![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_7bc8b337c94be291c036e3ea91d3fa75.svg) | 8,8-Diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine | IC50 | 38000.0 [1], 38300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_1065c9a850a610e560e1f7d81049387a.svg) | N-[3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide | IC50 | 3.3 [1], 4.5 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_1065c9a850a610e560e1f7d81049387a.svg) | N-[3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide | Ki | 0.22 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_38f4d151f4e09a03d9b7b3382c611f21.svg) | Verubecestat | IC50 | 0.38 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_38f4d151f4e09a03d9b7b3382c611f21.svg) | Verubecestat | Ki | 0.37 [1], 0.47 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_660bcf78d458eda252978ea31fa54645.svg) | (2e)-2-Imino-3-Methyl-5,5-Diphenylimidazolidin-4-One | IC50 | 770.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_842dc1dd43300bd8c41b505c4d1ddb38.svg) | 3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]benzamide | IC50 | 1160.0 [1], 1430.0 [2], 4260.0 [3] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_3a6f5d2fa5625bdaea61e36c656fc779.svg) | N-[(2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 263.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_5789f518316bb0bea4739758b5137006.svg) | N-[(2S,3R)-4-[[(2S)-1-(Cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide | IC50 | 1810.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_fdab4afdcc40d3a80c4b8f66f84bc1aa.svg) | 3-Ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 59.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_b9c28f8fb9f427eca3750c1362377adf.svg) | N-[3-[(4Ar,7aS)-2-amino-4a,5,6,7-tetrahydro-4H-cyclopenta[d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide | IC50 | 10.2 [1], 17.8 [2], 42.9 [3] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_32b1a99dc47e72aa5a795fd6eb6dda04.svg) | Bace-1 inhibitor | IC50 | 132.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_32b1a99dc47e72aa5a795fd6eb6dda04.svg) | Bace-1 inhibitor | Ki | 240.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_c8aa1141ac7cc30e73bcde767ec2a7f0.svg) | Lanabecestat | IC50 | 0.9 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_c8aa1141ac7cc30e73bcde767ec2a7f0.svg) | Lanabecestat | Ki | 372.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_0d78d629b9d41a432b31079ded962652.svg) | N-[Amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide | IC50 | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_59d986a96afb35a10453279024147c85.svg) | 2-Amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one | IC50 | 780.0 [1], 790.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_d17e2bf794bf7aca723d9de98692afe9.svg) | N-Carbamimidoyl-2-[2-(2-Chlorophenyl)-5-[4-(4-Ethanoylphenoxy)phenyl]pyrrol-1-Yl]ethanamide | IC50 | 2300.0 [1], 3200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_599a4cd8fa7b086832dc30e01dd78408.svg) | 2-Amino-1-methyl-4-(3-(pyridin-3-yl)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one | IC50 | 480.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_0f259a090296259360fe20fe58274528.svg) | 2-Amino-1-methyl-4-phenyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one | IC50 | 2010.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_ad31b73366faf599885607d5abc5b565.svg) | 2-Amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl)-1H-imidazol-5(4H)-one | IC50 | 140.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_95a7182ff86051f224227000412ee15d.svg) | 2-Amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-5-(4-methoxy-3-methylphenyl)-3-methylimidazol-4-one | IC50 | 780.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_0b37ddfcbdfd008ca8368cb4727a1021.svg) | (1S)-1-(2-(Difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine | IC50 | 0.9 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_0b37ddfcbdfd008ca8368cb4727a1021.svg) | (1S)-1-(2-(Difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine | Ki | 370.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_f555cc716f4d05f081210f3a56abd4d9.svg) | 3-(Ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-5-(2-oxopyrrolidin-1-yl)benzamide | IC50 | 4070.0 [1], 4485.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_9a7ceb83b7b197b0d1c88e772b19b2ba.svg) | 1-N-[(1R,2S)-3-(3,5-Difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenylmethoxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide | IC50 | 45.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_18cb4fb4affdbc27dd2fb756ee1ea33a.svg) | 1-N-[(1R,2S)-3-(3,5-Difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenoxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide | IC50 | 54.