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Cathepsin B Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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Standard Values (in nM)
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▼
[5-Amino-1-(benzenesulfonyl)pyrazol-3-yl] thiophene-2-carboxylateIC501800.0 [1]
LeupeptinIC509.4 [1], 47.0 [2], 117.0 [3]
LeupeptinKi5.0 [1], 7.0 [2]
NitroxolineKi154400.0 [1]
BalicatibIC5061.0 [1], 4750.0 [2], 4800.0 [3]
BalicatibKi2900.0 [1], 3800.0 [2]
(2R)-N-(Cyanomethyl)-4-methyl-2-[3-(4-piperazin-1-ylphenyl)phenyl]pentanamideIC503950.0 [1], 4400.0 [2], 86000.0 [3]
(2R)-N-(Cyanomethyl)-4-methyl-2-[3-(4-piperazin-1-ylphenyl)phenyl]pentanamideKi3843.0 [1]
e-64IC505.0 [1], 10.0 [2], 16.0 [3], 40.0 [4]
e-64Ki16000.0 [1]
L-873724IC504807.0 [1], 5239.0 [2]
2-Methyl-5-nitroquinoline-8-olKi77000.0 [1], 99000.0 [2], 153000.0 [3], 181000.0 [4], 469000.0 [5]
N-Benzyl-N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-7-carboxamideKi32000.0 [1], 64000.0 [2], 132000.0 [3], 182000.0 [4], 185000.0 [5]
N-(Cyanomethyl)-8-hydroxy-5,7-dinitroquinoline-2-carboxamideKi29000.0 [1], 34000.0 [2], 160000.0 [3], 201000.0 [4]
8-Hydroxy-5-nitroquinoline-2-carbonitrileKi68000.0 [1], 123000.0 [2], 142000.0 [3], 214000.0 [4]
CID 11199915IC50100.0 [1], 1360.0 [2]
CID 11199915Ki18.0 [1], 25.0 [2]
N-(1-((Cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamideIC5017.0 [1], 1050.0 [2], 1100.0 [3]
N-(1-((Cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamideKi1000.0 [1]
N-[[1-(1,3-Benzothiazol-2-ylmethyl)piperidin-4-yl]methyl]-8-hydroxy-N-(2-methoxyethyl)-5-nitroquinoline-7-carboxamideKi41000.0 [1], 181000.0 [2], 200000.0 [3]
2-(Morpholin-4-ylmethyl)-4-nitrophenolKi97000.0 [1], 212000.0 [2]
(2-Hydroxy-5-nitrophenyl)(morpholino)methanoneKi176000.0 [1], 237000.0 [2]
8-Hydroxy-5-nitroquinoline-2-carboxylic acidKi139000.0 [1], 240000.0 [2]
N-(Cyanomethyl)-5-nitroquinoline-8-carboxamideKi190000.0 [1], 240000.0 [2], 294000.0 [3]
N-(Cyanomethyl)-8-hydroxy-N-methyl-5-nitroquinoline-2-carboxamideKi102000.0 [1], 205000.0 [2], 263000.0 [3]
N-(Cyanomethyl)-2-hydroxy-5-nitrobenzamideKi168000.0 [1], 271000.0 [2]
8-(1-Methylpyrrol-2-yl)-5-nitroquinolineKi224000.0 [1], 333000.0 [2]
(8-Hydroxy-5-nitroquinolin-7-yl)-piperidin-1-ylmethanoneKi171000.0 [1], 311000.0 [2], 364000.0 [3]
N-[[1-(1,3-Benzothiazol-2-yl)piperidin-4-yl]methyl]-8-hydroxy-5-nitroquinoline-7-carboxamideKi12000.0 [1], 18000.0 [2], 322000.0 [3]
N-Benzyl-N-(cyanomethyl)-8-hydroxy-5,7-dinitroquinoline-2-carboxamideKi9000.0 [1], 35000.0 [2], 154000.0 [3], 163000.0 [4]
N-(Cyanomethyl)-8-hydroxy-N-methyl-5,7-dinitroquinoline-2-carboxamideKi109000.0 [1], 122000.0 [2], 257000.0 [3], 341000.0 [4]
N-Benzyl-N-(cyanomethyl)-2-hydroxy-5-nitrobenzamideKi96000.0 [1], 342000.0 [2]
N-(Cyanomethyl)-8-hydroxy-5-nitroquinoline-2-carboxamideKi116000.0 [1], 180000.0 [2], 190000.0 [3]
8-[4-Methoxy-3-(3-methoxypropoxy)phenyl]-5-nitroquinolineKi22000.0 [1], 118000.0 [2], 323000.0 [3]
N-(Cyanomethyl)-8-hydroxy-N-methyl-5-nitroquinoline-7-carboxamideKi121000.0 [1], 185000.0 [2]
(8-Hydroxy-5-nitroquinolin-7-yl)-(4-methylpiperidin-1-yl)methanoneKi94000.0 [1], 143000.0 [2], 162000.0 [3]
