Catechol O-methyltransferase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-(Biphenyl-3-Yl)-5-Hydroxy-3-Methylpyrimidin-4(3h)-One	IC50	170.0 [1], 5000.0 [2]
	5-(4-Methylbenzene-1-sulfonyl)quinolin-8-ol	IC50	19.95 [1], 501.19 [2]
	8-Hydroxyquinoline	IC50	1584.89 [1], 3162.28 [2]
	Tolcapone	IC50	1.0 [1], 127.0 [2]
	1-(Biphenyl-3-Yl)-3-Hydroxypyridin-4(1h)-One	IC50	47.0 [1], 1100.0 [2]
	5-Hydroxy-2-[hydroxy(phenyl)methyl]-1-(3-phenylphenyl)pyridin-4-one	IC50	88.0 [1], 1300.0 [2]
	5-Hydroxy-2-(1-hydroxybutyl)-1-(3-phenylphenyl)pyridin-4-one	IC50	57.0 [1], 1000.0 [2]
	5-Hydroxy-2-(1-hydroxy-2-methylpropyl)-1-(3-phenylphenyl)pyridin-4-one	IC50	180.0 [1], 1900.0 [2]
	2-(2-Aminoethyl)-5-hydroxy-1-(3-phenylphenyl)pyridin-4-one	IC50	13000.0 [1], 24000.0 [2]
	5-Cyclopentylsulfonyl-7-fluoroquinolin-8-ol	IC50	2.0 [1], 2511.89 [2]
	7-Fluoro-5-(4-fluorophenyl)sulfonylquinolin-8-ol	IC50	3.98 [1], 1584.89 [2]
	7-Chloro-5-(4-fluorophenyl)sulfonylquinolin-8-ol	IC50	199.53 [1], 10000.0 [2]
	7-Chloro-5-pyrrolidin-1-ylsulfonylquinolin-8-ol	IC50	10.0 [1], 3162.28 [2]
	7-Chloro-5-cyclopentylsulfonylquinolin-8-ol	IC50	19.95 [1], 7943.28 [2]
	7-Fluoro-5-[4-(trifluoromethyl)phenyl]sulfonylquinolin-8-ol	IC50	79.43 [1], 6309.57 [2]
	CID 122440031	IC50	7.94 [1], 1995.26 [2]
	5-Cyclopentylsulfonylquinolin-8-ol	IC50	6.31 [1], 501.19 [2]
	7-Chloro-5-(4-methylphenyl)sulfonylquinolin-8-ol	IC50	316.23 [1], 10000.0 [2]
	5-Cyclopentylsulfonyl-7-(trifluoromethyl)quinolin-8-ol	IC50	10000.0 [1]
	5-Ethylsulfonylquinolin-8-ol	IC50	50.12 [1], 1584.89 [2]
	7-Fluoranyl-5-(4-methylphenyl)sulfonyl-quinolin-8-ol	IC50	6.31 [1], 501.19 [2]
	5-[4-(Trifluoromethyl)phenyl]sulfonylquinolin-8-ol	IC50	63.1 [1], 1258.93 [2]
	7-Bromo-5-(4-methylphenyl)sulfonylquinolin-8-ol	IC50	1258.93 [1], 10000.0 [2]
	7-Methyl-5-pyrrolidin-1-ylsulfonylquinolin-8-ol	IC50	19.95 [1], 3162.28 [2]
	7-Fluoro-5-pyrrolidin-1-ylsulfonylquinolin-8-ol	IC50	3.98 [1], 1584.89 [2]
	5-(4-Methylphenyl)sulfonyl-7-(trifluoromethyl)quinolin-8-ol	IC50	10000.0 [1]
	5-(2-Benzylpyrrolidin-1-yl)sulfonylquinolin-8-ol	IC50	2.0 [1], 1995.26 [2]
	3-Hydroxy-1-(2-phenylpyridin-4-yl)pyridin-4-one	IC50	456.0 [1], 2325.0 [2]
	3-Hydroxy-1-(4-pyridin-2-yl-1,3-thiazol-2-yl)pyridin-4-one	IC50	5000.0 [1]
	3-Hydroxy-1-isoquinolin-1-ylpyridin-4-one	IC50	962.0 [1], 1268.0 [2]
	3-Hydroxy-1-(2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-4-one	IC50	1667.0 [1], 5000.0 [2]
	5-Hydroxy-2-(1-hydroxyethyl)-1-(3-phenylphenyl)pyridin-4-one	IC50	99.0 [1], 940.0 [2]
	3-Hydroxy-1-(6-phenylpyridin-2-yl)pyridin-4-one	IC50	128.0 [1], 2584.0 [2]
	1-Biphenyl-3-yl-5-hydroxy-2-methylpyridin-4(1H)-one	IC50	53.0 [1], 2100.0 [2]
	1-(Biphenyl-3-yl)-5-hydroxy-2-phenylpyridin-4(1H)-one	IC50	87.0 [1], 2500.0 [2]
