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Calcitonin gene-related peptide 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-Bromo-N-[(3,5-difluorophenyl)methyl]-6-(1,1-dioxothiazinan-2-yl)-3-hydroxypyridine-2-carboxamideIC502700.0 [1]
4-Bromo-N-[(3,5-difluorophenyl)methyl]-6-(1,1-dioxothiazinan-2-yl)-3-hydroxypyridine-2-carboxamideKi2700.0 [1], 3300.0 [2], 7500.0 [3], 100000.0 [4]
N-[2-(1-Adamantylamino)-2-oxoethyl]-4-bromo-6-(1,1-dioxothiazinan-2-yl)-3-hydroxypyridine-2-carboxamideIC502100.0 [1]
N-[2-(1-Adamantylamino)-2-oxoethyl]-4-bromo-6-(1,1-dioxothiazinan-2-yl)-3-hydroxypyridine-2-carboxamideKi710.0 [1], 840.0 [2], 5600.0 [3]
N-[(2R)-3-(3,5-Dibromo-4-hydroxyphenyl)-1-(dimethylamino)-1-oxopropan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideIC5041.0 [1]
N-[(2R)-3-(3,5-Dibromo-4-hydroxyphenyl)-1-(dimethylamino)-1-oxopropan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideKi8.0 [1], 9.0 [2], 9.3 [3]
Calcitonin gene-related peptide (8-37)IC504.87 [1]
Calcitonin gene-related peptide (8-37)Ki4.5 [1], 5.5 [2]
TelcagepantKi0.78 [1], 100000.0 [2]
5-(1,1-Dioxido-1,2-thiazinan-2-yl)-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamideIC5028000.0 [1]
5-(1,1-Dioxido-1,2-thiazinan-2-yl)-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamideKi7300.0 [1]
MK-3207IC500.12 [1]
MK-3207Ki0.02 [1]
Tert-butyl 2-[[4-bromo-6-(1,1-dioxothiazinan-2-yl)-3-hydroxypyridine-2-carbonyl]amino]acetateIC509800.0 [1]
Tert-butyl 2-[[4-bromo-6-(1,1-dioxothiazinan-2-yl)-3-hydroxypyridine-2-carbonyl]amino]acetateKi1700.0 [1]
4-Bromo-N-[2-(cyclobutylamino)-2-oxoethyl]-6-(1,1-dioxothiazinan-2-yl)-3-hydroxypyridine-2-carboxamideIC502400.0 [1]
4-Bromo-N-[2-(cyclobutylamino)-2-oxoethyl]-6-(1,1-dioxothiazinan-2-yl)-3-hydroxypyridine-2-carboxamideKi1800.0 [1]
N-[(3,5-Difluorophenyl)methyl]-5-(1,1-dioxothiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamideIC502600.0 [1]
N-[(3,5-Difluorophenyl)methyl]-5-(1,1-dioxothiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamideKi1900.0 [1]
CID 16132372Ki0.01 [1]
Tert-butyl 2-[[5-(1,1-dioxothiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carbonyl]amino]acetateIC5010000.0 [1]
Tert-butyl 2-[[5-(1,1-dioxothiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carbonyl]amino]acetateKi8000.0 [1]
5-(1,1-Dioxothiazinan-2-yl)-N-[(3-fluorophenyl)methyl]-8-hydroxy-1,6-naphthyridine-7-carboxamideIC5010000.0 [1]
5-(1,1-Dioxothiazinan-2-yl)-N-[(3-fluorophenyl)methyl]-8-hydroxy-1,6-naphthyridine-7-carboxamideKi5200.0 [1]
4-Bromo-N-[2-(tert-butylamino)-2-oxoethyl]-6-(1,1-dioxothiazinan-2-yl)-3-hydroxypyridine-2-carboxamideIC5010000.0 [1]
4-Bromo-N-[2-(tert-butylamino)-2-oxoethyl]-6-(1,1-dioxothiazinan-2-yl)-3-hydroxypyridine-2-carboxamideKi11000.0 [1]
OlcegepantKi0.01 [1]
CID 16728074Ki16000.0 [1]
(3S)-3-[[(2S,3R)-2-[[2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-2-methylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acidIC50740.0 [1]
4-(3-Bromophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC50130.0 [1]
4-(4-Bromophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC5013.0 [1]
4-(2-Fluorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC50170.0 [1]
4-(2-Chlorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC5015.0 [1]
4-(3-Chlorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC5019.0 [1]
4-(4-Chlorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC5077.0 [1]
4-(2-Bromophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC5012.0 [1]
4-(3-Bromophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC5022.0 [1]
4-[3,5-Bis(trifluoromethyl)phenyl]-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC50190.0 [1]
N-[(2R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-phenylpiperidine-1-carboxamideIC50460.0 [1]
4-(2-Chlorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC509.8 [1]
N-[(2R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-phenylpiperazine-1-carboxamideIC5044.0 [1]
4-(4-Bromophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC5033.0 [1]
4-(2-Fluorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC50130.0 [1]
4-(4-Fluorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC50130.0 [1]
