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Carnitine palmitoyltransferase 2 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
(2S,6R)-6-(Carboxymethyl)-2-hydroxy-4,4-dimethyl-2-pentadecylmorpholiniumKi160.0 [1], 2800.0 [2], 4200.0 [3]
4-{[1-(5-Chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}-benzoic acidIC50739.5 [1], 740.0 [2]
4-(5-Chloro-2-methoxyphenyl)sulfonyl-6-[(3-fluorophenyl)carbamoyl]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acidIC50100000.0 [1]
2-[4-[[1-(2-Methoxy-5-methylphenyl)sulfonyl-3,4-dihydro-2H-quinoline-7-carbonyl]amino]phenyl]acetic acidIC502800.0 [1], 2800.1 [2]
2-Phenoxy-1-[(2R)-2-(4-pyridin-2-yl-1,3-thiazol-2-yl)piperidin-1-yl]ethanoneIC504800.0 [1], 4830.1 [2]
3-[2-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,3-thiazol-4-yl]benzoic acidIC5028745.5 [1], 31814.1 [2]
AmiodaroneIC50100000.0 [1]
RosiglitazoneIC50100000.0 [1]
PioglitazoneIC50100000.0 [1]
TrimetazidineIC50100000.0 [1]
PerhexilineIC5072800.0 [1]
OxfenicineIC50100000.0 [1]
4-Hydroxyphenylglyoxylic acidIC50100000.0 [1]
[(2R)-2-Amino-3-carboxypropyl]-trimethylazaniumIC503900.0 [1]
2-[5-(2-Naphthalen-2-yloxyethoxy)thiophen-2-yl]-2-oxoacetic acidIC504700.0 [1]
(3r)-3-{[(Tetradecylamino)carbonyl]amino}-4-(Trimethylammonio)butanoateIC50160.0 [1]
2-[2-[4-[(4-Chlorophenyl)sulfonylamino]phenyl]ethyl]benzoic acidIC50100000.0 [1]
1-[(2R)-2-[3-(5-Chloro-3-ethyl-2-methylimidazol-4-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC5037263.0 [1]
1-[(2R)-2-[3-(5-Bromo-3-methylimidazol-4-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC5040467.1 [1]
1-[(2R)-2-[3-(4-Chloro-2,5-dimethylpyrazol-3-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC50100000.0 [1]
1-[(2R)-2-(5-Cyclohexyl-1,2,4-oxadiazol-3-yl)piperidin-1-yl]-2-phenoxyethanoneIC5047558.2 [1]
1-[(2R)-2-[5-(4-Methoxycyclohexyl)-1,2,4-oxadiazol-3-yl]piperidin-1-yl]-2-phenoxyethanoneIC5078439.3 [1]
1-[(2R)-2-[5-[(1S,4R)-2-Bicyclo[2.2.1]heptanyl]-1,2,4-oxadiazol-3-yl]piperidin-1-yl]-2-phenoxyethanoneIC5019922.2 [1]
Methyl (1S,2S)-2-[3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]cyclohexane-1-carboxylateIC5057261.5 [1]
4-[[3-(5-Chloro-2-methoxyphenyl)sulfanyl-1-ethylindole-5-carbonyl]amino]benzoic acidIC50100000.0 [1]
4-[[3-(5-Chloro-2-methoxyphenyl)sulfonyl-1-ethylindole-5-carbonyl]amino]benzoic acidIC50536.6 [1]
3-[4-Chloro-3-[3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]-5,5-dimethylimidazolidine-2,4-dioneIC506094.6 [1]
1-[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]phenyl]pyrrolidine-2,5-dioneIC5021379.8 [1]
4-[[(3R)-1-(5-Chloro-2-methoxyphenyl)sulfonyl-3-methyl-2,3-dihydroindole-6-carbonyl]amino]benzoic acidIC50698.3 [1]
4-[[(3S)-1-(5-Chloro-2-methoxyphenyl)sulfonyl-3-methyl-2,3-dihydroindole-6-carbonyl]amino]benzoic acidIC50452.8 [1]
4-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]benzoic acidIC5010782.8 [1]
2-[2-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC50100000.0 [1]
N-[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]tetrazol-2-yl]phenyl]acetamideIC508062.1 [1]
N-[[3-[3-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]methyl]acetamideIC5029091.7 [1]
N-[[3-[3-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]methyl]methanesulfonamideIC5022822.7 [1]
1-(5-Methoxy-1H-indol-3-yl)-2-pyridin-4-yloxyethanoneIC50100000.0 [1]
4-[[3-[[7-(Trifluoromethyl)-3,4-dihydro-2H-quinolin-1-yl]sulfonyl]benzoyl]amino]benzoic acidIC505730.8 [1]
4-[[3,4-Dimethyl-5-[[3-(trifluoromethyl)phenyl]sulfamoyl]benzoyl]amino]benzoic acidIC501821.3 [1]
