![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_b98d1479ed8bcbd1445c2ed6bf0913f2.svg) | l-685,458 | IC50 | 300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_56529029c28459a8fb265998ba34e411.svg) | Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate | IC50 | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_b0b23396765b2c49de9cf66d50c3fa98.svg) | (4S)-4-[[(2S)-2-[[(2S)-2-[[(3S,4S)-4-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-carboxy-2-[[(2S)-4-carboxy-2-[[(2S,3R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-hydroxybutanoyl]amino]butanoyl]amino]butanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acid | IC50 | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_41e1a50fdbc25abf528924b5346b84d6.svg) | 1-N-[(2S,3S,5R)-5-(Benzylcarbamoyl)-1-(3,5-difluorophenyl)-3-hydroxyheptan-2-yl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamide | IC50 | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_faf11703f3fac98a9335e4c55403bee8.svg) | 3-[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]propanoic acid | IC50 | 2800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_f11af88ed68bc7ff08c7c1ef4c1af15f.svg) | 5-[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]pentanoic acid | IC50 | 400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_37b7841aba560b73ea82e4ab366d6105.svg) | 1-N-[(2S,3S,5R)-1-(3,5-Difluorophenyl)-5-[[(3R,5S)-3,5-dimethoxycyclohexyl]carbamoyl]-3-hydroxyheptan-2-yl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamide | IC50 | 6600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_3b9b05cb21200fa29b5491bb8c3d468f.svg) | 1-N-[(2S,3S,5R)-1-(3,5-Difluorophenyl)-3-hydroxy-5-methyl-6-(2-methylpropylamino)-6-oxohexan-2-yl]-3-N,3-N-dipropylbenzene-1,3-dicarboxamide | IC50 | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_9d51bdd313d7aad266f7a448aad2dadb.svg) | 4-[[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]methyl]cyclohexane-1-carboxylic acid | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_d57bacf3db1fe79a44f89573bf67ce38.svg) | 4-[[[(4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-4-hydroxyhexanoyl]amino]methyl]cyclohexane-1-carboxylic acid | IC50 | 400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_c7b7f97cc8c5a32e37f3f7afb650777d.svg) | 4-[[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-4-hydroxy-2-methylhexanoyl]amino]methyl]cyclohexane-1-carboxylic acid | IC50 | 26.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_bddcf52410e1c87b6432343b10021317.svg) | 6-[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]hexanoic acid | IC50 | 240.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_2c5dfe412091db166582eaf208e9e39f.svg) | 4-[[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-4-hydroxy-2-(2-methylpropyl)hexanoyl]amino]methyl]cyclohexane-1-carboxylic acid | IC50 | 310.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_c02c9bfbc414a956f4d467ae674d8ddc.svg) | Methyl 8-[[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]octanoate | IC50 | 410.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_e4691d6f1b2118ffc0347b1e75f63f55.svg) | 4-[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]butanoic acid | IC50 | 310.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_fb0a8dbb3c9cf9c85b4822dae8871e80.svg) | 4-[[[(2R,4S,5S)-2-Benzyl-6-(3,5-difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-4-hydroxyhexanoyl]amino]methyl]cyclohexane-1-carboxylic acid | IC50 | 27000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_9ea2924bfa62e13373d4584c631a2928.svg) | 8-[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-2-ethyl-4-hydroxyhexanoyl]amino]octanoic acid | IC50 | 200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_fe89c6e2de64aa191535806bf9152cc6.svg) | 4-[[[(2R,4S,5S)-6-(3,5-Difluorophenyl)-5-[[3-(dipropylcarbamoyl)benzoyl]amino]-4-hydroxy-2-propylhexanoyl]amino]methyl]cyclohexane-1-carboxylic acid | IC50 | 45.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_e8c3935f2e7e3d2b4882e328865c175f.svg) | (1S,3R)-5-[[(2S)-2-[[(3S,4S)-5-(3,5-Difluorophenyl)-3-hydroxy-4-[[2-hydroxy-2-(2-phenylphenyl)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]cyclohexane-1,3-dicarboxylic acid | IC50 | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_09a0e4492c98f51b47e4b0d13f891743.svg) | (1R,3S)-5-[[(2S)-2-[[(3S,4S)-5-(3,5-Difluorophenyl)-4-[[3-(dipropylcarbamoyl)benzoyl]amino]-3-hydroxypentanoyl]amino]-3-methylbutanoyl]amino]cyclohexane-1,3-dicarboxylic acid | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_b970aaa058436033e29e5ef7008e1a98.svg) | (4S)-5-[[(1S)-1-Carboxy-2-phenylethyl]amino]-4-[[(2S)-2-[[(2S)-2-[[(3S,4S)-3-hydroxy-4-[(2-hydroxy-2-naphthalen-1-ylacetyl)amino]-6-methylheptanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid | IC50 | 4000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_4bd2759a03432b4305fd699e20a1a559.svg) | (4S)-5-[[(1S)-1-Carboxy-2-phenylethyl]amino]-4-[[(2S)-2-[[(2S,4S,5S)-4-hydroxy-5-[(2-hydroxy-2-naphthalen-1-ylacetyl)amino]-7-methyl-2-propan-2-yloctanoyl]amino]propanoyl]amino]-5-oxopentanoic acid | IC50 | 7500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_187e7833d43b4cc4dd034920f3c8cfc8.svg) | 4-[[(2S,3S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]-3-hydroxy-6-methylheptanamide | IC50 | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_e0e778f2e17995fe9172d939a7a6dbba.svg) | (4S)-4-[[(2S)-2-[[(2S,4S,5S)-5-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-hydroxy-7-methyl-2-propan-2-yloctanoyl]amino]propanoyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acid | IC50 | 30.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_6fc7be89430ef29dbd3476d01c2ada71.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3,5-dichloropyridine-2-carboxamide | IC50 | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_9ef1a07cdcb920ac28f75a87d68571b6.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-(2-methoxyethyl)-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-cyano-3-methylpyridine-2-carboxamide | IC50 | 49.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_72b148b5433d802a697931687e1c7d76.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4,6,6-trimethyl-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-cyanopyridine-2-carboxamide | IC50 | 7.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_2ff07115ea85a50dbcb6245ec185191e.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-cyanopyridine-2-carboxamide | IC50 | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_f23c6e28139df4d952030f83352f897c.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-(trifluoromethyl)pyridine-2-carboxamide | IC50 | 27.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_cdd7fa8120d78ba29e4f961aacba3001.svg) | 3-Amino-N-[6-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-(2,2-difluoroethoxy)pyrazine-2-carboxamide | IC50 | 440.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_d0fd2b63a5b377f725f6eca7a00df37a.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide | IC50 | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-bace_3dfa155202ec06fdaf8341acda5cf131.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-cyanopyridine-2-carboxamide | IC50 | 7.0 [1] |