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Caspase-1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Ac-Yvad-choIC508.4 [1], 17.0 [2], 2000.0 [3], 68000.0 [4]
Ac-Yvad-choKi0.76 [1], 6.0 [2]
PralnacasanIC502.0 [1], 3.6 [2], 420.0 [3]
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5010000.0 [1], 500000.0 [2]
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneKi17000.0 [1]
Caspase-3/7 Inhibitor IIC5015000.0 [1], 500000.0 [2]
Caspase-3/7 Inhibitor IKi25000.0 [1]
(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dioneIC5010000.0 [1], 50000.0 [2], 500000.0 [3]
(S)-3-(Benzyloxycarbonylamino)-4-oxo-5-(3-phenylpropanoyloxy)pentanoic acidIC5012000.0 [1], 35000.0 [2]
(S)-3-(Benzyloxycarbonylamino)-4-oxo-5-(3-phenylpropanoyloxy)pentanoic acidKi4500.0 [1]
1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dioneIC5020000.0 [1], 500000.0 [2]
N-[3-[1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]carbamoyl]cyclopropyl]-2,4-dioxo-1-propan-2-ylpyrimidin-5-yl]-2-methyl-4-(naphthalen-2-ylamino)benzamideIC509.8 [1], 38.0 [2], 160.0 [3]
(3S)-3-[[(4S,7S)-7-(Isoquinoline-1-carbonylamino)-6,10-dioxo-2,3,4,7,8,9-hexahydro-1H-pyridazino[1,2-a]diazepine-4-carbonyl]amino]-4-oxobutanoic acidIC503.4 [1], 4.0 [2], 670.0 [3]
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-naphthalen-2-yloxyacetyl)amino]pentanamideIC5010000.0 [1]
3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxo-9-phenylnonanoic acidIC5018.5 [1], 71.0 [2]
3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxo-9-phenylnonanoic acidKi14.0 [1]
N-[3-[1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-1-oxopropan-2-yl]-1-methyl-2,4-dioxopyrimidin-5-yl]-4-(quinoxalin-2-ylamino)benzamideIC505.01 [1], 31.62 [2], 48.0 [3]
(3S)-3-[(2-Acetamido-3-methylbutanoyl)amino]-5-[2-(2,6-dichlorophenyl)acetyl]oxy-4-oxopentanoic acidIC505.0 [1], 8.0 [2]
(3S)-3-[(2-Acetamido-3-methylbutanoyl)amino]-5-[2-(2,6-dichlorophenyl)acetyl]oxy-4-oxopentanoic acidKi82.0 [1]
(3S)-3-[(2-Acetamido-3-methylbutanoyl)amino]-4-oxo-5-[2-(2,3,6-trichlorophenyl)acetyl]oxypentanoic acidIC505.0 [1], 7.0 [2]
(3S)-3-[(2-Acetamido-3-methylbutanoyl)amino]-4-oxo-5-[2-(2,3,6-trichlorophenyl)acetyl]oxypentanoic acidKi113.0 [1]
Ac-DEVD-CHOIC50190.0 [1], 70000.0 [2]
CID 104934Ki50.0 [1]
Isatin Sulfonamide 34IC5010000.0 [1]
Isatin Sulfonamide 34Ki5000.0 [1]
(S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC505000.0 [1], 25000.0 [2]
(3S)-5-Benzylsulfanyl-3-[[(2S)-2-[[2-(5-bromo-2-methoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC503050.0 [1], 3100.0 [2]
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dioneIC5010000.0 [1], 500000.0 [2]
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-naphthalen-1-yloxyacetyl)amino]pentanamideIC50570.0 [1]
(S)-4-Oxo-3-(6-(4-(quinoxalin-2-ylamino)benzamido)hexanamido)butanoic acidIC50190.0 [1]
(S)-4-Oxo-3-(6-(4-(quinoxalin-2-ylamino)benzamido)hexanamido)butanoic acidKi190.0 [1]
(3S)-5-Benzylsulfanyl-3-[[(2S)-3-methyl-2-[(2-phenylacetyl)amino]butanoyl]amino]-4-oxopentanoic acidIC5021200.0 [1], 22000.0 [2]
(3S)-3-[[(2S)-2-[[2-(5-Acetyl-2-methoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-5-benzylsulfanyl-4-oxopentanoic acidIC505900.0 [1], 6190.0 [2]
(4S)-5-[[(2S)-1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acidIC506.5 [1]
Benzyl N-[(3R)-1-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-5-methyl-2-oxohexan-3-yl]carbamateIC5018820.0 [1]
Benzyl N-[(3R)-1-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-4-methyl-2-oxopentan-3-yl]carbamateIC505850.0 [1]
(3S)-3-[2-[3-(Naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]butanoylamino]-4-oxo-5-(2-phenylethylamino)pentanoic acidKi0.37 [1]
