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Beta-2 adrenergic receptor Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
SalmeterolIC505.01 [1]
1-[(7-Methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)-2-butanolIC500.49 [1], 0.74 [2], 1.2 [3], 2.3 [4], 2.5 [5]
1-[(7-Methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)-2-butanolKi0.13 [1], 1.0 [2]
PropranololIC5050.12 [1]
PropranololKi0.46 [1], 0.77 [2], 1.74 [3], 3.69 [4]
IsoprenalineKi2.44 [1], 46.0 [2], 169.0 [3], 192.0 [4], 676.08 [5]
SalbutamolIC501995.26 [1]
SalbutamolKi510.0 [1], 557.0 [2], 1828.0 [3]
2-(4-((2R)-2-(((2R)-2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxy)acetic acidIC503000.0 [1]
2-(4-((2R)-2-(((2R)-2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxy)acetic acidKi630.0 [1], 2850.0 [2]
R,R-FenoterolIC500.14 [1]
R,R-FenoterolKi4.0 [1], 345.0 [2], 346.74 [3]
5-[(1R)-1-Hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diolIC500.17 [1]
5-[(1R)-1-Hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diolKi4.09 [1], 474.0 [2], 478.63 [3]
5-[(1R)-1-Hydroxy-2-[[(2S)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diolIC502.01 [1]
5-[(1R)-1-Hydroxy-2-[[(2S)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diolKi26.1 [1], 1930.0 [2], 1949.84 [3]
(S,R)-(+)-FenoterolIC506.74 [1]
(S,R)-(+)-FenoterolKi1828.1 [1], 10232.93 [2], 10330.0 [3]
(R,S)-(-)-FenoterolIC506.09 [1]
(R,S)-(-)-FenoterolKi183.0 [1], 3695.0 [2], 3715.35 [3]
(S,S)-(+)-FenoterolIC50184.2 [1]
(S,S)-(+)-FenoterolKi3372.87 [1], 27542.29 [2], 27749.0 [3]
IndacaterolKi20.6 [1], 76.0 [2]
1-[(3,4,5-Trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diolIC506.1 [1]
1-[(3,4,5-Trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diolKi43.65 [1]
CID 9829836IC50190.0 [1], 3000.0 [2]
CID 9829836Ki160.0 [1]
L-796568 Free baseIC50670.0 [1], 2300.0 [2]
2-(2-Amino-1,3-thiazol-4-yl)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]acetamideIC5020000.0 [1]
5-[(1S)-1-Hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diolIC503.16 [1]
5-[(1S)-1-Hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diolKi91.3 [1], 5248.07 [2]
5-[(1S)-1-Hydroxy-2-[[(2S)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diolIC50337.2 [1]
5-[(1S)-1-Hydroxy-2-[[(2S)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diolKi2870.0 [1], 15848.93 [2]
5-[(1R)-1-Hydroxy-2-[[(2S)-1-naphthalen-1-ylpropan-2-yl]amino]ethyl]benzene-1,3-diolIC501.19 [1]
5-[(1R)-1-Hydroxy-2-[[(2S)-1-naphthalen-1-ylpropan-2-yl]amino]ethyl]benzene-1,3-diolKi338.84 [1], 341.0 [2]
5-[(1R)-1-Hydroxy-2-[[(2R)-1-naphthalen-1-ylpropan-2-yl]amino]ethyl]benzene-1,3-diolIC50229.1 [1]
5-[(1R)-1-Hydroxy-2-[[(2R)-1-naphthalen-1-ylpropan-2-yl]amino]ethyl]benzene-1,3-diolKi239.88 [1], 241.0 [2]
5-[(1R)-1-Hydroxy-2-[[(2R)-1-(4-methoxynaphthalen-1-yl)propan-2-yl]amino]ethyl]benzene-1,3-diolIC503.98 [1]
