | Morpholine-4-carboxylic acid (1-(3-benzenesulfonyl-1-phenethylallylcarbamoyl)-3-methylbutyl)-amide | IC50 | 1.0 [1], 1.2 [2], 1.9 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_c53f364eff4b1a49b7410c8510632995.svg) | (2S)-N-(Cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-piperazin-1-ylphenyl)phenyl]ethyl]amino]pentanamide | IC50 | 7.0 [1], 451.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_c75ff540b6d2763d34ea9d34ea081484.svg) | N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(2-morpholin-4-yl-1,3-thiazol-4-yl)benzamide | IC50 | 10000.0 [1], 27000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_c75ff540b6d2763d34ea9d34ea081484.svg) | N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(2-morpholin-4-yl-1,3-thiazol-4-yl)benzamide | Ki | 13000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_1b95eaffdd0e325d2986cbd9e8596e09.svg) | 4-[1-[2-Hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1,4-benzoxazin-3-one | IC50 | 10.0 [1], 28.0 [2], 800.0 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_d4372012ad028a29fa5bd4e02ad3e3d6.svg) | N-[(2S)-1-[[(1R)-1-Cyano-2-phenylmethoxyethyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]morpholine-4-carboxamide | IC50 | 5.5 [1], 6.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_7ed053b2b434f0326e0ba01c73f323df.svg) | (2R)-N-(1-Cyanocyclopropyl)-3-(cyclopropylmethylsulfonyl)-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propanamide | IC50 | 0.4 [1], 0.5 [2], 33.0 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_d602ceacbce84a7e46cea7ab88c65414.svg) | N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-morpholin-4-ylbenzamide | IC50 | 4800.0 [1], 52000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_d602ceacbce84a7e46cea7ab88c65414.svg) | N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-morpholin-4-ylbenzamide | Ki | 42000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_b7cd8787dbcc787e7d664e2d28a661bc.svg) | N-[(1S)-1-[1-[(1S)-1-Cyanopentyl]triazol-4-yl]-1-cyclohexylethyl]thiophene-3-carboxamide | IC50 | 10.0 [1], 76.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_b7cd8787dbcc787e7d664e2d28a661bc.svg) | N-[(1S)-1-[1-[(1S)-1-Cyanopentyl]triazol-4-yl]-1-cyclohexylethyl]thiophene-3-carboxamide | Ki | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_416072643305e4a1b4fbdc2a062e33e2.svg) | N-[(1S)-1-[1-[(1S)-1-Cyanopentyl]triazol-4-yl]-1-(4-methylcyclohexyl)ethyl]thiophene-3-carboxamide | IC50 | 9.0 [1], 30.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_416072643305e4a1b4fbdc2a062e33e2.svg) | N-[(1S)-1-[1-[(1S)-1-Cyanopentyl]triazol-4-yl]-1-(4-methylcyclohexyl)ethyl]thiophene-3-carboxamide | Ki | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_a65bde328047b4cf786d1f94de4a5bcb.svg) | 1-[1-[3-[3-(3,4-Dichlorophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-3-methylbenzimidazol-2-one | IC50 | 10.0 [1], 50.0 [2], 800.0 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_f39a3204d8dc3aa9751a36bcdeb30bf2.svg) | (2R)-N-(1-Cyanocyclopropyl)-3-methylsulfonyl-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propanamide | IC50 | 1.8 [1], 2.5 [2], 5.0 [3] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_f79553beeffca9c0cdff62035d6ce120.svg) | N-[2-[5-[1-[2-Hydroxy-3-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]propyl]-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanylethyl]-2-phenylacetamide | IC50 | 130.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_73efe208aa2c00dd43cdc86b34f1bbec.svg) | 2-(4-Ethoxy-3-(trifluoromethyl)phenyl)-9H-purine-6-carbonitrile | IC50 | 3.9 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_776181b2cc50937cf9aa27094faba77b.svg) | 2-[4-[2-[4-(4-Cyano-1-methylimidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy]ethyl]piperidin-1-yl]-N,N-dimethylacetamide | IC50 | 8.3 [1], 22.