Carboxypeptidase B2 isoform A Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(2s)-5-Amino-2-[(1-Propyl-1h-Imidazol-4-Yl)methyl]pentanoic Acid	IC50	450.0 [1], 5000.0 [2]
	(2s)-5-Amino-2-[(1-Propyl-1h-Imidazol-4-Yl)methyl]pentanoic Acid	Ki	10.0 [1], 16.0 [2]
	3-Pyridinepropanoic acid, 6-amino-alpha-1H-imidazol-5-yl-	IC50	35.0 [1], 80.0 [2], 1500.0 [3], 31000.0 [4]
	(5r)-5-(3-Aminopropyl)-1-Propyl-4,5,6,7-Tetrahydro-1h-Benzimidazole-5-Carboxylic Acid	IC50	8.0 [1], 76.0 [2], 1000.0 [3]
	2-Mercaptomethyl-5-guanidinopentanoic acid	IC50	8.0 [1]
	2-Mercaptomethyl-5-guanidinopentanoic acid	Ki	4.0 [1]
	3-(6-Aminopyridin-3-yl)-2-[1-(3-methylbutyl)imidazol-4-yl]propanoic acid	IC50	4.0 [1], 5.0 [2]
	(2S)-2-(2-Aminoethylamino)-3-(1-propylimidazol-4-yl)propanoic acid	Ki	84.0 [1], 150.0 [2]
	(2S)-6-Amino-2-[[(2R)-3-cyclohexyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]hexanoic acid	IC50	3.0 [1], 7.0 [2]
	(2S)-6-Amino-2-[[(2S)-3-cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]hexanoic acid;hydrochloride	IC50	51.0 [1], 123.0 [2]
	2-[(6-Amino-5-chloropyridin-3-yl)methyl]-3-propanoylselanylpropanoic acid	IC50	1.5 [1], 370000.0 [2]
	2-(2-Aminoethylamino)-3-(1-propylimidazol-4-yl)propanoic acid	IC50	620.0 [1], 8000.0 [2]
	Ethyl 7-amino-2-(propanoylselanylmethyl)heptanoate	IC50	30.0 [1], 1400.0 [2]
	2-(Propanoylselenomethyl)-7-aminoheptanoic acid	IC50	1.1 [1], 760.0 [2]
	2-[(4-Phenylbutyrylseleno)methyl]-7-aminoheptanoic acid	IC50	4.1 [1], 1600.0 [2]
	2-[(3-Phenylpropionylseleno)methyl]-7-aminoheptanoic acid	IC50	5.3 [1], 2000.0 [2]
	Ethyl 2-[(6-aminopyridin-3-yl)methyl]-3-propanoylselanylpropanoate	IC50	890.0 [1], 180000.0 [2]
	Ethyl 2-[(6-amino-5-chloropyridin-3-yl)methyl]-3-propanoylselanylpropanoate	IC50	2600.0 [1], 3800000.0 [2]
	7-Amino-2-[[(7-amino-2-carboxyheptyl)diselanyl]methyl]heptanoic acid	IC50	2.0 [1], 3800000.0 [2]
	3-(6-Aminopyridin-3-yl)-2-[[[3-(6-aminopyridin-3-yl)-2-carboxypropyl]diselanyl]methyl]propanoic acid	IC50	0.0 [1], 200.0 [2]
	3-(6-Amino-5-chloropyridin-3-yl)-2-[[[3-(6-amino-5-chloropyridin-3-yl)-2-carboxypropyl]diselanyl]methyl]propanoic acid	IC50	0.03 [1], 3300.0 [2]
	(2S,3R)-2-[(6-Aminopyridin-3-yl)methyl]-3-sulfanylbutanoic acid	IC50	87.0 [1], 400.0 [2]
	(5R)-5-(3-Aminopropyl)-1-cyclohexyl-6,7-dihydro-4H-benzimidazole-5-carboxylic acid	IC50	80.0 [1], 117.0 [2]
	(5R)-5-(3-Aminopropyl)-1-[(3-phenylphenyl)methyl]-6,7-dihydro-4H-benzimidazole-5-carboxylic acid	IC50	106.0 [1], 2500.0 [2]
	5-(3-Aminopropyl)-1-[2-(4-cyclohexylcyclohexyl)ethyl]-6,7-dihydro-4H-benzimidazole-5-carboxylic acid	IC50	124.0 [1], 16000.0 [2]
	5-(3-Aminopropyl)-1-phenyl-6,7-dihydro-4H-benzimidazole-5-carboxylic acid	IC50	585.0 [1], 7100.0 [2]
	7-(3-Aminopropyl)-3-ethyl-6,8-dihydro-5H-imidazo[1,2-a]pyridine-7-carboxylic acid	IC50	2270.0 [1], 100000.0 [2]
