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Caspase-8 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneIC5010000.0 [1], 50000.0 [2], 500000.0 [3]
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1], 500000.0 [2]
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneKi49000.0 [1]
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-naphthalen-2-yloxyacetyl)amino]pentanamideIC5010000.0 [1]
PralnacasanIC5040.0 [1]
Ac-IETD-CHOIC504.2 [1]
1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC5050000.0 [1], 500000.0 [2]
Caspase-3/7 Inhibitor IIC50500000.0 [1]
Caspase-3/7 Inhibitor IKi25000.0 [1]
Isatin Sulfonamide 34IC5050000.0 [1]
Isatin Sulfonamide 34Ki5000.0 [1]
(S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1], 500000.0 [2]
(3S)-5-Benzylsulfanyl-3-[[(2S)-2-[[2-(5-bromo-2-methoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC501890.0 [1], 2300.0 [2]
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1], 500000.0 [2]
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-naphthalen-1-yloxyacetyl)amino]pentanamideIC50770.0 [1]
(3S)-5-Benzylsulfanyl-3-[[(2S)-3-methyl-2-[(2-phenylacetyl)amino]butanoyl]amino]-4-oxopentanoic acidIC5022050.0 [1], 22500.0 [2]
(3S)-3-[[(2S)-2-[[2-(5-Acetyl-2-methoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-5-benzylsulfanyl-4-oxopentanoic acidIC502900.0 [1], 3880.0 [2]
(4S)-5-[[(2S)-1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acidIC5030.0 [1]
Benzyl N-[(3R)-1-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-5-methyl-2-oxohexan-3-yl]carbamateIC5050000.0 [1]
Benzyl N-[(3R)-1-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-4-methyl-2-oxopentan-3-yl]carbamateIC5011960.0 [1]
(3S)-3-[2-[5-Tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methylamino]-2-oxopyrazin-1-yl]butanoylamino]-4-oxo-7-phenylheptanoic acidIC505.28 [1], 5290.0 [2]
(3S)-5-Benzylsulfanyl-3-[[(2S)-2-[[2-(2,5-dimethoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC506600.0 [1], 7910.0 [2]
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[(4-methoxyphenyl)methyl]indole-2,3-dioneIC5010000.0 [1], 500000.0 [2]
1-[[4-(2-Fluoroethoxy)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5010000.0 [1], 25000.0 [2]
Ac-DEVD-CHOIC50130.0 [1]
Benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketoneKi18.0 [1]
3-((S)-2-(((Benzyloxy)carbonyl)amino)-3-methylbutanamido)-5-fluoro-4-oxopentanoic acidIC507.0 [1]
Isoquinoline-1,3,4(2H)-trioneIC501910.0 [1]
Grassystatin AIC505000.0 [1]
1-[(4-Methoxyphenyl)methyl]-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5050000.0 [1]
PlanktocyclinIC5093000.0 [1]
2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4-methyl-1,3-thiazole-5-carboxylic acidIC50200000.0 [1]
1-Methyl-5-nitroindoline-2,3-dioneKi50000.0 [1]
N-[3-[1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]carbamoyl]cyclopropyl]-2,4-dioxo-1-propan-2-ylpyrimidin-5-yl]-2-methyl-4-(naphthalen-2-ylamino)benzamideIC509999.0 [1]
(S)-1-Benzyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(S)-1-Methyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(S)-5-(2-(Methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-methylindoline-2,3-dioneIC50500000.0 [1]
1-Benzyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(S)-5-(2-Phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
1-Methyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)--1H-indole-2,3-dioneIC5050000.0 [1]
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
5-[(2S)-2-[(2,4-Difluorophenoxy)methyl]pyrrolidin-1-yl]sulfonyl-1-[[1-(2-fluoroethyl)triazol-4-yl]methyl]indole-2,3-dioneIC5050000.0 [1]
1-[[1-(2-Fluoroethyl)triazol-4-yl]methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5050000.0 [1]
[2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-1,3-thiazol-4-yl](thiophen-2-ylsulfanyl)methanoneIC5062000.0 [1]
(4-Chlorophenyl) 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-1,3-thiazole-4-carboxylateIC50200000.0 [1]
5-(Morpholin-4-ylsulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
5-(2-(Pyridin-4-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
[4-[[2,3-Dioxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-1-yl]methyl]phenyl] acetateIC5050000.0 [1]
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(S)-1-(6-Fluoropyridin-2-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(s)-1-(6-Fluoropyridin-3-yl-methyl)-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC5050000.0 [1]
(S)-1-(4-Iodobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatinIC50500000.0 [1]
