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Carnitine O-palmitoyltransferase 1, liver isoform Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2,6-Ditert-butyl-4-[3-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]propylsulfanyl]phenolIC5016800000.0 [1], 51000000.0 [2]
4-{[1-(5-Chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}-benzoic acidIC5020.6 [1], 21.0 [2]
4-(5-Chloro-2-methoxyphenyl)sulfonyl-6-[(3-fluorophenyl)carbamoyl]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acidIC5016.0 [1], 16.2 [2]
2-[4-[[1-(2-Methoxy-5-methylphenyl)sulfonyl-3,4-dihydro-2H-quinoline-7-carbonyl]amino]phenyl]acetic acidIC50158.9 [1], 160.0 [2]
2-Phenoxy-1-[(2R)-2-(4-pyridin-2-yl-1,3-thiazol-2-yl)piperidin-1-yl]ethanoneIC5019.6 [1], 20.0 [2]
3-[2-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,3-thiazol-4-yl]benzoic acidIC5019.65 [1], 33.5 [2]
AmiodaroneIC50140000.0 [1]
RosiglitazoneIC5010000.0 [1]
PioglitazoneIC5010000.0 [1]
TrimetazidineIC50100000.0 [1]
PerhexilineIC50100000.0 [1]
OxfenicineIC50100000.0 [1]
4-Hydroxyphenylglyoxylic acidIC50100000.0 [1]
4-[3-(3,4-Dichloro-benzenesulfonylamino)-benzoylamino]-benzoic acidIC50190.0 [1]
[(2R)-2-Amino-3-carboxypropyl]-trimethylazaniumIC5076400.0 [1]
2-[5-(2-Naphthalen-2-yloxyethoxy)thiophen-2-yl]-2-oxoacetic acidIC502400.0 [1]
(R)-1-{2-[3-(4-Methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-2-phenoxy-ethanoneIC5065.0 [1]
Sodium;2-[6-(4-chlorophenoxy)-1,1-difluorohexyl]oxirane-2-carboxylateIC50250.0 [1]
N-(Thiophen-2-ylmethyl)-1-[[3-(trifluoromethyl)phenyl]methyl]indazole-3-carboxamideIC5026.0 [1]
2-[1,1-Dimethyl-3-[(4-pentylphenyl)sulfonylamino]piperidin-1-ium-3-yl]acetateIC501000.0 [1]
(2R,3S)-4-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(4-Aminoimidazo[4,5-c]pyridazin-7-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanylmethyl]-2-octyl-5-oxooxolane-3-carboxylic acidIC50240.0 [1]
2-[1,1-Dimethyl-4-[(4-pentylphenyl)sulfonylamino]piperidin-1-ium-4-yl]acetateIC501000.0 [1]
(3r)-3-{[(Tetradecylamino)carbonyl]amino}-4-(Trimethylammonio)butanoateIC501050.0 [1]
2-[2-[4-[(4-Chlorophenyl)sulfonylamino]phenyl]ethyl]benzoic acidIC5010000.0 [1]
1-[(2R)-2-[3-(5-Chloro-3-ethyl-2-methylimidazol-4-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC5073.75 [1]
1-[(2R)-2-[3-(5-Bromo-3-methylimidazol-4-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC5079.3 [1]
1-[(2R)-2-[3-(4-Chloro-2,5-dimethylpyrazol-3-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC5079.1 [1]
1-[(2R)-2-(5-Cyclohexyl-1,2,4-oxadiazol-3-yl)piperidin-1-yl]-2-phenoxyethanoneIC5086.5 [1]
1-[(2R)-2-[5-(4-Methoxycyclohexyl)-1,2,4-oxadiazol-3-yl]piperidin-1-yl]-2-phenoxyethanoneIC50191.2 [1]
1-[(2R)-2-[5-[(1S,4R)-2-Bicyclo[2.2.1]heptanyl]-1,2,4-oxadiazol-3-yl]piperidin-1-yl]-2-phenoxyethanoneIC5032.6 [1]
Methyl (1S,2S)-2-[3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]cyclohexane-1-carboxylateIC50147.8 [1]
4-[[3-(5-Chloro-2-methoxyphenyl)sulfanyl-1-ethylindole-5-carbonyl]amino]benzoic acidIC50169.5 [1]
4-[[3-(5-Chloro-2-methoxyphenyl)sulfonyl-1-ethylindole-5-carbonyl]amino]benzoic acidIC5074.7 [1]
3-[4-Chloro-3-[3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]-5,5-dimethylimidazolidine-2,4-dioneIC5091.2 [1]
1-[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]phenyl]pyrrolidine-2,5-dioneIC50126.7 [1]
4-[[(3R)-1-(5-Chloro-2-methoxyphenyl)sulfonyl-3-methyl-2,3-dihydroindole-6-carbonyl]amino]benzoic acidIC5075.7 [1]
4-[[(3S)-1-(5-Chloro-2-methoxyphenyl)sulfonyl-3-methyl-2,3-dihydroindole-6-carbonyl]amino]benzoic acidIC5036.7 [1]
