![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_e9ba4f9eb5dd3211302bce2b3fcc2e84.svg) | 2-(Biphenyl-3-Yl)-5-Hydroxy-3-Methylpyrimidin-4(3h)-One | IC50 | 170.0 [1], 5000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_581c151b1620a1337f45e66f5d195aba.svg) | 5-(4-Methylbenzene-1-sulfonyl)quinolin-8-ol | IC50 | 19.95 [1], 501.19 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_1f8b1c0518e085a8f0fca5164adf52ed.svg) | 8-Hydroxyquinoline | IC50 | 1584.89 [1], 3162.28 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_4144082d3c34f90f55de601b70b12855.svg) | Tolcapone | IC50 | 1.0 [1], 127.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_f13516e8e4a5b5eb39a27e99db5b7ce3.svg) | 1-(Biphenyl-3-Yl)-3-Hydroxypyridin-4(1h)-One | IC50 | 47.0 [1], 1100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_e6d61fa8e12af62d2b237ffdb93ea96c.svg) | 5-Hydroxy-2-[hydroxy(phenyl)methyl]-1-(3-phenylphenyl)pyridin-4-one | IC50 | 88.0 [1], 1300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_49822c3611edc8036822f9307e4239c8.svg) | 5-Hydroxy-2-(1-hydroxybutyl)-1-(3-phenylphenyl)pyridin-4-one | IC50 | 57.0 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_6e5c017616715eb056a5ba36fbe7d390.svg) | 5-Hydroxy-2-(1-hydroxy-2-methylpropyl)-1-(3-phenylphenyl)pyridin-4-one | IC50 | 180.0 [1], 1900.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_4a4b2a09b62d0d56a29a17881792a035.svg) | 2-(2-Aminoethyl)-5-hydroxy-1-(3-phenylphenyl)pyridin-4-one | IC50 | 13000.0 [1], 24000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_98d0ed6e22633a55049548b7ba6c210a.svg) | 5-Cyclopentylsulfonyl-7-fluoroquinolin-8-ol | IC50 | 2.0 [1], 2511.89 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_b140faeb774295ef8205587c2f0b893a.svg) | 7-Fluoro-5-(4-fluorophenyl)sulfonylquinolin-8-ol | IC50 | 3.98 [1], 1584.89 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_e7cbb32d7c094f4ec544a949c0308d09.svg) | 7-Chloro-5-(4-fluorophenyl)sulfonylquinolin-8-ol | IC50 | 199.53 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_a1f05131e2eb9d47b197de7847dcf3ef.svg) | 7-Chloro-5-pyrrolidin-1-ylsulfonylquinolin-8-ol | IC50 | 10.0 [1], 3162.28 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_d290016c1944084d0a89d22c3ae90ea4.svg) | 7-Chloro-5-cyclopentylsulfonylquinolin-8-ol | IC50 | 19.95 [1], 7943.28 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_00bd0b08b07e7ddfe2d017797c552c71.svg) | 7-Fluoro-5-[4-(trifluoromethyl)phenyl]sulfonylquinolin-8-ol | IC50 | 79.43 [1], 6309.57 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_53666c78e682e1694a58c2d8e609264e.svg) | CID 122440031 | IC50 | 7.94 [1], 1995.26 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_52bbb322449d156eeee5e49a6d3b2a73.svg) | 5-Cyclopentylsulfonylquinolin-8-ol | IC50 | 6.31 [1], 501.19 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_45cfc8a078796f7eec27e52cd2a28242.svg) | 7-Chloro-5-(4-methylphenyl)sulfonylquinolin-8-ol | IC50 | 316.23 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_f2448b35cfe1ff2554573ebaf8dfca2b.svg) | 5-Cyclopentylsulfonyl-7-(trifluoromethyl)quinolin-8-ol | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_1a87c5d21e98d0c63fabc87697f1c325.svg) | 5-Ethylsulfonylquinolin-8-ol | IC50 | 50.12 [1], 1584.89 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_3068a6428eee27017ac7c25b5f3f2a32.svg) | 