	(7R)-7-(3-Aminopropyl)-3-phenyl-6,8-dihydro-5H-imidazo[1,2-a]pyridine-7-carboxylic acid	IC50	66.0 [1], 1300.0 [2]
	5-Amino-2-[[1-(4-methylcyclohexyl)imidazol-4-yl]methyl]pentanoic acid	IC50	8.3 [1], 9.3 [2]
	5-Amino-2-[[1-(4-hydroxycyclohexyl)imidazol-4-yl]methyl]pentanoic acid	IC50	19.0 [1], 26.0 [2]
	(5R)-5-(3-Aminopropyl)-1-(3-methylbutyl)-6,7-dihydro-4H-benzimidazole-5-carboxylic acid	IC50	41.0 [1], 100.0 [2]
	(7R)-7-(3-Aminopropyl)-3-[3-(2,4-dichlorophenyl)phenyl]-6,8-dihydro-5H-imidazo[1,2-a]pyridine-7-carboxylic acid	IC50	41.0 [1], 3200.0 [2]
	2-Benzylsuccinic acid	IC50	1600.0 [1]
	Anabaenopeptin F	IC50	1.5 [1]
	Anabaenopeptin B	IC50	1.5 [1]
	Oscillamide Y	IC50	400.0 [1]
	(2S)-7-Amino-2-[[hydroxy-[(1R)-2-methyl-1-(3-phenylpropanoylamino)propyl]phosphoryl]methyl]heptanoic acid	IC50	5.5 [1]
	alpha-Benzyl-1H-imidazole-4-acetic acid	IC50	100000.0 [1]
	5-Amino-2-[(1-propylimidazol-4-yl)methyl]pentanoic acid	Ki	46.0 [1]
	(2S)-2-(2-Aminoethoxy)-3-(1-phenylimidazol-4-yl)propanoic Acid	Ki	3.5 [1]
	6-Amino-2-(1H-imidazol-4-yl)-hexanoic acid	IC50	590.0 [1]
	(S)-2-((R)-1-Aminopropan-2-yloxy)-3-(1-phenyl-1H-imidazol-4-yl)propanoic acid	Ki	7.5 [1]
	3-Mercapto-2-(piperidin-4-yl)propanoic acid	IC50	37.0 [1]
	2-(1-Carbamimidoylpiperidin-4-yl)-3-mercaptopropanoic acid	IC50	1070.0 [1]
	2-(Mercaptomethyl)-3-(piperidin-4-yl)propanoic acid	IC50	139.0 [1]
	3-Mercapto-2-(piperidin-3-yl)propanoic acid	IC50	68.0 [1]
	2-(3-Aminophenyl)-3-mercaptopropanoic acid	IC50	785.0 [1]
	2-(1-Carbamimidoylpiperidin-3-yl)-3-mercaptopropanoic acid	IC50	45.0 [1]
	2-[3-(Diaminomethylideneamino)phenyl]-3-sulfanylpropanoic acid	IC50	3.0 [1]
	2-(2-Chloro-5-guanidinophenyl)-3-mercaptopropanoic acid	IC50	11.0 [1]
	2-(1-(1-Iminoethyl)piperidin-4-yl)-3-mercaptopropanoic acid	IC50	5300.0 [1]
	2-(1-(2-Aminoacetyl)piperidin-4-yl)-3-mercaptopropanoic acid	IC50	7350.0 [1]
	(2S)-2-[(2R)-1-Aminopropan-2-yl]oxy-3-(1-pyridin-2-ylimidazol-4-yl)propanoic acid	Ki	5.8 [1]
	(S)-2-(2-Aminoethylamino)-3-(1-isobutyl-1H-imidazol-4-yl)propanoic acid	Ki	100.0 [1]
	(2S)-2-[(2-Aminoethyl)amino]-3-(1H-imidazol-4-yl)propanoic acid	Ki	344.0 [1]
	(S)-2-(2-Aminoethylamino)-3-(1-butyl-1H-imidazol-4-yl)propanoic acid	Ki	70.0 [1]
	(2S)-6-Amino-2-[[(3S,6S,9S,12S,15R)-3-benzyl-9-[2-(4-hydroxyphenyl)ethyl]-6,7-dimethyl-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazacyclononadec-15-yl]carbamoylamino]hexanoic acid	IC50	1.9 [1]
	(2S)-6-Amino-2-[[(2R)-1-oxo-3-phenyl-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]hexanoic acid	IC50	15.0 [1]
	(2S)-6-Amino-2-[[(2R)-4-methyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]pentan-2-yl]carbamoylamino]hexanoic acid	IC50	57.0 [1]
	(2S)-6-Amino-2-[[(2R)-3-methyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]butan-2-yl]carbamoylamino]hexanoic acid	IC50	460.0 [1]
