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Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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OlcegepantIC500.1 [1]
OlcegepantKi0.01 [1]
4-(2-Oxo-3H-benzimidazol-1-yl)-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamideIC501580.0 [1]
4-(2-Oxo-3H-benzimidazol-1-yl)-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamideKi2370.0 [1]
FvptdvgpfafKi0.02 [1], 14.0 [2]
FvptdvgafafKi13.6 [1], 76.8 [2]
N-[(3R)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideIC503640.0 [1]
N-[(3R)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideKi2200.0 [1]
N-[(3R)-1-(Cyclopropylmethyl)-2-oxoazepan-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideIC502400.0 [1]
N-[(3R)-1-(Cyclopropylmethyl)-2-oxoazepan-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideKi7800.0 [1]
N-[(3R,6S)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-5-phenyl-1H-imidazol-3-yl)piperidine-1-carboxamideIC504.0 [1]
N-[(3R,6S)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-5-phenyl-1H-imidazol-3-yl)piperidine-1-carboxamideKi2.0 [1]
4-(2-Oxo-1,4-dihydroquinazolin-3-yl)-N-(2-oxo-5-phenyl-1-propan-2-yl-3H-1,4-benzodiazepin-3-yl)piperidine-1-carboxamideIC501810.0 [1]
4-(2-Oxo-1,4-dihydroquinazolin-3-yl)-N-(2-oxo-5-phenyl-1-propan-2-yl-3H-1,4-benzodiazepin-3-yl)piperidine-1-carboxamideKi1060.0 [1]
N-[(3S,6R)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideIC506626.0 [1]
N-[(3S,6R)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideKi5828.0 [1]
N-[(3R,7R)-1-(Cyclopropylmethyl)-2-oxo-7-phenylazepan-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideIC50408.0 [1]
N-[(3R,7R)-1-(Cyclopropylmethyl)-2-oxo-7-phenylazepan-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideKi689.0 [1]
N-[(3R,6S)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideIC5036.0 [1]
N-[(3R,6S)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideKi25.0 [1]
N-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideIC504450.0 [1]
N-[(3S)-1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideKi8400.0 [1]
N-[(3R)-1-Ethyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideIC50990.0 [1]
N-[(3R)-1-Ethyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideKi897.0 [1]
4-(2-Oxo-4,5-dihydro-1H-1,3-benzodiazepin-3-yl)-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamideIC5043.0 [1]
4-(2-Oxo-4,5-dihydro-1H-1,3-benzodiazepin-3-yl)-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamideKi61.0 [1]
N-[(3R,6S)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(5-oxo-3-phenyl-4H-1,2,4-triazol-1-yl)piperidine-1-carboxamideIC5045.0 [1]
N-[(3R,6S)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(5-oxo-3-phenyl-4H-1,2,4-triazol-1-yl)piperidine-1-carboxamideKi29.0 [1]
N-[1-(Cyclopropylmethyl)-2-oxo-5-phenylazepan-3-yl]-4-(5-oxo-3-phenyl-4H-1,2,4-triazol-1-yl)piperidine-1-carboxamideIC503821.0 [1]
N-[1-(Cyclopropylmethyl)-2-oxo-5-phenylazepan-3-yl]-4-(5-oxo-3-phenyl-4H-1,2,4-triazol-1-yl)piperidine-1-carboxamideKi544.0 [1]
N-[1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideIC50778.0 [1]
N-[1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideKi695.0 [1]
N-[(2R)-3-(3,5-Dibromo-4-hydroxyphenyl)-1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]-4-(2-oxo-3H-benzimidazol-1-yl)piperidine-1-carboxamideIC5075.0 [1]
N-[(2R)-3-(3,5-Dibromo-4-hydroxyphenyl)-1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]-4-(2-oxo-3H-benzimidazol-1-yl)piperidine-1-carboxamideKi83.0 [1]
4-(2-Oxo-1,4-dihydroquinazolin-3-yl)-N-[(3R)-2-oxo-5-phenyl-1-propan-2-yl-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamideIC5065.0 [1]
4-(2-Oxo-1,4-dihydroquinazolin-3-yl)-N-[(3R)-2-oxo-5-phenyl-1-propan-2-yl-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamideKi55.0 [1]
4-(2-Oxo-1,4-dihydroquinazolin-3-yl)-N-(2-oxo-1-propan-2-yl-4,5-dihydro-3H-1-benzazepin-3-yl)piperidine-1-carboxamideIC503100.0 [1]
4-(2-Oxo-1,4-dihydroquinazolin-3-yl)-N-(2-oxo-1-propan-2-yl-4,5-dihydro-3H-1-benzazepin-3-yl)piperidine-1-carboxamideKi3700.0 [1]
Tert-butyl 2-[2-oxo-3-[[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carbonyl]amino]-7-phenylazepan-1-yl]acetateIC502118.0 [1]
Tert-butyl 2-[2-oxo-3-[[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carbonyl]amino]-7-phenylazepan-1-yl]acetateKi16950.0 [1]
