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Beta-secretase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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EVNLPsiAAEFIC5010.0 [1]
EVNLPsiAAEFKi1.6 [1]
Bace-1 inhibitorIC5025.4 [1]
Bace-1 inhibitorKi233.0 [1]
(S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amineIC50240.0 [1]
N-[(2S,3R)-4-[[(2S)-1-(Cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamideIC50310.0 [1]
(2e)-2-Imino-3-Methyl-5,5-Diphenylimidazolidin-4-OneIC503440.0 [1]
3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-2-fluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]benzamideIC505.0 [1]
3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]benzamideIC5019.0 [1]
N-[3-[(4S)-2-Amino-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamideIC5051.0 [1]
3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-4-[(1-ethylpyrazol-4-yl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]benzamideIC5078.0 [1]
3-[[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(2H-tetrazole-5-carbonylamino)propanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-2-hydroxy-4-phenylbutanoyl]amino]benzoic acidIC508.2 [1]
5-[[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(2H-tetrazole-5-carbonylamino)propanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-2-hydroxy-4-phenylbutanoyl]amino]benzene-1,3-dicarboxylic acidIC503.9 [1]
8,8-Diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amineIC5038000.0 [1]
N-[(2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamideIC5016.32 [1]
3-[5-[(2R)-2-Amino-1-phenylpropan-2-yl]-1,3,4-oxadiazol-2-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamideIC509.0 [1], 12.0 [2], 60.0 [3], 65.0 [4]
3-[5-[(2R)-2-Amino-1-phenylpropan-2-yl]-1,3,4-oxadiazol-2-yl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamideKi39.81 [1]
N-[(2S,3R)-4-[[(4S)-6-(2,2-Dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]acetamideIC505.0 [1]
1-N-[(2S,3R)-1-(3,5-Difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamideIC5015.0 [1], 20.0 [2], 80.0 [3]
3-Ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamideIC502.0 [1]
2-Amino-6-[2-[3-(3-methoxyphenyl)phenyl]ethyl]-3-methylpyrimidin-4-oneIC505700.0 [1]
N-[(2S,3R)-4-(Benzylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)benzamideIC50120.0 [1]
N-[3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamideIC500.54 [1], 0.9 [2], 2.2 [3], 6.4 [4]
N-[3-[(5R)-3-Amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamideKi0.95 [1]
VerubecestatIC500.4 [1], 2.2 [2]
VerubecestatKi1.75 [1], 4.88 [2]
MemoquinIC50108.0 [1], 4600.0 [2]
LanabecestatIC500.2 [1], 0.57 [2], 0.6 [3], 25.0 [4]
LanabecestatKi26.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC502.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateKi2.5 [1]
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[(4S,5S,7R)-8-[[(2S)-1-[[(2S)-4-carboxy-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acidIC506.0 [1]
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[(4S,5S,7R)-8-[[(2S)-1-[[(2S)-4-carboxy-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acidKi0.3 [1], 0.31 [2], 1.2 [3]
(4S)-4-[[(2S)-2-[[(2S)-2-[[(3S,4S)-4-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-4-carboxy-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-carboxy-2-[[(2S)-4-carboxy-2-[[(2S,3R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-hydroxybutanoyl]amino]butanoyl]amino]butanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]butanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acidIC5030.0 [1], 120.0 [2], 200.0 [3]
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5R)-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(pyridin-4-ylmethylamino)butan-2-yl]amino]-6-oxo-1-phenylhexan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamateIC5082.0 [1], 2100.0 [2]
Example 1 (WO2011029803)IC500.84 [1], 1.0 [2], 6.7 [3], 16.0 [4], 18.0 [5]
