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cAMP-dependent protein kinase alpha-catalytic subunit Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
StaurosporineIC501.5 [1], 1.58 [2], 2.3 [3]
H-89 DihydrochlorideIC50100.0 [1], 850.0 [2]
(2S,3S,4R,5R)-N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamideIC5054.0 [1]
2-(3-Methoxyphenyl)-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]acetamideKi1400.0 [1], 2500.0 [2]
N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamideIC5014.0 [1], 82.0 [2]
Nvp-aew541IC5010000.0 [1]
EntrectinibIC5010000.0 [1]
BalanolIC5050.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC5010000.0 [1]
MilciclibIC5010000.0 [1]
1-Tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50500.0 [1]
Amg-458IC50100000.0 [1]
Pha-793887IC5010000.0 [1]
AcrylophenoneIC50100000.0 [1]
(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dioneIC5010000.0 [1]
(S)-1-(4-(1H-Pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanolIC5010.0 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
Pyrimidone, 22IC50100000.0 [1]
2-(4-Fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-oneIC50100000.0 [1]
4-(1-Ethyl-1H-benzimidazol-2-yl)-1,2,5-oxadiazol-3-amineKi960.0 [1]
N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamideIC50100000.0 [1]
[3-[[4-(Aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamateIC501.0 [1]
4-(1-Methyl-1H-benzoimidazol-2-yl)-furazan-3-ylamineKi4000.0 [1]
2-(4-Methoxyphenyl)-N-(4-(pyridin-4-yl)thiazol-2-yl)acetamideKi5000.0 [1]
8-[2-Methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamideIC5010000.0 [1]
(11R,15R,17R)-17-Methyl-12,16-dioxatetracyclo[8.7.0.03,8.011,15]heptadeca-1(10),3,5,7-tetraene-2,9,13-trioneIC50100000.0 [1]
5-(2-Aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamideIC5010000.0 [1]
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamideIC5010000.0 [1]
(7S)-2-(2-Aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneIC504000.0 [1]
Khk-IN-1IC5040000.0 [1]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC50780.0 [1]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5010000.0 [1]
4-(1-Isopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi3300.0 [1]
3-[(4-Morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[3,2-c]pyrazole-5-carboxamideIC50332.0 [1]
1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanoneIC50100000.0 [1]
CID 24832012Ki1850.0 [1]
(2S,3S,4R,5R)-N-[6-[[(2R)-1-[[(2R)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamideIC502600.0 [1]
(2S,3S,4R,5R)-N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamideIC505.32 [1]
(2S,3S,4R,5R)-N-[6-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamideIC50109.0 [1]
N-[6-[[(2R)-6-Amino-1-[[6-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-oxohexyl]amino]-1-oxohexan-2-yl]amino]-6-oxohexyl]-5-(2-aminopyrimidin-4-yl)thiophene-2-carboxamideIC505.5 [1]
4-[1-(Cyclopropylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amineKi380.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
2-[2,6-Dihydroxy-4-[(3R,4R)-3-[(4-hydroxybenzoyl)amino]oxepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50450.0 [1]
2-[2,6-Dihydroxy-4-[(3S,4R)-3-[(4-hydroxybenzoyl)amino]thiepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC507500.0 [1]
2-[2,6-Dihydroxy-4-[[(3R,4R)-3-[(4-hydroxybenzoyl)amino]-1-azabicyclo[3.2.2]nonan-4-yl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acidIC501700.0 [1]
4-(1-(Cyclobutylmethyl)-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi1400.0 [1]
4-(1-Cyclopropyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi3300.0 [1]
4-(1-Phenyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi1300.0 [1]
2-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)benzonitrileKi5000.0 [1]
4-(1-Cyclohexyl-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi600.0 [1]
2-[4-[(1R,2R,4S)-4-(Aminomethyl)-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dihydroxybenzoyl]-3-hydroxybenzoic acidIC50170.0 [1]
2-Fluoro-N-[4-(Pyridin-4-Yl)-1,3-Thiazol-2-Yl]benzamideKi5000.0 [1]
N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3,5-difluorobenzamideIC5010000.0 [1]
2-[2,6-Dihydroxy-4-[(1R,2R,4S)-2-[(4-hydroxybenzoyl)amino]-4-(hydroxymethyl)cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50230.0 [1]
2-[4-[(1R,2R,4R)-4-Amino-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dihydroxybenzoyl]-3-hydroxybenzoic acidIC5050.0 [1]
2-[2,6-Dihydroxy-4-[(1R,2R,4R)-4-hydroxy-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50250.0 [1]
2-[2,6-Dihydroxy-4-[(1R,2R,4R)-2-[(4-hydroxybenzoyl)amino]-4-(hydroxymethyl)cyclopentyl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC50220.0 [1]
2-[2,6-Dihydroxy-4-[(3S,4S)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC505200.0 [1]
