![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_5c34337c0d5def07626e9dd4c3e247d2.svg) | Telcagepant | IC50 | 2.4 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_bd249a154a6b3a9111ebda1022b3f98e.svg) | N-[(2R)-1'-Methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]-2-(2-oxo-3-pyridin-2-ylbenzimidazol-1-yl)acetamide | IC50 | 78.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_bd249a154a6b3a9111ebda1022b3f98e.svg) | N-[(2R)-1'-Methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]-2-(2-oxo-3-pyridin-2-ylbenzimidazol-1-yl)acetamide | Ki | 20.0 [1], 21.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_240a7ab4957a65d4355027bc6dd78665.svg) | 2-(2,10-Dioxo-1,3,9-triazatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-3-yl)-N-[(2S)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]acetamide | IC50 | 0.28 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_240a7ab4957a65d4355027bc6dd78665.svg) | 2-(2,10-Dioxo-1,3,9-triazatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-3-yl)-N-[(2S)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]acetamide | Ki | 0.04 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_9d364a53cf0114934066358f1b3cc91b.svg) | Olcegepant | IC50 | 0.02 [1], 0.03 [2], 4.0 [3] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_9d364a53cf0114934066358f1b3cc91b.svg) | Olcegepant | Ki | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_c25699c6615122e5a379d30702af6c4c.svg) | 2-[3-[2-(Dimethylamino)-2-oxoethyl]-4,6-dimethyl-2-oxobenzimidazol-1-yl]-N-[(2R)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]acetamide | IC50 | 12.0 [1], 14.0 [2], 23.0 [3] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_c25699c6615122e5a379d30702af6c4c.svg) | 2-[3-[2-(Dimethylamino)-2-oxoethyl]-4,6-dimethyl-2-oxobenzimidazol-1-yl]-N-[(2R)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]acetamide | Ki | 1.7 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_2ab59e848268564f5adca653a7698ddd.svg) | 2-(2,10-Dioxo-1,3,9-triazatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-3-yl)-N-[(2R)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]acetamide | IC50 | 2.4 [1], 5.4 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_2ab59e848268564f5adca653a7698ddd.svg) | 2-(2,10-Dioxo-1,3,9-triazatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-3-yl)-N-[(2R)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]acetamide | Ki | 0.51 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_4ff22d178c9c3a98c4d5ac441dc234b1.svg) | 2-(6,9-Dimethyl-2,10-dioxo-1,3,9-triazatricyclo[6.3.1.04,12]dodeca-4(12),5,7-trien-3-yl)-N-[(2R)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]acetamide | IC50 | 0.88 [1], 13.0 [2], 31.0 [3], 220.0 [4] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_4ff22d178c9c3a98c4d5ac441dc234b1.svg) | 2-(6,9-Dimethyl-2,10-dioxo-1,3,9-triazatricyclo[6.3.1.04,12]dodeca-4(12),5,7-trien-3-yl)-N-[(2R)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]acetamide | Ki | 0.23 [1], 7.1 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_76f4bad5e1cf09742fbb7edde1993a9b.svg) | 4-(8-Fluoro-2-oxo-1,4-dihydroquinazolin-3-yl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamide | IC50 | 0.03 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_76f4bad5e1cf09742fbb7edde1993a9b.svg) | 4-(8-Fluoro-2-oxo-1,4-dihydroquinazolin-3-yl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamide | Ki | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_5bdb7f04616ab0fdebd4946910186bee.svg) | 4-(2-Oxo-3H-imidazo[4,5-b]pyridin-1-yl)-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamide | IC50 | 49.0 [1], 730.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_5bdb7f04616ab0fdebd4946910186bee.svg) | 4-(2-Oxo-3H-imidazo[4,5-b]pyridin-1-yl)-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamide | Ki | 22.0 [1], 23.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_aa25678c02b6ad412791ca83a9cabee8.svg) | N-[(2R)-1'-Methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]-2-(2-oxo-3H-benzimidazol-1-yl)acetamide | IC50 | 110.0 [1], 120.0 [2], 1200.0 [3] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_aa25678c02b6ad412791ca83a9cabee8.svg) | N-[(2R)-1'-Methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]-2-(2-oxo-3H-benzimidazol-1-yl)acetamide | Ki | 38.0 [1], 43.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ba4ffc9c18e9811d592fb0af6787499e.svg) | N-[(2R)-1'-Methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]-2-[2-oxo-3-(oxolan-3-yl)benzimidazol-1-yl]acetamide | IC50 | 61.0 [1], 170.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ba4ffc9c18e9811d592fb0af6787499e.svg) | N-[(2R)-1'-Methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]-2-[2-oxo-3-(oxolan-3-yl)benzimidazol-1-yl]acetamide | Ki | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ca59fcac2f4b3546911c355596d517a6.svg) | N-[(2R)-1'-Methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]-2-(3,4,6-trimethyl-2-oxobenzimidazol-1-yl)acetamide | IC50 | 10.0 [1], 370.0 [2], 1200.0 [3] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ca59fcac2f4b3546911c355596d517a6.svg) | N-[(2R)-1'-Methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]-2-(3,4,6-trimethyl-2-oxobenzimidazol-1-yl)acetamide | Ki | 2.7 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_24597878df01113a50b5f94b00373ccd.svg) | 2-[(8R)-8-(3,5-Difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]acetamide | IC50 | 0.23 [1], 0.34 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_24597878df01113a50b5f94b00373ccd.svg) | 2-[(8R)-8-(3,5-Difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]acetamide | Ki | 0.05 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_c9664b3d4c0b295ade8c53a54fee2bf1.svg) | 4-(2-Oxo-3H-benzimidazol-1-yl)-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamide | IC50 | 1583.