(S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(S)-1-(2-Fluoro-pyridin-4-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(S)-1-(6-Fluoropyridin-3-ylmethyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
(S)-1-(6-Fluoro-pyridin-2-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5050000.0 [1]
N'-(2-Methoxyphenyl)-N-(1,3,4-trioxoisoquinolin-6-yl)butanediamideIC50835.0 [1]
1-(4-Methylthiobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC5050000.0 [1]
1-(4-Fluorobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC5050000.0 [1]
1-[(4-Hydroxyphenyl)methyl]-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5050000.0 [1]
1-[(4-Bromophenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5050000.0 [1]
1-(4-Bromo-benzyl)-5-[2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl]-1H-indole-2,3-dioneIC5050000.0 [1]
2-[1-Benzyl-2-oxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrileIC5050000.0 [1]
Phenyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazole-4-carboxylateIC5060000.0 [1]
5-(Pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneKi50000.0 [1]
4-(Ethoxycarbonylmethoxy)-1-hydroxy-naphthalene-2-carboxylic AcidIC50100000.0 [1]
1-[(3,4-Dichlorophenyl)methyl]-5-morpholin-4-ylsulfonylindole-2,3-dioneIC5050000.0 [1]
1-Benzyl-5-thiomorpholinosulfonyl IsatinIC5050000.0 [1]
5-(Azetidin-1-ylsulfonyl)-1-benzylindole-2,3-dioneIC5050000.0 [1]
5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneKi50000.0 [1]
(4S)-4-[[(2S)-2-Acetamido-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acidIC5080.0 [1]
(3S)-5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-3-[[(2S)-2-[[2-[2-ethoxy-5-[(E)-3-methoxy-3-oxoprop-1-enyl]phenyl]acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC503850.0 [1]
8-MercaptocaffeineIC50200000.0 [1]
2-[4-[4-[(2R)-4-[(2-Ethylphenyl)carbamoyl]-2-methyl-2,3-dihydro-1,4-benzoxazin-7-yl]phenyl]cyclohexyl]acetic acidIC506800.0 [1]
(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-succinic acidIC502960.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-oxo-7-phenylheptanoic acidIC500.02 [1]
(3S)-5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-3-[[(2S)-2-[[2-(2,5-dimethoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC502400.0 [1]
(3S)-3-[[(2S)-2-[[2-(2,5-Dimethoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-5-(2-methylpropylsulfanyl)-4-oxopentanoic acidIC507800.0 [1]
(3S)-3-[[(2S)-3-Methyl-2-[[2-oxo-2-(2-phenylethylamino)acetyl]amino]butanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi162.0 [1]
(3S)-3-[[(2S)-2-[[2-(4-Heptylanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi12.0 [1]
(3S)-3-[[(2S)-2-[[2-(4-Fluoroanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi15.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Methoxyanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi3.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Benzylanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi24.0 [1]
(3S)-3-[[(2S)-3-Methyl-2-[[2-oxo-2-(2-phenylanilino)acetyl]amino]butanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi30.0 [1]
(3S)-3-[[(2S)-3-Methyl-2-[[2-(naphthalen-1-ylmethylamino)-2-oxoacetyl]amino]butanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi4.0 [1]
(3S)-3-[[(2S)-2-[(2-Anilino-2-oxoacetyl)amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi5.0 [1]
(3S)-3-[[(2S)-2-[[2-(Benzylamino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi5.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Fluoroanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi40.0 [1]
(3S)-3-[[(2S)-3-Methyl-2-[[2-oxo-2-[2-(trifluoromethyl)anilino]acetyl]amino]butanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi6.0 [1]
(3S)-3-[[(2S)-2-[[2-(Benzhydrylamino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi36.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Tert-butylanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi3.0 [1]
(3S)-5-(Cyclohexylmethylsulfanyl)-3-[[(2S)-2-[[2-(2,5-dimethoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC502000.0 [1]
1-Benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dioneKi31000.0 [1]
Inhibitor 62bKi28000.0 [1]
(12S)-5-(2-Chlorophenyl)-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-2-oxo-1,4,8-triazatricyclo[7.3.0.03,7]dodeca-3(7),5,8-triene-12-carboxamideIC50336.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Caspase-8 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/caspase-8-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Caspase-8 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/caspase-8-inhibitors-ic50-ki.
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