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Calcium sensing receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Nps-2143IC500.06 [1], 43.0 [2], 50.0 [3]
(R)-2-(2-Hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)benzonitrileIC500.0 [1], 0.02 [2], 30.0 [3]
4-[(2S)-2-Hydroxy-3-[[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino]propoxy]-1,3-dihydrobenzimidazol-2-oneIC5011.0 [1], 31.8 [2], 31800.0 [3]
2-Furan-2-yl-3-phenethyl-3H-quinazolin-4-oneIC503500.0 [1]
2-(2-Hydroxyphenyl)-3-phenethylquinazolin-4(3H)-oneIC50300.0 [1]
(5S,7R)-N-(1-Adamantyl)-5-phenyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamideIC5040.0 [1]
(5S)-N-(1-Adamantyl)-7,7-dimethyl-5-phenyl-5,6-dihydro-4H-pyrazolo[1,5-a]pyrimidine-3-carboxamideIC5010.0 [1]
(R)-1-((R)-Cyclopropyl(o-tolyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-olIC5023.0 [1]
3-[3-Cyano-4-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]phenyl]propanoic acidIC500.02 [1], 0.2 [2]
3-[4-[(2R)-2-Hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]phenyl]propanoic acidIC504.8 [1], 25.0 [2]
Ethyl 3-[3-cyano-4-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]phenyl]propanoate;hydrochlorideIC500.0 [1], 0.03 [2]
(5R)-7,7-Dimethyl-N-[3-(4-methylphenyl)pentan-3-yl]-5-phenyl-5,6-dihydro-4H-pyrazolo[1,5-a]pyrimidine-3-carboxamideIC502.3 [1]
RonacaleretIC50146.0 [1]
EncaleretIC5012.0 [1]
6-[[(2S)-1-Hydroxy-3-phenylpropan-2-yl]amino]-N-(2-phenoxyethyl)-2-(3,4,5-trimethoxyphenyl)pyridine-3-carboxamideIC5076.0 [1]
SB-423562IC5073.0 [1]
Calcium-Sensing Receptor Antagonists IIC509.0 [1]
1-Benzyl-4-(4-isopropyl-phenyl)-6-propargyloxy-1H-quinazolin-2-oneIC504.4 [1]
7,7-Dimethyl-N-[3-(4-methylphenyl)pentan-3-yl]-5-phenyl-5,6-dihydro-4H-pyrazolo[1,5-a]pyrimidine-3-carboxamideIC505.5 [1]
2-Methyl-3-phenethyl-3H-pyrimidin-4-oneIC5097.0 [1]
Unii-N9LP5QC07KIC500.94 [1]
1-Arylmethylpyrrolidin-2-yl ethanol amineIC50270.0 [1]
2-Chloro-6-[2-hydroxy-3-[[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino]propoxy]benzonitrileIC5070.0 [1]
2-(3-Hydroxy-phenyl)-3-phenethyl-3H-quinazolin-4-oneIC502800.0 [1]
1-[[3-(2-Hydroxyethoxy)phenyl]methyl]-4-(4-propan-2-ylphenyl)-6-prop-2-ynoxyquinazoline-2-thioneIC500.4 [1]
2-Fluoro-6-[[(2R)-2-[(1R)-1-hydroxy-2-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]ethyl]pyrrolidin-1-yl]methyl]phenolIC50140.0 [1]
(2R)-1-(2-Methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-m-tolylethoxy)propan-2-olIC50170.0 [1]
2-(1-((R)-2-Hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)ethyl)benzonitrileIC50160.0 [1]
(2R)-1-[Cyclopropyl-(2-methoxyphenyl)methoxy]-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propan-2-olIC5041.0 [1]
1-[3-(2-Hydroxy-ethoxy)-benzyl]-4-(4-isopropyl-phenyl)-6-propargyloxy-1H-quinazolin-2-oneIC507.3 [1]
2-(4-Methylpiperazin-1-yl)-N-[3-[[2-oxo-4-(4-propan-2-ylphenyl)-6-prop-2-ynoxyquinazolin-1-yl]methyl]phenyl]acetamideIC502.4 [1]
6-Allyloxy-1-isopropyl-4-(4-isopropyl-phenyl)-1H-quinazolin-2-oneIC50180.0 [1]
(2R)-1-(Cyclopropyl(phenyl)methoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-olIC5070.0 [1]
Ethyl 3-[4-cyano-3-[(2R)-3-[[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]phenyl]propanoateIC50520.0 [1]
(2R)-1-[Cyclopropyl-(2-methylphenyl)methoxy]-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propan-2-olIC5037.0 [1]
2-[4-(2-Methoxyethyl)piperazin-1-yl]-N-[3-[[2-oxo-4-(4-propan-2-ylphenyl)-6-prop-2-ynoxyquinazolin-1-yl]methyl]phenyl]acetamideIC5013.0 [1]
(2R)-1-(2-Methyl-1-(naphthalen-2-yl)propan-2-ylamino)-3-(1-o-tolylethoxy)propan-2-olIC50200.0 [1]
(2R)-1-(1-(2-Methoxyphenyl)ethoxy)-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propan-2-olIC50120.0 [1]
