Carnitine O-palmitoyltransferase 1, liver isoform Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2,6-Ditert-butyl-4-[3-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]propylsulfanyl]phenol	IC50	16800000.0 [1], 51000000.0 [2]
	4-{[1-(5-Chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}-benzoic acid	IC50	20.6 [1], 21.0 [2]
	4-(5-Chloro-2-methoxyphenyl)sulfonyl-6-[(3-fluorophenyl)carbamoyl]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acid	IC50	16.0 [1], 16.2 [2]
	2-[4-[[1-(2-Methoxy-5-methylphenyl)sulfonyl-3,4-dihydro-2H-quinoline-7-carbonyl]amino]phenyl]acetic acid	IC50	158.9 [1], 160.0 [2]
	2-Phenoxy-1-[(2R)-2-(4-pyridin-2-yl-1,3-thiazol-2-yl)piperidin-1-yl]ethanone	IC50	19.6 [1], 20.0 [2]
	3-[2-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,3-thiazol-4-yl]benzoic acid	IC50	19.65 [1], 33.5 [2]
	Amiodarone	IC50	140000.0 [1]
	Rosiglitazone	IC50	10000.0 [1]
	Pioglitazone	IC50	10000.0 [1]
	Trimetazidine	IC50	100000.0 [1]
	Perhexiline	IC50	100000.0 [1]
	Oxfenicine	IC50	100000.0 [1]
	4-Hydroxyphenylglyoxylic acid	IC50	100000.0 [1]
	4-[3-(3,4-Dichloro-benzenesulfonylamino)-benzoylamino]-benzoic acid	IC50	190.0 [1]
	[(2R)-2-Amino-3-carboxypropyl]-trimethylazanium	IC50	76400.0 [1]
	2-[5-(2-Naphthalen-2-yloxyethoxy)thiophen-2-yl]-2-oxoacetic acid	IC50	2400.0 [1]
	(R)-1-{2-[3-(4-Methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-2-phenoxy-ethanone	IC50	65.0 [1]
	Sodium;2-[6-(4-chlorophenoxy)-1,1-difluorohexyl]oxirane-2-carboxylate	IC50	250.0 [1]
	N-(Thiophen-2-ylmethyl)-1-[[3-(trifluoromethyl)phenyl]methyl]indazole-3-carboxamide	IC50	26.0 [1]
	2-[1,1-Dimethyl-3-[(4-pentylphenyl)sulfonylamino]piperidin-1-ium-3-yl]acetate	IC50	1000.0 [1]
	(2R,3S)-4-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(4-Aminoimidazo[4,5-c]pyridazin-7-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanylmethyl]-2-octyl-5-oxooxolane-3-carboxylic acid	IC50	240.0 [1]
	2-[1,1-Dimethyl-4-[(4-pentylphenyl)sulfonylamino]piperidin-1-ium-4-yl]acetate	IC50	1000.0 [1]
	(3r)-3-{[(Tetradecylamino)carbonyl]amino}-4-(Trimethylammonio)butanoate	IC50	1050.0 [1]
	2-[2-[4-[(4-Chlorophenyl)sulfonylamino]phenyl]ethyl]benzoic acid	IC50	10000.0 [1]
	1-[(2R)-2-[3-(5-Chloro-3-ethyl-2-methylimidazol-4-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	73.75 [1]
	1-[(2R)-2-[3-(5-Bromo-3-methylimidazol-4-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	79.3 [1]
	1-[(2R)-2-[3-(4-Chloro-2,5-dimethylpyrazol-3-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	79.1 [1]
	1-[(2R)-2-(5-Cyclohexyl-1,2,4-oxadiazol-3-yl)piperidin-1-yl]-2-phenoxyethanone	IC50	86.5 [1]
	1-[(2R)-2-[5-(4-Methoxycyclohexyl)-1,2,4-oxadiazol-3-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	191.2 [1]
	1-[(2R)-2-[5-[(1S,4R)-2-Bicyclo[2.2.1]heptanyl]-1,2,4-oxadiazol-3-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	32.6 [1]
	Methyl (1S,2S)-2-[3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]cyclohexane-1-carboxylate	IC50	147.8 [1]
	4-[[3-(5-Chloro-2-methoxyphenyl)sulfanyl-1-ethylindole-5-carbonyl]amino]benzoic acid	IC50	169.5 [1]
	4-[[3-(5-Chloro-2-methoxyphenyl)sulfonyl-1-ethylindole-5-carbonyl]amino]benzoic acid	IC50	74.7 [1]
	3-[4-Chloro-3-[3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]-5,5-dimethylimidazolidine-2,4-dione	IC50	91.2 [1]
	1-[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]phenyl]pyrrolidine-2,5-dione	IC50	126.7 [1]
	4-[[(3R)-1-(5-Chloro-2-methoxyphenyl)sulfonyl-3-methyl-2,3-dihydroindole-6-carbonyl]amino]benzoic acid	IC50	75.7 [1]
	4-[[(3S)-1-(5-Chloro-2-methoxyphenyl)sulfonyl-3-methyl-2,3-dihydroindole-6-carbonyl]amino]benzoic acid	IC50	36.7 [1]