Tert-butyl 2-[(3S,7S)-2-oxo-3-[[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carbonyl]amino]-7-phenylazepan-1-yl]acetateIC50471.0 [1]
Tert-butyl 2-[(3S,7S)-2-oxo-3-[[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carbonyl]amino]-7-phenylazepan-1-yl]acetateKi10000.0 [1]
N-[(3R,6S)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-4,5-dihydro-1H-1,3-benzodiazepin-3-yl)piperidine-1-carboxamideIC5032.0 [1]
N-[(3R,6S)-1-(Cyclopropylmethyl)-2-oxo-6-phenylazepan-3-yl]-4-(2-oxo-4,5-dihydro-1H-1,3-benzodiazepin-3-yl)piperidine-1-carboxamideKi29.0 [1]
N-[1-(Cyclopropylmethyl)-2-oxo-5-phenylazepan-3-yl]-4-(2-oxo-5-phenyl-1H-imidazol-3-yl)piperidine-1-carboxamideIC50133.0 [1]
N-[1-(Cyclopropylmethyl)-2-oxo-5-phenylazepan-3-yl]-4-(2-oxo-5-phenyl-1H-imidazol-3-yl)piperidine-1-carboxamideKi17.0 [1]
(3S)-2-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(3S)-2-[2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]acetyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acidKi1.8 [1], 70.5 [2]
MK-3207Ki0.02 [1]
UbrogepantKi0.07 [1]
2-[(8R)-8-(3,5-Difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]acetamideKi0.05 [1]
4-(2-Oxo-1,4-dihydroquinazolin-3-yl)-N-[(3R)-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-3-yl]piperidine-1-carboxamideKi44.0 [1]
(3S)-3-[[(2S,3R)-2-[[2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-2-methylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi0.0 [1]
2-[(8R)-8-(3,5-Difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]acetamideKi0.04 [1]
Tert-butyl 2-[(3R,7R)-2-oxo-3-[[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carbonyl]amino]-7-phenylazepan-1-yl]acetateKi934.0 [1]
N-[(3S)-1-Benzyl-2-oxoazepan-3-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideKi11100.0 [1]
(R)-N-(1-Benzyl-2-oxoazepan-3-yl)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxamideKi1800.0 [1]
(3S)-3-[[(2S,3R)-2-[[(3S)-2-[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi0.02 [1]
N-(1-Methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl)-4-(2-oxo-3H-benzimidazol-1-yl)piperidine-1-carboxamideKi13000.0 [1]
(3S)-3-[[(2S,3R)-2-[[(1S,2S,3S)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-3-methoxycarbonylcyclopropanecarbonyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi10000.0 [1]
(3S)-3-[[(2S,3R)-2-[[(1R,2R,3R)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-3-methoxycarbonylcyclopropanecarbonyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi0.7 [1]
(3S)-3-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[2-[[(1R,2R,3R)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]-3-methoxycarbonylcyclopropyl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi10000.0 [1]
FvatdvgpfafKi8.4 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(1S,2S,3S)-2-[[2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-3-methoxycarbonylcyclopropanecarbonyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-3-phenylpropanoic acidKi10000.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(1R,2R,3R)-2-[[2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-3-methoxycarbonylcyclopropanecarbonyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-3-phenylpropanoic acidKi10000.0 [1]
(3S)-3-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[2-[[(1S,2S,3S)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]-3-methoxycarbonylcyclopropyl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi10000.0 [1]
1-(2',5'-Dioxospiro[7,8-dihydro-5H-naphthalene-6,4'-imidazolidine]-2-yl)-3-[(3R)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]ureaKi4250.0 [1]
N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-3,5-dimethyl-N-[(E)-3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-enyl]-1,2-oxazole-4-carboxamideKi2.39 [1]
N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-N-[(E)-3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-enyl]-1-(trifluoromethyl)cyclopropane-1-carboxamideKi0.05 [1]
N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-2,5-dimethyl-N-[(E)-3-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]prop-2-enyl]pyrazole-3-carboxamideKi0.45 [1]
N-[(1R)-1-(3-Fluoro-4-methylphenyl)ethyl]-2,2-dimethyl-N-[(E)-3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-enyl]propanamideKi0.13 [1]
2-[(8R)-8-(3,5-Difluorophenyl)-8-ethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]acetamideKi0.25 [1]