(1R)-2-[(2-Methyl-1-naphthalen-2-ylpropan-2-yl)amino]-1-[(2R)-1-[(4-nitrophenyl)methyl]pyrrolidin-2-yl]ethanolIC50790.0 [1]
3-[[(2R)-2-[(1R)-1-Hydroxy-2-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]ethyl]pyrrolidin-1-yl]methyl]benzonitrileIC50190.0 [1]
4,5-Dibromo-2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-1H-benzo[d]imidazoleIC5014.0 [1]
5-Bromo-4-iodo-2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-1H-benzo[d]imidazoleIC506.0 [1]
6-(1,3-Benzodioxol-5-ylmethylamino)-2-(2,6-dimethoxypyridin-3-yl)-N-(2-phenoxyethyl)pyridine-3-carboxamideIC5060.0 [1]
4-Bromo-7-methoxy-1-(2-methoxyethyl)-2-(4-propan-2-ylphenyl)-5-(pyridin-3-ylmethyl)benzimidazoleIC5015.0 [1]
4-Bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazoleIC5022.0 [1]
2-[(3-Chlorophenyl)methylamino]-N-(2-phenoxyethyl)-4-(3,4,5-trimethoxyphenyl)pyrimidine-5-carboxamideIC5070.0 [1]
4-Bromo-2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-5-(trifluoromethyl)-1H-benzo[d]imidazoleIC5011.0 [1]
4-Bromo-2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-1H-benzo[d]imidazole-5-carbonitrileIC5025.0 [1]
4-Bromo-7-methoxy-1-(2-methoxyethyl)-5-[(2-methylsulfinylphenyl)methyl]-2-(4-propan-2-ylphenyl)benzimidazoleIC505.0 [1]
3-[2-[(1R)-1-[(2R)-2-Hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]ethyl]phenyl]propanoic acidIC5024.0 [1]
2-(4-Isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-4-methyl-1H-benzo[d]imidazoleIC50210.0 [1]
4-Bromo-5-ethyl-2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-1H-benzo[d]imidazoleIC50190.0 [1]
4-Iodo-2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-1H-benzo[d]imidazoleIC5013.0 [1]
6-Allylamino-1-isopropyl-4-(4-isopropyl-phenyl)-1H-quinazolin-2-oneIC5070.0 [1]
4-Chloro-2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-1H-benzo[d]imidazoleIC5050.0 [1]
4-Bromo-2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-5-phenyl-1H-benzo[d]imidazoleIC5060.0 [1]
2-[[(2S)-1-Hydroxy-3-phenylpropan-2-yl]amino]-N-(2-phenoxyethyl)-4-(3,4,5-trimethoxyphenyl)pyrimidine-5-carboxamideIC50150.0 [1]
2-[4-Bromo-7-methoxy-2-(4-propan-2-ylphenyl)benzimidazol-1-yl]-N,N-dimethylethanamineIC50190.0 [1]
5-Benzyl-4-bromo-2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)-1H-benzo[d]imidazoleIC505.0 [1]
4,7-Dibromo-2-(4-isopropylphenyl)-1-(2-methoxyethyl)-1H-benzo[d]imidazoleIC501000.0 [1]
4-Bromo-5-[(3,4-dimethoxyphenyl)methyl]-7-methoxy-1-(2-methoxyethyl)-2-(4-propan-2-ylphenyl)benzimidazoleIC5043.0 [1]
6-[1-[(2R)-3-[[1-(2,3-Dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC50117.3 [1]
6-[1-[(2R)-2-Hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5064.3 [1]
6-[1-[(2R)-3-[[1-(4-Chloro-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC50202.7 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-3-[[1-(3,4-dimethylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5017.7 [1]
(1R,1Ar,6bS)-6-[(1R)-1-[(2R)-3-[[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5045.7 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-2-hydroxy-3-[(2-methyl-1-quinolin-6-ylpropan-2-yl)amino]propoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC50457.1 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-3-[[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5020.0 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-3-[[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5058.7 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-2-hydroxy-3-[(2-methyl-5-phenylpentan-2-yl)amino]propoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5028.4 