	3-Hydroxy-1-(4-phenylpyridin-2-yl)pyridin-4-one	IC50	40.0 [1], 3020.0 [2]
	3-Hydroxy-1-(2-phenylpyrimidin-4-yl)pyridin-4(1H)-one	IC50	706.0 [1], 2054.0 [2]
	5-Hydroxy-1-(3-phenylphenyl)-2-propan-2-ylpyridin-4-one	IC50	410.0 [1], 1500.0 [2]
	3-Hydroxy-1-(3-phenylpyridin-2-yl)pyridin-4-one	IC50	5000.0 [1]
	1-(3-Fluoro-4-phenylpyridin-2-yl)-3-hydroxypyridin-4-one	IC50	55.0 [1], 946.0 [2]
	5'-Deoxy-5'-methylthioadenosine	Ki	5400000.0 [1]
	Entacapone	IC50	386.0 [1]
	8-Hydroxyquinoline-5-sulfonic acid	IC50	6309.57 [1]
	Opicapone	Ki	10.0 [1]
	Hydroxy methylphenylpyridinone	IC50	18000.0 [1]
	2,4-Dimethyl-5-(1H-Pyrazol-3-Yl)-1,3-Thiazole	Ki	7943.28 [1]
	[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-dimethylsulfanium;iodide	Ki	6000000.0 [1]
	9-Hydroxy-6H-pyrido[2,1-c][1,4]benzothiazin-8-one	IC50	400.0 [1]
	5-Hydroxy-2-thiophen-2-yl-1H-pyrimidin-6-one	IC50	860.0 [1]
	5-Hydroxy-2-(hydroxymethyl)-1-(2-methoxyethyl)pyridin-4-one	IC50	10000.0 [1]
	5-Hydroxy-2-(hydroxymethyl)-1-(3-phenylpropyl)pyridin-4-one	IC50	4500.0 [1]
	1-(2,4-Dimethylphenyl)-5-hydroxy-2-(hydroxymethyl)pyridin-4-one	IC50	5800.0 [1]
	1-(3,5-Dimethylphenyl)-3-hydroxy-2-methylpyridin-4-one	IC50	5500.0 [1]
	1-(4-Butylphenyl)-5-hydroxy-2-(hydroxymethyl)pyridin-4-one	IC50	160.0 [1]
	5-Hydroxy-2-(hydroxymethyl)-1-(4-phenylphenyl)pyridin-4-one	IC50	140.0 [1]
	5-Hydroxy-2-(hydroxymethyl)-1-(3-phenylphenyl)pyridin-4-one	IC50	140.0 [1]
	5-[3-(4-Fluorophenyl)pyrrolidin-1-yl]sulfonylquinolin-8-ol	IC50	3.16 [1]
	5-Hydroxy-2-(hydroxymethyl)-1-phenylpyridin-4(1H)-one	IC50	3400.0 [1]
	3-Hydroxy-1-(4-pyridin-2-ylpyridin-2-yl)pyridin-4-one	IC50	826.0 [1]
	3-Hydroxy-1-(4-pyridin-4-ylpyridin-2-yl)pyridin-4-one	IC50	672.0 [1]
	3-Hydroxy-1-(4-pyridin-3-ylpyridin-2-yl)pyridin-4-one	IC50	574.0 [1]
	1-[4-(1-Benzylpyrazol-4-yl)pyridin-2-yl]-3-hydroxypyridin-4-one	IC50	49.5 [1]
	(5E)-5-[(3,4-Dihydroxy-5-nitrophenyl)methylidene]-3-ethyl-1,3-thiazolidine-2,4-dione	IC50	179.0 [1]
	2-N,2-N,3-N,3-N-Tetraethyl-6,7-dihydroxy-5-nitronaphthalene-2,3-dicarboxamide	IC50	54.0 [1]
	(2S)-N-[3-[2-[2-[3-[5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]propoxy]ethoxy]ethoxy]propyl]-2-[(4-azidobenzoyl)amino]-N'-[6-[[4-(3,4-dihydroxy-5-nitrobenzoyl)phenyl]methyl-methylamino]-6-oxohexyl]butanediamide	IC50	648.0 [1]
	5-Hydroxy-2-(hydroxymethyl)-1-(4-methylphenyl)pyridin-4-one	IC50	1700.0 [1]
	3-Hydroxy-5-(4-methoxyphenyl)-1-methyl-6-pyridin-4-ylpyridin-2-one	IC50	2100.0 [1]
	6-(4-Methylphenyl)sulfonylquinolin-8-ol	IC50	1584.89 [1]
	(8-Hydroxyquinolin-5-yl)-pyrrolidin-1-ylmethanone	IC50	10000.0 [1]
	5-(4-Methylphenyl)quinolin-8-ol	IC50	251.19 [1]
	(8-Hydroxyquinolin-5-yl)-(4-methylphenyl)methanone	IC50	3981.07 [1]
	8-Methoxy-5-pyrrolidin-1-ylsulfonylquinoline	IC50	10000.0 [1]