	4-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]benzoic acid	IC50	88.5 [1]
	2-[2-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]-1,3-thiazol-4-yl]acetic acid	IC50	58.7 [1]
	N-[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]tetrazol-2-yl]phenyl]acetamide	IC50	110.8 [1]
	N-[[3-[3-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]methyl]acetamide	IC50	99.3 [1]
	N-[[3-[3-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]methyl]methanesulfonamide	IC50	65.4 [1]
	1-(5-Methoxy-1H-indol-3-yl)-2-pyridin-4-yloxyethanone	IC50	657.6 [1]
	4-[[3-[[7-(Trifluoromethyl)-3,4-dihydro-2H-quinolin-1-yl]sulfonyl]benzoyl]amino]benzoic acid	IC50	34.2 [1]
	4-[[3,4-Dimethyl-5-[[3-(trifluoromethyl)phenyl]sulfamoyl]benzoyl]amino]benzoic acid	IC50	122.0 [1]
	4-[2-[3-[(5-Chloro-2-methoxyphenyl)sulfonylamino]phenyl]ethynyl]benzoic acid	IC50	226.45 [1]
	4-[[5-[(5-Chloro-2-methoxyphenyl)sulfonylamino]-1-methyl-6-oxopyridine-3-carbonyl]amino]benzoic acid	IC50	126.9 [1]
	6-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]-1H-indazole-3-carboxamide	IC50	63.5 [1]
	4-[[5-[(3,5-Dichlorophenyl)sulfonylamino]thiophene-2-carbonyl]amino]benzoic acid	IC50	152.6 [1]
	Ethyl 7-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]imidazo[1,2-a]pyridine-2-carboxylate	IC50	68.1 [1]
	7-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]imidazo[1,2-a]pyridine-2-carboxamide	IC50	96.4 [1]
	N-[(3R)-3-(Methoxymethyl)pyrrolidin-1-yl]-3-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]benzamide	IC50	159.1 [1]
	4-[2-[1-(5-Chloro-2-methoxyphenyl)sulfonyl-2,3-dihydroindol-6-yl]ethynyl]benzoic acid	IC50	111.2 [1]
	1-[[4-(Difluoromethoxy)phenyl]methyl]-5-methyl-N-[4-(2H-tetrazol-5-yl)phenyl]pyrazole-3-carboxamide	IC50	191.7 [1]
	N-[3-[3-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]acetamide	IC50	43.8 [1]
	2-Phenoxy-1-[2-(3-phenyl-1H-pyrazol-5-yl)piperidin-1-yl]ethanone	IC50	159.0 [1]
	5-Chloro-2-methoxy-N-[(3R)-1-(2-phenoxyacetyl)piperidin-3-yl]benzenesulfonamide	IC50	133.95 [1]
	1-[2-[5-(3-Nitrophenyl)-1,3-thiazol-2-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	206.1 [1]
	1-[2-[5-(3-Nitrophenyl)-1,3-oxazol-2-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	243.3 [1]
	2-(4-Fluorophenyl)-5-[1-(2-phenoxyacetyl)piperidin-2-yl]-1H-pyrazol-3-one	IC50	281.5 [1]
	3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]benzohydrazide	IC50	264.4 [1]
	1-[(2R)-2-[3-(6-Nitropyridin-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	254.2 [1]
	N-(2,4-Dioxoimidazolidin-1-yl)-3-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]benzamide	IC50	272.5 [1]
	1-[3-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-oxo-1,4-thiazinan-4-yl]-2-phenoxyethanone	IC50	163.7 [1]
	[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]phenyl]boronic acid	IC50	67.2 [1]
	N,N-Dimethyl-4-[5-[3-(2-phenoxyacetyl)-3-azabicyclo[3.1.0]hexan-2-yl]-1,2,4-oxadiazol-3-yl]benzamide	IC50	164.7 [1]
	5-[5-[(3R)-4-(2-Phenoxyacetyl)morpholin-3-yl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxamide	IC50	168.25 [1]
	N,N-Diethyl-5-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxamide	IC50	216.8 [1]
	5-[5-[3-(2-Phenoxyacetyl)-3-azabicyclo[3.1.0]hexan-2-yl]-1,2,4-oxadiazol-3-yl]-1,3-dihydroindol-2-one	IC50	136.3 [1]
	2-[2-[[4-[(5-Chloro-2-methoxyphenyl)methyl]-3-oxo-1,4-benzoxazine-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acid	IC50	141.6 [1]
	2-[2-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-3,3-dimethyl-2-oxoindole-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acid	IC50	46.8 [1]
