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C3a anaphylatoxin chemotactic receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
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▼
Standard Values (in nM)
▲
▼
(2S)-5-(Diaminomethylideneamino)-2-[[2-(2,2-diphenylethoxy)acetyl]amino]pentanoic acidIC501.3 [1], 28.0 [2], 501.19 [3], 1300.0 [4]
(2S)-2-[(5-Benzhydrylfuran-2-carbonyl)amino]-5-(diaminomethylideneamino)pentanoic acidIC5055.0 [1], 63.1 [2], 1800.0 [3]
CID 91827355IC500.8 [1], 8.0 [2]
(2S)-2-[(5-Benzhydryl-1,2,4-oxadiazole-3-carbonyl)amino]-5-(diaminomethylideneamino)pentanoic acidIC5054.0 [1], 1200.0 [2]
(2S)-2-[(2-Benzhydryl-4-methyl-1,3-oxazole-5-carbonyl)amino]-5-(diaminomethylideneamino)pentanoic acidIC50100.0 [1], 2900.0 [2]
(2S)-2-[(2-Benzhydryl-4-phenyl-1,3-oxazole-5-carbonyl)amino]-5-(diaminomethylideneamino)pentanoic acidIC50110.0 [1], 2000.0 [2]
(2S)-5-(Diaminomethylideneamino)-2-[[2-(2,2-diphenylethylamino)acetyl]amino]pentanoic acidIC504.0 [1], 150.0 [2]
(2S)-2-[(3-Benzhydryl-1,2,4-oxadiazole-5-carbonyl)amino]-5-(diaminomethylideneamino)pentanoic acidIC5012.0 [1], 1300.0 [2]
(2S)-2-[(5-Benzhydryl-1,3,4-oxadiazole-2-carbonyl)amino]-5-(diaminomethylideneamino)pentanoic acidIC50967.0 [1], 19000.0 [2]
(2S)-5-(Diaminomethylideneamino)-2-(5,5-diphenylpentanoylamino)pentanoic acidIC506.0 [1], 96.0 [2]
(2S)-5-(Carbamoylamino)-2-[[2-(2,2-diphenylethoxy)acetyl]amino]pentanoic acidIC5010.0 [1], 1300.0 [2]
2,7-Dichloro-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]-9H-xanthene-9-carboxamideIC50630.96 [1], 1584.89 [2]
2,2-Diphenyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC503162.28 [1], 12589.25 [2]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-cyclohexylpropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50238.0 [1], 240.0 [2]
(4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-oxopentanoic acidIC5026.3 [1], 1122.02 [2]
(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-carboxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-6-aminohexanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoic acidIC5015.49 [1], 8912.51 [2]
CID 71566654IC509.0 [1]
C3a-HexapeptideIC506309.57 [1]
(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50125.89 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5041.69 [1]
(2S)-2-[(2-Benzhydryl-5-methyl-1H-imidazole-4-carbonyl)amino]-5-(diaminomethylideneamino)pentanoic acidIC5010.0 [1]
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-Amino-3-(1H-indol-3-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5031622.78 [1]
(2S)-2-[(2-Benzhydryl-1H-imidazole-5-carbonyl)amino]-5-(diaminomethylideneamino)pentanoic acidIC507.0 [1]
(2S)-2-[(2-Benzhydryl-1,5-dimethylimidazole-4-carbonyl)amino]-5-(diaminomethylideneamino)pentanoic acidIC5031.0 [1]
(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC506309.57 [1]
(2S)-5-(Diaminomethylideneamino)-2-[[2-[(1S,2S)-1-[(2,3-dimethoxybenzoyl)amino]-2-methylbutyl]-1,3-oxazole-4-carbonyl]amino]pentanoic acidIC50710.0 [1]
(2S)-5-(Diaminomethylideneamino)-2-[[2-[(1S)-1-[[2-(4-fluorophenyl)acetyl]amino]-3-methylbutyl]-1,3-oxazole-4-carbonyl]amino]pentanoic acidIC50102.0 [1]
(2S)-5-(Diaminomethylideneamino)-2-[[2-[(1S,2S)-2-methyl-1-[(1-propan-2-ylcyclohexa-2,5-diene-1-carbonyl)amino]butyl]-1,3-oxazole-4-carbonyl]amino]pentanoic acidIC50754.0 [1]
(2S)-5-(Diaminomethylideneamino)-2-[[2-[(1S,2S)-1-[(2,4-dimethoxybenzoyl)amino]-2-methylbutyl]-1,3-oxazole-4-carbonyl]amino]pentanoic acidIC50870.0 [1]
(S)-2-(2-Benzhydryl-6-oxo-4,6-dihydro-5H-pyrrolo[3,4-d]thiazole-5-yl)-5-guanidinopentanoic acidIC50320.0 [1]
(2S)-5-(Diaminomethylideneamino)-2-[[2-[(1S)-3-methyl-1-[2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]propanoylamino]butyl]-1,3-oxazole-4-carbonyl]amino]pentanoic acidIC50450.0 [1]
