Beta-N-acetyl-D-hexosaminidase-A/B Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Pyrimethamine	IC50	3100.0 [1], 8900.0 [2], 14000.0 [3], 15000.0 [4], 17000.0 [5]
	6-Ethyl-5-phenylpyrimidine-2,4-diamine	IC50	11000.0 [1], 27000.0 [2], 30000.0 [3], 32000.0 [4]
	1H-Benz(de)isoquinoline-1,3(2H)-dione, 2-(2-(dimethylamino)ethyl)-	Ki	2810.0 [1]
	2-(2-Hydroxyethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione	Ki	30870.0 [1]
	6-Ethyl-5-(4-methylphenyl)pyrimidine-2,4-diamine	IC50	40000.0 [1]
	5-(4-Chlorophenyl)-6-methylpyrimidine-2,4-diamine	IC50	560000.0 [1]
	6-Ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine	IC50	18000.0 [1]
	2-[2-[2-(1,3-Dioxobenzo[de]isoquinolin-2-yl)ethylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	3220.0 [1]
	Naphthalimidopropylamine	Ki	29080.0 [1]
	6-Ethyl-5-[4-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine	IC50	15000.0 [1]
	(2-Aminoethyl)naphthalimide	Ki	2090.0 [1]
	4-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-butylamine	Ki	61740.0 [1]
	4-Ethyl-5-[4-(trifluoromethyl)phenyl]pyrimidine	IC50	940000.0 [1]
	5-(4-Chlorophenyl)-4-ethylpyrimidin-2-amine	IC50	400000.0 [1]
	4-Ethyl-5-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine	IC50	400000.0 [1]
	N-[(6S,7S,8R,8As)-7,8-dihydroxy-3-phenylimino-1,5,6,7,8,8a-hexahydro-[1,3]thiazolo[3,4-a]pyridin-6-yl]acetamide	IC50	315000.0 [1]
	N-[(6S,7S,8R,8As)-7,8-dihydroxy-3-octylimino-1,5,6,7,8,8a-hexahydro-[1,3]thiazolo[3,4-a]pyridin-6-yl]acetamide	IC50	315000.0 [1]
	4(1H)-Pyrimidinone, 2-amino-5-(4-chlorophenyl)-6-ethyl-	IC50	2100000.0 [1]
	5-(4-Chlorophenyl)-6-propylpyrimidine-2,4-diamine	IC50	18000.0 [1]
	6-Ethyl-5-(3-methylphenyl)pyrimidine-2,4-diamine	IC50	34000.0 [1]
	6-Ethyl-5-(2-methylphenyl)pyrimidine-2,4-diamine	IC50	43000.0 [1]
	5-(4-Chlorophenyl)-6-propan-2-ylpyrimidine-2,4-diamine	IC50	410000.0 [1]
	6-Butyl-5-(4-chlorophenyl)pyrimidine-2,4-diamine	IC50	1400000.0 [1]
	6-(Aminomethyl)-5-(4-chlorophenyl)pyrimidine-2,4-diamine	IC50	180000.0 [1]
	5-(3,5-Dimethylphenyl)-6-ethylpyrimidine-2,4-diamine	IC50	47000.0 [1]
	2-[2-[2-(4-Methoxyphenoxy)ethylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	1040.0 [1]
	2-[2-[2-(3-Methoxyphenoxy)ethylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	930.0 [1]
	2-[2-[2-(2-Methoxyphenoxy)ethylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	1350.0 [1]
	2-[2-[2-(4-Methoxyphenyl)sulfanylethylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	1130.0 [1]
	2-[2-[3-(4-Methoxyphenoxy)propylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	1230.0 [1]
	2-[2-[3-(3-Methoxyphenoxy)propylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	4390.0 [1]
	2-[2-[2-(1,3-Benzodioxol-5-yloxy)ethylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	3000.0 [1]
	2-[2-[2-(3,4-Dimethoxyphenoxy)ethylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	690.0 [1]
	Methyl 4-[2-[2-(1,3-dioxobenzo[de]isoquinolin-2-yl)ethylamino]ethoxy]benzoate	Ki	4200.0 [1]
	2-[2-[2-(4-Methoxyanilino)ethylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	1080.0 [1]
	2-[2-[2-(2,4-Dimethoxyanilino)ethylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	4630.0 [1]
	2-[2-[(4-Methoxyphenyl)methylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	630.0 [1]
	2-[2-[(3-Methoxyphenyl)methylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	6220.0 [1]
	2-[2-[(3,4-Dimethoxyphenyl)methylamino]ethyl]benzo[de]isoquinoline-1,3-dione	Ki	4990.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 39 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Beta-N-acetyl-D-hexosaminidase-A/B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/beta-n-acetyl-d-hexosaminidase-a-b-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Beta-N-acetyl-D-hexosaminidase-A/B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/beta-n-acetyl-d-hexosaminidase-a-b-inhibitors-ic50-ki.
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