(3S)-3-[2-[5-Tert-butyl-3-[(4-methyl-1,2,5-oxadiazol-3-yl)methylamino]-2-oxopyrazin-1-yl]butanoylamino]-4-oxo-7-phenylheptanoic acidIC505.13 [1], 5130.0 [2]
(3S)-4-Oxo-3-[[6-[[[4-(quinoxalin-2-ylamino)benzoyl]amino]methyl]pyridine-3-carbonyl]amino]butanoic acidIC505.0 [1]
(3S)-4-Oxo-3-[[6-[[[4-(quinoxalin-2-ylamino)benzoyl]amino]methyl]pyridine-3-carbonyl]amino]butanoic acidKi5.0 [1]
(3S)-5-Benzylsulfanyl-3-[[(2S)-2-[[2-(2,5-dimethoxyphenyl)acetyl]amino]-3-methylbutanoyl]amino]-4-oxopentanoic acidIC506000.0 [1], 7070.0 [2]
(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-succinic acidKi15.0 [1], 55.0 [2]
Z-Vad-choKi8.0 [1], 15.0 [2]
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[(4-methoxyphenyl)methyl]indole-2,3-dioneIC5010000.0 [1]
1-[[4-(2-Fluoroethoxy)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dioneIC5010000.0 [1], 25000.0 [2]
(3S)-4-Hydroxy-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-2-[(2S)-3-methyl-2-(naphthalene-2-carbonylamino)butanoyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5017.0 [1], 86.0 [2]
(1R)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-2-[(naphthalene-2-carbonylamino)-propan-2-ylcarbamoyl]cyclopentane-1-carboxamideIC5010000.0 [1]
(3S,9R,11S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-3-(naphthalene-2-carbonylamino)-2-oxo-8-oxa-1-azabicyclo[7.2.1]dodecane-11-carboxamideIC505011.87 [1], 10000.0 [2]
N-[1-[(2S)-1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-1-oxopropan-2-yl]-2,5-dioxoimidazolidin-4-yl]naphthalene-2-carboxamideIC5010000.0 [1]
N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-6-[(1S)-2-methyl-1-(naphthalene-2-carbonylamino)propyl]pyridine-3-carboxamideIC501258.93 [1], 10000.0 [2]
N-[3-[1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-1-oxopropan-2-yl]-1-methyl-2,4-dioxopyrimidin-5-yl]naphthalene-2-carboxamideIC50501.19 [1], 7943.28 [2]
(3S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-[(naphthalene-2-carbonylamino)-propan-2-ylcarbamoyl]pyrrolidine-3-carboxamideIC5010000.0 [1]
N-[3-[2-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-2-oxoethyl]-2,4-dioxo-1-propan-2-ylpyrimidin-5-yl]-4-(naphthalen-2-ylamino)benzamideIC5021.0 [1], 140.0 [2]
N-[1-[(2S)-1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-1-oxopropan-2-yl]-2,5-dioxopyrrolidin-3-yl]naphthalene-2-carboxamideIC5010000.0 [1]
N-[3-[1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]carbamoyl]cyclopropyl]-2,4-dioxo-1-propan-2-ylpyrimidin-5-yl]-4-(quinoxalin-2-ylamino)benzamideIC504.7 [1], 27.0 [2]
(1R)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-2-[(naphthalene-2-carbonylamino)-propan-2-ylcarbamoyl]cyclohexane-1-carboxamideIC5010000.0 [1]
N-[3-[2-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-2-oxoethyl]-2,4-dioxo-1-propan-2-ylpyrimidin-5-yl]-4-(quinoxalin-2-ylamino)benzamideIC503.0 [1], 53.0 [2]
N-[1-[(2S)-1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-1-oxopropan-2-yl]-2,6-dioxopiperidin-3-yl]naphthalene-2-carboxamideIC5010000.0 [1]
4-Hydroxy-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-2-[(2S)-3-methyl-2-(naphthalene-2-carbonylamino)butanoyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5015.85 [1], 100.0 [2]
N-[3-[1-[[(3S)-2-Hydroxy-5-oxooxolan-3-yl]amino]-1-oxopropan-2-yl]-2,4-dioxo-1-propan-2-ylpyrimidin-5-yl]-4-(quinoxalin-2-ylamino)benzamideIC505.6 [1], 50.0 [2]
5-Benzenesulfonylamino-3-benzyloxycarbonylamino-4-oxo-pentanoic acidIC50291000.0 [1]
5-Benzenesulfonylamino-3-benzyloxycarbonylamino-4-oxo-pentanoic acidKi37000.0 [1]
3-(Benzyloxycarbonylamino)-4-oxo-5-(phenethylsulfonylamino)pentanoic acidIC5073000.0 [1]
3-(Benzyloxycarbonylamino)-4-oxo-5-(phenethylsulfonylamino)pentanoic acidKi11000.0 [1]