	3-Chloro-5,6-dihydroxy-7-nitro-1-benzothiophene-2-carboxylic acid	Ki	1.0 [1]
	2'-Methyl-1H,2'H-3,3'-bipyrazole	Ki	25118.86 [1]
	(3-Amino-3-carboxypropyl)-[2-(2-methoxyphenyl)ethyl]-methylsulfanium;iodide	Ki	5800000.0 [1]
	[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-methyl-(2-phenylethyl)sulfanium;iodide	Ki	800000.0 [1]
	[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[2-(2-methoxyphenyl)ethyl]-methylsulfanium;iodide	Ki	800000.0 [1]
	[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[2-[5-[2-[benzyl(methyl)amino]-1-hydroxyethyl]-2-methoxyphenyl]ethyl]-methylsulfanium;iodide	Ki	500000.0 [1]
	Isobutyryloxymethyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate	Ki	17.0 [1]
	(2-Oxo-1,3-dioxol-4-yl)methyl 3-chloro-5,6-dihydroxy-7-nitro-1-benzothiophene-2-carboxylate	Ki	1.6 [1]
	Methyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate	Ki	2.2 [1]
	Propyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate	Ki	9.2 [1]
	Butyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate	Ki	1.3 [1]
	Isopropyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate	Ki	1.1 [1]
	Benzyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate	Ki	10.2 [1]
	1-(Isobutyryloxy)ethyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate	Ki	17.0 [1]
	Butyryloxymethyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate	Ki	10.6 [1]
	1-(Butyryloxy)ethyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate	Ki	16.6 [1]
	(2-Amino-3-methylbutanoyl)oxymethyl 3-chloro-5,6-dihydroxy-7-nitro-1-benzothiophene-2-carboxylate	Ki	6.0 [1]
	3-[2-Methyl-4-(Trifluoromethyl)-1,3-Thiazol-5-Yl]-1H-1,2,4-Triazole	Ki	251188.64 [1]
	[1-(Biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid	IC50	200.0 [1]
	1-[4-(3,4-Dichlorophenyl)pyridin-2-yl]-3-hydroxypyridin-4-one	IC50	35.0 [1]
	1-(3,5-Dimethylphenyl)-5-hydroxy-2-(hydroxymethyl)pyridin-4-one	IC50	680.0 [1]
	1-[4-(2-Tert-butyl-1,3-thiazol-4-yl)pyridin-2-yl]-3-hydroxypyridin-4-one	IC50	101.0 [1]
	3-Hydroxy-1-phenylpyridin-4-one	IC50	2400.0 [1]
	1',3'-Dimethyl-1H,1'H-3,4'-bipyrazole	Ki	15848.93 [1]
	3-Hydroxy-1-[4-[6-(trifluoromethyl)pyridin-2-yl]pyridin-2-yl]pyridin-4-one	IC50	84.0 [1]
	5-Hydroxy-2-[3-(2-phenylethynyl)phenyl]-1H-pyrimidin-6-one	IC50	590.0 [1]
	5-Hydroxy-2-(4-trifluoromethyl-phenyl)-3H-pyrimidin-4-one	IC50	210.0 [1]
	5-Hydroxy-2-[3-(4-methoxyphenoxy)phenyl]-3-methylpyrimidin-4(3H)-one	IC50	93.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Catechol O-methyltransferase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/catechol-o-methyltransferase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Catechol O-methyltransferase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/catechol-o-methyltransferase-inhibitors-ic50-ki.
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