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Cathepsin G Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
BortezomibIC50520.0 [1], 3100.0 [2]
BortezomibKi630.0 [1]
SivelestatIC5010000.0 [1], 100000.0 [2]
DelanzomibIC5013.7 [1], 2110.0 [2]
2-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,40S,43S,49S)-25-(4-Aminobutyl)-49-benzyl-4,19-bis[(2S)-butan-2-yl]-34-[3-(diaminomethylideneamino)propyl]-28-[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-3,6,12,18,21,24,27,30,33,36,39,42,48,51-tetradecaoxo-53,54-dithia-2,5,11,17,20,23,26,29,32,35,38,41,47,50-tetradecazapentacyclo[29.20.4.07,11.013,17.043,47]pentapentacontan-40-yl]acetic acidKi0.15 [1], 730.0 [2]
2-Amino-4-[(1R)-1-[[(6R)-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carbonyl]amino]propyl]benzoic acidIC5016000.0 [1]
Methyl (3S)-3-[[(2S)-1-[(2S)-2-[[(2S)-2-[(4-methoxy-4-oxobutanoyl)amino]propanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-2-oxo-4-phenylbutanoateKi200.0 [1], 7000.0 [2]
Methyl 4-oxo-4-[[(2S)-1-oxo-1-[[(2S)-1-oxo-1-[(2S)-2-[[(2S)-4,4,4-trifluoro-3-oxo-1-phenylbutan-2-yl]carbamoyl]pyrrolidin-1-yl]propan-2-yl]amino]propan-2-yl]amino]butanoateKi1600.0 [1], 17000.0 [2]
Methyl 4-[[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(2S)-4,4,4-trifluoro-3-oxo-1-phenylbutan-2-yl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]amino]-4-oxobutanoateKi200.0 [1], 3000.0 [2]
2-Amino-N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-(3-fluorothiophen-2-yl)propanamide;2,2,2-trifluoroacetic acidIC5090.0 [1], 10000.0 [2]
(2S)-2-Amino-N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acidIC50150.0 [1], 50000.0 [2]
CarfilzomibIC5030000.0 [1]
Tosylphenylalanyl chloromethyl ketoneIC50110000.0 [1]
Camostat mesylateIC50100000.0 [1]
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochlorideIC50250000.0 [1]
3,4-DichloroisocoumarinIC5093000.0 [1]
AloxistatinIC501100.0 [1]
Guttiferone AIC502700.0 [1]
Z-L-Phe chloromethyl ketoneIC5024000.0 [1]
(4-Carbamimidoylphenyl) 4-[(E)-3-[(2-ethoxy-2-oxoethyl)-prop-2-enylamino]-2-methyl-3-oxoprop-1-enyl]benzoateIC50100000.0 [1]
1-Hydroxy-2-methylanthraquinoneIC5060000.0 [1]
GW311616 hydrochlorideIC50100000.0 [1]
(2S)-1-[(2S)-2-[(4-Methoxybenzoyl)amino]-3-methylbutanoyl]-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]pyrrolidine-2-carboxamideKi250.0 [1]
4-(4-Guanidinobenzoyloxy)phenylacetateIC50100000.0 [1]
CID 118253852IC5020000.0 [1]
Jnj-10311795Ki38.0 [1]
6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrileIC50147910.84 [1]
3-Chloro-N-[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl]-4-[[4,5-dihydro-1,3-oxazol-2-yl(methyl)amino]methyl]thiophene-2-carboxamideKi10000.0 [1]
2,2',4-TrihydroxybenzophenoneIC50433200.0 [1]
4-({1-[(4-Methyl-1-Benzothiophen-3-Yl)methyl]-1h-Benzimidazol-2-Yl}sulfanyl)butanoic AcidIC5052.0 [1]
(2-Naphthalen-2-YL-1-naphthalen-1-YL-2-oxo-ethyl)-phosphonic acidIC504100.0 [1]
(E)-3-[4-[[1-[(3-Cyclopentyl-1-methyl-2-pyridin-2-ylindole-6-carbonyl)amino]cyclobutanecarbonyl]amino]phenyl]prop-2-enoic acidIC5010000.0 [1]
Methyl 2-[2-[[2-[5-amino-2-(4-fluorophenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-3-phenylpropanoyl]-1,3-benzoxazole-5-carboxylateKi720.0 [1]
N-[2-(Diaminomethylideneamino)oxyethyl]-2-[3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxopyrazin-1-yl]acetamideKi26000.0 [1]
Methyl 2-[2-[[2-[5-amino-2-(3-methoxyphenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-3-phenylpropanoyl]-1,3-benzoxazole-5-carboxylateKi379.0 [1]
1,3-Dibenzyl-1,3-diazetidine-2,4-dioneIC500.39 [1]
(3Ar,6S,6aS)-4-methylsulfonyl-6-propan-2-yl-1-[2-(pyrrolidin-1-ylmethyl)-1,3-oxazole-4-carbonyl]-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochlorideIC50100000.0 [1]