N-(1-Cyanocyclopropyl)-8-hydroxy-5-nitroquinoline-2-carboxamideKi66000.0 [1], 154000.0 [2], 157000.0 [3]
N-(Cyanomethyl)-8-hydroxy-5-nitroquinoline-7-carboxamideKi30000.0 [1], 67000.0 [2], 128000.0 [3], 206000.0 [4]
2-Amino-5-nitroquinolin-8-olKi202000.0 [1], 329000.0 [2]
(8-Hydroxy-5-nitroquinolin-7-yl)-morpholin-4-ylmethanoneKi122000.0 [1], 136000.0 [2]
N-[[1-(1,3-Benzoxazol-2-yl)piperidin-4-yl]methyl]-8-hydroxy-5-nitroquinoline-7-carboxamideKi8000.0 [1], 8200.0 [2], 13000.0 [3], 237000.0 [4]
N,N-Diethyl-1-(5-nitroquinolin-8-yl)piperidine-3-carboxamideKi36000.0 [1], 105000.0 [2], 117000.0 [3], 155000.0 [4]
TelaprevirIC50210.0 [1], 2300.0 [2], 4400.0 [3]
Morpholine-4-carboxylic acid (1-(3-benzenesulfonyl-1-phenethylallylcarbamoyl)-3-methylbutyl)-amideIC503.0 [1], 1360.0 [2], 4504.0 [3]
4-Nitro-1-naphthylamineKi111000.0 [1], 147000.0 [2], 217000.0 [3]
Benzyl N-[(2S)-4-methyl-1-[3-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-4-oxopyrrolidin-1-yl]-1-oxopentan-2-yl]carbamateKi1000.0 [1]
(2S)-N-(Cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-piperazin-1-ylphenyl)phenyl]ethyl]amino]pentanamideIC5082.0 [1], 1111.0 [2]
Pyrrolidine, 1-(4-nitro-1-naphthalenyl)-Ki34000.0 [1], 170000.0 [2], 277000.0 [3]
N-[(2S)-4-Methyl-1-oxo-1-[[(4S)-3-oxo-1-pyridin-2-ylsulfonylazepan-4-yl]amino]pentan-2-yl]-1-benzofuran-2-carboxamideKi500.0 [1]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(2-morpholin-4-yl-1,3-thiazol-4-yl)benzamideIC502900.0 [1], 4200.0 [2]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(2-morpholin-4-yl-1,3-thiazol-4-yl)benzamideKi3100.0 [1]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-morpholin-4-ylbenzamideIC504400.0 [1], 15400.0 [2]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-morpholin-4-ylbenzamideKi8600.0 [1]
N-[(2S)-3-(3-Bromophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl]-4-phenylbenzamideKi120.0 [1], 205.0 [2], 220.0 [3]
Methyl 2-[4-[[(2R)-2-[[(2S)-3-(3-bromophenyl)-2-[(4-phenylbenzoyl)amino]propanoyl]amino]-2-cyanoethoxy]methyl]triazol-1-yl]acetateKi26.0 [1], 131.0 [2], 136.0 [3]
2-[4-[[(2R)-2-[[(2S)-3-(3-Bromophenyl)-2-[(4-phenylbenzoyl)amino]propanoyl]amino]-2-cyanoethoxy]methyl]triazol-1-yl]acetic acidKi19.2 [1], 27.3 [2], 41.3 [3]
3-[4-[[(2R)-2-[[(2S)-3-(3-Bromophenyl)-2-[(4-phenylbenzoyl)amino]propanoyl]amino]-2-cyanoethoxy]methyl]triazol-1-yl]propanoic acidKi132.0 [1], 420.0 [2], 3640.0 [3]
2-[4-[(2S)-2-[[(2S)-3-(3-Bromophenyl)-2-[(4-phenylbenzoyl)amino]propanoyl]amino]-2-cyanoethyl]triazol-1-yl]acetic acidKi368.0 [1], 707.0 [2], 11200.0 [3]
8-Hydroxy-5,7-dinitroquinoline-2-carbonitrileKi39000.0 [1], 192000.0 [2]
N-(1-Cyanocyclopropyl)-2-hydroxy-5-nitrobenzamideKi128000.0 [1], 247000.0 [2]
N-(1-Cyanocyclopropyl)-8-hydroxy-5-nitroquinoline-7-carboxamideKi124000.0 [1], 185000.0 [2]
N-Benzyl-N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-2-carboxamideKi18000.0 [1], 34000.0 [2], 156000.0 [3]
8-(Morpholin-4-yl)-5-nitroquinolineKi153000.0 [1], 155000.0 [2], 180000.0 [3]
N-Benzyl-5-nitroquinolin-8-amineKi127000.0 [1], 349000.0 [2], 364000.0 [3]
N-Benzyl-N-methyl-5-nitroquinolin-8-amineKi137000.0 [1], 196000.0 [2], 242000.0 [3]
