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Beta-chymotrypsin Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
RazaxabanKi2300.0 [1], 8500.0 [2]
2-[3-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide;hydrochlorideKi17000.0 [1]
Ethyl N-[(2S)-6-amino-1-oxo-1-[5-[[4-(2-phenylethoxy)phenyl]methyl]-1,2,4-oxadiazol-3-yl]hexan-2-yl]carbamateKi150000.0 [1]
QuercetinIC50100000.0 [1]
BortezomibKi320.0 [1]
1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadieneIC50120000.0 [1]
IndigoIC5090000.0 [1]
6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-oneIC5010000.0 [1]
RottlerinIC5025000.0 [1]
Bisindolylmaleimide IXIC5020000.0 [1]
IndirubinIC50100000.0 [1]
Jodphthalein sodiumIC5011000.0 [1]
2-[3-(Aminomethyl)phenyl]-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamideKi17000.0 [1]
Bms-740808Ki2800.0 [1]
4-(4-Bromophenylazo)phenolIC5025000.0 [1]
2-Oxo-N-[(1R)-1-phenylethyl]-4-phenylsulfanylazetidine-1-carboxamideIC5075000.0 [1]
1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamideIC5034000.0 [1]
4-[2-(2,4-Difluoroanilino)-4-thiazolyl]pyrocatecholIC50100000.0 [1]
2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimideIC50200000.0 [1]
1-(Benzyloxycarbonyl)-2,3-dihydro-1H-indole-2,3-dioneKi3800.0 [1]
4-[5-[(Z)-(5-Cyano-4-methyl-2,6-dioxopyridin-3-ylidene)methyl]furan-2-yl]benzenesulfonamideIC5074100.0 [1]
(3S)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1-(cyclopropylamino)-5,5-difluoro-1,2-dioxopentan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamideKi50000.0 [1]
(Z)-3-((4-Phenoxyphenylamino)methylene)isobenzofuran-1(3H)-oneIC5015000.0 [1]
Z-L-PhenylalaninolIC503000000.0 [1]
2-Isopropylamino-5-methyl-4H-3,1-benzoxazin-4-oneIC502000.0 [1]
2-(3-Amino-1,2-benzoxazol-5-yl)-N-[4-[2-[(dimethylamino)methyl]phenyl]-2-fluorophenyl]-5-(trifluoromethyl)pyrazole-3-carboxamideKi1500.0 [1]
[3-[(4-Cyanobenzoyl)amino]-2,2-dimethyl-5-phenylpentanoyl] 3-[(4-cyanobenzoyl)amino]-2,2-dimethyl-5-phenylpentanoateIC502.1 [1]
(3S,3As,6aR)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-2-[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(pyrazine-2-carbonylamino)butanoyl]amino]butanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamideKi50000.0 [1]
2-(3-Amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(2-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamideKi2300.0 [1]
(3S)-N-[(3S)-1-(Cyclopropylamino)-1,2-dioxohexan-3-yl]-2-[(2S)-2-[[(2S)-3,3-dimethyl-2-(pyrazine-2-carbonylamino)butanoyl]amino]-3,3-dimethylbutanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamideKi50000.0 [1]
1-(3-Amino-1,2-benzoxazol-5-yl)-6-[4-[2-[(dimethylamino)methyl]phenyl]phenyl]-5-methyl-3-(trifluoromethyl)pyrazolo[4,3-d]pyrimidin-7-oneKi11000.0 [1]
(3S,3As,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamideKi50000.0 [1]
(4R)-4-[[(2S)-2-Acetamido-3-carboxypropanoyl]amino]-5-[[(1S)-2-[[(2S)-1-[(2S,4R)-2-[[(1S)-1-carboxybutyl]carbamoyl]-4-(naphthalen-2-ylmethoxy)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-1-cyclohexyl-2-oxoethyl]amino]-5-oxopentanoic acidIC50300000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[1-(benzylcarbamoyl)-4-oxoazetidin-2-yl]oxy-4-methylpentan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamateIC508300.0 [1]
Tert-butyl N-[(2S)-3,3-dimethyl-1-[[(2S)-4-methyl-1-[4-oxo-1-[[(1R)-1-phenylethyl]carbamoyl]azetidin-2-yl]oxypentan-2-yl]amino]-1-oxobutan-2-yl]carbamateIC5075000.0 [1]