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_c9664b3d4c0b295ade8c53a54fee2bf1.svg) | 4-(2-Oxo-3H-benzimidazol-1-yl)-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamide | Ki | 2200.0 [1], 2250.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_c2a43e65c4d1d39c807114f7f4ef5f47.svg) | 4-(2,4-Dioxoimidazolidin-1-yl)-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamide | IC50 | 100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_c2a43e65c4d1d39c807114f7f4ef5f47.svg) | 4-(2,4-Dioxoimidazolidin-1-yl)-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamide | Ki | 29.0 [1], 520.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_2e679e9eb38142436d0520da42909db9.svg) | 2-[(8R)-8-(3,5-Difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]acetamide | IC50 | 0.1 [1], 0.39 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_2e679e9eb38142436d0520da42909db9.svg) | 2-[(8R)-8-(3,5-Difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]acetamide | Ki | 0.05 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_7a9d85b1a8d75280fdc464c7d7f6c370.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-(2-methoxypropan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-2-oxospiro[1H-pyrido[2,3-d][1,3]oxazine-4,4'-piperidine]-1'-carboxamide | IC50 | 0.24 [1], 0.63 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_7a9d85b1a8d75280fdc464c7d7f6c370.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-(2-methoxypropan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-2-oxospiro[1H-pyrido[2,3-d][1,3]oxazine-4,4'-piperidine]-1'-carboxamide | Ki | 0.05 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_d4530244d0c548e77734352f6c86f4fe.svg) | [1-[6-Chloro-4-(dimethylcarbamoyl)pyridin-2-yl]-2-(7-methyl-1H-indazol-5-yl)ethyl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate | IC50 | 0.07 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_d4530244d0c548e77734352f6c86f4fe.svg) | [1-[6-Chloro-4-(dimethylcarbamoyl)pyridin-2-yl]-2-(7-methyl-1H-indazol-5-yl)ethyl] 4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate | Ki | 0.07 [1], 0.18 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_abb1154028d3dc8d4b46f72b0f5fa785.svg) | CID 73352948 | IC50 | 1.7 [1], 2.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_abb1154028d3dc8d4b46f72b0f5fa785.svg) | CID 73352948 | Ki | 0.03 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_69784bfff1a17e83ab6e6df5d62e4b82.svg) | N-[(3R,6S)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 38.0 [1], 340.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_69784bfff1a17e83ab6e6df5d62e4b82.svg) | N-[(3R,6S)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_bbbd1732cf97f0b4ab3cb1afec193ddd.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-(2-methylsulfinylethyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 5.0 [1], 8.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_bbbd1732cf97f0b4ab3cb1afec193ddd.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-(2-methylsulfinylethyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 1.7 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_377fd021c989f14d00230b37c046f7a5.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-(2-methylsulfonylethyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 2.0 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_377fd021c989f14d00230b37c046f7a5.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-(2-methylsulfonylethyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 0.5 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_013353600485d2159d5e6958ea7ae17c.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-methyl-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 8.0 [1], 22.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_013353600485d2159d5e6958ea7ae17c.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-methyl-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 2.7 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ec274d8ec22c501e189f43252954166a.svg) | N-[(3R,6S)-1-(2,2-Difluoroethyl)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 5.0 [1], 15.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ec274d8ec22c501e189f43252954166a.svg) | N-[(3R,6S)-1-(2,2-Difluoroethyl)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 0.9 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_983ca3aa34018bc0636a2237fa2acace.svg) | N-[(3R,6S)-6-(2-Fluorophenyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 65.0 [1], 120.