	4-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-3,3-dimethyl-2-oxoindole-6-carbonyl]amino]benzoic acid	IC50	67.1 [1]
	2-[4-[[3-(5-Chloro-2-methoxyphenyl)sulfonyl-1H-indole-5-carbonyl]amino]phenyl]acetic acid	IC50	21.9 [1]
	2-[2-[[3-(5-Chloro-2-methoxyphenyl)sulfonyl-1H-indole-5-carbonyl]amino]-1,3-thiazol-4-yl]acetic acid	IC50	39.3 [1]
	1-Ethyl-4,4-dimethyl-7-[3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]-3H-quinolin-2-one	IC50	168.5 [1]
	1-[(2R)-2-(5-Cyclopentyl-1,2,4-oxadiazol-3-yl)piperidin-1-yl]-2-phenoxyethanone	IC50	181.5 [1]
	2-Pyridin-4-yloxy-1-[(2R)-2-[3-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-5-yl]piperidin-1-yl]ethanone	IC50	165.1 [1]
	N-[3-[1-Methyl-5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-triazol-3-yl]phenyl]acetamide	IC50	200.9 [1]
	4-[[3-(3-Chlorophenyl)sulfanyl-1-methylindole-5-carbonyl]amino]benzoic acid	IC50	43.4 [1]
	4-[[3-(3-Chlorophenyl)sulfonyl-1-methylindole-5-carbonyl]amino]benzoic acid	IC50	18.8 [1]
	N-[3-[2-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]ethynyl]phenyl]acetamide	IC50	108.2 [1]
	2-[2-[[4-[(5-Chloro-2-methoxyphenyl)methyl]-3-oxo-1,4-benzothiazine-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acid	IC50	124.8 [1]
	2-Phenoxy-1-[(2R)-2-[5-[1-(trifluoromethyl)cyclopropyl]-1,2,4-oxadiazol-3-yl]piperidin-1-yl]ethanone	IC50	85.8 [1]
	1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-N-(1,3-thiazol-2-yl)-3,1-benzoxazine-7-carboxamide	IC50	277.5 [1]
	2-Phenoxy-1-[(2R)-2-(2-phenyltetrazol-5-yl)piperidin-1-yl]ethanone	IC50	156.0 [1]
	1-[(2R)-2-[2-(4-Fluorophenyl)tetrazol-5-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	197.3 [1]
	1-[(2R)-2-[2-(4-Methoxyphenyl)tetrazol-5-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	158.5 [1]
	2-[2-[[4-[(5-Chloro-2-methoxyphenyl)methyl]-1,1,3-trioxo-1lambda6,4-benzothiazine-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acid	IC50	219.4 [1]
	2-Chloro-4-[[1-[(5-chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]benzoic acid	IC50	244.6 [1]
	2-[2-Chloro-4-[[1-[(5-chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]phenyl]acetic acid	IC50	330.7 [1]
	2-[4-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]phenyl]acetic acid	IC50	146.5 [1]
	1-[(2R)-2-[3-(6-Aminopyridin-3-yl)-1H-1,2,4-triazol-5-yl]piperidin-1-yl]-2-phenoxyethanone;hydrochloride	IC50	325.3 [1]
	2-[2-[[3-(3-Chlorophenyl)sulfonyl-1-methylindole-5-carbonyl]amino]-1,3-thiazol-4-yl]acetic acid	IC50	75.4 [1]
	N-[[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]phenyl]methyl]acetamide	IC50	190.2 [1]
	(2R)-N-Benzyl-1-(2-phenoxyacetyl)piperidine-2-carboxamide	IC50	2547.2 [1]
	(2R)-N-Benzyl-N-methyl-1-(2-phenoxyacetyl)piperidine-2-carboxamide	IC50	1942.1 [1]
	N,N-Diethyl-3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazole-5-carboxamide	IC50	282.7 [1]
	1-[(2R)-2-[2-(4-Methylsulfonylphenyl)tetrazol-5-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	122.7 [1]
	1-[(2R)-2-[3-(5-Nitrothiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	223.0 [1]
	1-[(2R)-2-[3-(5-Nitrofuran-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanone	IC50	68.2 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Carnitine O-palmitoyltransferase 1, liver isoform Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/carnitine-o-palmitoyltransferase-1-liver-isoform-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Carnitine O-palmitoyltransferase 1, liver isoform Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/carnitine-o-palmitoyltransferase-1-liver-isoform-inhibitors-ic50-ki.
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