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C-C chemokine receptor-like 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-[1-[4-[Cyclopropyl(hydroxy)methyl]cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC508.0 [1], 22.0 [2]
N-[1-[4-(1-Hydroxy-2-methylpropyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC509.0 [1], 10.0 [2]
N-[1-[4-(3-Aminopyridin-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5017.0 [1]
N-[1-[4-(2-Cyanophenyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5021.0 [1]
N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[2-methyl-6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC508.0 [1]
N-[1-(4-Phenylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5015.0 [1]
N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[7-(trifluoromethyl)phthalazin-1-yl]amino]acetamideIC5025000.0 [1]
N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[7-(trifluoromethyl)isoquinolin-1-yl]amino]acetamideIC5025000.0 [1]
N-[1-(4-Pyridin-2-ylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC505.0 [1]
N-[1-(4-Pyridin-3-ylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC505.0 [1]
N-[1-[4-(5-Hydroxypyridin-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC506.0 [1]
N-[1-[4-(2-Hydroxyphenyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC507.0 [1]
N-[1-[4-(3-Methoxypyridin-4-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC506.0 [1]
N-[1-[4-Hydroxy-4-(1,2-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5022.0 [1]
N-[1-(4-Hydroxy-4-phenylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5015.0 [1]
2-[[2-Cyano-6-(trifluoromethyl)quinolin-4-yl]amino]-N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]acetamideIC5023.0 [1]
N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5040.0 [1]
N-[1-[4-Hydroxy-4-(2-propan-2-yl-1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5022.0 [1]
N-[1-[4-Hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5019.0 [1]
N-[1-[4-Hydroxy-4-(2-methyl-1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5027.0 [1]
N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[3-(trifluoromethyl)-1,6-naphthyridin-5-yl]amino]acetamideIC5025000.0 [1]
N-[1-[4-Hydroxy-4-(1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5010.0 [1]
N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinolin-4-yl]amino]acetamideIC5072.0 [1]
N-[1-[4-Hydroxy-4-(6-methoxypyridin-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5056.0 [1]
2-[[2,6-Bis(trifluoromethyl)quinazolin-4-yl]amino]-N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]acetamideIC5039.0 [1]
2-[[2,6-Bis(trifluoromethyl)quinolin-4-yl]amino]-N-[1-[4-hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]acetamideIC5050.0 [1]
2-[[6-(1,1-Difluoroethyl)quinazolin-4-yl]amino]-N-[1-(4-propan-2-ylcyclohexyl)azetidin-3-yl]acetamideIC5085.0 [1]
N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[2-propan-2-yl-6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC507.0 [1]
N-[1-[4-(1-Hydroxyprop-2-enyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5016.0 [1]
N-[1-[4-(1-Hydroxybut-3-enyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5016.0 [1]
N-[1-[4-(1-Hydroxyethyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5089.0 [1]
N-[1-[4-(1-Hydroxy-2,2-dimethylpropyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50753.0 [1]
N-[1-[4-[Cyclopentyl(hydroxy)methyl]cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5024.0 [1]
N-[1-[4-[Hydroxy(1,3-thiazol-5-yl)methyl]cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5019.0 [1]
N-Ethyl-4-[3-[[2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxamideIC50200.0 [1]
Tert-butyl N-[4-[3-[[2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexyl]carbamateIC50220.0 [1]
N-[1-[4-(Pyrrolidine-1-carbonyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC501000.0 [1]
N,N-Dimethyl-4-[3-[[2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexane-1-carboxamideIC50360.0 [1]
N-[1-(4-Thiomorpholin-4-ylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50200.0 [1]
N-[1-(4-Morpholin-4-ylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50190.0 [1]
2,2,2-Trifluoro-N-[1-[4-[3-[[2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexyl]propyl]acetamideIC502980.0 [1]
N-[1-[4-[1-(Methylcarbamoylamino)propyl]cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC501230.0 [1]
N-[1-[4-(3-Hydroxypyridin-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC504.0 [1]
N-[1-[4-(3,6-Dihydro-2H-pyran-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC505.0 [1]
N-[1-[4-[1-(Dimethylcarbamoylamino)propyl]cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5013840.0 [1]
N-[1-[4-[1-(Methanesulfonamido)propyl]cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC501450.0 [1]
N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)cinnolin-4-yl]amino]acetamideIC509.2 [1]
N-[1-[4-(1-Hydroxypropyl)cyclohexyl]azetidin-3-yl]-2-[[3-(trifluoromethyl)-1,6-naphthyridin-5-yl]amino]acetamideIC5025000.0 [1]
N-[1-(4-Ethenylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC509.0 [1]
N-[1-[4-(2,5-Dihydrofuran-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC509.0 [1]
N-[1-[4-(6-Oxo-2,3-dihydro-1H-pyridin-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5012.0 [1]
N-[1-[4-(5-Oxopyrrolidin-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5021.0 [1]