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_f8902ef79251a0a60858290ea07fa763.svg) | 3-Ethyl-N-[(2S,3R)-3-hydroxy-4-(oxan-4-ylamino)-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 210.0 [1], 490.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_735dbdbdb300f52dccb0ba198350c31b.svg) | 3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-[(6-methoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-phenylbutan-2-yl]benzamide | IC50 | 2950.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_cb2c4128b47698b975b349352d73d56c.svg) | 3-Ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-(3,3,3-trifluoropropylamino)butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 28.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_aec14eee25f508349c6c029651cc95fe.svg) | N-[(2S,3R)-4-[[(2S)-1-(Cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-methylsulfonylbenzamide | IC50 | 41770.0 [1], 42000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_31e9464990bf6d178bff4a9ce9f3d1cb.svg) | N-[(2S,3R)-4-[[(2S)-1-(Cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(2-oxopyrrolidin-1-yl)benzamide | IC50 | 78530.0 [1], 79000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_b0a6b2f78980cd0f0f225025f277bb9a.svg) | N-[(2S,3R)-4-(Cyclohexylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 114.0 [1], 210.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_56dc874fa2c3efc4bd2ea3ec26414359.svg) | N-[(2S,3R)-4-(2,6-Dimethylheptan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 110.0 [1], 210.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_92becc97f810a9d74aae1f7a5a7b89ab.svg) | 3-Ethyl-N-[(2S,3R)-3-hydroxy-4-(methylamino)-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide | IC50 | 1260.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_0ed6a9856c457c85506a2126f6ea320f.svg) | N-[2-[(4Ar,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-(difluoromethoxy)pyridine-2-carboxamide | IC50 | 194.0 [1], 238.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_360a6d1c29e508c934fd8ada2ae3e9bd.svg) | N-[2-[(4Ar,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-chloropyridine-2-carboxamide | IC50 | 20.0 [1], 21.6 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_47b5070c7508d416b93a481b666e01e4.svg) | N-[2-[(4Ar,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide | IC50 | 57.0 [1], 70.5 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_2e45fe52308d00e13733a9a52af9ecb5.svg) | N-[(2S,3R)-4-(Benzylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)benzamide | IC50 | 32360.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_ad9966e722ccbbf9d3b2a21f8c7cd5fb.svg) | N-[(2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)benzamide | IC50 | 19500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_9f1b3772d8b16c7d2a8cce97f839abb3.svg) | 6-Fluoro-2-[3-(7-fluoroimidazo[1,2-a]pyridin-2-yl)phenyl]-1H-benzimidazole | IC50 | 3675.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_9f1b3772d8b16c7d2a8cce97f839abb3.svg) | 6-Fluoro-2-[3-(7-fluoroimidazo[1,2-a]pyridin-2-yl)phenyl]-1H-benzimidazole | Ki | 3568.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_1b25b9d377137eb0043b5be7eb6621bd.svg) | 2-[4-(1H-Benzimidazol-2-yl)phenyl]-N-tert-butylimidazo[1,2-a]pyridin-3-amine | IC50 | 5675.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_1b25b9d377137eb0043b5be7eb6621bd.svg) | 2-[4-(1H-Benzimidazol-2-yl)phenyl]-N-tert-butylimidazo[1,2-a]pyridin-3-amine | Ki | 5509.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_32038ddf6d402b873302e5b63d29ac51.svg) | N-Tert-butyl-2-[4-(6-fluoro-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine | IC50 | 3725.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_32038ddf6d402b873302e5b63d29ac51.svg) | N-Tert-butyl-2-[4-(6-fluoro-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine | Ki | 3617.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_32d56f3c76569e98ae3d6bbd52939198.svg) | N-Tert-butyl-2-[4-(6-methoxy-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine | IC50 | 2895.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_32d56f3c76569e98ae3d6bbd52939198.svg) | N-Tert-butyl-2-[4-(6-methoxy-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine | Ki | 2810.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_8320f3d64038417d87f8352af10e4e17.svg) | 2-[3-(1H-Benzimidazol-2-yl)phenyl]-N-tert-butylimidazo[1,2-a]pyridin-3-amine | IC50 | 3785.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_8320f3d64038417d87f8352af10e4e17.svg) | 2-[3-(1H-Benzimidazol-2-yl)phenyl]-N-tert-butylimidazo[1,2-a]pyridin-3-amine | Ki | 3674.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_68b764c34e69e5f9b50bab217ef8a59e.svg) | N-Tert-butyl-2-[3-(6-fluoro-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine | IC50 | 4234.