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Bromodomain-containing protein 2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Tert-butyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetateIC5053.3 [1]
Tert-butyl 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetateKi12.5 [1], 13.2 [2]
MolibresibIC5032.5 [1], 150.0 [2], 790.0 [3], 810.0 [4]
MolibresibKi49.2 [1], 56.8 [2]
BirabresibIC5024.8 [1], 33.3 [2], 92.0 [3]
BirabresibKi5.4 [1], 16.6 [2]
4-[(2s,4r)-1-Acetyl-4-[(4-Chlorophenyl)amino]-2-Methyl-1,2,3,4-Tetrahydroquinolin-6-Yl]benzoic AcidIC503.16 [1], 30.0 [2], 158.49 [3], 720.0 [4], 31622.78 [5]
I-Bet151 (gsk1210151A)IC50500.0 [1], 501.19 [2]
I-Bet151 (gsk1210151A)Ki9.0 [1], 49.6 [2]
Tert-butyl 2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetateIC5016.0 [1], 17.0 [2], 26.1 [3], 144.0 [4]
Benzyl [(4r)-1-Methyl-6-Phenyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]carbamateIC5029.9 [1], 160.0 [2], 820.0 [3]
ApabetaloneIC50251.0 [1], 5780.0 [2]
8-[[(3R,4R)-3-[(1,1-Dioxothian-4-yl)methoxy]piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC5031622.78 [1]
1-[1-(Pyridin-2-Yl)indolizin-3-Yl]ethan-1-OneIC502000.0 [1], 12600.0 [2]
4-[1-(3-Cyclopropyl-5-methyl-1H-pyrazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indol-7-yl]-3,5-dimethyl-1,2-oxazoleKi11.1 [1], 11.7 [2]
5-(5-Methoxypyridin-3-Yl)-3-Methyl-8-[(Piperidin-4-Yl)amino]-1,2-Dihydro-1,7-Naphthyridin-2-OneIC503981.07 [1], 19952.62 [2]
3-Methyl-5-(5-methylpyridin-3-yl)-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-oneIC506309.57 [1], 19952.62 [2]
3-[(4-Chlorophenyl)methyl]-7-Ethyl-Purine-2,6-DioneIC501600.0 [1], 4700.0 [2]
4-[1-(5-Ethyl-3-phenyl-1H-pyrazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indol-7-yl]-3,5-dimethyl-1,2-oxazoleKi12.2 [1], 22.2 [2]
8-[[(3R,4R)-3-[(1,1-Dioxothian-4-yl)methoxy]-1-methylpiperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-oneIC5050118.72 [1]
Propan-2-yl N-[(2S,4R)-1-acetyl-6-(furan-2-yl)-2-methyl-3,4-dihydro-2H-quinolin-4-yl]carbamateIC50610.0 [1], 2020.0 [2]
7-(4-Chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepineIC5043.0 [1], 129.0 [2]
Methyl 7-(4-chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carboxylateIC5052.0 [1], 116.0 [2]
7-(4-Chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carboxylic acidIC5050.0 [1], 185.0 [2]
7-Benzyl-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepineIC50999.0 [1]
7-(4-Chlorophenyl)-1-methyl-9-(2H-tetrazol-5-yl)-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepineIC506.0 [1], 7.0 [2]
7-(4-Chlorophenyl)-1-methyl-9-(1H-pyrazol-5-yl)-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepineIC5025.0 [1], 35.0 [2]
5-[7-(4-Chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepin-9-yl]pyrimidin-2-amineIC5038.0 [1], 64.0 [2]
(5S)-7-(4-Chlorophenyl)-1,5-dimethyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepineIC5034.0 [1], 53.0 [2]
(5R)-7-(4-Chlorophenyl)-1,5-dimethyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepineIC5025.0 [1], 38.0 [2]
N-Benzhydryl-7-(4-chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carboxamideIC5044.0 [1], 151.0 [2]
7-(4-Chlorophenyl)-N-[(1S)-1-(4-fluorophenyl)ethyl]-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carboxamideIC504.0 [1], 95.0 [2]
2-[7-(4-Chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepin-5-yl]ethanolIC5045.0 [1], 340.0 [2]
[7-(4-Chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepin-9-yl]methanolIC5040.0 [1], 388.0 [2]
7-(4-Chlorophenyl)-1-methyl-9-(6-methylpyridin-3-yl)-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepineIC5028.0 [1], 53.0 [2]