7-Fluoranyl-5-(4-methylphenyl)sulfonyl-quinolin-8-ol | IC50 | 6.31 [1], 501.19 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_70358bf1e2663e801fd74812d2724a5f.svg) | 5-[4-(Trifluoromethyl)phenyl]sulfonylquinolin-8-ol | IC50 | 63.1 [1], 1258.93 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_122255e39a6bb0688a2e7dcbca62275e.svg) | 7-Bromo-5-(4-methylphenyl)sulfonylquinolin-8-ol | IC50 | 1258.93 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_f2bbbaef1a5b248c6cef752586ca6cef.svg) | 7-Methyl-5-pyrrolidin-1-ylsulfonylquinolin-8-ol | IC50 | 19.95 [1], 3162.28 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_f356bef5d90d3161796759d4bbe9be37.svg) | 7-Fluoro-5-pyrrolidin-1-ylsulfonylquinolin-8-ol | IC50 | 3.98 [1], 1584.89 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_39e70dee969ae517da95ebccb39a23bc.svg) | 5-(4-Methylphenyl)sulfonyl-7-(trifluoromethyl)quinolin-8-ol | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_129f09023cfa500fd93853f94553933d.svg) | 5-(2-Benzylpyrrolidin-1-yl)sulfonylquinolin-8-ol | IC50 | 2.0 [1], 1995.26 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_c83aa2512a09e9970149e6c120ae71c9.svg) | 3-Hydroxy-1-(2-phenylpyridin-4-yl)pyridin-4-one | IC50 | 456.0 [1], 2325.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_089e681a213d3fe0ce3f3bb40576150f.svg) | 3-Hydroxy-1-(4-pyridin-2-yl-1,3-thiazol-2-yl)pyridin-4-one | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_ca56ffe2b0096fac61d33cd48d80fdba.svg) | 3-Hydroxy-1-isoquinolin-1-ylpyridin-4-one | IC50 | 962.0 [1], 1268.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_6f9aad461ac8233dbe4b72727944cb64.svg) | 3-Hydroxy-1-(2-methylimidazo[1,2-b]pyridazin-6-yl)pyridin-4-one | IC50 | 1667.0 [1], 5000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_baa084cb053b9539ed4ce2875a1a14bf.svg) | 5-Hydroxy-2-(1-hydroxyethyl)-1-(3-phenylphenyl)pyridin-4-one | IC50 | 99.0 [1], 940.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_76aead4f1825778c6d614100053dbe0f.svg) | 3-Hydroxy-1-(6-phenylpyridin-2-yl)pyridin-4-one | IC50 | 128.0 [1], 2584.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_bd04ab9ad836bea3079cab86d491774b.svg) | 1-Biphenyl-3-yl-5-hydroxy-2-methylpyridin-4(1H)-one | IC50 | 53.0 [1], 2100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_52eb9ae472e36f0bfd8181cec0051e5d.svg) | 1-(Biphenyl-3-yl)-5-hydroxy-2-phenylpyridin-4(1H)-one | IC50 | 87.0 [1], 2500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_8975e74bbd41337ab9d479bfd8d69139.svg) | 3-Hydroxy-1-(4-phenylpyridin-2-yl)pyridin-4-one | IC50 | 40.0 [1], 3020.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_5446416e62c7088569fd00d0bcd43387.svg) | 3-Hydroxy-1-(2-phenylpyrimidin-4-yl)pyridin-4(1H)-one | IC50 | 706.0 [1], 2054.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_6a5c13ce5aadb0cd83cc6796598183e3.svg) | 5-Hydroxy-1-(3-phenylphenyl)-2-propan-2-ylpyridin-4-one | IC50 | 410.0 [1], 1500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_1eca29ccecf10369c2b7392f951c06f9.svg) | 3-Hydroxy-1-(3-phenylpyridin-2-yl)pyridin-4-one | IC50 | 5000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_d5c6ecdb49641601af5332904fdb2a38.svg) | 1-(3-Fluoro-4-phenylpyridin-2-yl)-3-hydroxypyridin-4-one | IC50 | 55.0 [1], 946.0 [2] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_7309c12cf040afe86914ce8964670e21.svg) | 5'-Deoxy-5'-methylthioadenosine | Ki | 5400000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_6efd0cd25e49a23a6d7cb9dbb636dfad.svg) | Entacapone | IC50 | 386.