2-[2,6-Dihydroxy-4-[(3S,4R)-3-[(4-hydroxybenzoyl)amino]-1,1-dioxothiepan-4-yl]oxycarbonylbenzoyl]-3-hydroxybenzoic acidIC5038000.0 [1]
2-[4-[(1R,2R,4R)-4-(Aminomethyl)-2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dihydroxybenzoyl]-3-hydroxybenzoic acidIC5090.0 [1]
2-[(2R,3R)-3-Hydroxy-5-oxooxolan-2-yl]naphthalene-1,4-dioneIC50430.0 [1]
4-(1-Isobutyl-4-phenyl-1H-imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi1200.0 [1]
4-(1-Isobutyl-4-methyl-1H-imidazol-2-yl)-1,2,5-oxadiazol-3-amineKi3300.0 [1]
2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-isobutyl-1H-imidazole-4-carbonitrileKi3300.0 [1]
3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-olIC5010000.0 [1]
5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-(2H-tetrazol-5-yl)-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amineKi4000.0 [1]
[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]phosphonic acidKi4000.0 [1]
2-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]ethylphosphonic acidKi4000.0 [1]
2-[[(2R,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]methyl]-1,2,4-oxadiazolidine-3,5-dioneKi4000.0 [1]
3-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-2H-1,2-oxazol-5-oneKi590.0 [1]
N-[[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]sulfonyl]acetamideKi4000.0 [1]
5-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-1,2-oxazol-3-oneKi4000.0 [1]
(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-sulfonamideKi490.0 [1]
1-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]ethane-1,2-diolKi230.0 [1]
5-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-1,2-dihydropyrazol-3-oneKi4000.0 [1]
(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-N-methylbicyclo[2.2.2]octane-2-carboxamideKi4000.0 [1]
1-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]ethanolKi4000.0 [1]
5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-(3-methyl-1,2,4-oxadiazol-5-yl)-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amineKi1100.0 [1]
5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-(5-methyl-1,3,4-oxadiazol-2-yl)-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amineKi4000.0 [1]
5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-[(2S,3S)-3-methylsulfonyl-2-bicyclo[2.2.2]octanyl]pyrimidin-4-amineKi1500.0 [1]
2-(4-Chloro-1,3-benzodioxol-5-yl)-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideKi310.0 [1]
2-(3-Methoxyphenyl)-N-(3-pyridin-4-yl-1,2,4-thiadiazol-5-yl)acetamideKi500.0 [1]
2-(Benzylamino)-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]-1,3-thiazol-4-olIC5050.0 [1]
3-[(2S,3S)-3-[[5-Fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-2-bicyclo[2.2.2]octanyl]-4H-1,2,4-oxadiazol-5-oneKi4000.0 [1]
1-Phenyl-4-methoxy-2-butene-1-oneIC50100000.0 [1]
2-Phenyl-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideKi3500.0 [1]
N-[4-(2-Chloropyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamideKi3300.0 [1]
2-(4-Fluorophenyl)-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideKi1580.0 [1]
(2E)-2-[(3,4-Dihydroxyphenyl)methylidene]-1-benzofuran-3-oneIC50100000.0 [1]
2-[2,6-Dihydroxy-4-[[2-[(4-hydroxybenzoyl)amino]-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acidIC5050000.0 [1]
2-[2,6-Dihydroxy-4-[[(8R,9R)-9-[(4-hydroxybenzoyl)amino]-8-tricyclo[5.2.1.02,6]decanyl]oxycarbonyl]benzoyl]-3-hydroxybenzoic acidIC5032000.0 [1]
Methyl (1S,3R,4R)-3-(6-aminopurin-9-yl)-4-hydroxycyclopentane-1-carboxylateIC50169824.37 [1]
2-(4-Fluoroanilino)-5-[5-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxypyridin-2-yl]-3-methylpyrimidin-4-oneIC5025000.0 [1]
2-(3-Methoxyphenyl)-N-[4-[2-(methylamino)pyridin-4-yl]-1,3-thiazol-2-yl]acetamideKi3300.0 [1]
2-(3-Methoxyphenyl)-N-[4-(2-methylpyridin-4-yl)-1,3-thiazol-2-yl]acetamideKi3300.0 [1]
N-[4-(2-Fluoropyridin-4-yl)thiophen-2-yl]-2-(3-methoxyphenyl)acetamideKi780.0 [1]
N-[4-(2-Chloropyridin-4-yl)thiophen-2-yl]-2-(3-methoxyphenyl)acetamideKi2200.0 [1]
N-[4-(2-Chloropyridin-4-yl)thiophen-2-yl]-2-[3-(methanesulfonamido)phenyl]acetamideKi3300.0 [1]
N-[4-(2-Aminopyridin-4-yl)thiophen-2-yl]-2-(3-methoxyphenyl)acetamideKi140.0 [1]
N-[4-(2-Fluoropyridin-4-Yl)thiophen-2-Yl]-2-{3-[(Methylsulfonyl)amino]phenyl}acetamideKi3000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ cAMP-dependent protein kinase alpha-catalytic subunit Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/camp-dependent-protein-kinase-alpha-catalytic-subunit-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ cAMP-dependent protein kinase alpha-catalytic subunit Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/camp-dependent-protein-kinase-alpha-catalytic-subunit-inhibitors-ic50-ki.
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