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C-C chemokine receptor type 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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1-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(2-hydroxy-2-methylpropyl)ureaIC506.0 [1]
1-[4-(4-Chloro-3-methoxyphenyl)piperazin-1-yl]-2-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanoneIC503.9 [1]
(1R,3R)-N-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-hydroxycyclopentane-1-carboxamideIC504.0 [1]
BX-471 free baseIC501.5 [1], 5.5 [2], 18.0 [3], 31.0 [4]
BX-471 free baseKi1.0 [1]
N-[(2R)-1-[4-(4-Chlorophenyl)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzamideIC5015.0 [1], 78.0 [2], 85.0 [3]
BX471 (hydrochloride)IC500.4 [1], 2.36 [2], 40.0 [3], 550.0 [4]
5-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidyl]-2,2-diphenyl-pentanenitrileIC5048.0 [1], 630.0 [2], 2500.0 [3]
5-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidyl]-2,2-diphenyl-pentanenitrileKi52.0 [1]
N-[(2S,3S,5R)-1-Cyclohexyl-3-hydroxy-7-methyl-5-(methylcarbamoyl)octan-2-yl]quinoline-3-carboxamideIC50840.0 [1], 2280.0 [2], 2300.0 [3]
J-113863 Cation, trans-IC500.73 [1], 0.9 [2], 47.0 [3]
(2R)-2-N-[(4-Chlorophenyl)methyl]-2-N-methyl-1-N-[4-(trifluoromethyl)phenyl]pyrrolidine-1,2-dicarboxamideIC5022.0 [1], 140.0 [2]
N-[5-Chloro-2-[(E)-3-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-3-oxoprop-1-enyl]-4-methoxyphenyl]acetamideIC501.5 [1], 4.0 [2], 20.0 [3], 69.7 [4]
N-[5-Chloro-2-[(E)-3-[3-[(4-fluorophenyl)methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-3-oxoprop-1-enyl]phenyl]-2-(dimethylamino)acetamideIC509.0 [1], 10.0 [2], 30.0 [3], 41.0 [4]
N-[5-Chloro-2-[(E)-3-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-3-oxoprop-1-enyl]phenyl]acetamideIC501.0 [1], 9.97 [2], 30.0 [3], 320.0 [4]
N-[5-Chloro-2-[(E)-3-[3-[(4-fluorophenyl)methyl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-3-oxoprop-1-enyl]-4-methoxyphenyl]acetamideIC500.0 [1], 1.0 [2], 7.0 [3], 7.5 [4]
[5-Chloro-2-[(E)-3-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-3-oxoprop-1-enyl]phenyl]ureaIC500.9 [1], 16.0 [2], 40.0 [3], 45.0 [4]
N-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-hydroxy-3-methylbutanamideIC503.0 [1], 5.2 [2]
N-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-hydroxy-3-methylbutanamideKi3.7 [1]
N-[(2S,3S,5R)-5-Carbamoyl-3-hydroxy-8-methyl-1-phenylnonan-2-yl]quinoxaline-2-carboxamideIC502.0 [1], 28.0 [2]
N-[2-[(2S)-3-(5-Fluorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]acetamideIC500.52 [1], 2.6 [2]
N-[2-[(2S)-3-(5-Chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-hydroxyphenyl]acetamideIC500.36 [1], 2.0 [2]
N-(2-(3-(4-(4-Fluorobenzyl)piperazin-1-yl)-3-oxoprop-1-enyl)-5-chlorophenyl)acetamideIC5058.0 [1], 150.0 [2], 190.0 [3]
N-[5-Chloro-2-[(E)-3-[(2S,5R)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-3-oxoprop-1-enyl]phenyl]acetamideIC501.0 [1], 100.0 [2], 10500.0 [3]
N-[6-[(E)-3-[(2R)-4-[(4-Fluorophenyl)methyl]-2-methylpiperazin-1-yl]-3-oxoprop-1-enyl]quinolin-7-yl]acetamideIC5020.0 [1], 30.0 [2], 300.0 [3]
(R)-N-(3-(3-(4-(4-Fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)naphthalen-2-yl)acetamideIC5013.0 [1], 80.0 [2], 1500.0 [3]
N-[5-Chloro-2-[(E)-3-[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-3-oxoprop-1-enyl]phenyl]acetamideIC500.1 [1], 9.0 [2], 1350.0 [3]
2-[4-Chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethanoneIC5093.0 [1], 307.0 [2], 310.0 [3]
3-Amino-4-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]cyclobut-3-ene-1,2-dioneIC504.0 [1], 7.0 [2], 10.0 [3]
N-[5-Chloro-2-[[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethyl]amino]phenyl]acetamideIC502.4 [1], 50.0 [2], 1700.0 [3]
N-[5-Chloro-2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazine-1-carbonyl]-1H-indol-7-yl]acetamideIC509.6 [1], 560.0 [2], 1000.0 [3]
N-[5-Chloro-2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazine-1-carbonyl]-1-benzofuran-7-yl]acetamideIC5028.0 [1], 120.0 [2], 1000.0 [3]
