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Caspase-7 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Ac-DEVD-CHOIC5059.1 [1]
1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC50190.0 [1], 304.0 [2], 310.0 [3]
1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneKi47.0 [1]
Caspase-3/7 Inhibitor IIC50170.0 [1], 1290.0 [2]
Caspase-3/7 Inhibitor IKi170.0 [1]
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC50294.0 [1], 540.0 [2]
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneKi47.0 [1]
(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneIC505.9 [1], 22.4 [2], 23.5 [3]
(S)-5-(2-(Methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-methylindoline-2,3-dioneIC50304.0 [1]
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-naphthalen-2-yloxyacetyl)amino]pentanamideIC508870.0 [1]
Isatin Sulfonamide 34IC5028.0 [1]
Isatin Sulfonamide 34Ki6.0 [1]
(S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5044.0 [1], 52.7 [2]
(3S)-5-Benzylsulfanyl-3-[[(2S)-2-[[2-(5-bromo-2-methoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC50285.0 [1], 3100.0 [2]
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5021.8 [1], 31.2 [2]
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-naphthalen-1-yloxyacetyl)amino]pentanamideIC501810.0 [1]
(3S)-5-Benzylsulfanyl-3-[[(2S)-3-methyl-2-[(2-phenylacetyl)amino]butanoyl]amino]-4-oxopentanoic acidIC508360.0 [1], 8400.0 [2]
(3S)-3-[[(2S)-2-[[2-(5-Acetyl-2-methoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-5-benzylsulfanyl-4-oxopentanoic acidIC50130.0 [1], 555.0 [2]
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-propylindole-2,3-dioneIC5058.0 [1]
1-Butyl-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC508.1 [1]
(4S)-5-[[(2S)-1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acidIC5010.0 [1]
Benzyl N-[(3R)-1-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-5-methyl-2-oxohexan-3-yl]carbamateIC5021900.0 [1]
Benzyl N-[(3R)-1-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-4-methyl-2-oxopentan-3-yl]carbamateIC506810.0 [1]
(3S)-3-[2-[5-Tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methylamino]-2-oxopyrazin-1-yl]butanoylamino]-4-oxo-7-phenylheptanoic acidIC500.14 [1], 140.0 [2]
1-Ethyl-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC50319.0 [1]
1-(4-Fluorobutyl)-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5028.0 [1]
(S)-3-((S)-2-(Benzyloxycarbonylamino)-3-methylbutanamido)-5-(methylsulfonyl)pent-4-enoic acidIC503330.0 [1], 200000.0 [2]
N-(4-Morpholin-4-ylphenyl)-3-oxo-1,2-benzothiazole-2-carboxamideIC50164.0 [1], 908.6 [2]
(3S)-5-Benzylsulfanyl-3-[[(2S)-2-[[2-(2,5-dimethoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC503200.0 [1], 3240.0 [2]
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[(4-methoxyphenyl)methyl]indole-2,3-dioneIC504.0 [1], 6.1 [2]
1-[[4-(2-Fluoroethoxy)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC504.6 [1], 93.3 [2]
(E,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-3-Carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-2-phenylacetyl]amino]-3-methylbutanoyl]amino]-5-methylsulfonylpent-4-enoic acidIC50800.0 [1]
1,2-Benzisothiazol-3(2H)-oneIC50137400.0 [1]
3-((S)-2-(((Benzyloxy)carbonyl)amino)-3-methylbutanamido)-5-fluoro-4-oxopentanoic acidIC507.0 [1]
Isoquinoline-1,3,4(2H)-trioneIC50386.0 [1]
Grassystatin AIC505000.0 [1]
1-[(4-Methoxyphenyl)methyl]-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5015.1 [1]
2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4-methyl-1,3-thiazole-5-carboxylic acidIC50200000.0 [1]
1-Methyl-5-nitroindoline-2,3-dioneKi290.0 [1]
N-[3-[1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]carbamoyl]cyclopropyl]-2,4-dioxo-1-propan-2-ylpyrimidin-5-yl]-2-methyl-4-(naphthalen-2-ylamino)benzamideIC509999.0 [1]
(S)-1-Benzyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5029.5 [1]
(S)-1-Methyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC50362.5 [1]
5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC50214.9 [1]
1-Benzyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5014.1 [1]
(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5023.0 [1]
(S)-5-(2-Phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC501350.0 [1]
1-Methyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)--1H-indole-2,3-dioneIC5094.9 [1]
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5023.2 [1]
5-[(2S)-2-[(2,4-Difluorophenoxy)methyl]pyrrolidin-1-yl]sulfonyl-1-[[1-(2-fluoroethyl)triazol-4-yl]methyl]indole-2,3-dioneIC5011.6 [1]
1-[[1-(2-Fluoroethyl)triazol-4-yl]methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5012.4 [1]
[2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-1,3-thiazol-4-yl](thiophen-2-ylsulfanyl)methanoneIC50200000.0 [1]