7-(4-Chlorophenyl)-1-methyl-N-methylsulfonyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carboxamideIC5025.0 [1], 44.0 [2]
1-Methyl-7-phenyl-5H-triazolo[1,5-d][1,4]benzodiazepin-6-oneIC5010000.0 [1]
5-[7-(4-Chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepin-9-yl]pyridin-2-amineIC5021.0 [1], 33.0 [2]
1-Methyl-7-phenyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepineIC5039.0 [1], 263.5 [2]
N-(Benzenesulfonyl)-7-(4-chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carboxamideIC5025.0 [1], 54.0 [2]
7-(4-Chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carboxamideIC5017.0 [1], 34.0 [2]
7-(4-Chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carbonitrileIC5024.0 [1], 56.0 [2]
1-[7-(4-Chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepin-9-yl]-2,2,2-trifluoroethanolIC50204.0 [1], 370.0 [2]
7-(4-Chlorophenyl)-1-methyl-N-phenyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carboxamideIC5018.0 [1], 79.0 [2]
N-Benzyl-7-(4-chlorophenyl)-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carboxamideIC5037.0 [1], 136.0 [2]
7-(4-Chlorophenyl)-1-methyl-N-[(1S)-1-phenylethyl]-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carboxamideIC503.0 [1], 51.0 [2]
7-(4-Chlorophenyl)-1-methyl-N-[(1R)-1-phenylethyl]-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepine-9-carboxamideIC5020.0 [1], 68.0 [2]
3-Butyl-7-ethylpurine-2,6-dioneIC506600.0 [1], 18800.0 [2]
Propan-2-yl N-[(2S,4R)-1-acetyl-2-methyl-6-thiophen-2-yl-3,4-dihydro-2H-quinolin-4-yl]carbamateIC50830.0 [1], 1770.0 [2]
Propan-2-yl N-[(2S,4R)-1-acetyl-2-methyl-6-(1H-pyrrol-3-yl)-3,4-dihydro-2H-quinolin-4-yl]carbamateIC50410.0 [1], 2480.0 [2]
Propan-2-yl N-[(2S,4R)-1-acetyl-6-(furan-3-yl)-2-methyl-3,4-dihydro-2H-quinolin-4-yl]carbamateIC501910.0 [1], 5800.0 [2]
Propan-2-yl N-[(2S,4R)-1-acetyl-2-methyl-6-(1H-pyrrol-2-yl)-3,4-dihydro-2H-quinolin-4-yl]carbamateIC501400.0 [1]
Propan-2-yl N-[(2S,4R)-1-acetyl-2-methyl-6-thiophen-3-yl-3,4-dihydro-2H-quinolin-4-yl]carbamateIC501080.0 [1], 5210.0 [2]
4-[(5-Cyclopropyl-2-ethylpyrazol-3-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-N-methyl-9H-pyrimido[4,5-b]indole-2-carboxamideIC503.1 [1], 3.9 [2]
5-(4-Hydroxy-3,5-dimethylphenyl)-11-methyl-8-thia-4,6,11-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),5-trien-3-oneIC5024600.0 [1], 100000.0 [2]
4-[(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-cyclopentylbenzenesulfonamideIC50772.0 [1], 1836.0 [2]
6-[(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-1H-quinolin-2-oneIC50803.0 [1], 1736.0 [2]
5-[(2S)-1-Acetyl-2-cyclopropyl-4-[[2-(hydroxymethyl)phenyl]methyl]-2,3-dihydroquinoxalin-6-yl]pyrimidine-2-carboxamideIC50100.0 [1], 1584.89 [2]
1-[(2S)-2-Cyclopropyl-4-[[2-(hydroxymethyl)phenyl]methyl]-6-(1,2,3,6-tetrahydropyridin-4-yl)-2,3-dihydroquinoxalin-1-yl]ethanoneIC50316.23 [1], 2511.89 [2]
7-(4-Chlorophenyl)-1-methyl-9-(pyrazol-1-ylmethyl)-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepineIC50147.0 [1], 273.0 [2]
7-[(3-Bromophenyl)methyl]-1-methyl-5,6-dihydrotriazolo[1,5-d][1,4]benzodiazepineIC5044.0 [1], 129.0 [2]
7-(3,5-Dimethyl-1,2-oxazol-4-yl)-6-methoxy-N-methyl-9H-pyrimido[4,5-b]indole-2-carboxamideIC50218.0 [1], 224.0 [2]
4-[1-(3,5-Diethyl-1H-pyrazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indol-7-yl]-3,5-dimethyl-1,2-oxazoleKi15.4 [1], 21.0 [2]
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneIC5010300.0 [1]
2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-oneIC507400.0 [1]
MivebresibKi1.0 [1]
4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-OneIC50100000.0 [1]
1-[2-(1H-Benzimidazol-2-ylsulfanyl)ethyl]-3-methyl-1,3-dihydro-2H-benzimidazole-2-thioneIC5028000.0 [1]
3,5 Dimethyl-4-Phenyl-1,2-OxazoleIC5034300.0 [1]