3-[5-Chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]-4-(methylamino)cyclobut-3-ene-1,2-dioneIC5017.0 [1], 18.0 [2], 26.0 [3]
3-[5-Bromo-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]-4-(methylamino)cyclobut-3-ene-1,2-dioneIC5014.0 [1], 25.0 [2]
3-[5-Chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]-4-(2-methoxyethylamino)cyclobut-3-ene-1,2-dioneIC5019.0 [1], 54.0 [2], 63.0 [3]
3-[5-Chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]-4-(2-hydroxyethylamino)cyclobut-3-ene-1,2-dioneIC5013.0 [1], 20.0 [2], 47.0 [3]
3-(2-Aminoethylamino)-4-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]cyclobut-3-ene-1,2-dioneIC506.0 [1], 18.0 [2], 23.0 [3]
3-[5-Chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]-4-(2-morpholin-4-ylethylamino)cyclobut-3-ene-1,2-dioneIC5012.0 [1]
3-[5-Chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]-4-(2-piperazin-1-ylethylamino)cyclobut-3-ene-1,2-dioneIC505.0 [1], 39.0 [2], 50.0 [3]
3-[5-Chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]anilino]-4-(pyridin-3-ylmethylamino)cyclobut-3-ene-1,2-dioneIC508.0 [1], 38.0 [2], 42.0 [3]
6-[2-(Dimethylamino)ethyl-methylamino]-1,3-dimethyl-N-[(3-propan-2-yloxyphenyl)carbamoyl]pyrazolo[3,4-b]pyridine-5-carboxamide;hydrochlorideIC5010000.0 [1]
1-[(2R)-Butan-2-yl]-3-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]ureaIC503.0 [1], 6.0 [2]
1-[(2R)-Butan-2-yl]-3-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]ureaKi2.1 [1]
N-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-methylbutanamideIC501.9 [1], 2.9 [2]
N-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-methylbutanamideKi2.6 [1]
N-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]cyclopentanecarboxamideIC501.4 [1], 2.5 [2]
N-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]cyclopentanecarboxamideKi0.7 [1]
N-[(2S,3S,5R)-3-Hydroxy-7-methyl-5-(methylcarbamoyl)-1-phenyloctan-2-yl]quinoline-3-carboxamideIC50650.0 [1]
1-(5-Amino-4,4-diphenyl-pentyl)-4-(4-chloro-phenyl)-piperidin-4-olIC50760.0 [1]
1-(5-Amino-4,4-diphenyl-pentyl)-4-(4-chloro-phenyl)-piperidin-4-olKi244.0 [1]
2-(Benzothiazol-2-ylsulfanyl)-N-[1-(3,4-dichloro-benzyl)-piperidin-4-yl]-acetamideIC50450.0 [1]
5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-phenyl-2-piperidin-1-yl-pentanenitrileIC504800.0 [1]
5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-phenyl-2-piperidin-1-yl-pentanenitrileKi130.0 [1]
5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-thiophen-2-yl-pentanenitrileIC508400.0 [1]
5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-thiophen-2-yl-pentanenitrileKi128.0 [1]
2-{4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-cyano-butyl}-benzonitrileIC505800.0 [1]
2-{4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-cyano-butyl}-benzonitrileKi98.0 [1]
6-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-hexanenitrileIC501600.0 [1]
6-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-hexanenitrileKi78.0 [1]
7-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-heptanenitrileIC505600.0 [1]
7-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-heptanenitrileKi99.0 [1]
11-[3-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-5-methyl-6-oxobenzo[c][1]benzazepine-11-carbonitrileIC503300.0 [1]
11-[3-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]propyl]-5-methyl-6-oxobenzo[c][1]benzazepine-11-carbonitrileKi32.0 [1]
5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-thiophen-3-yl-pentanenitrileIC509800.0 [1]
5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-thiophen-3-yl-pentanenitrileKi236.0 [1]
Ethyl 5-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2-cyano-2-phenylpentanoateIC507000.0 [1]
Ethyl 5-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2-cyano-2-phenylpentanoateKi33.0 [1]
2-(3-Bromo-4-methoxy-phenyl)-5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-pentanenitrileIC501900.0 [1]
2-(3-Bromo-4-methoxy-phenyl)-5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-pentanenitrileKi74.0 [1]