(2S)-5-(Diaminomethylideneamino)-2-[[2-[(1S)-3-methyl-1-[2-[4-(2-methylpropyl)phenyl]propanoylamino]butyl]-1,3-oxazole-4-carbonyl]amino]pentanoic acidIC501030.0 [1]
(2S)-5-(Diaminomethylideneamino)-2-[[5-methyl-2-[(1S)-3-methyl-1-[(2-methylpropan-2-yl)oxycarbonylamino]butyl]-1,3-oxazole-4-carbonyl]amino]pentanoic acidIC5014.0 [1]
(2S)-5-(Diaminomethylideneamino)-2-[[2-[(1S,2S)-2-methyl-1-(quinoline-2-carbonylamino)butyl]-1,3-oxazole-4-carbonyl]amino]pentanoic acidIC50123.0 [1]
1,3-Bis-[(Z)-4-methyl-benzylimino]-2,3-dihydro-1H-isoindoleIC501700.0 [1]
1,3-Bis-[(Z)-2-(4-fluoro-phenyl)-ethylimino]-2,3-dihydro-1H-isoindoleIC5011410.0 [1]
1,3-Bis-[(Z)-2-(4-fluoro-phenyl)-ethylimino]-5-propoxy-2,3-dihydro-1H-isoindoleIC505970.0 [1]
1-[(Z)-2-(4-Chloro-phenyl)-ethylimino]-3-[(Z)-isopropylimino]-2,3-dihydro-1H-isoindoleIC508450.0 [1]
1,3-Bis-[(Z)-2-(4-chloro-phenyl)-ethylimino]-2,3-dihydro-1H-isoindoleIC507160.0 [1]
5-Methoxy-1,3-bis-[(Z)-2-p-tolyl-ethylimino]-2,3-dihydro-1H-isoindoleIC5012550.0 [1]
1,3-Bis-[(Z)-2-p-tolyl-ethylimino]-2,3-dihydro-1H-isoindoleIC506140.0 [1]
1,3-Bis-[(Z)-2-(4-chloro-phenyl)-propylimino]-2,3-dihydro-1H-isoindoleIC505900.0 [1]
2-[1,3-Bis[2-(4-fluorophenyl)ethylimino]isoindol-5-yl]oxy-N,N-dimethylethanamineIC505360.0 [1]
5,6-Dichloro-1-N,3-N-bis[2-(4-methylphenyl)ethyl]isoindole-1,3-diimineIC5048000.0 [1]
N-[1,3-Bis[(4-methylphenyl)methylimino]isoindol-5-yl]acetamideIC5032000.0 [1]
1-N,3-N-Bis[2-(4-fluorophenyl)ethyl]pyrrolo[3,4-c]pyridine-1,3-diimineIC5013400.0 [1]
1,3-Bis-[(Z)-2-(3-chloro-phenyl)-ethylimino]-2,3-dihydro-1H-isoindoleIC507480.0 [1]
2-Cyclohexyl-2-(3-methylphenyl)-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC5079.43 [1]
(2S)-2-[[1-[(2-Bromophenyl)methyl]-2-oxopyridine-3-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5050.0 [1]
(2R)-5-(Diaminomethylideneamino)-2-[[5-(3-fluorophenyl)furan-2-carbonyl]amino]pentanoic acidIC50316.23 [1]
(2R)-5-(Diaminomethylideneamino)-2-[[5-(3-methylphenyl)furan-2-carbonyl]amino]pentanoic acidIC50125.89 [1]
(2R)-5-(Diaminomethylideneamino)-2-[[5-(3-methoxyphenyl)furan-2-carbonyl]amino]pentanoic acidIC50316.23 [1]
(2R)-5-(Diaminomethylideneamino)-2-[[5-(3-ethoxyphenyl)furan-2-carbonyl]amino]pentanoic acidIC50199.53 [1]
(2R)-5-(Diaminomethylideneamino)-2-[[5-[3-(hydroxymethyl)phenyl]furan-2-carbonyl]amino]pentanoic acidIC50794.33 [1]
(2R)-2-[[5-(3-Cyanophenyl)furan-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50199.53 [1]
(2R)-2-[[5-(3-Chlorophenyl)furan-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5079.43 [1]
(2R)-2-[[5-(3-Chloro-4-fluorophenyl)furan-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50199.53 [1]
(2R)-2-[[5-(5-Chloro-2-methylphenyl)furan-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50794.33 [1]
(2R)-5-(Diaminomethylideneamino)-2-[[5-(2,5-dichlorophenyl)furan-2-carbonyl]amino]pentanoic acidIC501584.89 [1]
(2R)-2-[[5-(1-Benzothiophen-3-yl)furan-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50316.23 [1]
(2R)-5-(Diaminomethylideneamino)-2-[(5-dibenzofuran-4-ylfuran-2-carbonyl)amino]pentanoic acidIC503981.07 [1]
(2R)-2-[[4-(3-Chlorophenyl)benzoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50100000.0 [1]
(2R)-2-[[3-(3-Chlorophenyl)benzoyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50794.33 [1]
(2R)-2-[[5-(3-Chlorophenyl)thiophene-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC506309.57 [1]
(2R)-2-[(4-Benzhydrylpiperazine-1-carbonyl)amino]-5-(diaminomethylideneamino)pentanoic acidIC5050118.72 [1]
(2R)-2-[(4-Benzhydrylbenzoyl)amino]-5-(diaminomethylideneamino)pentanoic acidIC50794.33 [1]
(2R)-2-[[5-[Bis(3-fluorophenyl)methyl]furan-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5031.62 [1]