(2R)-N-[(2S,3R)-1-(1,3-Benzodioxol-5-yl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]-2-methoxypropanamideIC5014.0 [1], 16.8 [2], 18.0 [3], 26.0 [4]
2-Amino-3-methyl-6-phenethyl-3H-pyrimidin-4-oneIC50150000.0 [1], 171000.0 [2], 180000.0 [3], 220000.0 [4]
N-[3-[(4S)-2-Amino-4-methyl-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamideIC5010.0 [1], 137.0 [2], 30000.0 [3]
N-[3-(3-Amino-1,5-dimethyl-6-oxo-2H-pyrazin-5-yl)phenyl]-5-chloropyridine-2-carboxamideIC5078.0 [1], 98.0 [2], 348.0 [3], 447.0 [4], 1040.0 [5]
(4Ar,6R,8aS)-8a-(2,4-difluorophenyl)-6-(fluoromethyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amineIC5061.0 [1], 1070.0 [2], 1390.0 [3]
(4Ar,6S,8aS)-8a-(2,4-difluorophenyl)-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amineIC5039.0 [1], 700.0 [2], 704.0 [3]
N-[(2S,3R)-4-(Cyclohexylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamideIC505.0 [1], 9.0 [2], 19.19 [3], 28.85 [4], 93.0 [5]
N-[(2S,3R)-4-(2,6-Dimethylheptan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamideIC505.0 [1], 9.0 [2], 21.31 [3], 27.38 [4], 72.0 [5]
3-Ethyl-N-[(2S,3R)-3-hydroxy-4-(methylamino)-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamideIC5015.0 [1], 48.9 [2], 57.03 [3], 106.0 [4]
3-(1,1-Dioxothiazinan-2-yl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]benzamideIC506.0 [1], 21.0 [2], 27.0 [3], 205.0 [4], 715.0 [5]
3-(1,1-Dioxothiazinan-2-yl)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-5-propylbenzamideIC505.0 [1], 40.0 [2], 366.0 [3], 844.0 [4]
3-(1,1-Dioxothiazinan-2-yl)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-5-(propan-2-ylamino)benzamideIC5011.0 [1], 58.0 [2], 62.0 [3], 414.0 [4], 910.0 [5]
3-(1,1-Dioxothiazinan-2-yl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethoxy)phenyl]methylamino]butan-2-yl]benzamideIC505.0 [1], 18.0 [2], 25.0 [3], 216.0 [4], 711.0 [5]
3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethoxy)phenyl]methylamino]butan-2-yl]benzamideIC505.0 [1], 34.0 [2], 39.0 [3], 47.0 [4], 102.0 [5]
3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]benzamideIC508.0 [1], 19.0 [2], 41.0 [3], 299.0 [4], 928.0 [5]
N-[(2S,3R)-1-(3,5-Difluorophenyl)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]butan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)benzamideIC505.0 [1], 26.0 [2], 30.0 [3], 203.0 [4], 450.0 [5]
3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-2-fluoro-N-[(2S,3R)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]benzamideIC504.0 [1], 12.0 [2], 14.0 [3], 92.0 [4], 283.0 [5]
3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-4-[(1-ethylpyrazol-4-yl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]-2-fluorobenzamideIC506.0 [1], 12.0 [2], 14.0 [3], 176.0 [4], 361.0 [5]
CID 86724311IC5096.0 [1], 316.0 [2], 383.0 [3]
CID 86724314IC502180.0 [1], 3350.0 [2], 3400.0 [3]
CID 90054972IC50400.0 [1], 588.0 [2], 1000.0 [3]
CID 90054977IC50859.0 [1], 900.0 [2], 1410.0 [3]
CID 90055967IC50747.0 [1], 810.0 [2], 1150.0 [3]
CID 90055976IC502240.0 [1], 3040.0 [2], 3100.0 [3]
CID 90055977IC5073.0 [1], 239.0 [2], 401.0 [3]
CID 90056005IC501400.0 [1], 2060.0 [2], 3240.0 [3]
CID 90056333IC50760.0 [1], 1270.0 [2], 2050.0 [3]
CID 90236720IC502.2 [1], 41.8 [2], 44.4 [3]
CID 90246747IC50490.0 [1], 1770.0 [2], 2030.0 [3]
CID 90246748IC50820.0 [1], 2130.0 [2], 2590.0 [3]
QuercetinIC505400.0 [1], 5600.0 [2], 6500.0 [3]
QuercetinKi14000.0 [1]
N-[Amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamideIC503700.0 [1]
3-N-[(2S,3R)-3-Hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamideIC500.4 [1], 1.0 [2], 2.5 [3]
3-N-[(2S,3R)-3-Hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamideKi1.8 [1]
Tert-butyl N-[(2R)-1-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-3-methylsulfonyl-1-oxopropan-2-yl]carbamateKi1129.0 [1]
N-[(2S)-2-Amino-3-[[(2S)-1-[[(2S)-1-[[(2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-[3-(2H-tetrazol-5-yl)anilino]butan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-oxopropyl]-2H-tetrazole-5-carboxamideIC504.8 [1]
