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Branched-chain-amino-acid aminotransferase, mitochondrial Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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5-Benzyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5025118.86 [1]
2-Ethoxy-5-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50501187.23 [1]
5-Ethyl-2-Methyl-7-Oxo-4,7-Dihydropyrazolo[1,5-A]pyrimidine-3-CarbonitrileIC50630957.34 [1]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-N-methyl-2-pyridin-2-ylbenzimidazole-5-carboxamideIC5050.12 [1], 100.0 [2]
2-[(4-Methylphenyl)methylamino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50251.19 [1], 1995.26 [2]
2-[(4-Chloro-3-methylphenyl)methylamino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50199.53 [1], 1000.0 [2]
2-[(5-Bromopyridin-2-yl)methylamino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50158.49 [1], 1995.26 [2]
2-[(4-Chloro-2-fluorophenyl)methylamino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5050.12 [1], 316.23 [2]
2-[(4-Bromo-2-fluorophenyl)methylamino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5025.12 [1], 158.49 [2]
2-[[(1R)-1-(4-Bromo-2-fluorophenyl)ethyl]amino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5019.95 [1], 63.1 [2]
5-Butyl-2-[(4-Chloro-2-Fluorobenzyl)amino]-7-Oxo-4,7-Dihydropyrazolo[1,5-A]pyrimidine-3-CarbonitrileIC5015.85 [1], 79.43 [2]
2-[(4-Bromo-2-fluorophenyl)methylamino]-5-butyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5012.59 [1], 50.12 [2]
2-[[(1R)-1-(4-Bromo-2-fluorophenyl)ethyl]amino]-5-butyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5012.59 [1], 50.12 [2]
5-Butyl-2-[(4-chloro-2,6-difluorophenyl)methylamino]-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5015.85 [1], 31.62 [2]
2-[(4-Bromo-2,6-difluorophenyl)methylamino]-5-butyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5010.0 [1], 63.1 [2]
7-Oxo-2-(2-oxo-2-pyrrolidin-1-ylethyl)-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50501.19 [1], 10000.0 [2]
2-[(4-Chlorobenzyl)amino]-7-Oxo-5-Propyl-4,7-Dihydropyrazolo[1,5-A]pyrimidine-3-CarbonitrileIC5079.43 [1], 630.96 [2]
2-[(4-Bromophenyl)methylamino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5025.12 [1], 251.19 [2]
5-Benzyl-2-[(4-chlorophenyl)methylamino]-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50100.0 [1], 1258.93 [2]
5-Butyl-2-[(4-chlorophenyl)methylamino]-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5039.81 [1], 199.53 [2]
2-[(4-Chlorophenyl)methylamino]-5-(2-methylpropyl)-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50251.19 [1], 1995.26 [2]
2-[(4-Chlorophenyl)methylamino]-5-(3-methylbutyl)-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50125.89 [1], 630.96 [2]
2-[(4-Chlorophenyl)methylamino]-5-(furan-3-ylmethyl)-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5031.62 [1], 1584.89 [2]
2-[2-(4-Chlorophenyl)ethylamino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50251.19 [1], 1000.0 [2]
2-[(4-Chlorophenoxy)methyl]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50199.53 [1], 5011.87 [2]
2-[2-(4-Chlorophenyl)ethyl]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50630.96 [1], 5011.87 [2]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-N-methyl-2-(2-methylsulfanylphenyl)benzimidazole-5-carboxamideIC50158.49 [1], 251.19 [2]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-N-methyl-2-phenylbenzimidazole-5-carboxamideIC5050.12 [1], 63.1 [2]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-2-pyridin-2-ylbenzimidazole-5-carboxamideIC5063.1 [1], 630.96 [2]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-N-methyl-2-thiophen-2-ylbenzimidazole-5-carboxamideIC5079.43 [1], 100.0 [2]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-N-methyl-2-thiophen-3-ylbenzimidazole-5-carboxamideIC50100.0 [1]
