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Calpain 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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CID 11199915IC5070.0 [1]
CID 11199915Ki10.0 [1], 15.0 [2], 15.5 [3]
CalpeptinIC505.0 [1], 40.0 [2], 52.0 [3], 1000.0 [4]
CalpeptinKi7.0 [1]
N-[(2S)-4-Amino-3,4-dioxo-1-phenylbutan-2-yl]-3-methyl-4-oxochromene-2-carboxamideIC5040.0 [1], 70.0 [2], 240.0 [3]
2-Ethyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC507.0 [1], 33.0 [2], 500.0 [3]
Calpain Inhibitor IIIIC5040.0 [1], 300.0 [2]
Calpain Inhibitor IIIKi8.0 [1]
2-Ethyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-7,8-dihydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC508.0 [1], 2100.0 [2]
(R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-methanesulfonylamino-propionamideIC5011.0 [1], 700.0 [2]
(R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-methanesulfonylamino-propionamideKi8.0 [1]
2-Methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1lambda6,2-benzothiazine-3-carboxamideIC5028.0 [1], 110.0 [2], 1700.0 [3]
6,7-Dimethoxy-2-methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1lambda6,2-benzothiazine-3-carboxamideIC5038.0 [1], 200.0 [2], 1900.0 [3]
2-Ethyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-1,1-dioxo-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5037.0 [1], 300.0 [2], 3000.0 [3]
2-Methyl-6-morpholin-4-yl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1lambda6,2-benzothiazine-3-carboxamideIC5030.0 [1], 500.0 [2], 4100.0 [3]
N-[(2S)-6-(Benzenesulfonamido)-1-oxohexan-2-yl]-2-methyl-1,1-dioxo-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5036.0 [1], 107.0 [2], 1800.0 [3]
6,7-Dichloro-2-methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1lambda6,2-benzothiazine-3-carboxamideIC507.0 [1], 21.0 [2], 1300.0 [3]
6-Chloro-2-methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1lambda6,2-benzothiazine-3-carboxamideIC505.0 [1], 15.0 [2], 2200.0 [3]
Acetylleucyl-leucyl-norleucinalIC501000.0 [1], 7000.0 [2]
AloxistatinIC504000.0 [1]
Val-pheIC5011.0 [1]
3-Acetyl-8-bromo-5-chloro-2-(4-chlorophenylamino)quinolin-4(1H)-oneIC503530.0 [1], 9940.0 [2]
gamma-Secretase Inhibitor VIC5010.0 [1], 35.0 [2]
N-(1-Benzyl-2-oxo-ethyl)-benzamideKi1080.0 [1]
Benzyl N-[1-[[1-(ethylamino)-1,2-dioxopentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamateKi250.0 [1]
N-(1-Benzyl-2-oxo-ethyl)-2-styryl-benzamideKi140.0 [1]
Benzyl N-[1-[[1-(cyclohexylmethylamino)-1,2-dioxopentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamateKi680.0 [1]
Benzyl N-[1-[[1,2-dioxo-1-(2-phenylethylamino)pentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamateKi200.0 [1]
Benzyl N-[1-[[4-(ethylamino)-3,4-dioxo-1-phenylbutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamateKi200.0 [1]
Benzyl N-[1-[[3,4-dioxo-1-phenyl-4-(2-phenylethylamino)butan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamateKi52.0 [1]
N-[(2S)-4-Amino-3,4-dioxo-1-phenylbutan-2-yl]-3-methyl-4-oxo-1H-quinoline-2-carboxamideIC50710.0 [1]
2-Benzenesulfonylamino-N-(1-benzyl-2-oxo-ethyl)-3-phenyl-propionamideIC5020.0 [1]
(3S)-N-Ethyl-3-[[(2R)-2-(methanesulfonamido)-3-phenylmethoxypropanoyl]amino]-2-oxo-4-phenylbutanamideKi130.0 [1]
Benzyl N-[1-[[3,4-dioxo-1-phenyl-4-(propylamino)butan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamateKi350.0 [1], 15000.0 [2]
Benzyl N-[1-[[1,2-dioxo-1-(3-phenylpropylamino)pentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamateKi800.0 [1]
Benzyl N-[1-[[1-(benzylamino)-1,2-dioxopentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamateKi200.0 [1]
(3S)-3-[[4-(2,5-Dimethoxyphenyl)-4-oxobutanoyl]amino]-2-oxo-4-phenylbutanamideIC50520.0 [1]
N-(4-Amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-phenylpyrazol-1-yl)pyridine-3-carboxamideKi18.0 [1]
N-(4-Amino-3,4-dioxo-1-phenylbutan-2-yl)-2-[3-(4-fluorophenyl)pyrazol-1-yl]pyridine-3-carboxamideKi34.0 [1]