	(2S)-6-Amino-2-[[(1R)-1-cyclohexyl-2-oxo-2-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]ethyl]carbamoylamino]hexanoic acid	IC50	1000.0 [1]
	(2S)-6-Amino-2-[[2-oxo-2-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]ethyl]carbamoylamino]hexanoic acid	IC50	3700.0 [1]
	(2S)-6-Amino-2-[[2-methyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]hexanoic acid	IC50	6100.0 [1]
	(2S)-6-Amino-2-[[(2R)-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]pentan-2-yl]carbamoylamino]hexanoic acid	IC50	15.0 [1]
	(2S)-6-Amino-2-[[(2R)-3-cyclopropyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]hexanoic acid	IC50	7.0 [1]
	(2S)-6-Amino-2-[[(2R)-3-cyclobutyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]hexanoic acid	IC50	9.0 [1]
	(2S)-6-Amino-2-[[3-cyclopentyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]hexanoic acid	IC50	4.0 [1]
	(2S)-5-Amino-2-[[(2R)-3-cyclohexyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]pentanoic acid	IC50	18.0 [1]
	(2R)-3-(2-Aminoethylsulfonyl)-2-[[(2R)-3-cyclohexyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]propanoic acid	IC50	38.0 [1]
	(2R)-3-(2-Aminoethylsulfanyl)-2-[[(2R)-3-cyclohexyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]propanoic acid	IC50	4.0 [1]
	(2S)-2-[[(2R)-3-Cyclohexyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]-5-(diaminomethylideneamino)pentanoic acid	IC50	4.0 [1]
	(2S)-2-[[(2R)-3-Cyclohexyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]-4-(diaminomethylideneamino)oxybutanoic acid	IC50	100.0 [1]
	(2S)-3-(6-Aminopyridin-3-yl)-2-[[(2R)-3-cyclohexyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]propanoic acid	IC50	1.0 [1]
	(2R)-3-(6-Aminopyridin-3-yl)-2-[[(2R)-3-cyclohexyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]propanoic acid	IC50	250.0 [1]
	(2S)-6-Amino-2-[[(2R)-3-cyclohexyl-1-oxo-1-[(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)amino]propan-2-yl]carbamoylamino]hexanamide	IC50	750.0 [1]
	(2R)-2-[[(2S)-1-Amino-3-(6-aminopyridin-3-yl)-1-oxopropan-2-yl]carbamoylamino]-3-cyclohexyl-N-(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)propanamide	IC50	570.0 [1]
	(2R)-2-[[(1S)-2-(6-Aminopyridin-3-yl)-1-cyanoethyl]carbamoylamino]-3-cyclohexyl-N-(4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)propanamide	IC50	54000.0 [1]
	(2S)-6-Amino-2-[[(2S)-3-cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]hexanoic acid	IC50	12.0 [1]
	(2S)-6-(Carbamoylamino)-2-[[(2S)-3-cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]hexanoic acid	IC50	30000.0 [1]
	(2S)-6-Amino-2-[[(2S)-3-cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]-6-oxohexanoic acid	IC50	30000.0 [1]
	(2S)-6-Amino-2-[[(2R)-1-(2-bicyclo[2.2.1]heptanylamino)-3-cyclohexyl-1-oxopropan-2-yl]sulfamoylamino]hexanoic acid	IC50	75000.0 [1]