4-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]benzoic acidIC5088.5 [1]
2-[2-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC5058.7 [1]
N-[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]tetrazol-2-yl]phenyl]acetamideIC50110.8 [1]
N-[[3-[3-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]methyl]acetamideIC5099.3 [1]
N-[[3-[3-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]methyl]methanesulfonamideIC5065.4 [1]
1-(5-Methoxy-1H-indol-3-yl)-2-pyridin-4-yloxyethanoneIC50657.6 [1]
4-[[3-[[7-(Trifluoromethyl)-3,4-dihydro-2H-quinolin-1-yl]sulfonyl]benzoyl]amino]benzoic acidIC5034.2 [1]
4-[[3,4-Dimethyl-5-[[3-(trifluoromethyl)phenyl]sulfamoyl]benzoyl]amino]benzoic acidIC50122.0 [1]
4-[2-[3-[(5-Chloro-2-methoxyphenyl)sulfonylamino]phenyl]ethynyl]benzoic acidIC50226.45 [1]
4-[[5-[(5-Chloro-2-methoxyphenyl)sulfonylamino]-1-methyl-6-oxopyridine-3-carbonyl]amino]benzoic acidIC50126.9 [1]
6-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]-1H-indazole-3-carboxamideIC5063.5 [1]
4-[[5-[(3,5-Dichlorophenyl)sulfonylamino]thiophene-2-carbonyl]amino]benzoic acidIC50152.6 [1]
Ethyl 7-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]imidazo[1,2-a]pyridine-2-carboxylateIC5068.1 [1]
7-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]imidazo[1,2-a]pyridine-2-carboxamideIC5096.4 [1]
N-[(3R)-3-(Methoxymethyl)pyrrolidin-1-yl]-3-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]benzamideIC50159.1 [1]
4-[2-[1-(5-Chloro-2-methoxyphenyl)sulfonyl-2,3-dihydroindol-6-yl]ethynyl]benzoic acidIC50111.2 [1]
1-[[4-(Difluoromethoxy)phenyl]methyl]-5-methyl-N-[4-(2H-tetrazol-5-yl)phenyl]pyrazole-3-carboxamideIC50191.7 [1]
N-[3-[3-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]phenyl]acetamideIC5043.8 [1]
2-Phenoxy-1-[2-(3-phenyl-1H-pyrazol-5-yl)piperidin-1-yl]ethanoneIC50159.0 [1]
5-Chloro-2-methoxy-N-[(3R)-1-(2-phenoxyacetyl)piperidin-3-yl]benzenesulfonamideIC50133.95 [1]
1-[2-[5-(3-Nitrophenyl)-1,3-thiazol-2-yl]piperidin-1-yl]-2-phenoxyethanoneIC50206.1 [1]
1-[2-[5-(3-Nitrophenyl)-1,3-oxazol-2-yl]piperidin-1-yl]-2-phenoxyethanoneIC50243.3 [1]
2-(4-Fluorophenyl)-5-[1-(2-phenoxyacetyl)piperidin-2-yl]-1H-pyrazol-3-oneIC50281.5 [1]
3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]benzohydrazideIC50264.4 [1]
1-[(2R)-2-[3-(6-Nitropyridin-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC50254.2 [1]
N-(2,4-Dioxoimidazolidin-1-yl)-3-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]benzamideIC50272.5 [1]
1-[3-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-oxo-1,4-thiazinan-4-yl]-2-phenoxyethanoneIC50163.7 [1]
[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]phenyl]boronic acidIC5067.2 [1]
N,N-Dimethyl-4-[5-[3-(2-phenoxyacetyl)-3-azabicyclo[3.1.0]hexan-2-yl]-1,2,4-oxadiazol-3-yl]benzamideIC50164.7 [1]
5-[5-[(3R)-4-(2-Phenoxyacetyl)morpholin-3-yl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxamideIC50168.25 [1]
N,N-Diethyl-5-[5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-3-yl]pyridine-3-carboxamideIC50216.8 [1]
5-[5-[3-(2-Phenoxyacetyl)-3-azabicyclo[3.1.0]hexan-2-yl]-1,2,4-oxadiazol-3-yl]-1,3-dihydroindol-2-oneIC50136.3 [1]
2-[2-[[4-[(5-Chloro-2-methoxyphenyl)methyl]-3-oxo-1,4-benzoxazine-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC50141.6 [1]
2-[2-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-3,3-dimethyl-2-oxoindole-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC5046.8 [1]
4-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-3,3-dimethyl-2-oxoindole-6-carbonyl]amino]benzoic acidIC5067.1 [1]