5-[(1R)-1-Hydroxy-2-[[(2R)-1-(4-methoxynaphthalen-1-yl)propan-2-yl]amino]ethyl]benzene-1,3-diolKi13.3 [1], 280.0 [2]
5-[(1R)-1-Hydroxy-2-[[(2R)-1-(4-hydroxyphenyl)butan-2-yl]amino]ethyl]benzene-1,3-diolIC501.44 [1]
5-[(1R)-1-Hydroxy-2-[[(2R)-1-(4-hydroxyphenyl)butan-2-yl]amino]ethyl]benzene-1,3-diolKi39.1 [1], 1270.0 [2]
5-[(1R)-1-Hydroxy-2-[[(2S)-1-(4-hydroxyphenyl)butan-2-yl]amino]ethyl]benzene-1,3-diolIC5017.88 [1]
5-[(1R)-1-Hydroxy-2-[[(2S)-1-(4-hydroxyphenyl)butan-2-yl]amino]ethyl]benzene-1,3-diolKi294.0 [1], 5760.0 [2]
5-[(1R)-1-Hydroxy-2-[[(2S)-1-(4-methoxynaphthalen-1-yl)propan-2-yl]amino]ethyl]benzene-1,3-diolIC504.37 [1]
5-[(1R)-1-Hydroxy-2-[[(2S)-1-(4-methoxynaphthalen-1-yl)propan-2-yl]amino]ethyl]benzene-1,3-diolKi12.7 [1], 320.0 [2]
5-[(1S)-1-Hydroxy-2-[[(2R)-1-naphthalen-1-ylpropan-2-yl]amino]ethyl]benzene-1,3-diolIC5014.8 [1]
5-[(1S)-1-Hydroxy-2-[[(2R)-1-naphthalen-1-ylpropan-2-yl]amino]ethyl]benzene-1,3-diolKi1778.28 [1], 1784.0 [2]
(6Ar,7R)-1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-7-olIC501.4 [1], 6.9 [2]
(6Ar,7R)-1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-7-olKi13.0 [1]
EpinephrineKi196.0 [1], 360.0 [2]
AtenololKi9549.93 [1], 10061.0 [2]
PindololKi0.38 [1], 0.4 [2]
TimololKi0.2 [1], 0.21 [2]
ClenbuterolKi28.0 [1], 570.0 [2]
LevalbuterolKi3801.89 [1], 4677.35 [2]
DarifenacinKi15.9 [1], 61.0 [2]
1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanolIC500.78 [1]
1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanolKi0.24 [1]
4-(3-Hexyl-2-oxoimidazol-1-yl)-N-[4-[2-[[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]benzenesulfonamideIC5012000.0 [1]
MilveterolKi3.16 [1]
1-Hexyl-3-[4-[[4-[2-[[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]sulfamoyl]phenyl]ureaIC503000.0 [1]
4-(3-Hexyl-2-oxoimidazolidin-1-yl)-N-[4-[2-[[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]benzenesulfonamideIC502300.0 [1]
1-[4-(Diphenylmethyl)piperazin-1-yl]-3-[(3-methyl-1H-indol-4-yl)oxy]propan-2-olKi0.3 [1], 0.31 [2]
1-(3,5-Diiodo-4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diolKi2.04 [1]
[3-[(2R)-2-[[(2R)-2-Hydroxy-2-[3-(thiophen-2-ylsulfonylamino)phenyl]ethyl]amino]propyl]-1H-indol-7-yl] methanesulfonateKi48.0 [1]
N-[4-[2-[[(2R)-2-Hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]-4-(3-octyl-2-oxoimidazolidin-1-yl)benzenesulfonamideIC50380.0 [1]
CID 16118894IC50120.0 [1]
1-(4-Methoxyphenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-olKi700.0 [1]
N-[4-[2-[[(2R)-2-Hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]-4-(3-octyl-2-oxoimidazol-1-yl)benzenesulfonamideIC50330.0 [1]
1-(Benzo[b]thiophen-2-yl)-N-methylmethanamineKi43200.0 [1], 373000.0 [2]
7-((R)-2-((1S,2S)-2-(Benzyloxy)cyclopentylamino)-1-hydroxyethyl)-4-hydroxybenzo[d]thiazol-2(3H)-oneKi2.5 [1], 6.1 [2]
4-[4-(3,4-Difluorophenyl)-1,3-thiazol-2-yl]-N-[4-[2-[[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]benzenesulfonamideIC501700.0 [1]