	(2S)-2-[[(2S)-3-Cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]-6-hydroxyhexanoic acid	IC50	30000.0 [1]
	(2S)-6-Amino-2-[[(2S)-3-cyclohexyl-1-(cyclohexylamino)-1-oxopropan-2-yl]sulfamoylamino]hexanoic acid	IC50	1700.0 [1]
	(2S)-2-[[(2S)-3-Cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]-3-phenylpropanoic acid	IC50	24000.0 [1]
	(2S)-2-[[(2S)-1-(1-Adamantylamino)-1-oxopropan-2-yl]sulfamoylamino]-6-aminohexanoic acid	IC50	30000.0 [1]
	(2S)-6-Amino-2-[[(2S)-3-cyclohexyl-1-oxo-1-[[(2S)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]carbamoylamino]hexanoic acid	IC50	3.0 [1]
	(2S)-2-[[(2S)-1-(1-Adamantylamino)-3-methyl-1-oxobutan-2-yl]sulfamoylamino]-6-aminohexanoic acid	IC50	30000.0 [1]
	(2S)-2-[[(2S)-3-Cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]-3-piperidin-4-ylpropanoic acid	IC50	880.0 [1]
	(2S)-3-(6-Aminopyridin-3-yl)-2-[[(2S)-3-cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]propanoic acid	IC50	26.0 [1]
	(2S)-5-(1-Aminoethylideneamino)-2-[[(2S)-3-cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]pentanoic acid	IC50	1500.0 [1]
	(2S)-2-[[(2S)-1-(1-Adamantylamino)-4-methyl-1-oxopentan-2-yl]sulfamoylamino]-6-aminohexanoic acid	IC50	10000.0 [1]
	(2S)-2-[[(2S)-3-Cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]-6-(dimethylamino)hexanoic acid	IC50	44000.0 [1]
	(2S)-3-(4-Aminocyclohexyl)-2-[[(2S)-3-cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]propanoic acid	IC50	30000.0 [1]
	(2S)-2-[[2-(1-Adamantylamino)-2-oxoethyl]sulfamoylamino]-6-aminohexanoic acid	IC50	30000.0 [1]
	(2S)-6-Amino-2-[[(2S)-1-(2-bicyclo[2.2.1]heptanylamino)-3-cyclohexyl-1-oxopropan-2-yl]carbamoylamino]hexanoic acid	IC50	38.0 [1]
	(2S)-6-Amino-2-[[(2S)-1-[[(1S,2S,4S)-2-bicyclo[2.2.1]heptanyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]sulfamoylamino]hexanoic acid	IC50	420.0 [1]
	(2S)-2-[[(1S)-2-(1-Adamantylamino)-2-oxo-1-phenylethyl]sulfamoylamino]-6-aminohexanoic acid	IC50	30000.0 [1]
	(2S)-2-[[(2S)-3-Cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]-3-(1H-imidazol-5-yl)propanoic acid	IC50	4400.0 [1]
	(2S)-6-Amino-2-[[(2S)-1-[[(1S,2R,4S)-2-bicyclo[2.2.1]heptanyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]sulfamoylamino]hexanoic acid	IC50	330.0 [1]
	(2S)-6-Acetamido-2-[[(2S)-3-cyclohexyl-1-oxo-1-[[(1R,2S,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]hexanoic acid	IC50	30000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Carboxypeptidase B2 isoform A Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Dec. 2024, https://www.aatbio.com/data-sets/carboxypeptidase-b2-isoform-a-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 20). Quest Database™ Carboxypeptidase B2 isoform A Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/carboxypeptidase-b2-isoform-a-inhibitors-ic50-ki.
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