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c-Jun N-terminal kinase, JNK Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
TanzisertibIC50200.0 [1], 1000.0 [2]
2-N-(4-Aminocyclohexyl)-9-cyclopentyl-8-N-(2,4-difluorophenyl)purine-2,8-diamineIC50350.0 [1], 400.0 [2]
trans-4-[(4-{4-[3-(Methylsulfonyl)propoxy]-1h-Indazol-1-Yl}pyrimidin-2-Yl)amino]cyclohexanolIC501000.0 [1]
2-Methyl-N-[4-[(7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl]propanamideIC5050.0 [1], 1232.0 [2]
1-[4-[(7-Oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl]-3-propan-2-ylureaIC5050.0 [1], 1733.0 [2]
SaracatinibIC5010000.0 [1]
Purvalanol BIC5010000.0 [1]
Purvalanol AIC501000.0 [1]
LY-3009120IC50470.0 [1]
4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenolIC503300.0 [1]
JNK Inhibitor VIIIKi4.0 [1]
4-[[9-[(3R)-3-Oxolanyl]-8-(2,4,6-trifluoroanilino)-2-purinyl]amino]-1-cyclohexanolIC501200.0 [1]
HalicinIC50700.0 [1]
4-Amino-5-cyano-6-ethoxy-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC50530.0 [1]
Urea, N-ethyl-N'-(3-((4-methylphenyl)amino)pyrido(2,3-b)pyrazin-6-yl)-IC50100000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi440.0 [1]
3-Pyridin-4-Yl-1h-IndazoleIC501584.89 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideIC50480.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopropylmethoxy)picolinamideIC50560.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(thiophen-3-yl)picolinamideIC50610.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopentylamino)picolinamideIC50480.0 [1]
6-Acetyl-8-cyclopentyl-5-methyl-2-(4-piperazin-1-yl-phenylamino)-8H-pyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanolIC5050000.0 [1]
Meridianin EIC501000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi9.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi13.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi4.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi1900.0 [1]
4-Amino-5-cyano-6-ethoxy-N-[(2-sulfamoylphenyl)methyl]pyridine-2-carboxamideIC50110.0 [1]
4-Amino-5-cyano-6-ethoxy-N-(pyridin-3-ylmethyl)pyridine-2-carboxamideIC501200.0 [1]
4-Amino-N-benzyl-5-cyano-6-ethoxypyridine-2-carboxamideIC501100.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-isopropoxypicolinamideIC50250.0 [1]
2-Methoxy-12-(2-hydroxyethyl)-13,14-dihydronaphthol[2,1-a]pyrrolo[3,4-c]carbazole-5-oneIC5030000.0 [1]
6-Chloro-9-hydroxy-1-methyl-3-(trifluoromethyl)-1H,4H,9H-pyrazolo[3,4-b]quinolin-4-oneIC5016400.0 [1]
1,3-Dimethyl-6-chloro-9-propoxy-1H-pyrazolo[3,4-b]quinoline-4(9H)-oneIC505600.0 [1]
6-Chloro-9-hydroxy-3-methyl-1-phenyl-1H,4H,9H-pyrazolo[3,4-b]quinolin-4-oneIC5030000.0 [1]
Methyl 7-chloro-3-[[4-(2-hydroxyethylcarbamoyl)phenyl]methyl]-4-oxo-1-phenylquinoline-2-carboxylateIC503000.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-6-ethoxy-5-ethynylpicolinamideIC501890.0 [1]
4-Amino-6-ethoxy-5-(3-hydroxyprop-1-ynyl)-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC505700.0 [1]
4-Amino-6-ethoxy-5-(4-hydroxybut-1-ynyl)-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC507360.0 [1]
4-Amino-6-ethoxy-5-[(E)-5-hydroxypent-3-en-1-ynyl]-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC505240.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-6-(3-chlorophenyl)-5-cyanopicolinamideIC501200.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(phenethylamino)picolinamideIC502700.0 [1]
4-Amino-6-[2-(carbamoylamino)ethylamino]-5-cyano-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC5010000.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(3-hydroxyphenyl)picolinamideIC509400.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(3-methoxyphenyl)picolinamideIC501800.0 [1]
4-Amino-6-[(3-amino-3-oxopropyl)amino]-5-cyano-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC5010000.0 [1]
N-(4-(Methylsulfonyl)benzyl)-6-(2-acetamidoethylamino)-4-amino-5-cyanopicolinamideIC5010000.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(3-(methylsulfonyl)phenyl)picolinamideIC5010500.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(3-hydroxypropylamino)picolinamideIC508300.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(2-hydroxyethylamino)picolinamideIC5010000.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(furan-3-yl)picolinamideIC504300.0 [1]
5-[4-Amino-3-cyano-6-[(4-methylsulfonylphenyl)methylcarbamoyl]pyridin-2-yl]thiophene-2-carboxylic acidIC5010000.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(2-methoxyethylamino)picolinamideIC505900.0 [1]
4-Amino-5-cyano-6-[2-(hydroxymethyl)thiophen-3-yl]-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC5010800.0 [1]
4-Amino-6-[2-[(benzylamino)methyl]thiophen-3-yl]-5-cyano-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC508010.0 [1]