Tert-butyl N-[(2S)-3,3-dimethyl-1-[[(2S)-4-methyl-1-[4-oxo-1-[[(1S)-1-phenylethyl]carbamoyl]azetidin-2-yl]oxypentan-2-yl]amino]-1-oxobutan-2-yl]carbamateIC5075000.0 [1]
Tert-butyl N-[(2S)-1-[[(2S)-1-[1-(benzylcarbamoyl)-4-oxoazetidin-2-yl]sulfanyl-4-methylpentan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamateIC50800.0 [1]
2-Benzylsulfanyl-4-oxo-N-[(1R)-1-phenylethyl]azetidine-1-carboxamideIC5075000.0 [1]
2-Oxo-4-phenethylsulfanyl-N-[(1R)-1-phenylethyl]azetidine-1-carboxamideIC5075000.0 [1]
2-Oxo-N-[(1R)-1-phenylethyl]-4-(pyridin-4-ylmethylsulfanyl)azetidine-1-carboxamideIC5075000.0 [1]
2-Oxo-N-[(1R)-1-phenylethyl]-4-(pyridin-3-ylmethylsulfanyl)azetidine-1-carboxamideIC5075000.0 [1]
2-Oxo-N-[(1R)-1-phenylethyl]-4-(pyridin-2-ylmethylsulfanyl)azetidine-1-carboxamideIC5075000.0 [1]
2-Oxo-4-phenacylsulfanyl-N-[(1R)-1-phenylethyl]azetidine-1-carboxamideIC5075000.0 [1]
Tert-butyl 2-[4-[[4-oxo-1-[[(1R)-1-phenylethyl]carbamoyl]azetidin-2-yl]sulfanylmethyl]phenyl]acetateIC5075000.0 [1]
2-Oxo-N-[(1R)-1-phenylpropyl]-4-(pyridin-2-ylmethylsulfanyl)azetidine-1-carboxamideIC5075000.0 [1]
2-Oxo-N-(2-phenylmethoxyethyl)-4-(pyridin-2-ylmethylsulfanyl)azetidine-1-carboxamideIC5075000.0 [1]
N-[(1S)-2-Hydroxy-1-phenylethyl]-2-oxo-4-(pyridin-2-ylmethylsulfanyl)azetidine-1-carboxamideIC5075000.0 [1]
1-(3-Methylbenzoyl)-1H-indazole-3-carbonitrileIC5066.0 [1]
1-(4-Methoxyphenyl)-7-oxo-6-[4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl]pyrazolo[4,3-d]pyrimidine-3-carboxamideKi7930.0 [1]
N-[(1S)-1-(4-Aminophenyl)-2-[4-(2-fluoroethyl)piperidin-1-yl]-2-oxoethyl]-4-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]pyridine-3-sulfonamideKi115250.0 [1]
4-Hydroxybutyl (Z)-2-cyano-3-[(2-methyl-1-benzofuran-5-yl)amino]-3-[[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]amino]prop-2-enoateKi9420.0 [1]
(1E,6E)-4-(1,3-Dithian-2-ylidene)-1,7-bis(furan-2-yl)hepta-1,6-diene-3,5-dioneIC5090300.0 [1]
(1-Acetamido-2-phenylethyl)boronic acidKi6500.0 [1]
[(R)-alpha-(Acetylamino)phenethyl]boronic acidKi2100.0 [1]
6-Iodomethylene-4-phenyl-tetrahydro-pyran-2-oneKi5.3 [1]
6-Iodomethylene-5-phenyl-tetrahydro-pyran-2-oneKi55000.0 [1]
4-[(1-Hydroxynaphthalen-2-yl)diazenyl]naphthalene-1-sulfonic acidIC5090000.0 [1]
2-Phenylcarboxamidopropanoic anhydrideIC504600.0 [1]
1-(3-Amino-1,2-benzoxazol-5-yl)-6-[4-[2-[(dimethylamino)methyl]phenyl]phenyl]-3,5-dimethylpyrazolo[4,3-d]pyrimidin-7-oneKi960.0 [1]
1-(3-Amino-1,2-benzoxazol-5-yl)-6-[4-[2-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]phenyl]phenyl]-3,5-dimethylpyrazolo[4,3-d]pyrimidin-7-oneKi580.0 [1]
N-((S)-1-Mercaptomethyl-2-phenyl-ethyl)-acetamideIC50800000.0 [1]
6-[2-Fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl]-1-(4-methoxyphenyl)-7-oxopyrazolo[4,3-d]pyrimidine-3-carboxamideKi530.0 [1]
2-(3-Amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamideKi1700.0 [1]
1-(3-Amino-1,2-benzoxazol-5-yl)-6-[4-[2-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]phenyl]phenyl]-3-(trifluoromethyl)-4,5-dihydropyrazolo[4,3-d]pyrimidin-7-oneKi3240.0 [1]
N-[(2S)-3,4-Dioxo-1-phenyl-4-[2-[(5-pyridin-2-ylthiophen-2-yl)sulfonylamino]ethylamino]butan-2-yl]-2-ethyl-1,1-dioxo-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5010000.0 [1]
N-[(2S)-4-[2-(Benzenesulfonamido)ethylamino]-3,4-dioxo-1-phenylbutan-2-yl]-2-ethyl-1,1-dioxo-3,4,7,8-tetrahydro-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamideIC5010000.0 [1]
2-[(2S)-2-[[(2S)-2-(3,3-Dimethylbutanoylamino)-3,3-dimethylbutanoyl]amino]-4-methylpentyl]sulfanyl-4-oxo-N-[(1S)-1-phenylpropyl]azetidine-1-carboxamideIC5075000.0 [1]
