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c-Jun N-terminal kinase 2 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
DoramapimodIC506.0 [1], 10.0 [2], 98.0 [3], 150.0 [4], 1000.0 [5]
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazoleIC50320.0 [1]
JNK Inhibitor VIC50220.0 [1], 5000.0 [2]
1,9-PyrazoloanthroneIC5040.0 [1]
Jnk-IN-8IC501.0 [1], 18.7 [2]
4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amineIC501170.0 [1], 2200.0 [2]
Methyl 6-bromo-2-[(4-methylsulfonylphenyl)methyl]-1-oxo-4-phenylisoquinoline-3-carboxylateIC5030.0 [1], 34.0 [2], 72.0 [3]
3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamideIC50200000.0 [1]
3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamideKi400000.0 [1]
JNK Inhibitor VIIIIC50160.0 [1]
JNK Inhibitor VIIIKi4.0 [1]
TanzisertibIC507.0 [1]
TanzisertibKi6.2 [1]
Amg-548IC5076.0 [1], 220.0 [2]
1-[1-(3-Aminophenyl)-3-Tert-Butyl-1h-Pyrazol-5-Yl]-3-Naphthalen-1-YlureaIC5070.0 [1], 90.0 [2]
4-Amino-5-cyano-6-ethoxy-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamideIC50120.0 [1]
4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyrimidin-2-amineIC50675.0 [1], 1550.0 [2]
1-[3-Tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)phenyl]ureaIC501800.0 [1], 12600.0 [2]
5-[(2S,3S,4R,5S)-5-(1,3-Benzodioxol-5-yl)-3,4-dimethyloxolan-2-yl]-1,3-benzodioxoleIC502200.0 [1], 2500.0 [2]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideIC5074.0 [1]
4-[3-(4-Fluorophenyl)-5-isopropylisoxazol-4-yl]pyridineIC501280.0 [1]
1-{4-[(6-Aminoquinazolin-4-Yl)amino]phenyl}-3-[3-Tert-Butyl-1-(3-Methylphenyl)-1h-Pyrazol-5-Yl]ureaIC50570.0 [1], 770.0 [2]
1-{3-[(6-Aminoquinazolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]ureaIC50150.0 [1], 1200.0 [2]
N-[[5-[4-(Benzotriazol-1-yl)piperidin-1-yl]sulfonylthiophen-2-yl]methyl]-4-chlorobenzamideIC50650.0 [1]
1-Benzyl-4-(benzyloxy)-3-bromopyridin-2(1H)-oneIC50200000.0 [1]
3-Bromo-4-[(2,4-difluorophenyl)methoxy]-1-[[4-[(dimethylamino)methyl]phenyl]methyl]-6-methylpyridin-2-oneIC50171000.0 [1], 200000.0 [2]
Methyl 3-[2-(2-thienyl)acetamido]thiophene-2-carboxylateIC5021400.0 [1], 23000.0 [2]
2,4-Bis(1,3-benzodioxol-5-yl)-4-oxobutanoic acidIC5010700.0 [1], 43000.0 [2]
1-{3-[(6-Aminoquinazolin-4-Yl)amino]phenyl}-3-[3-Tert-Butyl-1-(4-Methylphenyl)-1h-Pyrazol-5-Yl]ureaIC501400.0 [1], 1900.0 [2]
1-(3-Tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)-3-(4-chlorophenyl)ureaIC50440.0 [1], 1300.0 [2]
N-[4-Bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1-yl)acetamideIC5042.0 [1]
trans-4-[(4-{4-[3-(Methylsulfonyl)propoxy]-1h-Indazol-1-Yl}pyrimidin-2-Yl)amino]cyclohexanolIC5024.0 [1]
4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1R)-1-phenylethyl]pyrimidin-2-amineIC50300.0 [1], 675.0 [2]
Pyridine, 4-(2-(4-fluorophenyl)-5-(4-(methylsulfinyl)phenyl)-1H-pyrrol-3-yl)-IC501500.0 [1], 7610.0 [2]
4-[6-Morpholin-4-yl-3-[3-(trifluoromethyl)phenyl]pyridazin-4-yl]-N-[(1S)-1-phenylethyl]pyrimidin-2-amineIC50820.0 [1], 1400.0 [2]
1-Ethyl-3-[4-[(7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl]ureaIC5026.0 [1], 61.0 [2]
2-Methyl-N-[4-[(7-oxo-8-propan-2-ylpyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl]propanamideIC5029.0 [1], 143.0 [2]
[(E)-[(5Z)-5-(1,3-Benzodioxol-5-ylmethylidene)-4-oxo-1,3-thiazolidin-2-ylidene]amino]thioureaIC50630.0 [1], 1700.0 [2]
Naphtho(2',1':4,5)(1,3)thiazolo(2,3-c)(1,2,4)triazole, 8-(4-methoxyphenyl)-IC5021500.0 [1], 41000.0 [2]
2-((8-(2,3-Dimethoxyphenyl)-7-methyl-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromen-6-yl)amino)ethanolIC502200.0 [1]
3-[(4-Methylphenyl)diazenyl]-5,6,7,8-tetrahydropyrazolo[5,1-b]quinazolin-2-amineIC5014500.0 [1], 20000.0 [2]
10-[(4-Methoxyphenyl)diazenyl]-1,8,12-triazatricyclo[7.3.0.03,7]dodeca-2,7,9,11-tetraen-11-amineIC507800.0 [1], 15500.0 [2]
2-[[5-Chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyridin-4-yl]amino]-N-methylbenzamideIC5050.0 [1]
1-{4-[(6-Aminoquinolin-4-Yl)amino]phenyl}-3-[3-Tert-Butyl-1-(3-Methylphenyl)-1h-Pyrazol-5-Yl]ureaIC50100.0 [1], 380.0 [2]
4-(4-Imidazo[1,2-a]pyridin-3-yl-pyrimidin-2-ylamino)-cyclohexanolIC50250.0 [1], 253.5 [2]
