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Caspase-6 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1], 500000.0 [2]
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneKi29000.0 [1]
Caspase-3/7 Inhibitor IIC50500000.0 [1]
Caspase-3/7 Inhibitor IKi25000.0 [1]
(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneIC503700.0 [1], 10000.0 [2], 500000.0 [3]
1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC505000.0 [1], 500000.0 [2]
Isatin Sulfonamide 34IC505000.0 [1]
Isatin Sulfonamide 34Ki5000.0 [1]
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-naphthalen-2-yloxyacetyl)amino]pentanamideIC5018560.0 [1]
Ac-VEID-CHOIC508.0 [1]
(S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1], 500000.0 [2]
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1], 500000.0 [2]
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-naphthalen-1-yloxyacetyl)amino]pentanamideIC50940.0 [1]
2-[1-Benzyl-2-oxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrileIC50918.0 [1]
Benzyl N-[(3R)-1-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-5-methyl-2-oxohexan-3-yl]carbamateIC5014030.0 [1]
Benzyl N-[(3R)-1-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-4-methyl-2-oxopentan-3-yl]carbamateIC5010000.0 [1]
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[(4-methoxyphenyl)methyl]indole-2,3-dioneIC5010000.0 [1], 500000.0 [2]
1-[[4-(2-Fluoroethoxy)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5010000.0 [1], 25000.0 [2]
Benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketoneKi594.0 [1]
3-((S)-2-(((Benzyloxy)carbonyl)amino)-3-methylbutanamido)-5-fluoro-4-oxopentanoic acidIC5018.0 [1]
Isoquinoline-1,3,4(2H)-trioneIC50474.0 [1]
Grassystatin AIC505000.0 [1]
1-[(4-Methoxyphenyl)methyl]-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC505000.0 [1]
1-Methyl-5-nitroindoline-2,3-dioneKi1700.0 [1]
N-[3-[1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]carbamoyl]cyclopropyl]-2,4-dioxo-1-propan-2-ylpyrimidin-5-yl]-2-methyl-4-(naphthalen-2-ylamino)benzamideIC509999.0 [1]
(S)-1-Benzyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
(S)-1-Methyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
(S)-5-(2-(Methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-methylindoline-2,3-dioneIC50500000.0 [1]
1-Benzyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
(S)-5-(2-Phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
1-Methyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)--1H-indole-2,3-dioneIC505000.0 [1]
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
5-[(2S)-2-[(2,4-Difluorophenoxy)methyl]pyrrolidin-1-yl]sulfonyl-1-[[1-(2-fluoroethyl)triazol-4-yl]methyl]indole-2,3-dioneIC504425.0 [1]
1-[[1-(2-Fluoroethyl)triazol-4-yl]methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC509967.0 [1]
5-(Morpholin-4-ylsulfonyl)-1H-indole-2,3-dioneIC5020000.0 [1]
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
5-(2-(Pyridin-4-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
[4-[[2,3-Dioxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-1-yl]methyl]phenyl] acetateIC505000.0 [1]
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
(S)-1-(6-Fluoropyridin-2-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
(s)-1-(6-Fluoropyridin-3-yl-methyl)-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC505000.0 [1]
(S)-1-(4-Iodobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatinIC50500000.0 [1]
(S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
(S)-1-(2-Fluoro-pyridin-4-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
(S)-1-(6-Fluoropyridin-3-ylmethyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
(S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
(S)-1-(6-Fluoro-pyridin-2-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1]
N'-(2-Methoxyphenyl)-N-(1,3,4-trioxoisoquinolin-6-yl)butanediamideIC50137.0 [1]
1-(4-Methylthiobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC505000.0 [1]
1-(4-Fluorobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC505000.0 [1]
1-[(4-Hydroxyphenyl)methyl]-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC509550.0 [1]
1-[(4-Bromophenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC508900.0 [1]
1-(4-Bromo-benzyl)-5-[2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl]-1H-indole-2,3-dioneIC505025.0 [1]
5-(Pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneKi50000.0 [1]
1-[(3,4-Dichlorophenyl)methyl]-5-morpholin-4-ylsulfonylindole-2,3-dioneIC5015000.0 [1]
1-Benzyl-5-thiomorpholinosulfonyl IsatinIC5012833.0 [1]
5-(Azetidin-1-ylsulfonyl)-1-benzylindole-2,3-dioneIC509833.0 [1]
5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneKi57000.0 [1]