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_96b6a8dee84b99abb31a4148776f757c.svg) | Telaprevir | IC50 | 300.0 [1], 100000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_9db8e317c9ba46bc2f569ac279e16fd2.svg) | Boceprevir | IC50 | 120.0 [1], 100000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_fabe4373b1e2c9c5ff57121de1d04047.svg) | Relacatib | IC50 | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_fabe4373b1e2c9c5ff57121de1d04047.svg) | Relacatib | Ki | 1.6 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_801911a6d1f097db29401be9cb7cee8a.svg) | (1R,21S,24S)-21-Tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.14,7.06,11]heptacosa-6(11),7,9-triene-24-carboxamide | IC50 | 10000.0 [1], 78000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_b385b9937ce6181d158d6dd29953ab9c.svg) | Benzyl (S)-1-cyanomethylcarbamoyl-3-methylbutylcarbamate | Ki | 130.0 [1], 143.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_ed74c0c8e4f21ea554da9ef9dad07061.svg) | Cathepsin inhibitor 1 | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_5948504df93608c4e2850c1aa25f95d0.svg) | [(2S)-3,3-Dimethyl-1-[3-[4-(trifluoromethyl)phenyl]pyrazol-1-yl]butan-2-yl] N-[(3S)-1,2-dioxo-1-(1H-pyrazol-5-ylamino)heptan-3-yl]carbamate | IC50 | 0.21 [1], 210.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_791a3d54fd5bc4feb4f0bbce2327a4ab.svg) | N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-piperazin-1-ylphenyl)benzamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_791a3d54fd5bc4feb4f0bbce2327a4ab.svg) | N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-piperazin-1-ylphenyl)benzamide | Ki | 4900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_5ad22d3b6b8eb44cd563c834452a4e77.svg) | N-[(2S)-3-Cyclohexyl-1-[2-(4-methoxyanilino)ethylamino]-1-oxopropan-2-yl]-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamide | Ki | 3.0 [1], 3.3 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_a4e2392a1b83b31947c3b48a76c25df3.svg) | 5-Tert-butyl-N-[(2S)-1-(cyanomethylamino)-3-(3-methylphenyl)-1-oxopropan-2-yl]-2-methylpyrazole-3-carboxamide | IC50 | 794.33 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_a9a1e0cc87d22a7cdc67d9ef65bec628.svg) | (2S)-N-(Cyanomethyl)-4-methyl-2-[[4-(4-piperazin-1-ylphenyl)thiophen-3-yl]amino]pentanamide | IC50 | 102.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_48b9149ff3d510e807f4b0f7548523c7.svg) | 1-[3-[4-(2-Cyanophenyl)piperazin-1-yl]-2-hydroxypropyl]-3-(4-iodophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_04541ad1382eb97200476bc55a4a3113.svg) | N-[1-[[(2S)-1-Oxo-1-(5-phenyl-1,3,4-oxadiazol-2-yl)pentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamide | Ki | 45000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_6cee3a74bd4c838790be79f3ee995548.svg) | N-[1-[[(2S)-1-(5-Ethyl-1,3,4-oxadiazol-2-yl)-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamide | Ki | 470.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_48c378956273e372ed1279e647d211e6.svg) | N-[1-[[(2S)-1-[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamide | Ki | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_11ce9ed4018c51dfb4a8e8c4b6a7b580.svg) | N-[1-[[(2S)-1-Oxo-1-[5-[3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl]pentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamide | Ki | 3300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_e697c12c80ded6ad3a158ee05532ec8b.svg) | 2-[4-[3-[5-Acetyl-3-(4-iodophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]piperazin-1-yl]benzonitrile | IC50 | 120.