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Caspase-3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC5010000.0 [1]
1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneKi15.0 [1], 56.1 [2]
Ac-DEVD-CHOIC502.2 [1]
Caspase-3/7 Inhibitor IIC50119.95 [1]
Caspase-3/7 Inhibitor IKi41.8 [1], 60.0 [2]
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5044.0 [1]
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneKi8.3 [1], 15.0 [2]
(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneIC500.3 [1], 6.1 [2], 9.7 [3], 9.77 [4]
(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneKi0.2 [1]
Isatin Sulfonamide 34IC502.5 [1], 12.2 [2], 12.3 [3], 14.5 [4]
Isatin Sulfonamide 34Ki1.2 [1]
(S)-5-(2-(Methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-methylindoline-2,3-dioneIC502.4 [1]
(S)-5-(2-(Methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-methylindoline-2,3-dioneKi1.2 [1]
(S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC508.2 [1], 13.49 [2], 13.5 [3]
(S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneKi4.0 [1]
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC509.7 [1], 14.45 [2], 14.5 [3]
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneKi4.8 [1]
(3S)-5-Benzylsulfanyl-3-[[(2S)-2-[[2-(5-bromo-2-methoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC5017.7 [1], 18.0 [2], 60.0 [3]
5-(Pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneIC502798.98 [1], 2800.0 [2]
5-(Pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneKi1400.0 [1]
5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneIC505495.41 [1], 5500.0 [2]
5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneKi12000.0 [1]
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-naphthalen-2-yloxyacetyl)amino]pentanamideIC50940.0 [1], 944.0 [2]
(S)-3-((S)-2-(Benzyloxycarbonylamino)-3-methylbutanamido)-5-(methylsulfonyl)pent-4-enoic acidIC503330.0 [1], 35300.0 [2], 133400.0 [3]
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[(4-methoxyphenyl)methyl]indole-2,3-dioneIC5017.6 [1], 18.4 [2]
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[(4-methoxyphenyl)methyl]indole-2,3-dioneKi9.0 [1]
1-[[4-(2-Fluoroethoxy)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC508.3 [1], 36.4 [2]
1-[[4-(2-Fluoroethoxy)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneKi17.9 [1]
1,2-Benzisothiazol-3(2H)-oneIC5046740.0 [1]
3-((S)-2-(((Benzyloxy)carbonyl)amino)-3-methylbutanamido)-5-fluoro-4-oxopentanoic acidIC5030.0 [1]
1-[(4-Methoxyphenyl)methyl]-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC503.89 [1], 3.9 [2]
1-Methyl-5-nitroindoline-2,3-dioneIC501000.0 [1]
1-Methyl-5-nitroindoline-2,3-dioneKi500.0 [1]
(S)-1-Benzyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC509.7 [1], 9.77 [2]
(S)-1-Methyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5091.2 [1], 91.7 [2]
5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5058.3 [1], 58.88 [2]
1-Benzyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505.2 [1], 5.25 [2]
(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5012.02 [1], 12.1 [2]
(S)-5-(2-Phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC50286.7 [1], 288.4 [2]
1-Methyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)--1H-indole-2,3-dioneIC5023.3 [1], 23.44 [2]
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC508.32 [1], 8.4 [2]
5-[(2S)-2-[(2,4-Difluorophenoxy)methyl]pyrrolidin-1-yl]sulfonyl-1-[[1-(2-fluoroethyl)triazol-4-yl]methyl]indole-2,3-dioneIC500.5 [1], 10.8 [2]
1-[[1-(2-Fluoroethyl)triazol-4-yl]methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5012.2 [1], 16.7 [2]
5-(Piperidin-1-ylsulfonyl)-1H-indole-2,3-dioneIC502197.86 [1], 2200.0 [2]
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-naphthalen-1-yloxyacetyl)amino]pentanamideIC50135.0 [1]
N-(2-Methoxyethyl)-N-methyl-2,3-dioxo-1H-indole-5-sulfonamideIC50909.91 [1], 910.0 [2]
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5011.22 [1], 11.3 [2]
5-(2-(Pyridin-4-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5020.4 [1], 20.42 [2]
[4-[[2,3-Dioxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-1-yl]methyl]phenyl] acetateIC5012.0 [1], 12.02 [2]
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5012.3 [1], 12.4 [2]
(S)-1-(6-Fluoropyridin-2-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC505.75 [1], 5.8 [2]
(s)-1-(6-Fluoropyridin-3-yl-methyl)-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC5010.23 [1], 10.3 [2]
(S)-1-(4-Iodobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatinIC502.4 [1]
(S)-1-(4-Iodobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatinKi1.2 [1]
(S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5029.2 [1], 29.51 [2]
(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC508.71 [1], 8.8 [2]
(S)-1-(2-Fluoro-pyridin-4-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5021.3 [1], 21.38 [2]