2-(Hydroxymethyl)-4-[2-hydroxy-3-[[1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-yl]amino]propoxy]phenolIC502250.0 [1]
2-(Hydroxymethyl)-4-[2-hydroxy-3-[[1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-yl]amino]propoxy]phenolKi14.0 [1]
1-[2-(2-Phenylphenoxy)ethylamino]propan-2-olKi9.0 [1], 470.0 [2]
6-[2-[[2-Hydroxy-3-(1H-indol-4-yloxy)propyl]amino]propoxy]-4H-1,4-benzoxazin-3-oneKi0.63 [1], 1.58 [2]
6-[2-[3-(1H-Indol-4-yloxy)propylamino]ethoxy]-4H-1,4-benzoxazin-3-oneKi1000.0 [1]
4-[(2S)-2-Hydroxy-3-[[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino]propoxy]-1,3-dihydrobenzimidazol-2-oneIC500.0 [1], 1.3 [2]
7-[(1R)-2-[[(1R,2R)-2-Cyclopentylcyclopentyl]amino]-1-hydroxyethyl]-4-hydroxy-3H-1,3-benzothiazol-2-oneKi0.6 [1], 0.8 [2]
(6S)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxamideIC5020000.0 [1]
(4R)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamideIC5020000.0 [1]
4-(3,5-Diiodo-4-methoxybenzyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-amineIC5056.0 [1]
4-(3,5-Diiodo-4-methoxybenzyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-amineKi426.58 [1]
1H-Indole-3-ethanamine, 5-methoxy-1-methyl-Ki20400.0 [1], 36200.0 [2]
Ethyl (1S,5R)-3-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]benzoyl]-3-azabicyclo[3.1.0]hexane-6-carboxylateIC5013400.0 [1], 20000.0 [2]
N-(1-Benzothiophen-2-ylmethyl)-3-methyloxetan-3-amineKi1000000.0 [1]
N-[2-(5-Methoxy-1-methylindol-3-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amineKi10400.0 [1], 25000.0 [2]
N-[[2-Fluoro-5-(trifluoromethoxy)phenyl]methyl]-2-(5-methoxy-1-methylindol-3-yl)ethanamineKi80400.0 [1], 83800.0 [2]
1-(2-Methylphenyl)-N-[(4-pyrimidin-2-ylphenyl)methyl]ethanamineKi4390.0 [1], 268000.0 [2]
3-(4-Chlorophenyl)-N-[2-(5-methoxy-1-methylindol-3-yl)ethyl]propan-1-amineKi520.0 [1], 3900.0 [2]
2-(Furan-2-yl)-2-[[4-(1,3-thiazol-2-yl)phenyl]methylamino]ethanolKi95400.0 [1], 1000000.0 [2]
4,4,4-Trifluoro-N-[[4-(1,3-thiazol-2-yl)phenyl]methyl]butan-2-amineKi52300.0 [1], 393000.0 [2]
5-[(1S)-1-Hydroxy-2-[[(2R)-1-phenylpropan-2-yl]amino]ethyl]benzene-1,3-diolKi22908.68 [1], 23125.0 [2]
5-[(1S)-1-Hydroxy-2-[[(2S)-1-phenylpropan-2-yl]amino]ethyl]benzene-1,3-diolKi28624.0 [1], 28840.32 [2]
(S)-(+)-5-(1-Hydroxy-2-phenethylaminoethyl)-1,3-benzenediolKi20417.38 [1], 20562.0 [2]
5-[(1S)-1-Hydroxy-2-[[(2S)-1-naphthalen-1-ylpropan-2-yl]amino]ethyl]benzene-1,3-diolKi2511.89 [1], 2535.0 [2]
Items per page: 1 - 10 of 96
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References

This online tool may be cited as follows

MLA

"Quest Database™ Beta-2 adrenergic receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/beta-2-adrenergic-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Beta-2 adrenergic receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/beta-2-adrenergic-receptor-inhibitors-ic50-ki.
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