N-(2-Phenyl ethyl)benzamide difluoroboraneKi650.0 [1]
N-(2-Phenyl ethyl)benzamide boronic acidKi650.0 [1]
2-Amino-N-(1-difluoroboranyl-2-phenylethyl)propanamideKi1400.0 [1]
2-Amino-N-[(R)-difluoroboranyl(phenyl)methyl]propanamideKi6500.0 [1]
2-Amino-N-[(1R)-1-difluoroboranyl-2-phenylethyl]propanamideKi290.0 [1]
2-Amino-N-[difluoroboranyl(phenyl)methyl]propanamideKi2000.0 [1]
N-Benzylbenzamide difluoroboraneKi5000.0 [1]
N-[(1R)-1-Difluoroboranyl-2-phenylethyl]acetamideKi1700.0 [1]
N-[(1R)-1-Difluoroboranyl-2-phenylethyl]benzamideKi270.0 [1]
[(1R)-1-Benzamido-2-phenylethyl]boronic acidKi360.0 [1]
[(1R)-1-(2-Aminopropanoylamino)-2-phenylethyl]boronic acidKi320.0 [1]
N-(1-Difluoroboranyl-2-phenylethyl)acetamideKi7400.0 [1]
Methyl (3S)-3-[[(2S)-1-[(2S)-2-[[(2S)-2-[(4-methoxy-4-oxobutanoyl)amino]propanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-2-oxo-4-phenylbutanoateKi79.0 [1]
Methyl 4-oxo-4-[[(2S)-1-oxo-1-[[(2S)-1-oxo-1-[(2S)-2-[[(2S)-4,4,4-trifluoro-3-oxo-1-phenylbutan-2-yl]carbamoyl]pyrrolidin-1-yl]propan-2-yl]amino]propan-2-yl]amino]butanoateKi17.0 [1]
(3-Benzamido-2,2-dimethylhexanoyl) 3-benzamido-2,2-dimethylhexanoateIC5049.0 [1]
(3-Benzamido-2,2-dimethylpropanoyl) 3-benzamido-2,2-dimethylpropanoateIC50140.0 [1]
[3-(Butanoylamino)-2,2-dimethyloctanoyl] 3-(butanoylamino)-2,2-dimethyloctanoateIC50810.0 [1]
(3-Benzamido-2,2-dimethylheptanoyl) 3-benzamido-2,2-dimethylheptanoateIC505.3 [1]
[3-(Butanoylamino)-2,2-dimethyl-5-phenylpentanoyl] 3-(butanoylamino)-2,2-dimethyl-5-phenylpentanoateIC50530.0 [1]
(3-Benzamido-2,2-dimethylpentanoyl) 3-benzamido-2,2-dimethylpentanoateIC5072.0 [1]
[3-(2-Chlorophenyl)-3-[(4-cyanobenzoyl)amino]-2,2-dimethylpropanoyl] 3-(2-chlorophenyl)-3-[(4-cyanobenzoyl)amino]-2,2-dimethylpropanoateIC50250.0 [1]
[3-[(4-Cyanobenzoyl)amino]-2,2-dimethyl-3-phenylpropanoyl] 3-[(4-cyanobenzoyl)amino]-2,2-dimethyl-3-phenylpropanoateIC5015.0 [1]
[3-[(4-Cyanobenzoyl)amino]-2,2-dimethyl-3-(2-methylphenyl)propanoyl] 3-[(4-cyanobenzoyl)amino]-2,2-dimethyl-3-(2-methylphenyl)propanoateIC50190.0 [1]
[3-[(4-Cyanobenzoyl)amino]-3-cyclohex-3-en-1-yl-2,2-dimethylpropanoyl] 3-[(4-cyanobenzoyl)amino]-3-cyclohex-3-en-1-yl-2,2-dimethylpropanoateIC50220.0 [1]
(3-Benzamido-2,2-dimethyloctanoyl) 3-benzamido-2,2-dimethyloctanoateIC5031.0 [1]
(3-Benzamido-2,2-dimethylnonanoyl) 3-benzamido-2,2-dimethylnonanoateIC5044.0 [1]
(3-Benzamido-5-phenylpentanoyl) 3-benzamido-5-phenylpentanoateIC5010000.0 [1]
N-((S)-1-Mercaptomethyl-2-phenyl-ethyl)-benzamideIC5023000.0 [1]
((S)-1-Mercaptomethyl-2-phenyl-ethyl)-carbamic acid benzyl esterIC503800.0 [1]
((R)-1-Mercaptomethyl-2-phenyl-ethyl)-carbamic acid benzyl esterIC506000.0 [1]
(S)-2-((S)-1-Mercaptomethyl-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl esterIC508000.0 [1]
(3S)-N-[1-[[(2R)-Butan-2-yl]amino]-1,2-dioxohexan-3-yl]-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamideKi50000.0 [1]
(3S)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]hexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamideKi50000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Beta-chymotrypsin Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/beta-chymotrypsin-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Beta-chymotrypsin Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/beta-chymotrypsin-inhibitors-ic50-ki.
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