[3-[(4-Cyanobenzoyl)amino]-2,2-dimethyl-5-phenylpentanoyl] 3-[(4-cyanobenzoyl)amino]-2,2-dimethyl-5-phenylpentanoateIC501.4 [1]
2-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,40S,43S,49S)-40,49-Bis(2-amino-2-oxoethyl)-4-[(2S)-butan-2-yl]-25-[3-(diaminomethylideneamino)propyl]-28,34-bis[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-3,6,12,18,21,24,27,30,33,36,39,42,48,51-tetradecaoxo-53,54-dithia-2,5,11,17,20,23,26,29,32,35,38,41,47,50-tetradecazapentacyclo[29.20.4.07,11.013,17.043,47]pentapentacontan-19-yl]acetic acidKi12.0 [1]
2-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,40S,43S,49S)-49-(2-Amino-2-oxoethyl)-4,19-bis[(2S)-butan-2-yl]-25-[3-(diaminomethylideneamino)propyl]-28,34-bis[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-3,6,12,18,21,24,27,30,33,36,39,42,48,51-tetradecaoxo-53,54-dithia-2,5,11,17,20,23,26,29,32,35,38,41,47,50-tetradecazapentacyclo[29.20.4.07,11.013,17.043,47]pentapentacontan-40-yl]acetamideKi490.0 [1]
3-Chloro-N-[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl]-4-(methylaminomethyl)thiophene-2-carboxamideKi10000.0 [1]
3-Chloro-N-[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl]-4-[[2-(methylamino)imidazol-1-yl]methyl]thiophene-2-carboxamideKi5000.0 [1]
(2R)-2-[[(1S)-1-(4-Bromophenyl)-2,2,2-trifluoroethyl]amino]-N-(1-cyanocyclopropyl)-3-methylsulfonylpropanamideIC5050000.0 [1]
4-{3-[(4-Methyl-1-Benzothiophen-3-Yl)methyl]-2-Oxo-2,3-Dihydro-1h-Benzimidazol-1-Yl}butanoic AcidIC501400.0 [1]
Benzyl (3aS,6R,6aR)-4-methylsulfonyl-5-oxo-6-prop-2-enyl-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrole-1-carboxylateIC5053000.0 [1]
CID 66561876IC5014200.0 [1]
6-ChlorooxindoleIC501000000.0 [1]
4-[[(6R,7R)-7-[(2-Ethoxybenzoyl)amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carbonyl]oxymethyl]benzoic acidIC50280.0 [1]
4-[[2-[5-Amino-2-(3-chlorophenyl)-6-oxopyrimidin-1-yl]acetyl]amino]-N-benzyl-2,2-difluoro-3-oxo-5-phenylpentanamideKi1390.0 [1]
3-(3,4-Dichloro-benzenesulfonyl)-1-(3,4-dimethyl-phenyl)-imidazolidine-2,4-dioneIC5020000.0 [1]
1-Oxo-2-[2-oxo-2-[(1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)amino]ethyl]-9H-pyrido[3,4-b]indole-8-carboxylic acidKi130000.0 [1]
1,3-Diethyl-1,3-diazetidine-2,4-dioneIC50740.0 [1]
3-(Methylsulfonyl)-4-(3-methyl-5-chlorobenzo[b]thiophene-2-ylsulfonylamino)benzoic acid methyl esterIC501000.0 [1]
(3S)-1-Diazo-3-[(aminoacetyl)amino]-4-(4-iodophenyl)-2-butanoneIC5050000.0 [1]
3-(4-Chlorophenyl)sulfonyl-1-(3,4-dichlorophenyl)imidazolidine-2,4-dioneIC5022000.0 [1]
N-(4-Acetyl-2-methylsulfonylphenyl)-5-fluoro-3-methyl-1-benzothiophene-2-sulfonamideIC501000.0 [1]
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(2-fluoro-phenyl)-propionamideIC501000000.0 [1]
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-nonanoylamino]-3-phenyl-propionic acid ethyl esterIC5010.0 [1]
3-(4-Chlorophenyl)sulfonyl-1-(3,4-dimethylphenyl)imidazolidine-2,4-dioneIC503700.0 [1]
3-(3,4-Dimethoxy-benzenesulfonyl)-1-(3,4-dimethyl-phenyl)-imidazolidine-2,4-dioneIC50100000.0 [1]
(3Ar,6S,6aS)-1-[1-(2,2-dimethylpropyl)azetidine-3-carbonyl]-4-methylsulfonyl-6-propan-2-yl-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochlorideIC50100000.0 [1]
(2,5-Dioxo-3-phenylimidazolidin-1-yl)methyl benzoateIC50100000.0 [1]
4-(2,5-Dioxo-3-phenyl-imidazolidine-1-sulfonyl)-benzonitrileIC50330.0 [1]
3-(3,4-Dimethyl-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC50220.0 [1]
3-(4-Chlorophenyl)sulfonyl-1-pyridin-2-ylimidazolidine-2,4-dioneIC508500.0 [1]
3-(3,4-Dimethyl-benzenesulfonyl)-1-(3,4-dimethyl-phenyl)-imidazolidine-2,4-dioneIC501700.0 [1]