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_65674e762f58e74ba71d23796724daca.svg) | 1-[1-[3-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-hydroxypropyl]-3-(4-chlorophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone | IC50 | 20.0 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_49a104181e53adc5bf272acab4acba74.svg) | N-[(2S)-4-Methyl-1-oxo-1-[[(2S)-3-oxo-4-(pyridin-2-ylsulfonylamino)butan-2-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamide | IC50 | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_49a104181e53adc5bf272acab4acba74.svg) | N-[(2S)-4-Methyl-1-oxo-1-[[(2S)-3-oxo-4-(pyridin-2-ylsulfonylamino)butan-2-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamide | Ki | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_09749d7fc8a1c1e5ae49e3270f8be8c1.svg) | N-[(2S)-3-Naphthalen-2-yl-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]propan-2-yl]naphthalene-1-carboxamide | Ki | 15.6 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_840fa5b9d9d5f31b181641cfbd70c357.svg) | N-[(2S)-1-[[(1R)-2-[(4-Chlorophenyl)methoxy]-1-cyanoethyl]amino]-4-methyl-1-oxopentan-2-yl]morpholine-4-carboxamide | IC50 | 9.0 [1], 27.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_0f628894372353a5a603dd6e9a705632.svg) | N-[1-[[(2S)-1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamide | Ki | 350.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_9582fb89963ef382249c9f2405de142d.svg) | CID 16108900 | IC50 | 0.13 [1], 130.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_ce5ae4b3bf7ebfb85a12573d193ab891.svg) | (2R)-2-[[(1S)-1-(4-Bromophenyl)-2,2,2-trifluoroethyl]amino]-N-(1-cyanocyclopropyl)-3-methylsulfonylpropanamide | IC50 | 10.0 [1], 11.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_4729cb8e518478622e17740fd2692466.svg) | 6-[[4-(4-Acetylpiperazin-1-yl)phenoxy]methyl]-7-(2-cyclohexylethyl)pyrrolo[2,3-d]pyrimidine-2-carbonitrile | IC50 | 9.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_24953a226d08367690bc96947fa860dd.svg) | N-[(2S)-3-(3-Chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl]benzamide | IC50 | 125.89 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_207ee1d72b179d813058d865d5cdb141.svg) | N-[1-[[(2S)-1-(5-Methoxy-1,3,4-oxadiazol-2-yl)-1-oxopentan-2-yl]carbamoyl]cyclohexyl]-4-(trifluoromethoxy)benzamide | Ki | 320.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_78aa436f97cecaca322177917c529e6b.svg) | 6-(4-Chlorobenzyl)-7-neopentyl-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | IC50 | 460.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_bd9247616c62c8bc0eca0d1596e5ab98.svg) | 4-(3-Tert-butylphenyl)-6-propylpyrimidine-2-carbonitrile | IC50 | 191.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_a3703c1a7d6c46ae0e2852534037c741.svg) | 4-(3-Cyclopentylphenyl)-6-propylpyrimidine-2-carbonitrile | IC50 | 155.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_25c9d34c30daf6b5ef464f8331f7853a.svg) | 4-(3-(Methylsulfonyl)phenyl)-6-propylpyrimidine-2-carbonitrile | IC50 | 93.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_0abbfd8f1ebccc46b286f4c186862f00.svg) | 4-Propyl-6-m-tolylpyrimidine-2-carbonitrile | IC50 | 950.0 [1], 1300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_a0f0b014dd4e4014f1d4fff123f75b59.svg) | 4-Phenyl-6-propylpyrimidine-2-carbonitrile | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_b955521e6c6c082156f0d3e1d898a3ee.svg) | 4-Propyl-6-(2-(trifluoromethyl)phenyl)pyrimidine-2-carbonitrile | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_15ff24d505403b7121c79dd9bd623de3.svg) | 4-Propyl-6-(4-(trifluoromethyl)phenyl)pyrimidine-2-carbonitrile | IC50 | 1259.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_3f680754cf8eb75ecf2064b487f35954.svg) | 4-(4-Chloro-3-(trifluoromethyl)phenyl)-6-propylpyrimidine-2-carbonitrile | IC50 | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_e8c87d52e44ae23475358464d5891d74.svg) | 4-(4-Ethoxy-3-(trifluoromethyl)phenyl)-6-propylpyrimidine-2-carbonitrile | IC50 | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_11b72b92bf3536a9bd3c4dba36d9cdd9.svg) | 6-(4-(2-(2-Oxopyrrolidin-1-yl)ethoxy)-3-(trifluoromethyl)phenyl)picolinonitrile | IC50 | 29.