N-[1-[4-(1-Hydroxypropyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)cinnolin-4-yl]amino]acetamideIC50530.0 [1]
N-[1-[4-(1-Hydroxypropyl)cyclohexyl]azetidin-3-yl]-2-[[7-(trifluoromethyl)phthalazin-1-yl]amino]acetamideIC506080.0 [1]
N-[1-[4-(1-Hydroxy-2-methylpropyl)cyclohexyl]azetidin-3-yl]-2-[[3-(trifluoromethyl)-1,6-naphthyridin-5-yl]amino]acetamideIC5025000.0 [1]
N-[1-[4-(6-Oxopiperidin-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5010.0 [1]
N-[1-[4-(Oxolan-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5049.0 [1]
N-[1-[4-(Oxan-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5015.0 [1]
N-[1-[4-(2-Oxo-1,3-oxazolidin-4-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5035.0 [1]
N-[1-[4-(2-Oxo-1,3-oxazinan-4-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5058.0 [1]
N-[3-[4-Hydroxy-4-(1,3-thiazol-5-yl)piperidin-1-yl]cyclobutyl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5025000.0 [1]
N-[1-[4-(1-Hydroxypropyl)cyclohexyl]azetidin-3-yl]-2-[[7-(trifluoromethyl)isoquinolin-1-yl]amino]acetamideIC5025000.0 [1]
N-[1-[4-(1-Hydroxy-2-methylsulfanylethyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5010.0 [1]
N-[1-[4-(2-Azido-1-hydroxyethyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5016.0 [1]
N-[1-[4-(1-Hydroxy-2-methoxyethyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5058.0 [1]
N-[1-[4-(1-Hydroxy-2-methylsulfinylethyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50172.0 [1]
N-[1-[4-(1-Hydroxy-2-methylpropyl)cyclohexyl]azetidin-3-yl]-2-[[7-(trifluoromethyl)isoquinolin-1-yl]amino]acetamideIC5035.0 [1]
N-[1-[4-(1-Hydroxypropyl)cyclohexyl]azetidin-3-yl]-2-[[7-(1,1,2,2,2-pentafluoroethyl)isoquinolin-1-yl]amino]acetamideIC5072.0 [1]
N-[1-(4-Oxocyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50530.0 [1]
N-[1-[4-(Hydroxymethyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5058.0 [1]
N-[1-[4-(Acetamidomethyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5037.0 [1]
N-[1-[4-[2-(Dimethylamino)-1-hydroxyethyl]cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50714.0 [1]
N-[1-[4-(1-Hydroxypropyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5021.0 [1]
N-[1-[4-(2-Hydroxypropan-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5033.0 [1]
N-[1-[4-(3-Hydroxypentan-3-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50209.0 [1]
N-[1-[4-(4-Hydroxyhepta-1,6-dien-4-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50300.0 [1]
N-[1-[4-(4-Hydroxyheptan-4-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50690.0 [1]
N-[1-[4-(2,2,2-Trifluoro-1-hydroxyethyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5073.0 [1]
N-[1-(4-Cyclopentylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50140.0 [1]
N-[1-(4-Prop-1-en-2-ylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5075.0 [1]
N-[1-[4-(Oxan-4-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50160.0 [1]
N-[1-[4-(1-Methyl-5-oxopyrrolidin-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50231.0 [1]
N-[1-(4-Acetamidocyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50670.0 [1]
Benzyl N-methyl-N-[4-[3-[[2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexyl]carbamateIC50210.0 [1]
N,2-Dimethyl-N-[4-[3-[[2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexyl]propanamideIC50300.0 [1]
N-Methyl-N-[4-[3-[[2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexyl]propanamideIC50390.0 [1]
N-Methyl-N-[4-[3-[[2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexyl]butanamideIC50810.0 [1]
Benzyl N-ethyl-N-[4-[3-[[2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetyl]amino]azetidin-1-yl]cyclohexyl]carbamateIC50160.0 [1]
N-[1-[4-[Methyl(methylsulfonyl)amino]cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50950.0 [1]
N-[1-[4-[Acetyl(ethyl)amino]cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50810.0 [1]
N-[1-[4-[Formyl(propyl)amino]cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5037.0 [1]
N-[1-[4-[(2-Oxopiperidin-1-yl)methyl]cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50720.0 [1]
N-[1-[4-(Oxazinan-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5064.0 [1]
N-[1-[4-(2,5-Dioxopyrrolidin-1-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50280.0 [1]
N-[1-[4-(2-Oxopyridin-1-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinolin-4-yl]amino]acetamideIC5091.0 [1]
N-[1-[4-(2-Oxopyridin-1-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC5015.0 [1]
2-[[2,6-Bis(trifluoromethyl)quinolin-4-yl]amino]-N-[1-[4-(2-oxopyridin-1-yl)cyclohexyl]azetidin-3-yl]acetamideIC50130.0 [1]
2-[[2-Cyano-6-(trifluoromethyl)quinolin-4-yl]amino]-N-[1-[4-(2-oxopyridin-1-yl)cyclohexyl]azetidin-3-yl]acetamideIC5040.0 [1]
4-[[2-[[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]amino]-6-(trifluoromethyl)quinoline-2-carboxamideIC509.0 [1]
N-[1-[4-Hydroxy-4-(1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]-2-[methyl-[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamideIC50830.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ C-C chemokine receptor-like 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/c-c-chemokine-receptor-like-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ C-C chemokine receptor-like 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/c-c-chemokine-receptor-like-2-inhibitors-ic50-ki.
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