4-Amino-5-cyano-6-[[(2S)-1-hydroxypropan-2-yl]amino]-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC502600.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(pyridin-3-yl)picolinamideIC507300.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(pyrimidin-5-yl)picolinamideIC5010000.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(prop-1-enyl)picolinamideIC50890.0 [1]
4-Amino-5-cyano-6-(1,3-dihydroxypropan-2-ylamino)-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC5010000.0 [1]
4-Amino-5-cyano-N-[(4-methylsulfonylphenyl)methyl]-6-[(Z)-prop-1-enyl]pyridine-2-carboxamideIC505500.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-styrylpicolinamideIC50350.0 [1]
4-Amino-5-cyano-6-[(E)-4-hydroxybut-1-enyl]-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC505300.0 [1]
3-(6-((4-(Methylsulfonyl)benzyl)carbamoyl)-4-amino-3-cyanopyridin-2-yl)acrylic acidIC502500.0 [1]
N6-(4-(Methylsulfonyl)benzyl)-4-amino-3-cyano-N2-isopropylpyridine-2,6-dicarboxamideIC502900.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-isobutoxypicolinamideIC50700.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopentylmethoxy)picolinamideIC50490.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(isopropylamino)picolinamideIC50490.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-6-ethoxy-5-vinylpicolinamideIC504630.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-6-ethoxy-5-styrylpicolinamideIC506920.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopropylamino)picolinamideIC501200.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclobutylamino)picolinamideIC50620.0 [1]
4-Amino-5-[(E)-3,3-dimethylbut-1-enyl]-6-ethoxy-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC5010000.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-(2-cyanovinyl)-6-ethoxypicolinamideIC50807.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-(but-1-en-3-ynyl)-6-ethoxypicolinamideIC501400.0 [1]
N2-(4-(Methylsulfonyl)benzyl)-4-amino-6-ethoxypyridine-2,5-dicarboxamideIC507540.0 [1]
N-[4-Chloro-3-(pyridin-3-yloxymethyl)phenyl]-3-fluoro-5-morpholin-4-ylbenzamideIC5010000.0 [1]
2-Isopropoxy-12-(2-hydroxyethyl)-13,14-dihydronaphthol[2,1-a]pyrrolo[3,4-c]carbazole-5-oneIC5030000.0 [1]
5-(3-Tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4-difluorophenyl)-1,3-oxazoleIC5010000.0 [1]
N-(5-Chloro-1,3-benzodioxol-4-yl)-5-(oxan-4-yloxy)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC5010000.0 [1]
5-(3-Propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazoleIC5010000.0 [1]
(2S)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-3-hydroxypropanamideIC5010000.0 [1]
(S)-1-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamideIC5010000.0 [1]
(R)-1-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamideIC5010000.0 [1]
(R)-2-((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methylamino)propanamideIC5010000.0 [1]
3-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-(2-methoxyethyl)azetidine-3-carboxamideIC5010000.0 [1]
(R)-2-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)propanamideIC5010000.0 [1]
(R)-1-((4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamideIC5010000.0 [1]
3-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-methylazetidine-3-carboxamideIC5010000.0 [1]
(S)-1-((4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamideIC5010000.0 [1]
3-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-propan-2-ylazetidine-3-carboxamideIC5010000.0 [1]
(S)-2-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)propanamideIC5010000.0 [1]
4-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-1-methylpiperidine-4-carboxamideIC5010000.0 [1]
6-Chloro-17-methyl-2-oxido-14,16,17-triaza-2-azoniatetracyclo[8.7.0.03,8.011,16]heptadeca-1,3(8),4,6,10-pentaene-9,15-dioneIC50850.0 [1]
(2R)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-N-methylpropanamideIC5010000.0 [1]
2-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)acetamideIC5010000.0 [1]
(2S)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-4-methoxybutanamideIC5010000.0 [1]
(2S)-2-[[4-(3-Chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]methyl-methylamino]-3-methoxypropanamideIC5010000.0 [1]
4-[[4-Cyclopentyloxy-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-N-methylbenzamideIC501300.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ c-Jun N-terminal kinase, JNK Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/c-jun-n-terminal-kinase-jnk-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ c-Jun N-terminal kinase, JNK Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/c-jun-n-terminal-kinase-jnk-inhibitors-ic50-ki.
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