(4-Chlorophenyl) 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-1,3-thiazole-4-carboxylateIC50200000.0 [1]
5-(Morpholin-4-ylsulfonyl)-1H-indole-2,3-dioneIC5020000.0 [1]
3-Oxo-N-(2-phenylethyl)-1,2-benzothiazole-2-carboxamideIC501050.0 [1]
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5026.7 [1]
5-(2-(Pyridin-4-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC50142.3 [1]
[4-[[2,3-Dioxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-1-yl]methyl]phenyl] acetateIC5034.8 [1]
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5041.0 [1]
(S)-1-(6-Fluoropyridin-2-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5022.7 [1]
(s)-1-(6-Fluoropyridin-3-yl-methyl)-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC5014.5 [1]
(S)-1-(4-Iodobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatinIC5018.6 [1]
(S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC50135.0 [1]
(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5021.0 [1]
(S)-1-(2-Fluoro-pyridin-4-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5058.0 [1]
(S)-1-(6-Fluoropyridin-3-ylmethyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5017.0 [1]
(S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5026.0 [1]
(S)-1-(6-Fluoro-pyridin-2-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5022.2 [1]
N'-(2-Methoxyphenyl)-N-(1,3,4-trioxoisoquinolin-6-yl)butanediamideIC50218.0 [1]
1-(4-Methylthiobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC5023.3 [1]
1-(4-Fluorobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC5015.1 [1]
1-[(4-Hydroxyphenyl)methyl]-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5011.7 [1]
1-[(4-Bromophenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5034.8 [1]
1-(4-Bromo-benzyl)-5-[2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl]-1H-indole-2,3-dioneIC506.6 [1]
2-[1-Benzyl-2-oxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrileIC5051.7 [1]
Phenyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazole-4-carboxylateIC50200000.0 [1]
5-(Pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneKi3000.0 [1]
4-(Ethoxycarbonylmethoxy)-1-hydroxy-naphthalene-2-carboxylic AcidIC5084900.0 [1]
1-[(3,4-Dichlorophenyl)methyl]-5-morpholin-4-ylsulfonylindole-2,3-dioneIC502233.0 [1]
1-Benzyl-5-thiomorpholinosulfonyl IsatinIC501483.0 [1]
5-(Azetidin-1-ylsulfonyl)-1-benzylindole-2,3-dioneIC50132.0 [1]
5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneKi10000.0 [1]
(4S)-4-[[(2S)-2-Acetamido-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acidIC5010.0 [1]
(E,3S)-5-(Benzenesulfonyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)pent-4-enoic acidIC50200000.0 [1]
(E,3S)-3-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-methylsulfonylpent-4-enoic acidIC50200000.0 [1]
(E,3S)-5-(Benzenesulfonyl)-3-[[(2S,3S)-3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pent-4-enoic acidIC50200000.0 [1]
(E,3S)-3-[[(2S,3S)-3-Methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-methylsulfonylpent-4-enoic acidIC50200000.0 [1]
(E,3S)-5-(Benzenesulfonyl)-3-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]pent-4-enoic acidIC50200000.0 [1]
(E,3S)-3-[[(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]-5-methylsulfonylpent-4-enoic acidIC50200000.0 [1]
(3S)-5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-3-[[(2S)-2-[[2-[2-ethoxy-5-[(E)-3-methoxy-3-oxoprop-1-enyl]phenyl]acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC5024.0 [1]
(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-succinic acidIC5010000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-oxo-7-phenylheptanoic acidIC500.01 [1]
(3S)-5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-3-[[(2S)-2-[[2-(2,5-dimethoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC502500.0 [1]
(3S)-3-[[(2S)-2-[[2-(2,5-Dimethoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-5-(2-methylpropylsulfanyl)-4-oxopentanoic acidIC501800.0 [1]
2-[3-(3-Methoxyphenyl)propanoyl]-1,2-benzothiazol-3-oneIC5054.0 [1]
2-[3-(4-Methoxyphenyl)propanoyl]-1,2-benzothiazol-3-oneIC5051.9 [1]
(3S)-5-(Cyclohexylmethylsulfanyl)-3-[[(2S)-2-[[2-(2,5-dimethoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC5010000.0 [1]
1-Benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dioneKi170.0 [1]
Inhibitor 62bKi90.0 [1]
3-Oxo-N-(2-thiophen-2-ylethyl)-1,2-benzothiazole-2-carboxamideIC5030.87 [1]
5-Fluoro-3-((S)-3-methyl-2-phenylcarbamoyloxy-butyrylamino)-4-oxo-pentanoic acidIC5011.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Caspase-7 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/caspase-7-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Caspase-7 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/caspase-7-inhibitors-ic50-ki.
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