2-[(8R)-8-(4-Chloro-3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]acetamideKi0.01 [1]
2-[(8R)-8-(4-Chloro-3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]acetamideKi0.02 [1]
2-[(8R)-8-(3,5-Difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]acetamideKi0.03 [1]
N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-2,2-dimethyl-N-[(E)-3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-enyl]propanamideKi0.04 [1]
2,2-Dimethyl-N-[(E)-3-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]prop-2-enyl]-N-[(1R)-1-phenylethyl]propanamideKi0.35 [1]
N-[(1R)-2,3-Dihydro-1H-inden-1-yl]-2,2-dimethyl-N-[(E)-3-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]prop-2-enyl]propanamideKi0.2 [1]
N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-2-methyl-N-[(E)-3-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]prop-2-enyl]propanamideKi1.27 [1]
N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-N-[(E)-3-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]prop-2-enyl]oxane-4-carboxamideKi0.09 [1]
(2S)-N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-1-methyl-N-[(E)-3-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]prop-2-enyl]pyrrolidine-2-carboxamideKi3.38 [1]
2,2-Dimethyl-N-[(E)-3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-enyl]-N-[(1R)-1-phenylethyl]propanamideKi0.22 [1]
N-[(1R)-2,3-Dihydro-1H-inden-1-yl]-2,2-dimethyl-N-[(E)-3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-enyl]propanamideKi0.08 [1]
N-[(3,5-Difluorophenyl)methyl]-2,2-dimethyl-N-[(E)-3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-enyl]propanamideKi0.93 [1]
N-Cycloheptyl-2,2-dimethyl-N-[(E)-3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-enyl]propanamideKi0.89 [1]
N-[(1R)-1-(4-Chlorophenyl)ethyl]-2,2-dimethyl-N-[(E)-3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-enyl]propanamideKi0.31 [1]
N-[(1R)-2,3-Dihydro-1H-inden-1-yl]-2,2-dimethyl-N-[3-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]prop-2-ynyl]propanamideKi0.2 [1]
2,2-Dimethyl-N-[3-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]prop-2-ynyl]-N-[(1R)-1-phenylethyl]propanamideKi0.82 [1]
N-[(1R)-2,3-Dihydro-1H-inden-1-yl]-2,2-dimethyl-N-[3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-ynyl]propanamideKi0.05 [1]
2,2-Dimethyl-N-[3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-ynyl]-N-[(1R)-1-phenylethyl]propanamideKi0.13 [1]
N-[(1R)-2,3-Dihydro-1H-inden-1-yl]-2,2-dimethyl-N-[3-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]propyl]propanamideKi2.06 [1]
2,2-Dimethyl-N-[3-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]propyl]-N-[(1R)-1-phenylethyl]propanamideKi7.6 [1]
N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-2,2-dimethyl-N-[3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]propyl]propanamideKi0.22 [1]
N-[(1R)-2,3-Dihydro-1H-inden-1-yl]-2,2-dimethyl-N-[3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]propyl]propanamideKi0.61 [1]
2,2-Dimethyl-N-[3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]propyl]-N-[(1R)-1-phenylethyl]propanamideKi1.35 [1]
N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-2,2-dimethyl-N-[(E)-3-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]prop-2-enyl]propanamideKi0.16 [1]
(3S)-3-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]piperidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi10000.0 [1]
(3S)-3-[[(2S,3R)-2-[[(2S,4R)-1-[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]-4-hydroxypyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidKi0.01 [1]
N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-1-methyl-N-[(E)-3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-enyl]imidazole-2-carboxamideKi0.16 [1]
N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-3-methyl-N-[(E)-3-[(3S)-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl]prop-2-enyl]thiophene-2-carboxamideKi0.13 [1]
N-[(3R,6S)-6-(2,3-Difluorophenyl)-1-methyl-2-oxoazepan-3-yl]-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-carboxamideKi7.4 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/calcitonin-gene-related-peptide-receptor-calcrl-ramp1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/calcitonin-gene-related-peptide-receptor-calcrl-ramp1-inhibitors-ic50-ki.
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