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-3-[[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5021.8 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-3-[[1-(2-chloro-4-methoxyphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5019.6 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-3-(2-benzyl-2-methylpyrrolidin-1-yl)-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC501332.0 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-3-[[1-(3-fluoro-4-methylsulfanylphenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5027.6 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC507.45 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-2-hydroxy-3-[(2-methyl-4-phenylsulfanylbutan-2-yl)amino]propoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5050.8 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-2-hydroxy-3-[[2-methyl-1-(4-methylsulfanylphenyl)propan-2-yl]amino]propoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5039.3 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-3-[[1-(1,1-dioxo-2,3-dihydro-1-benzothiophen-5-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5010000.0 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-3-[[1-(1-benzothiophen-5-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC509.62 [1]
(1R,1Ar,6bS)-6-[(1R)-1-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5021.6 [1]
(1S,1As,6bR)-6-[(1R)-1-[(2R)-3-(2-benzylpyrrolidin-1-yl)-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC50489.1 [1]
(1R,1Ar,6bS)-6-[(1R)-1-[(2R)-3-[[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]-3-methyl-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-1-carboxylic acidIC5077.2 [1]
1-Isopropyl-4-phenyl-6-methoxy-1H-quinazolin-2-oneIC5030000.0 [1]
2-(2-Hydroxy-phenyl)-5-methyl-3-phenethyl-3H-quinazolin-4-oneIC50250.0 [1]
2-(2-Hydroxy-phenyl)-5,6-dimethyl-3-phenethyl-3H-pyrimidin-4-oneIC50200.0 [1]
3-[2-(3-Fluorophenyl)ethyl]-2-(2-hydroxyphenyl)-6-methyl-5-propylpyrimidin-4-oneIC50140.0 [1]
3-[2-(3-Fluorophenyl)ethyl]-2-(2-hydroxyphenyl)-6-methyl-5-propan-2-ylpyrimidin-4-oneIC5095.0 [1]
3-[2-(3-Fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-5-methyl-3H-quinazolin-4-oneIC50250.0 [1]
5-Ethyl-2-(2-hydroxy-phenyl)-6-methyl-3-phenethyl-3H-pyrimidin-4-oneIC50100.0 [1]
3-[2-(3-Chloro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-3H-quinazolin-4-oneIC50800.0 [1]
7-Chloro-3-[2-(3-fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-3H-quinazolin-4-oneIC501600.0 [1]
3-[2-(2-Fluoro-phenyl)ethyl]-2-(2-hydroxy-phenyl)-6-methyl-3H-pyrimidin-4-oneIC501600.0 [1]
6-Fluoro-3-[2-(3-fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-3H-quinazolin-4-oneIC50190.0 [1]
2-(2-Hydroxy-phenyl)-6-methyl-3-phenethyl-3H-pyrimidin-4-oneIC501900.0 [1]
6-Chloro-2-(2-hydroxy-phenyl)-3-phenethyl-3H-quinazolin-4-oneIC50300.0 [1]
3-[2-(3-Fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-6-methyl-3H-pyrimidin-4-oneIC501100.0 [1]
5-Cyclopropyl-3-[2-(3-fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-6-methyl-3H-pyrimidin-4-oneIC50120.0 [1]
3-[2-(3-Fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-6-methyl-3H-quinazolin-4-oneIC50520.0 [1]
2-(2-Hydroxy-phenyl)-8-methyl-3-phenethyl-3H-quinazolin-4-oneIC50700.0 [1]
2-(2-Hydroxy-phenyl)-5-methyl-3-phenethyl-6-trifluoromethyl-3H-pyrimidin-4-oneIC50800.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Calcium sensing receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/calcium-sensing-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Calcium sensing receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/calcium-sensing-receptor-inhibitors-ic50-ki.
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