1-[(1R,3S)-3-[(5-Cyanothiophene-2-carbonyl)amino]cyclohexyl]-2-pyridin-2-ylbenzimidazole-5-carboxamideIC50251.19 [1], 1258.93 [2]
5-Bromo-N-[(1S,3R)-3-(2-pyridin-2-ylbenzimidazol-1-yl)cyclohexyl]thiophene-2-carboxamideIC501000.0 [1], 50118.72 [2]
2-[(4-Chlorobenzyl)amino]-5-propyl[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-oneIC501258.93 [1], 1995.26 [2]
2-[(4-Bromobenzyl)amino]-5-Propyl[1,2,4]triazolo[1,5-A]pyrimidin-7(4h)-OneIC50630.96 [1], 794.33 [2]
2-[(4-Chloro-2,6-difluorophenyl)methylamino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5050.12 [1], 158.49 [2]
BenzanilideIC50630957.34 [1]
3,5-Dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acidIC5063095.73 [1]
5-Methyl-4-oxo-N-o-tolyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamideIC5050118.72 [1]
[1,1'-Biphenyl]-2-carboxamideIC50158489.32 [1]
5-Methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acidIC5050118.72 [1]
5-Methyl-4-oxo-N-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamideIC507943.28 [1]
2-(1,2-Benzisoxazol-3-yl)acetic acidIC501258925.41 [1]
5-Methyl-4-Oxo-N-(1,3,4-Thiadiazol-2-Yl)-3,4-Dihydrothieno[2,3-D]pyrimidine-6-CarboxamideIC50199.53 [1]
2-[4-(1H-Pyrazol-5-yl)phenyl]-3,4-dihydroisoquinolin-1-oneIC501584.89 [1]
4-BenzamidobenzamideIC5050118.72 [1]
Benzeneacetic acid, 2-[(phenylamino)carbonyl]-IC50316227.77 [1]
{2-[(5-Methyl-4-Oxo-3,4-Dihydrothieno[2,3-D]pyrimidine-6-Carbonyl)amino]phenyl}acetic AcidIC501000.0 [1]
(2-{[4-(1h-Pyrazol-3-Yl)phenyl]carbamoyl}phenyl)acetic AcidIC501995.26 [1]
2-Amino-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC5010000.0 [1]
2-(Benzylamino)-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC501258.93 [1]
2-[(4-Chloro-2-methoxyphenyl)methylamino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50630.96 [1]
2-(Oxan-4-ylmethylamino)-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC506309.57 [1]
2-[(6-Chloropyridin-3-yl)methylamino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC502511.89 [1]
2-[(4-Chloro-3-fluorophenyl)methylamino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50316.23 [1]
2-[[(1S)-1-(4-Bromo-2-fluorophenyl)ethyl]amino]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC501584.89 [1]
N-(4-Chlorophenyl)-3-cyano-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-2-carboxamideIC50794.33 [1]
2-[(4-Chlorophenyl)methylamino]-5-ethyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC501258.93 [1]
2-[(4-Chlorophenyl)methylamino]-5-(methoxymethyl)-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC503981.07 [1]
2-[(4-Chloroanilino)methyl]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC501258.93 [1]
2-[(4-Chlorophenyl)methoxy]-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrileIC50251.19 [1]
4-Chloro-N-(3-cyano-7-oxo-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-2-yl)benzamideIC501000.0 [1]
3-[3-[1-[5-Bromo-2-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]pyrrolidin-3-yl]oxy-4-(methylcarbamoyl)phenyl]benzoic acidIC50100000.0 [1]
3-[3-[1-(2-Amino-5-bromobenzoyl)pyrrolidin-3-yl]oxy-4-(methylcarbamoyl)phenyl]benzoic acidIC50100000.0 [1]
3-[3-[1-(5-Bromothiophene-2-carbonyl)pyrrolidin-3-yl]oxy-4-(methylcarbamoyl)phenyl]benzoic acidIC5074100.0 [1]
2-[1-(5-Bromothiophene-2-carbonyl)pyrrolidin-3-yl]oxy-4-[2-(methanesulfonamido)phenyl]-N-methylbenzamideIC503900.0 [1]
2-[(3R)-1-(5-Chlorothiophene-2-carbonyl)pyrrolidin-3-yl]oxy-4-[2-(methanesulfonamido)phenyl]-N-methylbenzamideIC502800.0 [1]
2-[(3R)-1-(5-Cyanothiophene-2-carbonyl)pyrrolidin-3-yl]oxy-4-[2-(methanesulfonamido)phenyl]-N-methylbenzamideIC5015100.0 [1]
2-[(3R)-1-(5-Bromothiophene-2-carbonyl)pyrrolidin-3-yl]oxy-N-methyl-4-(2-methylphenyl)benzamideIC5064600.0 [1]