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_68b764c34e69e5f9b50bab217ef8a59e.svg) | N-Tert-butyl-2-[3-(6-fluoro-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine | Ki | 4110.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_22139495cd82a34f568856b5579178fb.svg) | N-Tert-butyl-2-[3-(6-methoxy-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine | IC50 | 4123.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_22139495cd82a34f568856b5579178fb.svg) | N-Tert-butyl-2-[3-(6-methoxy-1H-benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-amine | Ki | 4003.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_6a41e3b497003162c339d2f6b0e13938.svg) | 2-[3-(1H-Benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridine | IC50 | 3890.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_6a41e3b497003162c339d2f6b0e13938.svg) | 2-[3-(1H-Benzimidazol-2-yl)phenyl]imidazo[1,2-a]pyridine | Ki | 3777.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_a1e926273b9c0b657c87a1610d1d9977.svg) | 6-Fluoro-2-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-1H-benzimidazole | IC50 | 3173.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_a1e926273b9c0b657c87a1610d1d9977.svg) | 6-Fluoro-2-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-1H-benzimidazole | Ki | 3081.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_fa0028126799f2acb19bdeab5397bc65.svg) | 2-(3-Imidazo[1,2-a]pyridin-2-ylphenyl)-6-methoxy-1H-benzimidazole | IC50 | 3321.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_fa0028126799f2acb19bdeab5397bc65.svg) | 2-(3-Imidazo[1,2-a]pyridin-2-ylphenyl)-6-methoxy-1H-benzimidazole | Ki | 3224.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_19333b178c6fd9da8f11ba4d3d0d2f7b.svg) | 3-[5-(3-Methoxyphenyl)-1H-imidazol-2-yl]-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide | IC50 | 2350.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_19333b178c6fd9da8f11ba4d3d0d2f7b.svg) | 3-[5-(3-Methoxyphenyl)-1H-imidazol-2-yl]-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide | Ki | 2281.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_2306e41aa45d3a300603e860144077f7.svg) | 3-[Methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]-5-(5-phenyl-1H-imidazol-2-yl)benzamide | IC50 | 1786.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_2306e41aa45d3a300603e860144077f7.svg) | 3-[Methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]-5-(5-phenyl-1H-imidazol-2-yl)benzamide | Ki | 1733.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_c60cfafa342567bd48fa8b4d6beeff50.svg) | 3-[5-(3-Fluorophenyl)-1H-imidazol-2-yl]-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide | IC50 | 1873.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_c60cfafa342567bd48fa8b4d6beeff50.svg) | 3-[5-(3-Fluorophenyl)-1H-imidazol-2-yl]-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide | Ki | 1818.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_33c3b2776ad8d4f1373398e3793bcfe9.svg) | 3-(6-Methoxy-1H-benzimidazol-2-yl)-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide | IC50 | 2425.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_33c3b2776ad8d4f1373398e3793bcfe9.svg) | 3-(6-Methoxy-1H-benzimidazol-2-yl)-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide | Ki | 2354.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_c60826a5302031d62794f639f5b518f5.svg) | 3-(6-Fluoro-1H-benzimidazol-2-yl)-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide | IC50 | 2127.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_c60826a5302031d62794f639f5b518f5.svg) | 3-(6-Fluoro-1H-benzimidazol-2-yl)-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide | Ki | 2065.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_d92103abf5a563f87a4799a608aaad32.svg) | 3-(1H-Benzimidazol-2-yl)-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide | IC50 | 2130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_d92103abf5a563f87a4799a608aaad32.svg) | 3-(1H-Benzimidazol-2-yl)-5-[methyl(methylsulfonyl)amino]-N-[(1S)-1-phenylethyl]benzamide | Ki | 2067.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_37ce8153fddcb505be4c75fd4818cd0a.svg) | (5S)-5-[3-Chloro-5-(5-prop-1-ynylpyridin-3-yl)thiophen-2-yl]-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-3-amine | Ki | 0.37 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_6fc7be89430ef29dbd3476d01c2ada71.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3,5-dichloropyridine-2-carboxamide | IC50 | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_9ef1a07cdcb920ac28f75a87d68571b6.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-(2-methoxyethyl)-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-cyano-3-methylpyridine-2-carboxamide | IC50 | 580.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_72b148b5433d802a697931687e1c7d76.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4,6,6-trimethyl-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-cyanopyridine-2-carboxamide | IC50 | 71.0 [1], 140.