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_b09139f66af94ceb15d21accc537e3fa.svg) | 8-Hydroxyquinoline-5-sulfonic acid | IC50 | 6309.57 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_862a9c1020b229644e86972e7af15869.svg) | Opicapone | Ki | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_7e9d25f4027a0d5f079a10362eecb9fb.svg) | Hydroxy methylphenylpyridinone | IC50 | 18000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_f8ba7421f2cb2813ded37d607d780570.svg) | 2,4-Dimethyl-5-(1H-Pyrazol-3-Yl)-1,3-Thiazole | Ki | 7943.28 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_66d79a8345aabbef40062f4c59a5bf27.svg) | [(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-dimethylsulfanium;iodide | Ki | 6000000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_edd211384113268eeea8aecfcaef89ae.svg) | 9-Hydroxy-6H-pyrido[2,1-c][1,4]benzothiazin-8-one | IC50 | 400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_8a7b498b5af91c48ff3bd7896b2c5082.svg) | 5-Hydroxy-2-thiophen-2-yl-1H-pyrimidin-6-one | IC50 | 860.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_84885b2b35fb298512d392f913c25a65.svg) | 5-Hydroxy-2-(hydroxymethyl)-1-(2-methoxyethyl)pyridin-4-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_3e3168735244f8ab09cd1010e9102191.svg) | 5-Hydroxy-2-(hydroxymethyl)-1-(3-phenylpropyl)pyridin-4-one | IC50 | 4500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_a233a414c93682b06719d020d93ddbfe.svg) | 1-(2,4-Dimethylphenyl)-5-hydroxy-2-(hydroxymethyl)pyridin-4-one | IC50 | 5800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_21b4d3faefea980c6b7a6bd563e999b8.svg) | 1-(3,5-Dimethylphenyl)-3-hydroxy-2-methylpyridin-4-one | IC50 | 5500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_aca410c9f102f38addcfdd1b0dad3e24.svg) | 1-(4-Butylphenyl)-5-hydroxy-2-(hydroxymethyl)pyridin-4-one | IC50 | 160.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_442852fa0fef9388d67b70ab58e9bb3a.svg) | 5-Hydroxy-2-(hydroxymethyl)-1-(4-phenylphenyl)pyridin-4-one | IC50 | 140.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_2f0ce1fd119a4475e7b1b50457bfa6dd.svg) | 5-Hydroxy-2-(hydroxymethyl)-1-(3-phenylphenyl)pyridin-4-one | IC50 | 140.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_8ab5774c0a5d9bcaf6c1c3e47d38bb96.svg) | 5-[3-(4-Fluorophenyl)pyrrolidin-1-yl]sulfonylquinolin-8-ol | IC50 | 3.16 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_81e6fc16000e297be08806d609c4e137.svg) | 5-Hydroxy-2-(hydroxymethyl)-1-phenylpyridin-4(1H)-one | IC50 | 3400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_c6a9fc30b785abf1184bc6890c67666c.svg) | 3-Hydroxy-1-(4-pyridin-2-ylpyridin-2-yl)pyridin-4-one | IC50 | 826.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_169dbdf24d01c83d0bf0de4cd92414ca.svg) | 3-Hydroxy-1-(4-pyridin-4-ylpyridin-2-yl)pyridin-4-one | IC50 | 672.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_4f5e95507c342f19b0032f210212df77.svg) | 3-Hydroxy-1-(4-pyridin-3-ylpyridin-2-yl)pyridin-4-one | IC50 | 574.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_4f6eeb4bb99575c9c7f8ae8548289efb.svg) | 1-[4-(1-Benzylpyrazol-4-yl)pyridin-2-yl]-3-hydroxypyridin-4-one | IC50 | 49.5 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_a4b9da4cac2770b12cedd0d1eb321a43.svg) | (5E)-5-[(3,4-Dihydroxy-5-nitrophenyl)methylidene]-3-ethyl-1,3-thiazolidine-2,4-dione | IC50 | 179.