1-(5-Nitroquinoline-8-yl)piperidine-4-carboxylic acid ethyl esterKi38000.0 [1], 113000.0 [2], 162000.0 [3]
5-Nitro-N-(pyridin-2-ylmethyl)quinolin-8-amineKi47000.0 [1], 87000.0 [2], 107000.0 [3]
4-(4-Nitronaphthalen-1-yl)morpholineKi85000.0 [1], 125000.0 [2], 289000.0 [3]
7-[(Benzylamino)methyl]-5-nitroquinolin-8-olKi58000.0 [1], 154000.0 [2], 198000.0 [3]
7-(Ethylaminomethyl)-5-nitroquinolin-8-olKi82000.0 [1], 117000.0 [2], 136000.0 [3]
2-[Benzyl-[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino]acetonitrileKi8000.0 [1], 19000.0 [2], 79000.0 [3]
2-[(8-Hydroxy-5-nitroquinolin-7-yl)methyl-methylamino]acetonitrileKi76000.0 [1], 126000.0 [2], 172000.0 [3]
7-[[(2R)-2-Methylpiperidin-1-yl]methyl]-5-nitroquinolin-8-olKi116000.0 [1], 203000.0 [2], 243000.0 [3]
Ethyl 4-[(8-hydroxy-5-nitroquinolin-7-yl)methyl]piperazine-1-carboxylateKi87000.0 [1], 129000.0 [2], 156000.0 [3]
Ethyl (1R,2S)-2-[(8-hydroxy-5-nitroquinolin-7-yl)methylamino]cyclohexane-1-carboxylateKi74000.0 [1], 130000.0 [2], 132000.0 [3]
(1R,2S)-2-[(8-Hydroxy-5-nitroquinolin-7-yl)methylamino]cyclohexane-1-carboxylic acidKi125000.0 [1], 181000.0 [2], 250000.0 [3]
5-Nitro-7-[[4-(pyridin-3-ylmethyl)piperazin-1-yl]methyl]quinolin-8-olKi171000.0 [1], 311000.0 [2], 364000.0 [3]
5-Nitro-7-[[4-(pyridin-4-ylmethyl)piperazin-1-yl]methyl]quinolin-8-olKi94000.0 [1], 143000.0 [2], 162000.0 [3]
5-Nitro-8-(4-methylpiperidino)quinolineKi24000.0 [1], 105000.0 [2], 207000.0 [3]
Z-Leu-leu-leu-alKi12.0 [1], 230.0 [2]
BoceprevirIC503300.0 [1], 6200.0 [2]
OdanacatibIC501034.0 [1], 1050.0 [2]
RelacatibIC5014.0 [1]
RelacatibKi13.0 [1]
Gallinamide AIC501700.0 [1], 4200.0 [2]
Pyrrolidine-1-carbonitrileIC5015000.0 [1], 25118.86 [2]
5,7-Dinitroquinolin-8-olKi72000.0 [1], 146000.0 [2]
Benzyl (S)-1-cyanomethylcarbamoyl-3-methylbutylcarbamateKi32000.0 [1], 123000.0 [2]
Benzyl N-[(2S)-1-(cyanomethylamino)-1-oxo-3-phenylpropan-2-yl]carbamateIC5062000.0 [1]
Benzyl N-[(2S)-1-(cyanomethylamino)-1-oxo-3-phenylpropan-2-yl]carbamateKi330.0 [1]
CID 44572423Ki7300.0 [1]
Cathepsin inhibitor 1IC506309.57 [1]
1,3-Bis[[n-[(phenylmethoxy)carbonyl]-l-leucyl]amino]-2-propanoneKi1300.0 [1]
[(2S)-3,3-Dimethyl-1-[3-[4-(trifluoromethyl)phenyl]pyrazol-1-yl]butan-2-yl] N-[(3S)-1,2-dioxo-1-(1H-pyrazol-5-ylamino)heptan-3-yl]carbamateIC5020.0 [1], 20000.0 [2]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-piperazin-1-ylphenyl)benzamideIC50614.0 [1]
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-piperazin-1-ylphenyl)benzamideKi420.0 [1]
Benzyl 1-((cyanomethyl)carbamoyl)cyclohexylcarbamateKi330.0 [1], 64000.0 [2]
(S)-2-Amino-N-((S)-2-biphenyl-4-yl-1-cyano-ethyl)-butyramideIC5010000.0 [1]
(S)-2-Amino-N-((S)-2-biphenyl-4-yl-1-cyano-ethyl)-butyramideKi10.0 [1]
(2S)-N-[(1S)-1-Cyano-2-phenylethyl]-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamideIC50163.0 [1], 953.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cathepsin B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/cathepsin-b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Cathepsin B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cathepsin-b-inhibitors-ic50-ki.
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