4-[1-(4-Cyano-4,4-diphenylbutyl)-4-hydroxypiperidin-4-yl]benzonitrileIC5010900.0 [1]
4-[1-(4-Cyano-4,4-diphenylbutyl)-4-hydroxypiperidin-4-yl]benzonitrileKi92.0 [1]
5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(3-chloro-propyl)-2-phenyl-pentanenitrileIC508300.0 [1]
5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(3-chloro-propyl)-2-phenyl-pentanenitrileKi51.0 [1]
2-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-2-phenyl-succinonitrileIC503200.0 [1]
2-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-2-phenyl-succinonitrileKi125.0 [1]
5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(3-hydroxy-phenyl)-pentanenitrileIC509000.0 [1]
5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(3-hydroxy-phenyl)-pentanenitrileKi156.0 [1]
1-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(1R,3S)-3-hydroxycyclopentyl]ureaIC502.0 [1], 4.0 [2]
1-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(2S)-2-hydroxypropyl]ureaIC502.0 [1], 7.0 [2]
1-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(2R)-2-hydroxypropyl]ureaIC502.0 [1], 6.0 [2]
N-[(2R)-1-[(4S)-4-(4-Chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-hydroxy-4-methylpentanamideIC502.0 [1], 22.0 [2]
N-[(2R)-1-[4-(4-Chlorophenyl)-3,3-dimethylpiperazin-1-yl]-3-methyl-1-oxobutan-2-yl]cyclopentanecarboxamideIC504.1 [1], 18.0 [2]
(2R)-2-N-[(4-Chlorophenyl)methyl]-2-N-methyl-1-N-[2-methyl-4-(trifluoromethyl)phenyl]pyrrolidine-1,2-dicarboxamideIC5016.0 [1], 50.0 [2]
1-[1-(2-Bromophenyl)sulfonylpiperidin-4-yl]-4-(4-chlorophenyl)piperidin-4-olIC5090.0 [1]
(2R)-2-N-[(4-Chlorophenyl)methyl]-1-N-(4-methoxyphenyl)-2-N-methylpyrrolidine-1,2-dicarboxamideIC50290.0 [1], 440.0 [2]
(2R)-2-N-[(4-Chlorophenyl)methyl]-1-N-[2-chloro-4-(trifluoromethyl)phenyl]-2-N-methylpyrrolidine-1,2-dicarboxamideIC5035.0 [1], 120.0 [2]
(2R)-2-N-[(4-Chlorophenyl)methyl]-1-N-[2-fluoro-4-(trifluoromethyl)phenyl]-2-N-methylpyrrolidine-1,2-dicarboxamideIC5022.0 [1], 23.0 [2]
(2R)-2-N-[(4-Chlorophenyl)methyl]-1-N-[2,6-dimethyl-4-(trifluoromethyl)phenyl]-2-N-methylpyrrolidine-1,2-dicarboxamideIC506.0 [1], 11.0 [2]
(2R)-2-[4-[(4-Chlorophenyl)methyl]-1,2,4-triazol-3-yl]-N-[4-(trifluoromethyl)phenyl]pyrrolidine-1-carboxamideIC504.0 [1], 17.0 [2]
(2R)-2-[1-[(4-Chlorophenyl)methyl]tetrazol-5-yl]-N-[4-(trifluoromethyl)phenyl]pyrrolidine-1-carboxamideIC506.5 [1], 20.0 [2]
(2R)-2-[2-[(4-Chlorophenyl)methyl]-1,2,4-triazol-3-yl]-N-[4-(trifluoromethyl)phenyl]pyrrolidine-1-carboxamideIC5022.0 [1], 32.0 [2]
N-[(2S,3S)-8-Fluoro-3-hydroxy-8-methyl-5-(4-methylpiperazine-1-carbonyl)-1-phenylnonan-2-yl]quinoxaline-2-carboxamideIC505600.0 [1], 7050.0 [2]
N-[(2S,3S)-8-Fluoro-3-hydroxy-5-(hydroxycarbamoyl)-8-methyl-1-phenylnonan-2-yl]quinoxaline-2-carboxamideIC5027.0 [1], 31.0 [2]
N-[(2S,3S)-8-Fluoro-3-hydroxy-8-methyl-1-phenyl-5-(pyrrolidine-1-carbonyl)nonan-2-yl]quinoxaline-2-carboxamideIC50740.0 [1], 2320.0 [2]
N-[(2S,3S)-8-Fluoro-5-(hydrazinecarbonyl)-3-hydroxy-8-methyl-1-phenylnonan-2-yl]quinoxaline-2-carboxamideIC501.0 [1], 7.0 [2]
N-[(2S,3S)-6-Amino-3-hydroxy-5-(oxan-4-yl)-6-oxo-1-phenylhexan-2-yl]quinoxaline-2-carboxamideIC503460.0 [1], 12500.0 [2]
N-[(2S,3S,5R)-5-Carbamoyl-3,8-dihydroxy-8-methyl-1-phenylnonan-2-yl]quinoxaline-2-carboxamideIC50580.0 [1], 1180.0 [2]
N-[(2S,3S)-6-Amino-5-(4,4-difluorocyclohexyl)-3-hydroxy-6-oxo-1-phenylhexan-2-yl]quinoxaline-2-carboxamideIC5020.0 [1], 220.0 [2]
N-[(2S,3S)-6-Amino-5-(4,4-difluoro-1-hydroxycyclohexyl)-3-hydroxy-6-oxo-1-phenylhexan-2-yl]quinoxaline-2-carboxamideIC5068.0 [1], 560.0 [2]
N-[(2S,3S)-5-(Benzylcarbamoyl)-8-fluoro-3-hydroxy-8-methyl-1-phenylnonan-2-yl]quinoxaline-2-carboxamideIC50440.0 [1], 850.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ C-C chemokine receptor type 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/c-c-chemokine-receptor-type-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ C-C chemokine receptor type 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/c-c-chemokine-receptor-type-1-inhibitors-ic50-ki.
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