(S)-1-(6-Fluoropyridin-3-ylmethyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dioneIC5010.9 [1], 10.96 [2]
(S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dioneIC509.33 [1], 9.4 [2]
(S)-1-(6-Fluoro-pyridin-2-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC509.1 [1], 9.12 [2]
1-(4-Methylthiobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC504.37 [1], 4.4 [2]
1-(4-Fluorobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC508.32 [1], 8.4 [2]
1-[(4-Hydroxyphenyl)methyl]-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC503.89 [1], 3.9 [2]
1-[(4-Bromophenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC509.77 [1], 9.85 [2]
1-(4-Bromo-benzyl)-5-[2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl]-1H-indole-2,3-dioneIC503.6 [1], 3.63 [2]
2-[1-Benzyl-2-oxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrileIC5027.8 [1]
Tert-butyl 1-[(2,3-dioxo-1H-indol-5-yl)sulfonyl]pyrrolidine-2-carboxylateIC5069.98 [1], 70.0 [2]
Methyl 1-[(2,3-dioxo-1H-indol-5-yl)sulfonyl]pyrrolidine-2-carboxylateIC50169.82 [1], 170.0 [2]
(3S)-5-Benzylsulfanyl-3-[[(2S)-3-methyl-2-[(2-phenylacetyl)amino]butanoyl]amino]-4-oxopentanoic acidIC50746.0 [1], 750.0 [2]
(3S)-3-[[(2S)-2-[[2-(5-Acetyl-2-methoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-5-benzylsulfanyl-4-oxopentanoic acidIC5010.0 [1], 13.0 [2]
1-[(3,4-Dichlorophenyl)methyl]-5-morpholin-4-ylsulfonylindole-2,3-dioneIC501430.0 [1], 1445.44 [2]
1-Benzyl-5-thiomorpholinosulfonyl IsatinIC501023.29 [1], 1028.0 [2]
5-(Azetidin-1-ylsulfonyl)-1-benzylindole-2,3-dioneIC50114.0 [1], 114.82 [2]
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-propylindole-2,3-dioneIC505.3 [1]
1-Butyl-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5029.0 [1]
1-[(2,3-Dioxo-1H-indol-5-yl)sulfonyl]-N,N-dimethylpyrrolidine-2-carboxamideIC50410.0 [1], 410.2 [2]
5-[2-(Phenylsulfanylmethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dioneIC5043.95 [1], 44.0 [2]
Benzyl N-[(4S,7S,10aS)-4-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-6-oxo-2,3,4,7,8,9,10,10a-octahydro-1H-pyrido[1,2-a]azepin-7-yl]carbamateIC5010000.0 [1]
(3S)-3-Acetamido-4-[[(3R,6S,9aR)-3-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]carbamoyl]-5-oxo-3,6,7,8,9,9a-hexahydro-2H-[1,3]thiazolo[3,2-a]azepin-6-yl]amino]-4-oxobutanoic acidIC5018.0 [1]
(4S)-4-[[(2S)-2-Acetamido-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(3S)-2-hydroxy-5-oxooxolan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acidIC501.2 [1], 3.5 [2]
(4S)-5-[[(2S)-1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acidIC502.3 [1]
Benzyl N-[(3R)-1-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-5-methyl-2-oxohexan-3-yl]carbamateIC503470.0 [1]
Benzyl N-[(3R)-1-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-4-methyl-2-oxopentan-3-yl]carbamateIC501750.0 [1]
(3S)-3-[2-[5-Tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methylamino]-2-oxopyrazin-1-yl]butanoylamino]-4-oxo-7-phenylheptanoic acidIC500.01 [1], 14.0 [2]
1-Ethyl-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC50183.0 [1]
1-(4-Fluorobutyl)-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5041.0 [1]
(E,3S)-5-(Benzenesulfonyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)pent-4-enoic acidIC5016200.0 [1], 228000.0 [2]
(E,3S)-3-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-methylsulfonylpent-4-enoic acidIC5023700.0 [1], 163200.0 [2]
(E,3S)-5-(Benzenesulfonyl)-3-[[(2S,3S)-3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pent-4-enoic acidIC5028300.0 [1], 185400.0 [2]
(E,3S)-3-[[(2S,3S)-3-Methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-methylsulfonylpent-4-enoic acidIC5030500.0 [1], 94600.0 [2]
(E,3S)-5-(Benzenesulfonyl)-3-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]pent-4-enoic acidIC5029900.0 [1], 69100.0 [2]
(E,3S)-3-[[(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]-5-methylsulfonylpent-4-enoic acidIC5028800.0 [1], 34000.0 [2]
1-[(3-Benzyltriazol-4-yl)methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC509.0 [1]
1-[(3-Benzyltriazol-4-yl)methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneKi10.5 [1]
1-[[1-(2,3-Dihydro-1,4-benzodioxin-6-yl)triazol-4-yl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5017.0 [1]
1-[[1-(2,3-Dihydro-1,4-benzodioxin-6-yl)triazol-4-yl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneKi14.5 [1]
(3S)-5-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-3-[[(2S)-2-[[2-[2-ethoxy-5-[(E)-3-methoxy-3-oxoprop-1-enyl]phenyl]acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC507.95 [1], 8.0 [2]
N-(4-Morpholin-4-ylphenyl)-3-oxo-1,2-benzothiazole-2-carboxamideIC501.15 [1], 106.3 [2]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Caspase-3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/caspase-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Caspase-3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/caspase-3-inhibitors-ic50-ki.
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