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_0fff9e015174b9a4d337119a5431cb27.svg) | 6-(4-Ethoxy-3-(trifluoromethyl)phenyl)picolinonitrile | IC50 | 1660.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_066f4f8d58c56bf64a8dd72df1fc74c7.svg) | 6-(Cyclohexylamino)-9-[2-(4-methylpiperazin-1-YL)-ethyl]-9H-purine-2-carbonitrile | IC50 | 150.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_8c80cecc4d317f30fe2eed9166b00750.svg) | (1R,2R)-N-(Cyanomethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexane-1-carboxamide | IC50 | 1030.0 [1] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_98d9480bdb455a45e8f347963778d664.svg) | (1r,2r)-N-(1-Cyanocyclopropyl)-2-{[4-(4-Fluorophenyl)piperazin-1-Yl]carbonyl}cyclohexanecarboxamide | IC50 | 1258.93 [1], 1310.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_4a8bfa873b9404b06a23eb1ef8ada03a.svg) | N-[(2S)-3-(1-Methylcyclohexyl)-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]morpholine-4-carboxamide | IC50 | 0.4 [1], 570.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_a1e037a0711bc8572cbca60c82d99f1f.svg) | N-[(2S)-4,4-Dimethyl-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopentan-2-yl]furan-2-carboxamide | IC50 | 1.3 [1], 4800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_e64645032c2aa50ebd3f023a84409215.svg) | Ethyl 3-[1-[2-hydroxy-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1H-indole-5-carboxylate | IC50 | 27.0 [1], 410.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_c531627b0547e5d9452383a23a569cb4.svg) | N-Ethyl-6-fluoro-3-[1-[3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1-benzothiophene-2-carboxamide | IC50 | 37.0 [1], 1200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_d8b66c5417d55f1cfa8774938fcf9632.svg) | N-(2-Aminoethyl)-6-fluoro-3-[1-[3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-1-benzothiophene-2-carboxamide | IC50 | 47.0 [1], 5500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_c4f996503ef3f6c0eab5a585c1983c67.svg) | 1-[5-Methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(1H-pyrrolo[2,3-c]pyridin-3-yl)piperidin-1-yl]propan-2-ol | IC50 | 30.0 [1], 38.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_11f7d3162d06835b16d59169feaca803.svg) | 1-[5-Methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-1-yl]propan-2-ol | IC50 | 27.0 [1], 860.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_a1dadc909986449e3d6562facc2a84b8.svg) | 1-[4-(5-Hydroxypyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl]-3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propan-2-ol | IC50 | 200.0 [1], 240.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_e2174d4108f9957f229e59aa39b49d93.svg) | 1-[5-Methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(1H-pyrrolo[3,2-b]pyridin-3-yl)piperidin-1-yl]propan-2-ol | IC50 | 95.0 [1], 120.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_da99df3ef25de7feb55bb8c5264636d9.svg) | 1-[3-(4-Bromophenyl)-5-methylsulfonyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(1H-pyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl]propan-2-ol | IC50 | 77.0 [1], 150.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_a1110febcaf8df34e52fa22ab7d82074.svg) | 6-Fluoro-3-[1-[3-[5-methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]propyl]piperidin-4-yl]-N-(2-morpholin-4-ylethyl)-1-benzothiophene-2-carboxamide | IC50 | 39.0 [1], 340.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_40a328b0415a6a633fa9183e00ef3a0b.svg) | 1-[5-Methylsulfonyl-3-[4-(trifluoromethyl)phenyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-3-[4-(1H-pyrrolo[3,2-c]pyridin-3-yl)piperidin-1-yl]propan-2-ol | IC50 | 25.0 [1], 58.0 [2] |
![](https://images.aatbio.com/dataset/ic50/cathepsin-s_595207980eba8567ace501ddf48db6a5.svg) | N-[(2S)-3-(1-Methylcyclohexyl)-1-[[(4S,7R)-7-methyl-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]-1-oxopropan-2-yl]furan-2-carboxamide | IC50 | 0.4 [1], 1400.0 [2] |