4-[2-[3-[(5-Chloro-2-methoxyphenyl)sulfonylamino]phenyl]ethynyl]benzoic acidIC50100000.0 [1]
4-[[5-[(5-Chloro-2-methoxyphenyl)sulfonylamino]-1-methyl-6-oxopyridine-3-carbonyl]amino]benzoic acidIC503230.9 [1]
6-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]-1H-indazole-3-carboxamideIC50100000.0 [1]
4-[[5-[(3,5-Dichlorophenyl)sulfonylamino]thiophene-2-carbonyl]amino]benzoic acidIC50100000.0 [1]
Ethyl 7-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]imidazo[1,2-a]pyridine-2-carboxylateIC50100000.0 [1]
7-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]imidazo[1,2-a]pyridine-2-carboxamideIC5012075.0 [1]
N-[(3R)-3-(Methoxymethyl)pyrrolidin-1-yl]-3-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]benzamideIC5074263.5 [1]
4-[2-[1-(5-Chloro-2-methoxyphenyl)sulfonyl-2,3-dihydroindol-6-yl]ethynyl]benzoic acidIC50100000.0 [1]
1-[[4-(Difluoromethoxy)phenyl]methyl]-5-methyl-N-[4-(2H-tetrazol-5-yl)phenyl]pyrazole-3-carboxamideIC5072557.7 [1]
N-[3-[3-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]acetamideIC5072767.6 [1]
2-Phenoxy-1-[2-(3-phenyl-1H-pyrazol-5-yl)piperidin-1-yl]ethanoneIC5060649.6 [1]
5-Chloro-2-methoxy-N-[(3R)-1-(2-phenoxyacetyl)piperidin-3-yl]benzenesulfonamideIC5021045.9 [1]
1-[2-[5-(3-Nitrophenyl)-1,3-thiazol-2-yl]piperidin-1-yl]-2-phenoxyethanoneIC50100000.0 [1]
1-[2-[5-(3-Nitrophenyl)-1,3-oxazol-2-yl]piperidin-1-yl]-2-phenoxyethanoneIC5012802.1 [1]
2-(4-Fluorophenyl)-5-[1-(2-phenoxyacetyl)piperidin-2-yl]-1H-pyrazol-3-oneIC50100000.0 [1]
3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]benzohydrazideIC5023474.2 [1]
1-[(2R)-2-[3-(6-Nitropyridin-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC5017153.1 [1]
N-(2,4-Dioxoimidazolidin-1-yl)-3-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]benzamideIC5019385.1 [1]
1-[3-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-oxo-1,4-thiazinan-4-yl]-2-phenoxyethanoneIC50100000.0 [1]
[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]phenyl]boronic acidIC5015583.5 [1]
N,N-Dimethyl-4-[5-[3-(2-phenoxyacetyl)-3-azabicyclo[3.1.0]hexan-2-yl]-1,2,4-oxadiazol-3-yl]benzamideIC5047128.25 [1]
5-[5-[(3R)-4-(2-Phenoxyacetyl)morpholin-3-yl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxamideIC50100000.0 [1]
N,N-Diethyl-5-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxamideIC509180.0 [1]
5-[5-[3-(2-Phenoxyacetyl)-3-azabicyclo[3.1.0]hexan-2-yl]-1,2,4-oxadiazol-3-yl]-1,3-dihydroindol-2-oneIC5065001.9 [1]
2-[2-[[4-[(5-Chloro-2-methoxyphenyl)methyl]-3-oxo-1,4-benzoxazine-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC50100000.0 [1]
2-[2-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-3,3-dimethyl-2-oxoindole-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC50100000.0 [1]
4-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-3,3-dimethyl-2-oxoindole-6-carbonyl]amino]benzoic acidIC505511.5 [1]
2-[4-[[3-(5-Chloro-2-methoxyphenyl)sulfonyl-1H-indole-5-carbonyl]amino]phenyl]acetic acidIC50100000.0 [1]
2-[2-[[3-(5-Chloro-2-methoxyphenyl)sulfonyl-1H-indole-5-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC50100000.0 [1]
1-Ethyl-4,4-dimethyl-7-[3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]-3H-quinolin-2-oneIC50100000.0 [1]
1-[(2R)-2-(5-Cyclopentyl-1,2,4-oxadiazol-3-yl)piperidin-1-yl]-2-phenoxyethanoneIC50100000.0 [1]
2-Pyridin-4-yloxy-1-[(2R)-2-[3-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-5-yl]piperidin-1-yl]ethanoneIC5043528.5 [1]