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_2ff07115ea85a50dbcb6245ec185191e.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-cyanopyridine-2-carboxamide | IC50 | 71.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_cad5fd9c0a4af9b40f5f82984402766c.svg) | N-[3-[(4As,7aS)-3-amino-2-methyl-1,1-dioxo-7,7a-dihydro-5H-furo[3,4-e][1,2,4]thiadiazin-4a-yl]-4-fluorophenyl]-5-(difluoromethyl)pyrazine-2-carboxamide | Ki | 17.4 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_f23c6e28139df4d952030f83352f897c.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-(trifluoromethyl)pyridine-2-carboxamide | IC50 | 290.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_cdd7fa8120d78ba29e4f961aacba3001.svg) | 3-Amino-N-[6-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-(2,2-difluoroethoxy)pyrazine-2-carboxamide | IC50 | 2900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_d0fd2b63a5b377f725f6eca7a00df37a.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide | IC50 | 7.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_3dfa155202ec06fdaf8341acda5cf131.svg) | N-[6-[(4R)-2-Amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-cyanopyridine-2-carboxamide | IC50 | 66.0 [1], 260.0 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_dce9996124d455a45cb35f5d8d873b32.svg) | (6R,8As)-8a-(2,4-difluorophenyl)-6-(3-methyl-1,2-oxazol-5-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine | IC50 | 4550.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_3e5e33eb5210a4622f7c135e5f739693.svg) | N-[3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-methylpyrazine-2-carboxamide | Ki | 4.85 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_86e4b6b56a0a916b4d0ea957bf07997e.svg) | N-[3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-methylpyridine-2-carboxamide | Ki | 0.45 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_933275b037c983d764a337c6e327719b.svg) | N-[3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4,5-difluorophenyl]-5-methoxypyrazine-2-carboxamide | Ki | 2.15 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_061ee2f1c483996d8ba10e94e7f08324.svg) | 5-[5-[(5S)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]thiophen-3-yl]-2-fluorobenzonitrile | Ki | 8.23 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_604e938af6ec2e6a9f1d6a3646a71846.svg) | N-[3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-(trifluoromethyl)pyridine-2-carboxamide | Ki | 2.46 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_cc9c7d2c7a47db58aec5fa40ffe30037.svg) | N-[3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide | Ki | 1.99 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_6f1ecf3820351a98333b540e04973692.svg) | N-[3-[(7R)-9-Amino-2-hydroxy-7-methyl-5,5-dioxo-5lambda6-thia-8-azaspiro[3.5]non-8-en-7-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide | Ki | 1.7 [1], 3.8 [2] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_83ebacb436659f04a24927924097abe6.svg) | (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine | IC50 | 2880.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_2da69220e39477ea109cbebfe8c599f7.svg) | CID 66665322 | IC50 | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_56529029c28459a8fb265998ba34e411.svg) | Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate | IC50 | 500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_e615e23acc0bcd018f5546414ffda5ad.svg) | 3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-2-fluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]benzamide | IC50 | 177.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_88996033e9415c88376b033ee6b9d0ad.svg) | (4S)-4-Amino-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[(4S,5S,7R)-8-[[(2S)-1-[[(2S)-4-carboxy-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid | Ki | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_b1ed6e6c6677a6976484a9ed0de5b15c.svg) | (4S)-7'-(2-Fluoropyridin-3-yl)-3'-[2-(3-methyloxetan-3-yl)ethynyl]spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine | IC50 | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_c2de415735ac4f8efd66e777cda53b11.svg) | 3-[5-[(2R)-2-Amino-1-phenylpropan-2-yl]-1,3,4-oxadiazol-2-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide | IC50 | 620.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_16d7a10a49ef8b6f0d3237be98064268.svg) | [3-[2-(5-Aminopentylamino)-2-oxoethoxy]-5-[[(1R)-1-(4-fluorophenyl)ethyl]carbamoyl]phenyl] phenylmethanesulfonate | IC50 | 137000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_0aa8539d170bee7942094b0ea64d4323.svg) | Example 1 (WO2011029803) | IC50 | 9.0 [1] |
![](https://images.aatbio.com/dataset/ic50/beta-secretase-2_59544ad5b4276653b482fc97fb959939.svg) | Bace1-IN-1 | IC50 | 24.0 [1] |