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_14d714c383d9d19f837795506abc88c3.svg) | 2-N,2-N,3-N,3-N-Tetraethyl-6,7-dihydroxy-5-nitronaphthalene-2,3-dicarboxamide | IC50 | 54.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_33710b9d4276975b839a1fad8a474846.svg) | (2S)-N-[3-[2-[2-[3-[5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]propoxy]ethoxy]ethoxy]propyl]-2-[(4-azidobenzoyl)amino]-N'-[6-[[4-(3,4-dihydroxy-5-nitrobenzoyl)phenyl]methyl-methylamino]-6-oxohexyl]butanediamide | IC50 | 648.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_22fe7384acee35a207f24ec7cd4fac2c.svg) | 5-Hydroxy-2-(hydroxymethyl)-1-(4-methylphenyl)pyridin-4-one | IC50 | 1700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_0cc09dc37c621368048f5ff7498d5286.svg) | 3-Hydroxy-5-(4-methoxyphenyl)-1-methyl-6-pyridin-4-ylpyridin-2-one | IC50 | 2100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_ec96f3593d3959e325f56548d95660af.svg) | 6-(4-Methylphenyl)sulfonylquinolin-8-ol | IC50 | 1584.89 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_de08ec1596a00731dc3ae6638607c84e.svg) | (8-Hydroxyquinolin-5-yl)-pyrrolidin-1-ylmethanone | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_fdabc5acc1296511f55be66152363b6a.svg) | 5-(4-Methylphenyl)quinolin-8-ol | IC50 | 251.19 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_48cac6a8f45a943efdb61f3809a5ef7b.svg) | (8-Hydroxyquinolin-5-yl)-(4-methylphenyl)methanone | IC50 | 3981.07 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_600ed74664febeef4cd45f1db74b526f.svg) | 8-Methoxy-5-pyrrolidin-1-ylsulfonylquinoline | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_34c48c1c75489fe16d60eccba8fd7b1d.svg) | 3-Chloro-5,6-dihydroxy-7-nitro-1-benzothiophene-2-carboxylic acid | Ki | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_9ca1f57a30e3bf806dbf181a8dca34f2.svg) | 2'-Methyl-1H,2'H-3,3'-bipyrazole | Ki | 25118.86 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_57f44e6f21784ca70240eb84d390adb0.svg) | (3-Amino-3-carboxypropyl)-[2-(2-methoxyphenyl)ethyl]-methylsulfanium;iodide | Ki | 5800000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_a03e87823d5f55c2f22225d1d66d10d2.svg) | [(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-methyl-(2-phenylethyl)sulfanium;iodide | Ki | 800000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_1910c7431e4ad08689d81dbf798a51ab.svg) | [(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[2-(2-methoxyphenyl)ethyl]-methylsulfanium;iodide | Ki | 800000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_c77ea8f875242e99cb3bcb9d4c52763b.svg) | [(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[2-[5-[2-[benzyl(methyl)amino]-1-hydroxyethyl]-2-methoxyphenyl]ethyl]-methylsulfanium;iodide | Ki | 500000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_8dd43b6ba7525681f26dcb1f95acb42b.svg) | Isobutyryloxymethyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate | Ki | 17.