(2R)-2-[[5-[Bis(3-chlorophenyl)methyl]furan-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC5015.85 [1]
(2R)-2-[[5-[Bis(4-chlorophenyl)methyl]furan-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acidIC50158.49 [1]
N-[1-(3-Pyridin-3-ylpropanoyl)piperidin-4-yl]-9,10-dihydroanthracene-9-carboxamideIC5079432.82 [1]
2,2-Bis(4-chlorophenyl)-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC5019952.62 [1]
C3A Receptor AgonistIC50794.33 [1]
2-(4,4-Dimethylcyclohexyl)-2-phenyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC501000.0 [1]
2-(4,4-Difluorocyclohexyl)-2-phenyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC50630.96 [1]
2-Phenyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]-2-(3,3,5,5-tetramethylcyclohexyl)acetamideIC5063095.73 [1]
(E)-3-Cyclohexyl-2-phenyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]prop-2-enamideIC5025118.86 [1]
3-Cyclohexyl-2-phenyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]propanamideIC50794.33 [1]
2-Cyclopentyl-2-phenyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC50794.33 [1]
2-Cyclopent-3-en-1-yl-2-phenyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC503162.28 [1]
2-Cyclohexyl-2-(4-methylphenyl)-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC50794.33 [1]
2-Cyclohexyl-2-(2-methylphenyl)-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC502511.89 [1]
2-Cyclohexyl-2-(3,5-dimethylphenyl)-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC50125.89 [1]
2-Cyclohexyl-2-(4-methoxyphenyl)-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC50630.96 [1]
2-(4-Chlorophenyl)-2-cyclohexyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC50199.53 [1]
2-(2-Chlorophenyl)-2-cyclohex-2-en-1-yl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC501995.26 [1]
2-(3-Chlorophenyl)-2-cyclohex-2-en-1-yl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC5050.12 [1]
2-Cyclohexyl-2-(4-fluorophenyl)-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC50158.49 [1]
2-Cyclohexyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]-2-(3,4,5-trifluorophenyl)acetamideIC50100.0 [1]
2-Cyclohexyl-2-(4-nitrophenyl)-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC50316.23 [1]
2-Cyclohexyl-2-naphthalen-2-yl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC50794.33 [1]
2,2-Dicyclohexyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamideIC501000.0 [1]
2-Cyclohexyl-N-[1-[3-(2-methoxypyridin-3-yl)propanoyl]piperidin-4-yl]-2-phenylacetamideIC5015848.93 [1]
2-Cyclohexyl-N-[1-[3-(2-fluoropyridin-3-yl)propanoyl]piperidin-4-yl]-2-phenylacetamideIC5031.62 [1]
2-Cyclohexyl-N-[1-[3-(6-fluoropyridin-3-yl)propanoyl]piperidin-4-yl]-2-phenylacetamideIC501258.93 [1]
2-Cyclohexyl-2-phenyl-N-[1-[(E)-3-pyridin-3-ylprop-2-enoyl]piperidin-4-yl]acetamideIC501000.0 [1]
2-Cyclohexyl-N-[1-[(E)-3-(5-methylpyridin-3-yl)prop-2-enoyl]piperidin-4-yl]-2-phenylacetamideIC5050118.72 [1]
2-Cyclohexyl-N-[1-[3-(2-fluorophenyl)propanoyl]piperidin-4-yl]-2-phenylacetamideIC501995.26 [1]
2-Cyclohexyl-N-[1-[2-(2,3-difluorophenyl)acetyl]piperidin-4-yl]-2-phenylacetamideIC5010000.0 [1]
2-Cyclohexyl-N-[1-[(E)-3-(2-fluorophenyl)prop-2-enoyl]piperidin-4-yl]-2-phenylacetamideIC5012589.25 [1]
2-Cyclohexyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]-2-thiophen-3-ylacetamideIC50199.53 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ C3a anaphylatoxin chemotactic receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Dec. 2024, https://www.aatbio.com/data-sets/c3a-anaphylatoxin-chemotactic-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 20). Quest Database™ C3a anaphylatoxin chemotactic receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/c3a-anaphylatoxin-chemotactic-receptor-inhibitors-ic50-ki.
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