10-[(4-Bromophenyl)diazenyl]-1,3,4,8,12-pentazatricyclo[7.3.0.02,6]dodeca-2,5,7,11-tetraene-5,7,11-triamineIC5014000.0 [1], 58000.0 [2]
4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrrol-3-yl]-pyridineIC501080.0 [1], 6850.0 [2]
StaurosporineIC502270.0 [1]
SotrastaurinIC5010000.0 [1]
FuraltadoneIC5013500.0 [1]
Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-IC505.0 [1]
NeflamapimodIC50200000.0 [1]
2-({5-Chloro-2-[(2-Methoxy-4-Morpholin-4-Ylphenyl)amino]pyrimidin-4-Yl}amino)-N-MethylbenzamideIC5042.0 [1]
Amg-458IC50100000.0 [1]
4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidineIC5020.0 [1]
2-(2-(2-Methoxy-4-morpholinophenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzamideIC50120.0 [1]
4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[(5-nitro-2-thiazolyl)thio]-1H-1,2,4-triazol-5-oneIC50500.0 [1]
TCS JNK 5aIC50316.23 [1]
4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamideIC50173.0 [1]
Pyrimidone, 22IC50100000.0 [1]
2-(2-Quinolin-3-Ylpyridin-4-Yl)-1,5,6,7-Tetrahydro-4h-Pyrrolo[3,2-C]pyridin-4-OneIC50200000.0 [1]
2-(4-Fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-oneIC50100000.0 [1]
CID 72547959IC50514.0 [1]
N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamideIC50100000.0 [1]
N-[4-[3-(6-Methylpyridin-3-yl)-1,2,4-triazol-1-yl]phenyl]-4-(3-morpholin-4-ylphenyl)pyrimidin-2-amineIC50283.0 [1]
6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3-oneIC5010000.0 [1]
4-[[9-[(3R)-3-Oxolanyl]-8-(2,4,6-trifluoroanilino)-2-purinyl]amino]-1-cyclohexanolIC5038.0 [1]
8-N-(2,2-Dimethylpropyl)-2-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineIC5076.0 [1]
2-[2-(2-Fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-oneIC5021000.0 [1]
3-Nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamideIC507700.0 [1]
CID 44814409IC5010000.0 [1]
4-(4-Fluorophenyl)-5-(4-pyridyl)-1H-imidazoleIC50195.0 [1]
Methyl 3-(2-(4-methoxyphenyl)acetamido)thiophene-2-carboxylateIC5014100.0 [1]
N-[3-Cyano-7-(cyclopropanecarbonyl)-5,6-dihydro-4H-thieno[2,3-b]pyridin-2-yl]naphthalene-1-carboxamideIC50316.23 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideIC501100.0 [1]
Lck InhibitorIC5040000.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopropylmethoxy)picolinamideIC5047.0 [1]
CID 25222038IC5099.0 [1]
Zuihonin AIC502500.0 [1]
6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylic acidIC50200000.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(thiophen-3-yl)picolinamideIC50390.0 [1]
N-(4-(Methylsulfonyl)benzyl)-4-amino-5-cyano-6-(cyclopentylamino)picolinamideIC50290.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
Jnk-IN-7IC500.7 [1]
2-[[1-Cyclopentyl-5-[1-(Oxetan-3-Yl)piperidin-4-Yl]pyrazol-3-Yl]amino]pyridine-4-CarbonitrileIC505000.0 [1]
1-Benzyl-4-(benzyloxy)pyridin-2(1H)-oneIC50200000.0 [1]
[5-(3-Amino-3-methyl-but-1-ynyl)-2-methoxy-phenyl]-[4-(2,4-difluoro-phenylamino)-phenyl]-methanoneIC5010000.0 [1]
4-[4-(4-Fluorophenyl)-2-(1-methylpiperidin-4-yl)-1,3-thiazol-5-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amineIC50261.0 [1]
2-Phenyl-4-[3-(trifluoromethyl)phenyl]-5-(4-pyridyl)-1H-imidazoleIC50910.0 [1]
4-(2,4-Diphenyl-1H-imidazol-5-yl)-N-methylpyrimidin-2-amineIC50175.0 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideIC50150.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-phenylacetamideIC50770.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideIC5070.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)isobutyramideIC508400.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideIC5064.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideIC507700.0 [1]
3-[2-(Pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetrahydroquinazolin-2-oneIC5010000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ c-Jun N-terminal kinase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/c-jun-n-terminal-kinase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ c-Jun N-terminal kinase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/c-jun-n-terminal-kinase-2-inhibitors-ic50-ki.
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