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_08d7223143211da7c0f037cdde44ab79.svg) | (2-Oxo-1,3-dioxol-4-yl)methyl 3-chloro-5,6-dihydroxy-7-nitro-1-benzothiophene-2-carboxylate | Ki | 1.6 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_a30fa8d31cf3a7a5d34ba96ef3d9148e.svg) | Methyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate | Ki | 2.2 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_750d026368c29d8b848801d64ac7736a.svg) | Propyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate | Ki | 9.2 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_17c4fd3aa5e9836f968531ac9b54f4a9.svg) | Butyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate | Ki | 1.3 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_a33cfe13976036214b63daf16f3d7883.svg) | Isopropyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate | Ki | 1.1 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_d168128b734b19d7b4a40cb465ca6927.svg) | Benzyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate | Ki | 10.2 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_e02267c328d73f8ee4fb19e40b4b2bc2.svg) | 1-(Isobutyryloxy)ethyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate | Ki | 17.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_22b6860948eaabbb0e8620386032fc38.svg) | Butyryloxymethyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate | Ki | 10.6 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_cc16814fda3d19d97bc22a4b44850fe9.svg) | 1-(Butyryloxy)ethyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiophene-2-carboxylate | Ki | 16.6 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_5ae747b607aaaffb476de2bc981acb37.svg) | (2-Amino-3-methylbutanoyl)oxymethyl 3-chloro-5,6-dihydroxy-7-nitro-1-benzothiophene-2-carboxylate | Ki | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_85d9dd6b9c6bb37db1cafc5861313b23.svg) | 3-[2-Methyl-4-(Trifluoromethyl)-1,3-Thiazol-5-Yl]-1H-1,2,4-Triazole | Ki | 251188.64 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_6ec4b438c84cd1dc6f7d4f243232365f.svg) | [1-(Biphenyl-3-yl)-5-hydroxy-4-oxo-1,4-dihydropyridin-3-yl]boronic acid | IC50 | 200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_941e3e21eb9b7864b78c90bf227d59ab.svg) | 1-[4-(3,4-Dichlorophenyl)pyridin-2-yl]-3-hydroxypyridin-4-one | IC50 | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_e314f6fe83710c43c580d85ce25148f2.svg) | 1-(3,5-Dimethylphenyl)-5-hydroxy-2-(hydroxymethyl)pyridin-4-one | IC50 | 680.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_64d8763d664e3b67c0ece572628e45c5.svg) | 1-[4-(2-Tert-butyl-1,3-thiazol-4-yl)pyridin-2-yl]-3-hydroxypyridin-4-one | IC50 | 101.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_95d68120636e39278ca7ddf4f05a0512.svg) | 3-Hydroxy-1-phenylpyridin-4-one | IC50 | 2400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_ffe70168df323f649252230dd15c5a34.svg) | 1',3'-Dimethyl-1H,1'H-3,4'-bipyrazole | Ki | 15848.93 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_7f9f0147d731de25bf0f87824f8c5849.svg) | 3-Hydroxy-1-[4-[6-(trifluoromethyl)pyridin-2-yl]pyridin-2-yl]pyridin-4-one | IC50 | 84.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_117a344b185105724451f832f5cfbe63.svg) | 5-Hydroxy-2-[3-(2-phenylethynyl)phenyl]-1H-pyrimidin-6-one | IC50 | 590.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_13ef695d77f20b25143928d2628dc66a.svg) | 5-Hydroxy-2-(4-trifluoromethyl-phenyl)-3H-pyrimidin-4-one | IC50 | 210.0 [1] |
![](https://images.aatbio.com/dataset/ic50/catechol-o-methyltransferase_0b3a7b518bc13c705f9102971aa97c07.svg) | 5-Hydroxy-2-[3-(4-methoxyphenoxy)phenyl]-3-methylpyrimidin-4(3H)-one | IC50 | 93.0 [1] |