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-heptanoylamino]-3-phenyl-propionic acid ethyl esterIC5083000.0 [1]
2-Allyl-1-hydroxy-8-methoxy-anthraquinoneIC5060000.0 [1]
1-Phenyl-3-(toluene-4-sulfonyl)-imidazolidine-2,4-dioneIC504500.0 [1]
3-(4-Bromo-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC50600.0 [1]
3-(4-Chloro-benzenesulfonyl)-1-(4-phenoxy-phenyl)-imidazolidine-2,4-dioneIC504800.0 [1]
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-nonanoylamino]-3-phenyl-propionic acid propyl esterIC50200.0 [1]
3-(4-Methoxy-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC504200.0 [1]
3-[3-(4-Methylpiperazine-1-carbonyl)phenyl]sulfonyl-1-phenylimidazolidine-2,4-dioneIC504800.0 [1]
2-[3-(4-Chlorophenyl)sulfonyl-2,4-dioxoimidazolidin-1-yl]benzoic acidIC5026000.0 [1]
4-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-benzoic acidIC50100000.0 [1]
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-decanoylamino]-3-phenyl-propionic acid ethyl esterIC50440000.0 [1]
3-(2,5-Dioxo-3-phenyl-imidazolidine-1-sulfonyl)-benzonitrileIC50780.0 [1]
3-(4-Chlorophenyl)-1-(4-chlorophenyl)sulfonylimidazolidine-2,4-dioneIC50100000.0 [1]
1-(3,4-Dichlorophenyl)-3-(3,4-dichlorophenyl)sulfonylimidazolidine-2,4-dioneIC502300.0 [1]
3-(4-Chlorobenzoyl)-1-phenylimidazolidine-2,4-dioneIC503000.0 [1]
1-Phenyl-3-phenylmethanesulfonyl-imidazolidine-2,4-dioneIC50100000.0 [1]
3-(4-Fluoro-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC501500.0 [1]
3-(2-Chloro-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC502200.0 [1]
4-(2,5-Dioxo-3-phenyl-imidazolidine-1-sulfonyl)-benzoic acid methyl esterIC50340.0 [1]
3-(3,4-Dichloro-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC50230.0 [1]
[4-(2,5-Dioxo-3-phenyl-imidazolidine-1-sulfonyl)-phenyl]-acetic acid methyl esterIC506500.0 [1]
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-nonanoylamino]-3-phenyl-propionic acid isopropyl esterIC5077.0 [1]
3-(4-Chlorophenyl)sulfonyl-1-pyrimidin-2-ylimidazolidine-2,4-dioneIC50100000.0 [1]
3-(4-Chloro-benzenesulfonyl)-1-cyclohexyl-imidazolidine-2,4-dioneIC5075000.0 [1]
2-[2-[[4-[[5-(Carboxymethoxy)-4-[[4-[[5-(carboxymethoxy)-2-methoxy-4-[[2-methoxy-5-(2-methoxyethoxymethoxy)-4-methylphenyl]methyl]phenyl]methyl]-2-methoxy-5-(2-methoxyethoxymethoxy)phenyl]methyl]-2-methoxyphenyl]methyl]-2-methoxy-5-(2-methoxyethoxymethoxy)phenyl]methyl]-4-methoxyphenoxy]acetic acidKi15000.0 [1]
2-[2-[[4-[[5-(Carboxymethoxy)-4-[[4-[[5-(carboxymethoxy)-4-[[5-(cyclohexylmethoxy)-2-methoxy-4-methylphenyl]methyl]-2-methoxyphenyl]methyl]-5-(cyclohexylmethoxy)-2-methoxyphenyl]methyl]-2-methoxyphenyl]methyl]-5-(cyclohexylmethoxy)-2-methoxyphenyl]methyl]-4-methoxyphenoxy]acetic acidKi15000.0 [1]
4-(2,5-Dioxo-3-phenyl-imidazolidine-1-sulfonyl)-benzoic acidIC501900.0 [1]
1-(2-Chlorophenyl)-3-(4-chlorophenyl)sulfonylimidazolidine-2,4-dioneIC502000.0 [1]
3-(4-Nitro-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC506500.0 [1]
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-undecanoylamino]-3-phenyl-propionic acid ethyl esterIC506600.0 [1]
3-(3-Chloro-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC502500.0 [1]
3-(2,5-Dioxo-3-phenyl-imidazolidine-1-sulfonyl)-benzoic acid methyl esterIC50640.0 [1]
3-(3,4-Dimethoxy-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dioneIC504100.0 [1]
3-(4-Chloro-benzenesulfonyl)-1-(3-chloro-phenyl)-imidazolidine-2,4-dioneIC503900.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cathepsin G Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/cathepsin-g-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Cathepsin G Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cathepsin-g-inhibitors-ic50-ki.
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