N-[3-[1-Methyl-5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-triazol-3-yl]phenyl]acetamideIC50100000.0 [1]
4-[[3-(3-Chlorophenyl)sulfanyl-1-methylindole-5-carbonyl]amino]benzoic acidIC505073.3 [1]
4-[[3-(3-Chlorophenyl)sulfonyl-1-methylindole-5-carbonyl]amino]benzoic acidIC501500.0 [1]
N-[3-[2-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]ethynyl]phenyl]acetamideIC50100000.0 [1]
2-[2-[[4-[(5-Chloro-2-methoxyphenyl)methyl]-3-oxo-1,4-benzothiazine-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC50100000.0 [1]
2-Phenoxy-1-[(2R)-2-[5-[1-(trifluoromethyl)cyclopropyl]-1,2,4-oxadiazol-3-yl]piperidin-1-yl]ethanoneIC50100000.0 [1]
1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-N-(1,3-thiazol-2-yl)-3,1-benzoxazine-7-carboxamideIC50100000.0 [1]
2-Phenoxy-1-[(2R)-2-(2-phenyltetrazol-5-yl)piperidin-1-yl]ethanoneIC50100000.0 [1]
1-[(2R)-2-[2-(4-Fluorophenyl)tetrazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC50100000.0 [1]
1-[(2R)-2-[2-(4-Methoxyphenyl)tetrazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC5024194.0 [1]
2-[2-[[4-[(5-Chloro-2-methoxyphenyl)methyl]-1,1,3-trioxo-1lambda6,4-benzothiazine-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC50100000.0 [1]
2-Chloro-4-[[1-[(5-chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]benzoic acidIC504058.0 [1]
2-[2-Chloro-4-[[1-[(5-chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]phenyl]acetic acidIC50100000.0 [1]
2-[4-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]phenyl]acetic acidIC50100000.0 [1]
1-[(2R)-2-[3-(6-Aminopyridin-3-yl)-1H-1,2,4-triazol-5-yl]piperidin-1-yl]-2-phenoxyethanone;hydrochlorideIC5080001.5 [1]
2-[2-[[3-(3-Chlorophenyl)sulfonyl-1-methylindole-5-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC50100000.0 [1]
N-[[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]phenyl]methyl]acetamideIC5054274.0 [1]
(2R)-N-Benzyl-1-(2-phenoxyacetyl)piperidine-2-carboxamideIC50100000.0 [1]
(2R)-N-Benzyl-N-methyl-1-(2-phenoxyacetyl)piperidine-2-carboxamideIC502671.3 [1]
N,N-Diethyl-3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazole-5-carboxamideIC50100000.0 [1]
1-[(2R)-2-[2-(4-Methylsulfonylphenyl)tetrazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC5017424.7 [1]
1-[(2R)-2-[3-(5-Nitrothiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC5062309.7 [1]
1-[(2R)-2-[3-(5-Nitrofuran-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC509992.5 [1]
1-[(2R)-2-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-3-phenylprop-2-yn-1-oneIC50100000.0 [1]
4-[2-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]ethynyl]benzonitrileIC50100000.0 [1]
4-[2-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]ethynyl]benzenesulfonamideIC50100000.0 [1]
7-[2-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]ethynyl]-4H-1,4-benzoxazin-3-oneIC50100000.0 [1]
1-[(2R)-2-[2-(1H-Indol-5-yl)tetrazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC5047323.6 [1]
N-[4-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]tetrazol-2-yl]phenyl]acetamideIC5049684.4 [1]
4-[2-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]ethynyl]benzamideIC5042067.1 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Carnitine palmitoyltransferase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/carnitine-palmitoyltransferase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Carnitine palmitoyltransferase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/carnitine-palmitoyltransferase-2-inhibitors-ic50-ki.
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