N-[(2S,3R)-4-[[1-(3-Tert-butylphenyl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamideIC5047.0 [1]
N-[(2S)-2-Amino-3-[[(2S)-1-[[(2S)-1-[[(2S,3R)-4-[3,5-bis(2H-tetrazol-5-yl)anilino]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-oxopropyl]-2H-tetrazole-5-carboxamideIC501.2 [1]
N-[(2S)-2-Amino-3-[[(2S)-1-[[(2S)-3-cyclohexyl-1-[[(2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-[3-(2H-tetrazol-5-yl)anilino]butan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-oxopropyl]-5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxamideIC505.6 [1]
5-[(1R)-3-Amino-4-fluoro-1-[3-(5-prop-1-ynylpyridin-3-yl)phenyl]isoindol-1-yl]-1-ethyl-3-methylpyridin-2-oneIC500.16 [1], 0.2 [2], 2.0 [3], 2.44 [4]
N-Carbamimidoyl-2-[2-(2-Chlorophenyl)-5-[4-(4-Ethanoylphenoxy)phenyl]pyrrol-1-Yl]ethanamideIC50160.0 [1], 700.0 [2], 3800.0 [3]
(1S)-1-(2-(Difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amineIC500.6 [1], 16.7 [2], 35.1 [3]
(1S)-1-(2-(Difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amineKi25.7 [1]
N-[3-[(1S,7S)-3-Amino-4-thia-2-azabicyclo[5.1.0]oct-2-en-1-yl]phenyl]-5-chloropyridine-2-carboxamideIC502.0 [1], 5.0 [2], 27.0 [3]
3-[5-[(4Ar,7aR)-2-amino-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrileIC5016.0 [1]
3-[5-[(4Ar,7aR)-2-amino-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrileKi4.0 [1]
N-[(2S,3R)-4-[[(4S)-6-(2,2-Dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamideIC503.0 [1], 3.1 [2], 5.8 [3], 6.0 [4]
3-(Ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-5-(2-oxopyrrolidin-1-yl)benzamideIC5040.0 [1], 49.0 [2], 180.0 [3], 200.0 [4]
1-N-[(1R,2S)-3-(3,5-Difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenylmethoxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamideIC505.0 [1], 150.0 [2]
1-N-[(1R,2S)-3-(3,5-Difluorophenyl)-1-[(2R,4S)-4-ethoxypiperidin-2-yl]-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamideIC507.0 [1], 8.0 [2], 106.0 [3]
1-N-[(1R,2S)-3-(3,5-Difluorophenyl)-1-hydroxy-1-[(2R,4R)-4-phenoxypyrrolidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamideIC503.0 [1], 165.0 [2]
2-Amino-3-methyl-6-[2-(3-phenylphenyl)ethyl]pyrimidin-4-oneIC506500.0 [1], 29000.0 [2], 30000.0 [3]
3-Ethyl-N-[(2S,3R)-3-hydroxy-4-(oxan-4-ylamino)-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamideIC509.0 [1], 15.0 [2], 90.0 [3]
N-[3-[(2R,3R)-5-Amino-2-fluoro-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamideIC509.1 [1], 12.0 [2], 13.2 [3]
1-N-[(1R,2S)-1-[(2R,4S)-4-Benzylpiperidin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamideIC5014.0 [1], 522.0 [2]
3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-[(6-methoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-phenylbutan-2-yl]benzamideIC5018.0 [1], 26.0 [2], 36.0 [3]
3-Ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-(3,3,3-trifluoropropylamino)butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamideIC507.0 [1], 8.0 [2]
1-N-[(1R,2S)-3-(3,5-Difluorophenyl)-1-hydroxy-1-[(2R)-piperidin-2-yl]propan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamideIC50130.0 [1], 240.0 [2]
(4Ar,7aS)-2-amino-7a-(2,5-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-oneIC5023.0 [1], 28.0 [2]
(4Ar,7aS)-2-amino-7a-(2,5-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-4-oneKi8.5 [1], 9.0 [2]
(4s)-2'-(2,2-Dimethylpropoxy)-7'-(Pyrimidin-5-Yl)spiro[1,3-Oxazole-4,9'-Xanthen]-2-AmineIC502.0 [1], 2.2 [2], 25.0 [3]
(4s)-2'-(2-Methylpropoxy)-7'-(Pyrimidin-5-Yl)spiro[1,3-Oxazole-4,9'-Xanthen]-2-AmineIC508.0 [1], 36.0 [2]
N-[3-[(3R)-5-Amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamideIC503.0 [1], 4.1 [2], 22.0 [3], 31.0 [4]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Beta-secretase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/beta-secretase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Beta-secretase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/beta-secretase-1-inhibitors-ic50-ki.
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