4-(2-Cyanophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC508.9 [1]
4-(4-Cyanophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC5099.0 [1]
Methyl 2-[4-[[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]carbamoyl]piperazin-1-yl]benzoateIC50110.0 [1]
Ethyl 4-[4-[[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]carbamoyl]piperazin-1-yl]benzoateIC5044.0 [1]
N-[(2R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-(2-phenylphenyl)piperazine-1-carboxamideIC50120.0 [1]
4-(2,3-Dichlorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC50350.0 [1]
4-(2,4-Dichlorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC504.3 [1]
4-(3,4-Dichlorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC5012.0 [1]
4-(2,4-Difluorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC50140.0 [1]
4-(3,4-Difluorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC5097.0 [1]
4-(3-Chlorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC50150.0 [1]
4-(4-Chlorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC5041.0 [1]
N-[(2R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-(4-phenylphenyl)piperazine-1-carboxamideIC5046.0 [1]
4-(2-Chloro-4-methylsulfonylphenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC507.0 [1]
4-(2-Fluoro-4-methylsulfonylphenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC5034.0 [1]
4-(4-Fluoro-2-methylsulfonylphenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperazine-1-carboxamideIC502.9 [1]
N-[(2R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-naphthalen-2-ylpiperidine-1-carboxamideIC5014.0 [1]
4-(3-Chloronaphthalen-2-yl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC500.23 [1]
4-(3-Cyanonaphthalen-2-yl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC500.11 [1]
N-[(2R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-(2-methylphenyl)piperidine-1-carboxamideIC50170.0 [1]
4-(2,4-Difluorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC5092.0 [1]
4-(2-Fluoro-3-methylphenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC50120.0 [1]
N-[(2R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-(4-methylphenyl)piperidine-1-carboxamideIC50240.0 [1]
Methyl 2-[1-[[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]carbamoyl]piperidin-4-yl]benzoateIC5054.0 [1]
4-(2,4-Dichlorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC501.1 [1]
4-(3,4-Dichlorophenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC5019.0 [1]
4-(2-Chloro-4-methylphenyl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC5016.0 [1]
4-[2,4-Bis(trifluoromethyl)phenyl]-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC5024.0 [1]
N-[(2R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-naphthalen-1-ylpiperidine-1-carboxamideIC50430.0 [1]
Wvthrlagllsrsggvvknnfvptnvgskaf-NH2IC500.64 [1]
CID 44563410IC501.74 [1]
CID 44563411IC500.71 [1]
CID 44563412IC500.2 [1]
CID 44563413IC500.57 [1]
CID 44563414IC500.58 [1]
CID 44563415IC501.73 [1]
CID 44563416IC500.53 [1]
CID 44563417IC502.1 [1]
CID 44563418IC501.82 [1]
CID 44563419IC501.27 [1]
CID 44563420IC501.02 [1]
CID 44563421IC504.98 [1]
CID 44563422IC503.54 [1]
CID 44563423IC501.97 [1]
CID 44563426IC503.81 [1]
CID 44563427IC5011.21 [1]
CID 44563429IC5078.9 [1]
CID 44563430IC501000.0 [1]
CID 44563431IC502.18 [1]
CID 44563432IC500.79 [1]
CID 44563433IC501.56 [1]
CID 44563436IC5089.91 [1]
1-(1,1-Dioxothiazinan-2-yl)-N-[(3-fluorophenyl)methyl]-4-hydroxyisoquinoline-3-carboxamideKi26000.0 [1]
N-[(3,5-Difluorophenyl)methyl]-5-(1,1-dioxothiazinan-2-yl)-8-hydroxyquinoline-7-carboxamideKi100000.0 [1]
5-(1,1-Dioxothiazinan-2-yl)-N-[(4-fluorophenyl)methyl]-1,6-naphthyridine-7-carboxamideKi100000.0 [1]
5-(1,1-Dioxothiazinan-2-yl)-8-hydroxy-N-(pyridin-3-ylmethyl)-1,6-naphthyridine-7-carboxamideKi14000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Calcitonin gene-related peptide 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/calcitonin-gene-related-peptide-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Calcitonin gene-related peptide 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/calcitonin-gene-related-peptide-1-inhibitors-ic50-ki.
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