N-(1-Carbamoyl-pentyl)-2-[2-(4-dimethylaminomethyl-phenyl)-vinyl]-benzamideIC50800.0 [1]
N-(1-Carbamoyl-pentyl)-2-[2-(4-dimethylaminomethyl-phenyl)-vinyl]-benzamideKi13.3 [1]
2-Methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-7,8-dihydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC506.0 [1], 900.0 [2]
N-[(2S)-1-[[(3S)-2-Hydroxyoxolan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]-10H-phenothiazine-2-carboxamideIC5022.5 [1], 23490.0 [2]
(2R)-2-(Methanesulfonamido)-N-[(2S)-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]-3-phenylmethoxypropanamideIC50700.0 [1]
(2R)-2-(Methanesulfonamido)-N-[(2S)-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]-3-phenylmethoxypropanamideKi4.0 [1]
(2R)-2-(Methanesulfonamido)-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3-phenylpropanamideIC50600.0 [1]
(2R)-2-(Methanesulfonamido)-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3-phenylpropanamideKi11.0 [1]
(R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-ethanesulfonylamino-propionamideIC50400.0 [1]
(R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-ethanesulfonylamino-propionamideKi9.0 [1]
(2R)-2-(Methanesulfonamido)-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3-thiophen-2-ylpropanamideIC50300.0 [1]
(2R)-2-(Methanesulfonamido)-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3-thiophen-2-ylpropanamideKi11.0 [1]
(2S)-3-Benzylsulfanyl-2-(methanesulfonamido)-N-[(2S)-1-oxo-3-phenylpropan-2-yl]propanamideIC50800.0 [1]
(2S)-3-Benzylsulfanyl-2-(methanesulfonamido)-N-[(2S)-1-oxo-3-phenylpropan-2-yl]propanamideKi6.0 [1]
6,7-Dichloro-2-methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-1lambda6,2-benzothiazine-3-carboxamideIC5015.0 [1], 2900.0 [2]
1,1-Dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-2-propan-2-yl-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5030.0 [1], 2600.0 [2]
2-Methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5024.0 [1], 2000.0 [2]
6,7-Dimethoxy-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-2,1lambda6-benzoxathiine-3-carboxamideIC5051.0 [1], 2200.0 [2]
4-Methoxy-2-methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-1lambda6,2-benzothiazine-3-carboxamideIC5037.0 [1], 3200.0 [2]
6-Fluoro-2-methyl-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1lambda6,2-benzothiazine-3-carboxamideIC5028.0 [1], 2400.0 [2]
6,7-Dimethoxy-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-2H-1lambda6,2-benzothiazine-3-carboxamideIC50700.0 [1], 800.0 [2]
2-Fluoroethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylateIC50500.0 [1], 3000.0 [2]
2-Chloroethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylateIC50300.0 [1], 2000.0 [2]
2-Bromoethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylateIC501000.0 [1], 2000.0 [2]
2,2,2-Trichloroethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylateIC50700.0 [1], 1000.0 [2]
(2S,3S)-3-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-N-[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]oxirane-2,3-dicarboxamideIC504000.0 [1], 6000.0 [2]
3-Acetyl-5,8-dichloro-2-(2,4-dichlorophenylamino)quinolin-4(1H)-oneIC503170.0 [1], 3990.0 [2]
2-Ethyl-N-[(2S)-4-[3-[(4-nitrophenyl)sulfonylamino]propylamino]-3,4-dioxo-1-phenylbutan-2-yl]-1,1-dioxo-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5050.0 [1], 3600.0 [2]
2-Ethyl-N-[(2S)-4-[2-[(4-nitrophenyl)sulfonylamino]ethylamino]-3,4-dioxo-1-phenylbutan-2-yl]-1,1-dioxo-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5047.0 [1], 4200.0 [2]
N-[(2S)-3,4-Dioxo-1-phenyl-4-[2-[(5-pyridin-2-ylthiophen-2-yl)sulfonylamino]ethylamino]butan-2-yl]-2-ethyl-1,1-dioxo-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5020.0 [1], 1300.0 [2]
2-Ethyl-N-[(2S)-4-[3-[(4-fluorophenyl)sulfonylamino]propylamino]-3,4-dioxo-1-phenylbutan-2-yl]-1,1-dioxo-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5050.0 [1], 2400.0 [2]