(4S)-4-[[(2S)-2-Acetamido-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acidIC5010.0 [1]
(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-succinic acidIC5010000.0 [1]
(3S)-3-[[(2S)-3-Methyl-2-[[2-oxo-2-(2-phenylethylamino)acetyl]amino]butanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi175.0 [1]
(3S)-3-[[(2S)-2-[[2-(4-Heptylanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi59.0 [1]
(3S)-3-[[(2S)-2-[[2-(4-Fluoroanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi59.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Methoxyanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi88.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Benzylanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi82.0 [1]
(3S)-3-[[(2S)-3-Methyl-2-[[2-oxo-2-(2-phenylanilino)acetyl]amino]butanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi85.0 [1]
(3S)-3-[[(2S)-3-Methyl-2-[[2-(naphthalen-1-ylmethylamino)-2-oxoacetyl]amino]butanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi40.0 [1]
(3S)-3-[[(2S)-2-[(2-Anilino-2-oxoacetyl)amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi100.0 [1]
(3S)-3-[[(2S)-2-[[2-(Benzylamino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi125.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Fluoroanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi221.0 [1]
(3S)-3-[[(2S)-3-Methyl-2-[[2-oxo-2-[2-(trifluoromethyl)anilino]acetyl]amino]butanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi12.0 [1]
(3S)-3-[[(2S)-2-[[2-(Benzhydrylamino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi1150.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Tert-butylanilino)-2-oxoacetyl]amino]-3-methylbutanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi41.0 [1]
1-Benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dioneKi1000.0 [1]
Inhibitor 62bKi190.0 [1]
5-Fluoro-3-((S)-3-methyl-2-phenylcarbamoyloxy-butyrylamino)-4-oxo-pentanoic acidIC5050.0 [1]
1-[(4-Iodophenyl)methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC50500000.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Chloroanilino)-2-oxoacetyl]amino]propanoyl]amino]-5-diphenylphosphoryloxy-4-oxopentanoic acidKi11.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-5-(2,6-dichlorobenzoyl)oxy-4-oxopentanoic acidKi13.0 [1]
2-[4-[[5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-2,3-dioxoindol-1-yl]methyl]phenoxy]ethyl 4-methylbenzenesulfonateIC50500000.0 [1]
3-Chloro-N-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)propanamideIC50283.0 [1]
1-[[4-[Tert-butyl(dimethyl)silyl]oxyphenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC50500000.0 [1]
(3S)-3-[[(2S)-2-[[2-(Benzylamino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi70.0 [1]
3-[(1,3,4-Trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)carbamoyl]propanoic acidIC50201.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Chloroanilino)-2-oxoacetyl]amino]propanoyl]amino]-5-(2,6-dichlorobenzoyl)oxy-4-oxopentanoic acidKi7.0 [1]
1-[[4-(2-Bromoethoxy)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC50500000.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Benzylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi544.0 [1]
(3S)-3-[[(2S)-2-[[2-(2,5-Ditert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-5-(2,6-dichlorobenzoyl)oxy-4-oxopentanoic acidKi49.0 [1]
2-[4-[[2,3-Dioxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-1-yl]methyl]phenoxy]ethyl 4-methylbenzenesulfonateIC50500000.0 [1]
Phenyl[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)carbamoyl]methyl acetateIC50216.0 [1]
4-Oxo-4-piperidin-1-yl-N-(1,3,4-trioxo-1,2,3,4-tetrahydro-isoquinolin-6-yl)-butyramideIC50124.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-5-diphenylphosphoryloxy-4-oxopentanoic acidKi11.0 [1]
(3S)-3-[[(2S)-2-[[2-(2-Fluoroanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidKi22.0 [1]
N-(1,2,3,4-Tetrahydro-1,3,4-trioxoisoquinolin-7-yl)-4-nitrobenzamideIC502850.0 [1]
1-[[4-[Tert-butyl(dimethyl)silyl]oxyphenyl]methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC50500000.0 [1]
(3S)-3-[[(2S)-2-[[2-(2,5-Ditert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-5-diphenylphosphoryloxy-4-oxopentanoic acidKi15.0 [1]
1-[[4-(2-Bromoethoxy)phenyl]methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC50500000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Caspase-6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/caspase-6-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Caspase-6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/caspase-6-inhibitors-ic50-ki.
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