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Beta-secretase (BACE) Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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l-685,458IC50300.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC503.0 [1]
(4S)-4-[[(2S)-2-[[(2S)-2-[[(3S,4S)-4-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-carboxy-2-[[(2S)-4-carboxy-2-[[(2S,3R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-hydroxybutanoyl]amino]butanoyl]amino]butanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acidIC5030.0 [1]
1-N-[(2S,3S,5R)-5-(Benzylcarbamoyl)-1-(3,5-difluorophenyl)-3-hydroxyheptan-2-yl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamideIC501400.0 [1]
3-[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]propanoic acidIC502800.0 [1]
5-[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]pentanoic acidIC50400.0 [1]
1-N-[(2S,3S,5R)-1-(3,5-Difluorophenyl)-5-[[(3R,5S)-3,5-dimethoxycyclohexyl]carbamoyl]-3-hydroxyheptan-2-yl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamideIC506600.0 [1]
1-N-[(2S,3S,5R)-1-(3,5-Difluorophenyl)-3-hydroxy-5-methyl-6-(2-methylpropylamino)-6-oxohexan-2-yl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamideIC5030.0 [1]
4-[[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]methyl]cyclohexane-1-carboxylic acidIC5050.0 [1]
4-[[[(4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-4-hydroxyhexanoyl]amino]methyl]cyclohexane-1-carboxylic acidIC50400.0 [1]
4-[[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-4-hydroxy-2-methylhexanoyl]amino]methyl]cyclohexane-1-carboxylic acidIC5026.0 [1]
6-[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]hexanoic acidIC50240.0 [1]
4-[[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-4-hydroxy-2-(2-methylpropyl)hexanoyl]amino]methyl]cyclohexane-1-carboxylic acidIC50310.0 [1]
Methyl 8-[[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]octanoateIC50410.0 [1]
4-[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]butanoic acidIC50310.0 [1]
4-[[[(2R,4S,5S)-2-Benzyl-6-(3,5-difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-4-hydroxyhexanoyl]amino]methyl]cyclohexane-1-carboxylic acidIC5027000.0 [1]
8-[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]octanoic acidIC50200.0 [1]
4-[[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-4-hydroxy-2-propylhexanoyl]amino]methyl]cyclohexane-1-carboxylic acidIC5045.0 [1]
(1S,3R)-5-[[(2S)-2-[[(3S,4S)-5-(3,5-Difluorophenyl)-3-hydroxy-4-[[2-hydroxy-2-(2-phenylphenyl)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]cyclohexane-1,3-dicarboxylic acidIC5020.0 [1]
(1R,3S)-5-[[(2S)-2-[[(3S,4S)-5-(3,5-Difluorophenyl)-4-[[3-(dipropylcarbamoyl)benzoyl]amino]-3-hydroxypentanoyl]amino]-3-methylbutanoyl]amino]cyclohexane-1,3-dicarboxylic acidIC501.0 [1]
(4S)-5-[[(1S)-1-Carboxy-2-phenylethyl]amino]-4-[[(2S)-2-[[(2S)-2-[[(3S,4S)-3-hydroxy-4-[(2-hydroxy-2-naphthalen-1-ylacetyl)amino]-6-methylheptanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acidIC504000.0 [1]
(4S)-5-[[(1S)-1-Carboxy-2-phenylethyl]amino]-4-[[(2S)-2-[[(2S,4S,5S)-4-hydroxy-5-[(2-hydroxy-2-naphthalen-1-ylacetyl)amino]-7-methyl-2-propan-2-yloctanoyl]amino]propanoyl]amino]-5-oxopentanoic acidIC507500.0 [1]
4-[[(2S,3S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]-3-hydroxy-6-methylheptanamideIC501400.0 [1]
(4S)-4-[[(2S)-2-[[(2S,4S,5S)-5-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-hydroxy-7-methyl-2-propan-2-yloctanoyl]amino]propanoyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acidIC5030.0 [1]
N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3,5-dichloropyridine-2-carboxamideIC5012.0 [1]
N-[6-[(4R)-2-Amino-5,5-difluoro-4-(2-methoxyethyl)-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-cyano-3-methylpyridine-2-carboxamideIC5049.0 [1]
N-[6-[(4R)-2-Amino-5,5-difluoro-4,6,6-trimethyl-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-cyanopyridine-2-carboxamideIC507.0 [1]
N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-cyanopyridine-2-carboxamideIC508.0 [1]
N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-(trifluoromethyl)pyridine-2-carboxamideIC5027.0 [1]
3-Amino-N-[6-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-(2,2-difluoroethoxy)pyrazine-2-carboxamideIC50440.0 [1]
N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamideIC5013.0 [1]
N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-cyanopyridine-2-carboxamideIC507.0 [1]
Items per page: 1 - 10 of 32
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References

This online tool may be cited as follows

MLA

"Quest Database™ Beta-secretase (BACE) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/beta-secretase-bace-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Beta-secretase (BACE) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/beta-secretase-bace-inhibitors-ic50-ki.
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