2-Ethyl-N-[(2S)-4-[2-[(4-fluorophenyl)sulfonylamino]ethylamino]-3,4-dioxo-1-phenylbutan-2-yl]-1,1-dioxo-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5029.0 [1], 2000.0 [2]
N-[(2S)-4-[3-(Benzenesulfonamido)propylamino]-3,4-dioxo-1-phenylbutan-2-yl]-2-ethyl-1,1-dioxo-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5035.0 [1], 2700.0 [2]
N-[(2S)-4-[2-(Benzenesulfonamido)ethylamino]-3,4-dioxo-1-phenylbutan-2-yl]-2-ethyl-1,1-dioxo-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5040.0 [1], 5000.0 [2]
[3-[2-[(2-Methylpropan-2-yl)oxycarbonylamino]ethyl]-1H-indol-5-yl] (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylateIC502000.0 [1]
N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-2-[(E)-2-[4-(diethylaminomethyl)phenyl]ethenyl]benzamideIC50700.0 [1]
N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-2-[(E)-2-[4-(diethylaminomethyl)phenyl]ethenyl]benzamideKi27.0 [1]
N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-2-[(E)-2-[4-[(dimethylamino)methyl]phenyl]ethenyl]pyridine-3-carboxamideIC501000.0 [1]
N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-2-[(E)-2-[4-[(dimethylamino)methyl]phenyl]ethenyl]pyridine-3-carboxamideKi18.3 [1]
N-(1-Carbamoyl-2-phenyl-ethyl)-2-(2-naphthalen-1-yl-vinyl)-benzamideIC501400.0 [1]
N-(1-Carbamoyl-2-phenyl-ethyl)-2-(2-naphthalen-1-yl-vinyl)-benzamideKi8.4 [1]
(R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-methanesulfonylamino-butyramideIC50500.0 [1]
(R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-methanesulfonylamino-butyramideKi9.0 [1]
[(S)-1-(1-Ethylcarbamoyl-butylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl esterKi66.0 [1], 78.0 [2]
Benzyl N-[(2S)-1-[[1-(ethylamino)-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamateKi74.0 [1], 89.0 [2]
[(S)-1-(3-Ethylcarbamoyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl esterKi77.0 [1], 210.0 [2]
2-Methyl-1-oxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydroisoquinoline-3-carboxamideIC5085.0 [1], 1000.0 [2]
2-Benzyl-6,7-dimethoxy-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1lambda6,2-benzothiazine-3-carboxamideIC50150.0 [1], 1000.0 [2]
6-Chloro-2-(2-methylpropyl)-1,1-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-3,4-dihydro-1lambda6,2-benzothiazine-3-carboxamideIC50200.0 [1]
1-Benzyl-N-[(2S)-1-[[(3S)-2-hydroxyoxolan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]-2,3-dihydroindole-5-carboxamideIC5020.0 [1], 100000.0 [2]
3-Acetyl-5,8-dibromo-2-(4-bromophenylamino)quinolin-4(1H)-oneIC501690.0 [1], 3590.0 [2]
3-Acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-methylquinolin-4(1H)-oneIC50277.0 [1], 3060.0 [2]
3-Acetyl-8-chloro-2-(4-chlorophenylamino)-6-nitroquinolin-4(1H)-oneIC504560.0 [1], 8080.0 [2]
3-Acetyl-2-(4-tert-butylphenylamino)-8-chloro-6-nitroquinolin-4(1H)-oneIC503690.0 [1], 7430.0 [2]
3-Acetyl-6-chloro-2-(2-chloro-4-methylanilino)-8-nitro-1H-quinolin-4-oneIC502390.0 [1], 3730.0 [2]
3-Acetyl-6-chloro-2-(2,4-dichloroanilino)-8-nitro-1H-quinolin-4-oneIC503160.0 [1], 4640.0 [2]
(2S,3S)-3-[[(2S)-1-[[1-(4-Fluorophenyl)triazol-4-yl]methylamino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]carbamoyl]oxirane-2-carboxylic acidIC50100.0 [1]
(2S,3S)-3-[[(2S)-1-[[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acidIC5050.0 [1], 250.0 [2]
(2S,3S)-3-[[1-[[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl]oxirane-2-carboxylic acidIC50100.0 [1]
(2S,3S)-3-[[(2S)-1-[[4-(4-Ethynylphenyl)-1,3-thiazol-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]carbamoyl]oxirane-2-carboxylic acidIC50100.0 [1]
(2S,3S)-3-[[(2S)-1-(2,6-Difluoroanilino)-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acidIC50100.0 [1], 1000.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Calpain 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/calpain-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Calpain 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/calpain-1-inhibitors-ic50-ki.
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