2-[4-[[3-(5-Chloro-2-methoxyphenyl)sulfonyl-1H-indole-5-carbonyl]amino]phenyl]acetic acidIC5021.9 [1]
2-[2-[[3-(5-Chloro-2-methoxyphenyl)sulfonyl-1H-indole-5-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC5039.3 [1]
1-Ethyl-4,4-dimethyl-7-[3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazol-5-yl]-3H-quinolin-2-oneIC50168.5 [1]
1-[(2R)-2-(5-Cyclopentyl-1,2,4-oxadiazol-3-yl)piperidin-1-yl]-2-phenoxyethanoneIC50181.5 [1]
2-Pyridin-4-yloxy-1-[(2R)-2-[3-[3-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-5-yl]piperidin-1-yl]ethanoneIC50165.1 [1]
N-[3-[1-Methyl-5-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-triazol-3-yl]phenyl]acetamideIC50200.9 [1]
4-[[3-(3-Chlorophenyl)sulfanyl-1-methylindole-5-carbonyl]amino]benzoic acidIC5043.4 [1]
4-[[3-(3-Chlorophenyl)sulfonyl-1-methylindole-5-carbonyl]amino]benzoic acidIC5018.8 [1]
N-[3-[2-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]ethynyl]phenyl]acetamideIC50108.2 [1]
2-[2-[[4-[(5-Chloro-2-methoxyphenyl)methyl]-3-oxo-1,4-benzothiazine-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC50124.8 [1]
2-Phenoxy-1-[(2R)-2-[5-[1-(trifluoromethyl)cyclopropyl]-1,2,4-oxadiazol-3-yl]piperidin-1-yl]ethanoneIC5085.8 [1]
1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-N-(1,3-thiazol-2-yl)-3,1-benzoxazine-7-carboxamideIC50277.5 [1]
2-Phenoxy-1-[(2R)-2-(2-phenyltetrazol-5-yl)piperidin-1-yl]ethanoneIC50156.0 [1]
1-[(2R)-2-[2-(4-Fluorophenyl)tetrazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC50197.3 [1]
1-[(2R)-2-[2-(4-Methoxyphenyl)tetrazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC50158.5 [1]
2-[2-[[4-[(5-Chloro-2-methoxyphenyl)methyl]-1,1,3-trioxo-1lambda6,4-benzothiazine-6-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC50219.4 [1]
2-Chloro-4-[[1-[(5-chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]benzoic acidIC50244.6 [1]
2-[2-Chloro-4-[[1-[(5-chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]phenyl]acetic acidIC50330.7 [1]
2-[4-[[1-[(5-Chloro-2-methoxyphenyl)methyl]-4,4-dimethyl-2-oxo-3,1-benzoxazine-7-carbonyl]amino]phenyl]acetic acidIC50146.5 [1]
1-[(2R)-2-[3-(6-Aminopyridin-3-yl)-1H-1,2,4-triazol-5-yl]piperidin-1-yl]-2-phenoxyethanone;hydrochlorideIC50325.3 [1]
2-[2-[[3-(3-Chlorophenyl)sulfonyl-1-methylindole-5-carbonyl]amino]-1,3-thiazol-4-yl]acetic acidIC5075.4 [1]
N-[[3-[5-[(2R)-1-(2-Phenoxyacetyl)piperidin-2-yl]-1H-1,2,4-triazol-3-yl]phenyl]methyl]acetamideIC50190.2 [1]
(2R)-N-Benzyl-1-(2-phenoxyacetyl)piperidine-2-carboxamideIC502547.2 [1]
(2R)-N-Benzyl-N-methyl-1-(2-phenoxyacetyl)piperidine-2-carboxamideIC501942.1 [1]
N,N-Diethyl-3-[(2R)-1-(2-phenoxyacetyl)piperidin-2-yl]-1,2,4-oxadiazole-5-carboxamideIC50282.7 [1]
1-[(2R)-2-[2-(4-Methylsulfonylphenyl)tetrazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC50122.7 [1]
1-[(2R)-2-[3-(5-Nitrothiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC50223.0 [1]
1-[(2R)-2-[3-(5-Nitrofuran-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanoneIC5068.2 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Carnitine O-palmitoyltransferase 1, liver isoform Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/carnitine-o-palmitoyltransferase-1-liver-isoform-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Carnitine O-palmitoyltransferase 1, liver isoform Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/carnitine-o-palmitoyltransferase-1-liver-isoform-inhibitors-ic50-ki.
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