2-[(3R)-1-(5-Bromothiophene-2-carbonyl)pyrrolidin-3-yl]oxy-N-methyl-4-phenylbenzamideIC50100000.0 [1]
2-[1-(5-Bromothiophene-2-carbonyl)pyrrolidin-3-yl]oxy-N-methylbenzamideIC50100000.0 [1]
6-Phenoxypyridazin-3-amineIC50125892.54 [1]
N-[2-(1H-Pyrazol-5-yl)pyrimidin-5-yl]benzamideIC503162.28 [1]
5-Methyl-4-oxo-N-pyridin-3-yl-3H-thieno[2,3-d]pyrimidine-6-carboxamideIC50251188.64 [1]
5-Methyl-N-(1,2-oxazol-3-yl)-4-oxo-3H-thieno[2,3-d]pyrimidine-6-carboxamideIC5063095.73 [1]
Ethyl 2-[2-[(5-methyl-4-oxo-3H-thieno[2,3-d]pyrimidine-6-carbonyl)amino]phenyl]acetateIC5063095.73 [1]
5-Methyl-4-oxo-N-(2-sulfamoylphenyl)-3H-thieno[2,3-d]pyrimidine-6-carboxamideIC5012589.25 [1]
5-Methyl-N-(2-methylsulfonylphenyl)-4-oxo-3H-thieno[2,3-d]pyrimidine-6-carboxamideIC5063095.73 [1]
5-Methyl-4-oxo-N-thiophen-2-yl-3H-thieno[2,3-d]pyrimidine-6-carboxamideIC501584.89 [1]
4-(1-Oxo-3,4-dihydroisoquinolin-2-yl)benzamideIC5015848.93 [1]
N-[2-(Hydroxymethyl)phenyl]-5-methyl-4-oxo-3H-thieno[2,3-d]pyrimidine-6-carboxamideIC5010000.0 [1]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-2-pyridin-3-ylbenzimidazole-5-carboxamideIC50501.19 [1]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-2-pyridin-4-ylbenzimidazole-5-carboxamideIC501584.89 [1]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-N-methyl-2-(1,3-thiazol-2-yl)benzimidazole-5-carboxamideIC50794.33 [1]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-N-methyl-2-(2-methyl-1,3-thiazol-4-yl)benzimidazole-5-carboxamideIC50630.96 [1]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-N-methyl-2-(1H-pyrazol-5-yl)benzimidazole-5-carboxamideIC502511.89 [1]
1-[(1R,3S)-3-[(5-Chlorothiophene-2-carbonyl)amino]cyclohexyl]-2-pyridin-2-ylbenzimidazole-5-carboxamideIC50251.19 [1]
1-[(1R,3S)-3-[(5-Methylthiophene-2-carbonyl)amino]cyclohexyl]-2-pyridin-2-ylbenzimidazole-5-carboxamideIC501258.93 [1]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)-methylamino]cyclohexyl]-2-pyridin-2-ylbenzimidazole-5-carboxamideIC501995.26 [1]
1-[(1R,3S)-3-[(5-Bromothiophen-2-yl)sulfonylamino]cyclohexyl]-2-pyridin-2-ylbenzimidazole-5-carboxamideIC5019952.62 [1]
2-Bromo-N-[(1S,3R)-3-[5-(methylcarbamoyl)-2-pyridin-2-ylbenzimidazol-1-yl]cyclohexyl]-1,3-thiazole-5-carboxamideIC503162.28 [1]
1-[(1R,3S)-3-[(5-Bromo-1-methylpyrrole-2-carbonyl)amino]cyclohexyl]-N-methyl-2-pyridin-2-ylbenzimidazole-5-carboxamideIC502511.89 [1]
1-[(1R,3S)-3-[(4-Bromo-1H-pyrrole-2-carbonyl)amino]cyclohexyl]-N-methyl-2-pyridin-2-ylbenzimidazole-5-carboxamideIC501584.89 [1]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-N-propan-2-yl-2-pyridin-2-ylbenzimidazole-5-carboxamideIC50630.96 [1]
3-Chloro-N-[(1S,3R)-3-[5-(methylcarbamoyl)-2-pyridin-2-ylbenzimidazol-1-yl]cyclohexyl]-1,2-oxazole-5-carboxamideIC506309.57 [1]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-N,N-dimethyl-2-pyridin-2-ylbenzimidazole-5-carboxamideIC5019952.62 [1]
1-[(1R,3S)-3-[(5-Bromothiophene-2-carbonyl)amino]cyclohexyl]-N-cyclopropyl-2-pyridin-2-ylbenzimidazole-5-carboxamideIC50251.19 [1]
2-Hydroxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamideIC501258925.41 [1]
3,5-Dimethyl-6-(piperidine-1-carbonyl)thieno[2,3-d]pyrimidin-4-oneIC50630957.34 [1]
(2-Hydroxy-2-phenylethyl)ureaIC50794328.23 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Branched-chain-amino-acid aminotransferase, mitochondrial Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Dec. 2024, https://www.aatbio.com/data-sets/branched-chain-amino-acid-aminotransferase-mitochondrial-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 22). Quest Database™ Branched-chain-amino-acid aminotransferase, mitochondrial Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/branched-chain-amino-acid-aminotransferase-mitochondrial-inhibitors-ic50-ki.
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