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_983ca3aa34018bc0636a2237fa2acace.svg) | N-[(3R,6S)-6-(2-Fluorophenyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 22.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_4fbab0122a3b075d9e951902bdf801a7.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 2.0 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_4fbab0122a3b075d9e951902bdf801a7.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-(2-methoxyethyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 0.3 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_0bbf1027646127447b36ca01a4ee55fb.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-ethyl-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 6.0 [1], 30.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_0bbf1027646127447b36ca01a4ee55fb.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-ethyl-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 2.4 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_d625c97c54e6f3c9c0460f53d588f585.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(pyridin-2-ylmethyl)azepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 2.0 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_d625c97c54e6f3c9c0460f53d588f585.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(pyridin-2-ylmethyl)azepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 0.9 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_a0e24d0999978fa1cef11cac5c78f2b0.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 14.0 [1], 22.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_a0e24d0999978fa1cef11cac5c78f2b0.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 3.6 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_d1a44222458711e7f201504d08134a1e.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(6-oxo-1H-pyridazin-5-yl)piperidine-1-carboxamide | IC50 | 44.0 [1], 112.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_d1a44222458711e7f201504d08134a1e.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(6-oxo-1H-pyridazin-5-yl)piperidine-1-carboxamide | Ki | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_6d92c841260c46a64130df4c3f76d6be.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-(2-methylsulfanylethyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 2.0 [1], 8.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_6d92c841260c46a64130df4c3f76d6be.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-(2-methylsulfanylethyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 0.7 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_139bbd0b9f975c5b24c71cfaf9f3d13c.svg) | 4-(2-Oxo-3H-imidazo[4,5-b]pyridin-1-yl)-N-[(3R,6S)-2-oxo-6-phenylazepan-3-yl]piperidine-1-carboxamide | IC50 | 520.0 [1], 700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_139bbd0b9f975c5b24c71cfaf9f3d13c.svg) | 4-(2-Oxo-3H-imidazo[4,5-b]pyridin-1-yl)-N-[(3R,6S)-2-oxo-6-phenylazepan-3-yl]piperidine-1-carboxamide | Ki | 83.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_3238c5a47d9caed8c74a5eb74077cc55.svg) | N-[(3R,6S)-6-(3-Fluorophenyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 220.0 [1], 250.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_3238c5a47d9caed8c74a5eb74077cc55.svg) | N-[(3R,6S)-6-(3-Fluorophenyl)-2-oxoazepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 51.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_9afbb1a3a1a44606723c1d5e230680f1.svg) | N-(1-Methyl-2-oxo-5-phenylpyridin-3-yl)-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 495.0 [1], 10900.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_9afbb1a3a1a44606723c1d5e230680f1.svg) | N-(1-Methyl-2-oxo-5-phenylpyridin-3-yl)-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 498.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_f6a84fbcd0ac434e993fbf58fca948ff.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-[1-(trifluoromethyl)cyclopropyl]-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,4'-piperidine]-1'-carboxamide | IC50 | 1.4 [1], 8.6 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_f6a84fbcd0ac434e993fbf58fca948ff.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-[1-(trifluoromethyl)cyclopropyl]-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,4'-piperidine]-1'-carboxamide | Ki | 0.63 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ba03f61bf550bc951cfb9b8400f48ab3.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2-oxospiro[1,3-dihydro-1,8-naphthyridine-4,4'-piperidine]-1'-carboxamide | IC50 | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ba03f61bf550bc951cfb9b8400f48ab3.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2-oxospiro[1,3-dihydro-1,8-naphthyridine-4,4'-piperidine]-1'-carboxamide | Ki | 3.5 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_b96d3fb3e8eef97952d935357fd7edf6.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 2.6 [1], 34.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_b96d3fb3e8eef97952d935357fd7edf6.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-phenyl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 1.1 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_02721e2cc386f8bea26a409b76ae3aaf.