3-(Benzyloxycarbonylamino)-4-oxo-5-(indan-1-ylmethylsulfonylamino)pentanoic acidIC50194000.0 [1]
3-(Benzyloxycarbonylamino)-4-oxo-5-(indan-1-ylmethylsulfonylamino)pentanoic acidKi65000.0 [1]
3-(Benzyloxycarbonylamino)-4-oxo-5-(1-naphthylsulfonylamino)pentanoic acidIC50174000.0 [1]
3-(Benzyloxycarbonylamino)-4-oxo-5-(1-naphthylsulfonylamino)pentanoic acidKi22000.0 [1]
3-(Benzyloxycarbonylamino)-4-oxo-5-[2-(1-naphthyl)ethylsulfonylamino]pentanoic acidIC5055600.0 [1]
3-(Benzyloxycarbonylamino)-4-oxo-5-[2-(1-naphthyl)ethylsulfonylamino]pentanoic acidKi16000.0 [1]
3-Benzyloxycarbonylamino-4-oxo-5-(3-phenyl-propane-1-sulfonylamino)-pentanoic acidIC50245000.0 [1]
3-Benzyloxycarbonylamino-4-oxo-5-(3-phenyl-propane-1-sulfonylamino)-pentanoic acidKi34500.0 [1]
3-Benzyloxycarbonylamino-5-methanesulfonylamino-4-oxo-pentanoic acidIC501833000.0 [1]
3-Benzyloxycarbonylamino-5-methanesulfonylamino-4-oxo-pentanoic acidKi735000.0 [1]
3-(Benzyloxycarbonylamino)-4-oxo-5-(2-cyclohexylethylsulfonylamino)pentanoic acidIC50136000.0 [1]
3-(Benzyloxycarbonylamino)-4-oxo-5-(2-cyclohexylethylsulfonylamino)pentanoic acidKi33000.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxo-9-phenylnonanoic acidIC5078.0 [1]
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxo-9-phenylnonanoic acidKi18.5 [1]
(3S)-3-[[2-[3-(Naphthalene-2-carbonylamino)-2-oxopyridin-1-yl]-2-phenylacetyl]amino]-4-oxo-5-phenoxypentanoic acidKi1.3 [1]
(3S)-3-[[2-[3-(Naphthalene-1-carbonylamino)-2-oxopyridin-1-yl]-2-phenylacetyl]amino]-4-oxo-5-phenoxypentanoic acidIC5010.0 [1]
(3S)-3-[[2-[3-(Naphthalene-1-carbonylamino)-2-oxopyridin-1-yl]-2-phenylacetyl]amino]-4-oxo-5-phenoxypentanoic acidKi1.8 [1]
3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]propanoic acidIC50200000.0 [1]
3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]propanoic acidKi20000.0 [1]
(2R)-2-[[2-(4-Cyclopentylphenoxy)phenyl]sulfonylamino]-3-oxopropanoic acidIC504800.0 [1]
(2R)-2-[[2-(4-Cyclopentylphenoxy)phenyl]sulfonylamino]-3-oxopropanoic acidKi880.0 [1]
(2R)-3-Oxo-2-[[2-(4-phenylphenoxy)phenyl]sulfonylamino]propanoic acidIC504400.0 [1]
(2R)-3-Oxo-2-[[2-(4-phenylphenoxy)phenyl]sulfonylamino]propanoic acidKi290.0 [1]
(2R)-2-[[2-(4-Cyclohexylphenoxy)phenyl]sulfonylamino]-3-oxopropanoic acidIC504300.0 [1]
(2R)-2-[[2-(4-Cyclohexylphenoxy)phenyl]sulfonylamino]-3-oxopropanoic acidKi900.0 [1]
(2R)-2-[[2-(3-Methyl-4-propan-2-ylphenoxy)phenyl]sulfonylamino]-3-oxopropanoic acidIC501000.0 [1]
(2R)-2-[[2-(3-Methyl-4-propan-2-ylphenoxy)phenyl]sulfonylamino]-3-oxopropanoic acidKi110.0 [1]
4-[4-[2-[[(1R)-1-Carboxy-2-oxoethyl]sulfamoyl]phenoxy]phenyl]benzoic acidIC5058000.0 [1]
4-[4-[2-[[(1R)-1-Carboxy-2-oxoethyl]sulfamoyl]phenoxy]phenyl]benzoic acidKi4200.0 [1]
(2R)-2-[[2-(4-Butan-2-yl-3-methylphenoxy)phenyl]sulfonylamino]-3-oxopropanoic acidIC501000.0 [1]
(2R)-2-[[2-(4-Butan-2-yl-3-methylphenoxy)phenyl]sulfonylamino]-3-oxopropanoic acidKi100.0 [1]
(2R)-2-[[2-(2,3-Dimethylphenoxy)phenyl]sulfonylamino]-3-oxopropanoic acidIC5013000.0 [1]
(2R)-2-[[2-(2,3-Dimethylphenoxy)phenyl]sulfonylamino]-3-oxopropanoic acidKi1000.0 [1]
(2R)-3-Oxo-2-[[2-(3-propan-2-ylphenoxy)phenyl]sulfonylamino]propanoic acidIC503700.0 [1]
(2R)-3-Oxo-2-[[2-(3-propan-2-ylphenoxy)phenyl]sulfonylamino]propanoic acidKi410.0 [1]
(2R)-2-[[2-(4-Butan-2-ylphenoxy)phenyl]sulfonylamino]-3-oxopropanoic acidIC502200.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Caspase-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/caspase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Caspase-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/caspase-1-inhibitors-ic50-ki.
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