4-[4-[(Dimethylamino)methyl]-3,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-OneIC50100000.0 [1]
Benzyl N-(1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)carbamateIC501258.93 [1]
1-[3-(3,5-Dimethyl-1,2-oxazol-4-yl)-5-ethoxyphenyl]ethanolIC501600.0 [1]
4-[(2-Tert-Butylphenyl)amino]-7-(3,5-Dimethyl-1,2-Oxazol-4-Yl)quinoline-3-Carboxylic AcidIC50794.33 [1]
5-{4-[(Dimethylamino)methyl]-3,5-dimethoxyphenyl}-1,3,6-trimethyl-1,2-dihydro-pyridin-2-oneIC5033234.0 [1]
4-{4-[(Dimethylamino)methyl]-3,5-dimethoxyphenyl}-2-methyl-1,2-dihydroisoquinolin-1-oneIC5050857.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
7-(3,5-Dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-(pyridin-2-ylmethyl)-3H-imidazo[4,5-c]quinolin-2-oneIC501584.89 [1]
7-(3,5-Dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-phenylethyl]-3H-imidazo[4,5-c]quinolin-2-oneIC50398.11 [1]
3-(3,5-Dimethyl-1,2-Oxazol-4-Yl)-5-Ethoxybenzoic AcidIC5028200.0 [1]
7-(3,5-Dimethyl-1,2-oxazol-4-yl)-1-(2-fluorophenyl)-8-methoxy-3H-imidazo[4,5-c]quinolin-2-oneIC502511.89 [1]
7-(3,5-Dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1S)-1-phenylethyl]-3H-imidazo[4,5-c]quinolin-2-oneIC501995.26 [1]
7-(3,5-Dimethyl-1,2-oxazol-4-yl)-4-(2-fluoroanilino)quinoline-3-carboxamideIC5012589.25 [1]
7-(3,5-Dimethyl-1,2-oxazol-4-yl)-4-(2-fluoroanilino)-6-methoxyquinoline-3-carboxamideIC50501.19 [1]
7-(3,5-Dimethyl-1,2-oxazol-4-yl)-6-methoxy-4-(quinolin-8-ylamino)quinoline-3-carboxamideIC501000.0 [1]
1-(2-Tert-butylphenyl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-3H-imidazo[4,5-c]quinolin-2-oneIC50501.19 [1]
4-(Cyclohexylamino)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxyquinoline-3-carboxamideIC501995.26 [1]
1-Benzyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-3H-imidazo[4,5-c]quinolin-2-oneIC50501.19 [1]
N-[3-(3-Methyl-4-Oxo-4,5,6,7-Tetrahydro-2h-Isoindol-1-Yl)-4-Phenoxyphenyl]methanesulfonamideKi14.0 [1]
1-[2-(2,4-Difluorophenoxy)-5-methylsulfonylphenyl]-3-methyl-2,5,6,7-tetrahydropyrrolo[3,4-c]pyridin-4-oneKi27.0 [1]
4-[(5-Phenylpyridin-3-Yl)carbonyl]-3,4-Dihydroquinoxalin-2(1h)-OneIC5020000.0 [1]
1-[(2S,4R)-4-Anilino-2-methyl-6-phenyl-3,4-dihydro-2H-quinolin-1-yl]ethanoneIC50794.33 [1]
4-[(2S,4R)-1-Acetyl-4-anilino-2-methyl-3,4-dihydro-2H-quinolin-6-yl]benzonitrileIC501000.0 [1]
1-[(2S,4R)-4-Anilino-2-methyl-6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-quinolin-1-yl]ethanoneIC501995.26 [1]
1-[(2S,4R)-4-Anilino-6-(4-methoxyphenyl)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]ethanoneIC501258.93 [1]
1-[(2S,4R)-4-Anilino-6-[4-(hydroxymethyl)phenyl]-2-methyl-3,4-dihydro-2H-quinolin-1-yl]ethanoneIC50794.33 [1]
1-[(2S,4R)-4-Anilino-2-methyl-6-[4-(morpholin-4-ylmethyl)phenyl]-3,4-dihydro-2H-quinolin-1-yl]ethanoneIC50794.33 [1]
1-[(2S,4R)-4-Anilino-2-methyl-6-[3-(piperidin-1-ylmethyl)phenyl]-3,4-dihydro-2H-quinolin-1-yl]ethanoneIC501258.93 [1]
1-[(2R,4S)-4-Anilino-2-methyl-6-[4-(piperidin-1-ylmethyl)phenyl]-3,4-dihydro-2H-quinolin-1-yl]ethanoneIC5025118.86 [1]
Methyl 4-[(2S,4R)-1-acetyl-4-(4-tert-butylanilino)-2-methyl-3,4-dihydro-2H-quinolin-6-yl]benzoateIC50501.19 [1]
4-[(2S,4R)-1-Acetyl-2-methyl-4-(4-methylsulfonylanilino)-3,4-dihydro-2H-quinolin-6-yl]benzoic acidIC501000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Bromodomain-containing protein 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/bromodomain-containing-protein-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Bromodomain-containing protein 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/bromodomain-containing-protein-2-inhibitors-ic50-ki.
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