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-oxo-2-phenyl-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxamide | IC50 | 23.0 [1], 871.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_02721e2cc386f8bea26a409b76ae3aaf.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-oxo-2-phenyl-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxamide | Ki | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_3ee66f0d411b7f6f29bbefdf9ff567d3.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2-oxospiro[1H-3,1-benzoxazine-4,4'-piperidine]-1'-carboxamide | IC50 | 60.0 [1], 792.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_3ee66f0d411b7f6f29bbefdf9ff567d3.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2-oxospiro[1H-3,1-benzoxazine-4,4'-piperidine]-1'-carboxamide | Ki | 46.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_201a5b1c76f6469d543aadb43258b8a4.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,4'-piperidine]-1'-carboxamide | IC50 | 3.3 [1], 11.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_201a5b1c76f6469d543aadb43258b8a4.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,4'-piperidine]-1'-carboxamide | Ki | 1.7 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_750896a97ea23948bd18ae0b86fe997f.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-1-oxo-3-phenyl-2,8-diazaspiro[4.5]decane-8-carboxamide | IC50 | 120.0 [1], 692.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_750896a97ea23948bd18ae0b86fe997f.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-1-oxo-3-phenyl-2,8-diazaspiro[4.5]decane-8-carboxamide | Ki | 380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_89c28c72d6b823467b8cca9bec8b020c.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-propan-2-yl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 0.62 [1], 3.2 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_89c28c72d6b823467b8cca9bec8b020c.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-propan-2-yl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 0.69 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_d629607149edde0d3997d287b8178f74.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-2-(hydroxymethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 12.0 [1], 26.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_d629607149edde0d3997d287b8178f74.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-2-(hydroxymethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 3.2 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_c88bc1f7f02ff8e1dff3f6ccb5f814a2.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 6.7 [1], 19.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_c88bc1f7f02ff8e1dff3f6ccb5f814a2.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 3.1 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_e67867af9271b396334eac66ef182d3e.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-2-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 8.7 [1], 28.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_e67867af9271b396334eac66ef182d3e.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-2-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ca27a39b2e870ebc8330ff3629a57160.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2-oxospiro[1H-pyrido[2,3-d][1,3]oxazine-4,4'-piperidine]-1'-carboxamide | IC50 | 2.7 [1], 13.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ca27a39b2e870ebc8330ff3629a57160.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2-oxospiro[1H-pyrido[2,3-d][1,3]oxazine-4,4'-piperidine]-1'-carboxamide | Ki | 1.1 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_21db2078755a898c12a3c6d6cb3c95e6.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-2-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 7.2 [1], 33.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_21db2078755a898c12a3c6d6cb3c95e6.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-2-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 3.9 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_fa097fe3216828ec1dcd75a90603fa19.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxamide | IC50 | 94.0 [1], 122.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_fa097fe3216828ec1dcd75a90603fa19.svg) | N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxamide | Ki | 46.0 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ece67a954dc04404a955535d299593d2.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-2-oxospiro[1H-pyrido[2,3-d][1,3]oxazine-4,4'-piperidine]-1'-carboxamide | IC50 | 0.41 [1], 2.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_ece67a954dc04404a955535d299593d2.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-2-oxospiro[1H-pyrido[2,3-d][1,3]oxazine-4,4'-piperidine]-1'-carboxamide | Ki | 0.07 [1] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_bdedae6e9e4982c20b2faa0682da84de.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-(1,3-thiazol-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | IC50 | 3.6 [1], 64.0 [2] |
![](https://images.aatbio.com/dataset/ic50/calcitonin-gene-related-peptide-type-1-receptor_bdedae6e9e4982c20b2faa0682da84de.svg) | N-[(6S,9R)-6-(2,3-Difluorophenyl)-3-(1,3-thiazol-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Ki | 1.1 [1] |